{"id":23189,"date":"2026-03-26T09:27:48","date_gmt":"2026-03-26T01:27:48","guid":{"rendered":"https:\/\/stemcell-malaysia.com\/?p=23189"},"modified":"2026-07-17T19:35:01","modified_gmt":"2026-07-17T11:35:01","slug":"stem-cells-and-til-therapy-how-two-cancer-patients-responded-to-a-new-immune-cell-treatment","status":"publish","type":"post","link":"https:\/\/stemcell-malaysia.com\/zh\/stem-cells-and-til-therapy-how-two-cancer-patients-responded-to-a-new-immune-cell-treatment\/","title":{"rendered":"\u5e72\u7ec6\u80de\u4e0eTIL\u7597\u6cd5\uff1a\u4e24\u540d\u764c\u75c7\u60a3\u8005\u5bf9\u65b0\u578b\u514d\u75ab\u7ec6\u80de\u7597\u6cd5\u7684\u53cd\u5e94"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"23189\" class=\"elementor elementor-23189\" data-elementor-post-type=\"post\">\n\t\t\t\t        <section class=\"elementor-section elementor-top-section elementor-element elementor-element-5a6d5f85 elementor-section-boxed elementor-section-height-default 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data-index-in-node=\"108\">\u5e72\u7ec6\u80de\u4e0eTIL\u7597\u6cd5\uff1a\u4e24\u540d\u764c\u75c7\u60a3\u8005\u5bf9\u65b0\u578b\u514d\u75ab\u7ec6\u80de\u7597\u6cd5\u7684\u53cd\u5e94<\/b><\/h1>\n\n<figure><img decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/03\/pexels-mart-production-7089329-1024x683.jpg\" alt=\"\" \/><\/figure>\n\n<p class=\"wp-block-paragraph\" style=\"text-align: center;\"><em>\u4e86\u89e3\u5e72\u7ec6\u80de\uff08Stem Cells\uff09\u4e0e\u80bf\u7624\u6d78\u6da6\u6dcb\u5df4\u7ec6\u80de\uff08Tumor-Infiltrating Lymphocyte\uff0cTIL\uff09\u7597\u6cd5\u5982\u4f55\u5e2e\u52a9\u4e24\u540d\u5bab\u9888\u764c\u60a3\u8005\u5b9e\u73b0\u80bf\u7624\u63a7\u5236\uff0c\u5e76\u63d0\u4f9b\u6709\u5173\u5b89\u5168\u6027\u3001\u514d\u75ab\u53cd\u5e94\u53ca\u5176\u5bf9\u672a\u6765\u6cbb\u7597\u610f\u4e49\u7684\u4e34\u5e8a\u75c5\u4f8b\u6570\u636e\u3002<\/em><\/p>\n\n<h2 class=\"wp-block-heading\" style=\"text-align: center;\"><br 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src=\"https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/03\/pexels-wutthichai-charoenburi-553075115-19921278-1024x768.jpg\" alt=\"\" \/><\/figure>\n\n<p class=\"wp-block-paragraph\" style=\"text-align: center;\">\u8be5\u7814\u7a76\u8bb0\u5f55\u4e86\u4e24\u540d\u60a3\u6709\u665a\u671f\u5bab\u9888\u764c\u7684\u4e9a\u6d32\u5973\u6027\u63a5\u53d7\u81ea\u4f53TIL\u5355\u836f\u7597\u6cd5\uff08Autologous TIL Monotherapy\uff09\u7684\u75c5\u4f8b\u2014\u2014\u8fd9\u610f\u5473\u7740\u8be5\u6cbb\u7597\u4f7f\u7528\u4e86\u6bcf\u4f4d\u60a3\u8005\u81ea\u8eab\u7684\u514d\u75ab\u7ec6\u80de\uff0c\u4e14\u672a\u8054\u5408\u4f7f\u7528\u5316\u7597\u3002<\/p>\n\n<h3 class=\"wp-block-heading\" style=\"text-align: center;\"><br \/>\u60a3\u80051\uff1a68\u5c81\uff0cIV\u671f\uff0c\u56e0\u5316\u7597\u800c\u7cbe\u75b2\u529b\u7aed<\/h3>\n\n<p class=\"wp-block-paragraph\" data-path-to-node=\"10\">\u7b2c\u4e00\u4f4d\u60a3\u8005\u662f\u4e00\u540d68\u5c81\u7684\u5973\u6027\uff0c\u56e0\u51fa\u73b0\u9634\u9053\u6d41\u8840\uff0c\u4e8e2021\u5e7411\u6708\u88ab\u8bca\u65ad\u4e3aIV\u671f\u5bab\u9888\u9cde\u72b6\u7ec6\u80de\u764c\u3002\u5176\u8bca\u65ad\u901a\u8fc7\u6d3b\u68c0\u548cPET-CT\u6210\u50cf\u5f97\u5230\u8bc1\u5b9e\u3002<\/p>\n<p data-path-to-node=\"11\">\u57282021\u5e7410\u6708\u81f32022\u5e747\u6708\u671f\u95f4\uff0c\u5979\u63a5\u53d7\u4e8610\u4e2a\u5468\u671f\u7684\u5316\u7597\u3002\u6bcf\u4e00\u4e2a\u5468\u671f\u90fd\u8ba9\u5979\u51fa\u73b0\u4e25\u91cd\u7684\u9aa8\u9ad3\u6291\u5236\uff08Bone Marrow Suppression\uff09\u2014\u2014\u8fd9\u610f\u5473\u7740\u5979\u7684\u514d\u75ab\u548c\u8840\u7ec6\u80de\u751f\u6210\u53cd\u590d\u5d29\u6e83\uff0c\u6bcf\u6b21\u90fd\u9700\u8981\u5927\u7ea6\u4e00\u4e2a\u6708\u7684\u65f6\u95f4\u6765\u6062\u590d\u3002\u8fd9\u662f\u4e00\u4e2a\u4ee4\u4eba\u7cbe\u75b2\u529b\u7aed\u4e14\u6536\u76ca\u9012\u51cf\u7684\u5faa\u73af\u3002<\/p>\n<p data-path-to-node=\"12\">\u52302022\u5e747\u6708\uff0c\u5979\u7684\u80bf\u7624\u5df2\u957f\u81f34.5\u5398\u7c73\uff0c\u5e76\u4e14\u5728\u9ac2\u52a8\u8109\u9644\u8fd1\u51fa\u73b0\u4e86\u65b0\u7684\u8f6c\u79fb\u6027\u6dcb\u5df4\u7ed3\u53d7\u7d2f\u3002\u5979\u7684\u75c7\u72b6\u6b63\u5728\u6076\u5316\u3002\u5e38\u89c4\u6cbb\u7597\u663e\u7136\u5df2\u8fbe\u5230\u5176\u6781\u9650\u3002<\/p>\n\n<h3 class=\"wp-block-heading\" style=\"text-align: center;\">\u60a3\u80052\uff1a24\u5c81\uff0cIIIB\u671f\uff0c\u5c3d\u7ba1\u91c7\u53d6\u4e86\u4e00\u5207\u63aa\u65bd\u75be\u75c5\u4ecd\u5728\u8fdb\u5c55<\/h3>\n\n<p class=\"wp-block-paragraph\" data-path-to-node=\"14\">\u7b2c\u4e8c\u4f4d\u60a3\u8005\u662f\u4e00\u540d24\u5c81\u7684\u5973\u6027\uff0c\u4e8e2022\u5e7411\u6708\u88ab\u8bca\u65ad\u4e3aIIIB\u671f\u5bab\u9888\u817a\u764c\u3002\u5979\u63a5\u53d7\u4e86\u653e\u5c04\u6cbb\u7597\u3001\u5316\u7597\u4ee5\u53ca\u4e24\u8f6e\u5e15\u535a\u5229\u73e0\u5355\u6297\uff08Pembrolizumab\uff09\u2014\u2014\u4e00\u79cd\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\uff08Immune Checkpoint Inhibitor\uff09\u2014\u2014\u7684\u6cbb\u7597\uff0c\u4f46\u5979\u7684\u764c\u75c7\u7ee7\u7eed\u5feb\u901f\u8fdb\u5c55\u3002\u5979\u7684\u80bf\u7624\u4e9a\u578b\u4f3c\u4e4e\u5bf9\u6240\u63a5\u53d7\u7684\u6cbb\u7597\u53cd\u5e94\u4e0d\u4f73\u3002<\/p>\n<p data-path-to-node=\"15\">\u4e24\u540d\u60a3\u8005\u5728\u7b26\u5408\u7814\u7a76\u8d44\u683c\u6807\u51c6\u540e\uff0c\u5747\u88ab\u7eb3\u5165\u4e86\u4e00\u9879TIL\u7597\u6cd5\u7684\u4e34\u5e8a\u8bd5\u9a8c\u3002<\/p>\n\n<h2 class=\"wp-block-heading\" style=\"text-align: center;\"><br \/>\u6cbb\u7597\u5982\u4f55\u53d1\u6325\u4f5c\u7528<\/h2>\n\n<figure><img decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/03\/pexels-shkrabaanthony-6749715-1024x693.jpg\" alt=\"\" \/><\/figure>\n\n<p class=\"wp-block-paragraph\" data-path-to-node=\"17\">\u5728\u63a5\u53d7TIL\u56de\u8f93\u4e4b\u524d\uff0c\u4e24\u540d\u60a3\u8005\u90fd\u63a5\u53d7\u4e86\u6dcb\u5df4\u7ec6\u80de\u6e05\u9664\uff08Lymphodepletion\uff09\u2014\u2014\u8fd9\u662f\u4e00\u4e2a\u51c6\u5907\u6b65\u9aa4\uff0c\u53ef\u6682\u65f6\u6291\u5236\u73b0\u6709\u7684\u514d\u75ab\u73af\u5883\uff0c\u4e3a\u65b0\u56de\u8f93\u7684\u7ec6\u80de\u6709\u6548\u6269\u589e\u548c\u53d1\u6325\u529f\u80fd\u817e\u51fa\u7a7a\u95f4\u3002<\/p>\n<p data-path-to-node=\"18\">\u60a3\u80051\u5728100 mL\u7684\u8f93\u6db2\u4e2d\u63a5\u53d7\u4e861 \u00d7 10\u2079\u4e2aTIL\u7ec6\u80de\u3002\u60a3\u80052\u5728170 mL\u7684\u8f93\u6db2\u4e2d\u63a5\u53d7\u4e865.1 \u00d7 10\u2079\u4e2a\u7ec6\u80de\u7684\u66f4\u5927\u5242\u91cf\u3002\u56de\u8f93\u540e\uff0c\u4e24\u540d\u60a3\u8005\u5747\u63a5\u53d7\u4e86\u4e3a\u671f10\u5929\u7684\u5927\u5242\u91cf\u767d\u7ec6\u80de\u4ecb\u7d20-2\uff08Interleukin-2, IL-2\uff09\u6cbb\u7597\u2014\u2014\u8fd9\u662f\u4e00\u79cd\u7ec6\u80de\u56e0\u5b50\uff08Cytokine\uff09\uff0c\u6709\u52a9\u4e8e\u56de\u8f93\u7684T\u7ec6\u80de\u5728\u4f53\u5185\u4e3b\u8981\u5b58\u6d3b\u3001\u589e\u6b96\u5e76\u4fdd\u6301\u6d3b\u6027\u3002<\/p>\n\n<h2 class=\"wp-block-heading\" style=\"text-align: center;\"><br \/>\u63a5\u4e0b\u6765\u53d1\u751f\u4e86\u4ec0\u4e48<\/h2>\n\n<h3 class=\"wp-block-heading\" style=\"text-align: center;\">\u60a3\u80051\uff1a\u80bf\u7624\u7f29\u5c0f\u4e8633%<\/h3>\n\n<p class=\"wp-block-paragraph\" data-path-to-node=\"21\">\u5728TIL\u56de\u8f93\u516d\u5468\u540e\uff0c\u60a3\u80051\u5b9e\u73b0\u4e86\u90e8\u5206\u4e34\u5e8a\u7f13\u89e3\uff08Partial Clinical Response\uff09\u3002\u572812\u5468\u7684\u968f\u8bbf\u4e2d\uff0c\u5979\u7684\u80bf\u7624\u51fa\u73b0\u4e86\u53ef\u6d4b\u91cf\u7684\u7f29\u5c0f\u2014\u2014\u4ece\u57fa\u7ebf\uff08Baseline\uff09\u65f6\u76844.9\u5398\u7c73\u7f29\u5c0f\u5230\u516d\u5468\u65f6\u76843.3\u5398\u7c73\uff0c\u5e76\u5728\u7b2c12\u5468\u964d\u81f33.0\u5398\u7c73\u3002\u8fd9\u4ee3\u8868\u80bf\u7624\u4f53\u79ef\u7f29\u5c0f\u4e8633%\u3002\u5728\u6cbb\u7597\u524d\u4e0d\u65ad\u6076\u5316\u7684\u9634\u9053\u5206\u6ccc\u7269\u5b8c\u5168\u6d88\u5931\u4e86\u3002<\/p>\n<p 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class=\"wp-block-paragraph\">\u4e24\u540d\u60a3\u8005\u5728TIL\u56de\u8f93\u540e\u5747\u51fa\u73b0\u4e86\u526f\u4f5c\u7528\uff0c\u4f46\u90fd\u5f88\u8f7b\u5fae\uff0c\u5e76\u5728\u4e03\u5929\u5185\u6d88\u9000\uff0c\u65e0\u9700\u8fdb\u884c\u91cd\u5927\u7684\u533b\u7597\u5e72\u9884\u3002\u8fd9\u662f\u4e00\u4e2a\u503c\u5f97\u6ce8\u610f\u7684\u53d1\u73b0\uff0c\u7279\u522b\u662f\u4e0e\u60a3\u80051\u5728\u6bcf\u4e2a\u5316\u7597\u5468\u671f\u4e2d\u6240\u627f\u53d7\u7684\u4e25\u91cd\u9aa8\u9ad3\u6291\u5236\u76f8\u6bd4\u3002<\/p>\n\n<h2 class=\"wp-block-heading\" style=\"text-align: center;\"><br \/>\u8eab\u4f53\u5185\u90e8\u53d1\u751f\u4e86\u4ec0\u4e48<\/h2>\n\n<figure><img decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/03\/pexels-roger-brown-3435524-5149754-1024x683.jpg\" alt=\"\" \/><\/figure>\n\n<p class=\"wp-block-paragraph\" 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Cells\uff09\u2014\u2014\u514d\u75ab\u7cfb\u7edf\u7684\u4e3b\u8981\u6297\u764c\u7ec6\u80de\u2014\u2014\u7684\u6bd4\u4f8b\u66f4\u9ad8\u3002\u8fd9\u4e0eTIL\u7fa4\u4f53\u5728\u8840\u6d41\u4e2d\u6269\u589e\u5e76\u6301\u7eed\u5b58\u5728\uff0c\u800c\u4e0d\u662f\u5728\u56de\u8f93\u540e\u8fc5\u901f\u6d88\u9000\u7684\u60c5\u51b5\u76f8\u4e00\u81f4\u3002<\/p>\n<p data-path-to-node=\"31\">\u5728\u56de\u8f93\u540e\u56db\u5230\u516d\u5468\uff0c\u5e72\u6270\u7d20-\u03b3\uff08IFN-\u03b3\uff09\u548c\u80bf\u7624\u574f\u6b7b\u56e0\u5b50-\u03b1\uff08TNF-\u03b1\uff09\u2014\u2014\u4e24\u79cd\u4e0e\u6d3b\u8dc3\u7684\u6297\u80bf\u7624\u514d\u75ab\u6d3b\u6027\u5bc6\u5207\u76f8\u5173\u7684\u7ec6\u80de\u56e0\u5b50\u2014\u2014\u7684\u6c34\u5e73\u6025\u5267\u4e0a\u5347\u3002\u8fd9\u79cd\u7ec6\u80de\u56e0\u5b50\u6fc0\u589e\u7684\u65f6\u95f4\u4e0e\u5728\u516d\u5468\u548c12\u5468\u8bc4\u4f30\u4e2d\u89c2\u5bdf\u5230\u7684\u80bf\u7624\u6d88\u9000\u5bc6\u5207\u543b\u5408\uff0c\u8868\u660e\u514d\u75ab\u6fc0\u6d3b\u4e0e\u4e34\u5e8a\u53cd\u5e94\u4e4b\u95f4\u5b58\u5728\u751f\u7269\u5b66\u8054\u7cfb\u3002<\/p>\n<p data-path-to-node=\"32\">\u4ece\u6cbb\u7597\u540e\u7b2c4\u5929\u8d77\uff0c\u8fd8\u6ce8\u610f\u5230\u4e2d\u6027\u7c92\u7ec6\u80de\u8ba1\u6570\uff08Neutrophil Counts\uff09\u548cC\u53cd\u5e94\u86cb\u767d\uff08C-reactive Protein, CRP\uff09\u6c34\u5e73\u5347\u9ad8\u2014\u2014\u8fd9\u662f\u514d\u75ab\u53cd\u5e94\u6fc0\u6d3b\u7684\u6307\u6807\u3002CRP\u6c34\u5e73\u5728\u5927\u7ea6\u4e00\u4e2a\u6708\u5185\u6062\u590d\u5230\u63a5\u8fd1\u6b63\u5e38\u6c34\u5e73\uff0c\u8fd9\u8868\u660e\u8fd9\u662f\u4e00\u4e2a\u53d7\u63a7\u7684\u3001\u81ea\u9650\u6027\u7684\u8fc7\u7a0b\uff0c\u800c\u4e0d\u662f\u4e00\u79cd\u6301\u7eed\u7684\u708e\u75c7\u5e76\u53d1\u75c7\u3002<\/p>\n<h2 style=\"text-align: center;\"><br \/>\u4e3a\u4ec0\u4e48\u8fd9\u9879\u7814\u7a76\u5f88\u91cd\u8981<\/h2>\n\n<figure><img decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/03\/1-3-1024x634.jpg\" alt=\"\" \/><\/figure>\n\n<p class=\"wp-block-paragraph\" 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