{"id":22813,"date":"2026-03-10T09:10:56","date_gmt":"2026-03-10T01:10:56","guid":{"rendered":"https:\/\/stemcell-malaysia.com\/?p=22813"},"modified":"2026-07-17T19:35:25","modified_gmt":"2026-07-17T11:35:25","slug":"stem-cells-for-knee-osteoarthritis-sun-yat-sen-university-leads-phase-ii-clinical-trial-with-human-umbilical-cord-mesenchymal-stem-cells","status":"publish","type":"post","link":"https:\/\/stemcell-malaysia.com\/zh\/stem-cells-for-knee-osteoarthritis-sun-yat-sen-university-leads-phase-ii-clinical-trial-with-human-umbilical-cord-mesenchymal-stem-cells\/","title":{"rendered":"\u819d\u9aa8\u5173\u8282\u708e\u7684\u7ec6\u80de\u7597\u6cd5\uff1a\u4e2d\u5c71\u5927\u5b66\u7275\u5934\u5f00\u5c55\u4eba\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u4e8c\u671f\u4e34\u5e8a\u8bd5\u9a8c"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"22813\" class=\"elementor elementor-22813\" data-elementor-post-type=\"post\">\n\t\t\t\t        <section 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data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t\n<h1 style=\"text-align: center;\" data-path-to-node=\"1\">\u819d\u9aa8\u5173\u8282\u708e\u7684\u7ec6\u80de\u7597\u6cd5\uff1a\u4e2d\u5c71\u5927\u5b66\u7275\u5934\u5f00\u5c55\u4eba\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u4e8c\u671f\u4e34\u5e8a\u8bd5\u9a8c<\/h1>\n\n<figure><img decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/03\/5-1-1024x682.jpg\" alt=\"\" \/><\/figure>\n\n<p class=\"wp-block-paragraph\" style=\"text-align: center;\"><em>\u4e00\u9879\u591a\u4e2d\u5fc3\u4e8c\u671f\u4e34\u5e8a\u8bd5\u9a8c\u63a2\u7d22\u6e90\u81ea\u4eba\u8110\u5e26\u7684\u5e72\u7ec6\u80de\u7528\u4e8e\u6cbb\u7597\u819d\u9aa8\u5173\u8282\u708e\uff0c\u63a8\u52a8\u4e2d\u56fd\u5faa\u8bc1\u518d\u751f\u533b\u5b66\u7814\u7a76\u7684\u53d1\u5c55\u3002<\/em><\/p>\n\n<h2 class=\"wp-block-heading\" style=\"text-align: center;\"><br \/>\u819d\u9aa8\u5173\u8282\u708e\u7684\u5e72\u7ec6\u80de\u7597\u6cd5\uff1a\u4e00\u9879\u591a\u4e2d\u5fc3\u4e8c\u671f\u4e34\u5e8a\u8bd5\u9a8c\u5728\u534e\u5357\u5730\u533a\u521d\u5177\u89c4\u6a21<\/h2>\n\n<p class=\"wp-block-paragraph\" data-path-to-node=\"4\">\u5bf9\u4e8e\u76ee\u524d\u6cbb\u7597\u624b\u6bb5\u4ecd\u4ee5\u5bf9\u75c7\u4e3a\u4e3b\u7684\u819d\u9aa8\u5173\u8282\u708e\u60a3\u8005\u800c\u8a00\uff0c\u5e72\u7ec6\u80de\u80fd\u5426\u4e3a\u4ed6\u4eec\u63d0\u4f9b\u4e00\u6761\u5177\u6709\u4e34\u5e8a\u610f\u4e49\u7684\u51fa\u8def\uff1f\u4e2d\u5c71\u5927\u5b66\u9644\u5c5e\u7b2c\u4e00\u533b\u9662\u7684\u7814\u7a76\u4eba\u5458\u8ba4\u4e3a\uff0c\u76f8\u5173\u8bc1\u636e\u503c\u5f97\u4e25\u683c\u63a2\u7d22\u3002\u8be5\u673a\u6784\u7684\u9aa8\u663e\u5fae\u533b\u5b66\u90e8\u53d1\u8d77\u4e86\u4e00\u9879\u591a\u4e2d\u5fc3\u4e8c\u671f\u4e34\u5e8a\u8bd5\u9a8c\uff0c\u8bc4\u4f30\u4eba\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08Human Umbilical Cord Mesenchymal Stem Cells, UC-MSCs\uff09\u6ce8\u5c04\u6db2\u4f5c\u4e3a\u819d\u9aa8\u5173\u8282\u708e\uff08Knee Osteoarthritis, KOA\uff09\u6f5c\u5728\u5e72\u9884\u63aa\u65bd\u7684\u6548\u679c\u3002\u622a\u81f32026\u5e742\u6708\u4e0a\u65ec\uff0c\u9996\u6279\u5165\u7ec4\u53d7\u8bd5\u8005\u5df2\u63a5\u53d7\u4e86\u9996\u6b21\u7ed9\u836f\u3002<\/p>\n<p data-path-to-node=\"5\">\u8be5\u8bd5\u9a8c\u662f\u76ee\u524d\u4e2d\u56fd\u5728\u8be5\u6cbb\u7597\u9886\u57df\u6b63\u5728\u8fdb\u884c\u7684\u8f83\u4e3a\u5148\u8fdb\u7684\u5e72\u7ec6\u80de\u7814\u7a76\u4e4b\u4e00\uff0c\u5728\u56fd\u5bb6\u836f\u54c1\u76d1\u7763\u7ba1\u7406\u5c40\uff08National Medical Products Administration, NMPA\uff09\u7684\u76d1\u7ba1\u4e0b\u5f00\u5c55\uff0c\u5e76\u9075\u5faa\u56fd\u9645\u516c\u8ba4\u7684\u968f\u673a\u3001\u53cc\u76f2\u3001\u5e73\u884c\u5bf9\u7167\u4e34\u5e8a\u7814\u7a76\u6807\u51c6\u3002<\/p>\n\n<h2 class=\"wp-block-heading\" style=\"text-align: center;\"><br \/>\u4e86\u89e3\u819d\u9aa8\u5173\u8282\u708e\u53ca\u5f53\u524d\u6cbb\u7597\u7684\u5c40\u9650\u6027<\/h2>\n\n<p class=\"wp-block-paragraph\">\u819d\u9aa8\u5173\u8282\u708e\u662f\u4e00\u79cd\u6162\u6027\u9000\u884c\u6027\u5173\u8282\u75be\u75c5\uff0c\u4f1a\u663e\u8457\u964d\u4f4e\u60a3\u8005\u7684\u751f\u6d3b\u8d28\u91cf\u3002\u8be5\u75be\u75c5\u7684\u5b9a\u4e49\u4e3a\u819d\u5173\u8282\u5185\u5173\u8282\u8f6f\u9aa8\u3001\u534a\u6708\u677f\u548c\u6ed1\u819c\u7ec4\u7ec7\u7684\u8fdb\u884c\u6027\u9000\u5316\uff0c\u5176\u4e34\u5e8a\u8868\u73b0\u7279\u5f81\u4e3a\u6301\u7eed\u6027\u75bc\u75db\u3001\u5173\u8282\u80bf\u80c0\u3001\u6668\u50f5\u4ee5\u53ca\u6d3b\u52a8\u5ea6\u4e0b\u964d\u3002\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\uff0c\u5173\u8282\u7684\u7ed3\u6784\u6027\u635f\u4f24\u4f1a\u5bfc\u81f4\u53ef\u6d4b\u91cf\u7684\u529f\u80fd\u969c\u788d\uff0c\u9650\u5236\u60a3\u8005\u8fdb\u884c\u65e5\u5e38\u6d3b\u52a8\u7684\u80fd\u529b\u3002<\/p>\n\n<h3 class=\"wp-block-heading\" style=\"text-align: center;\"><br \/>\u6d41\u884c\u75c5\u5b66\u8d1f\u62c5<\/h3>\n\n<p class=\"wp-block-paragraph\" data-path-to-node=\"9\">\u968f\u7740\u4eba\u53e3\u8001\u9f84\u5316\u3001\u80a5\u80d6\u548c\u4e45\u5750\u751f\u6d3b\u65b9\u5f0f\u7684\u589e\u52a0\uff0c\u5168\u7403\u819d\u9aa8\u5173\u8282\u708e\u7684\u60a3\u75c5\u7387\u6301\u7eed\u4e0a\u5347\u3002\u5177\u4f53\u5230\u4e2d\u56fd\uff0c\u4e2d\u534e\u533b\u5b66\u4f1a\u9aa8\u79d1\u5b66\u5206\u4f1a\u5173\u8282\u5916\u79d1\u5b66\u7ec4\u53d1\u5e03\u7684\u300a\u9aa8\u5173\u8282\u708e\u8bca\u7597\u6307\u5357\uff082018\u5e74\u7248\uff09\u300b\u4e2d\u5f15\u7528\u7684\u6570\u636e\u663e\u793a\uff0c\u5728\u4e2d\u56fd\u4eba\u7fa4\u4e2d\uff0c\u75c7\u72b6\u6027\u819d\u9aa8\u5173\u8282\u708e\u2014\u2014\u5b9a\u4e49\u4e3aKellgren &amp; Lawrence (KL) \u653e\u5c04\u5b66\u8bc4\u5206\u8fbe\u5230II\u7ea7\u6216\u4ee5\u4e0a\uff0c\u5e76\u4f34\u6709\u819d\u5173\u8282\u75bc\u75db\u2014\u2014\u7684\u60a3\u75c5\u7387\u7ea6\u4e3a8.1%\u3002\u8003\u8651\u5230\u4e2d\u56fd\u7684\u4eba\u53e3\u89c4\u6a21\uff0c\u8fd9\u4e00\u6570\u5b57\u4ee3\u8868\u7740\u6570\u4ee5\u5343\u4e07\u8ba1\u7684\u4e2a\u4f53\u60a3\u6709\u8be5\u75be\u75c5\u3002<\/p>\n<p data-path-to-node=\"10\">\u57fa\u4e8e\u6807\u51c6\u5316X\u5c04\u7ebf\u8bc4\u4f30\u7684Kellgren &amp; Lawrence\u5206\u7ea7\u7cfb\u7edf\u5c06\u819d\u9aa8\u5173\u8282\u708e\u5206\u4e3a\u4e94\u4e2a\u9636\u6bb5\uff1a0\u7ea7\uff08\u6b63\u5e38\uff09\u3001I\u7ea7\uff08\u53ef\u7591\u72ed\u7a84\uff09\u3001II\u7ea7\uff08\u660e\u786e\u7684\u9aa8\u8d58\uff0c\u53ef\u80fd\u6709\u72ed\u7a84\uff09\u3001III\u7ea7\uff08\u4e2d\u7b49\u91cf\u591a\u53d1\u9aa8\u8d58\uff0c\u660e\u786e\u7684\u72ed\u7a84\uff09\u548cIV\u7ea7\uff08\u5927\u91cf\u9aa8\u8d58\uff0c\u660e\u663e\u7684\u72ed\u7a84\u548c\u4e25\u91cd\u7684\u786c\u5316\uff09\u3002\u8be5\u5206\u7ea7\u7cfb\u7edf\u662f\u4e34\u5e8a\u51b3\u7b56\u548c\u7814\u7a76\u65b9\u6848\u4e2d\u60a3\u8005\u5165\u7ec4\u6807\u51c6\u7684\u57fa\u7840\u3002<\/p>\n\n<h3 class=\"wp-block-heading\" style=\"text-align: center;\"><br \/>\u73b0\u6709\u7597\u6cd5\u7684\u4e0d\u8db3\u4e4b\u5904<\/h3>\n\n<p class=\"wp-block-paragraph\" data-path-to-node=\"12\">\u76ee\u524d\u9488\u5bf9\u819d\u9aa8\u5173\u8282\u708e\u7684\u6807\u51c6\u6cbb\u7597\u65b9\u6cd5\u5305\u62ec\u975e\u836f\u7269\u5e72\u9884\uff08\u5982\u7269\u7406\u6cbb\u7597\u3001\u4f53\u91cd\u7ba1\u7406\u548c\u77eb\u5f62\u652f\u6301\uff09\u3001\u836f\u7269\u7ba1\u7406\uff08\u5305\u62ec\u9547\u75db\u836f\u3001\u975e\u753e\u4f53\u6297\u708e\u836f\u4ee5\u53ca\u5173\u8282\u8154\u5185\u6ce8\u5c04\u76ae\u8d28\u7c7b\u56fa\u9187\u6216\u900f\u660e\u8d28\u9178\uff09\u4ee5\u53ca\u4ece\u5173\u8282\u955c\u6e05\u7406\u672f\u5230\u5168\u819d\u5173\u8282\u7f6e\u6362\u672f\u7684\u5916\u79d1\u624b\u672f\u3002\u867d\u7136\u8fd9\u4e9b\u65b9\u6cd5\u4e2d\u7684\u6bcf\u4e00\u79cd\u90fd\u5728\u63a7\u5236\u75bc\u75db\u548c\u51cf\u7f13\u529f\u80fd\u8870\u9000\u65b9\u9762\u8bc1\u660e\u4e86\u7597\u6548\uff0c\u4f46\u6ca1\u6709\u4efb\u4f55\u4e00\u79cd\u80fd\u591f\u5c06\u53d7\u635f\u7684\u5173\u8282\u8f6f\u9aa8\u6709\u610f\u4e49\u5730\u6062\u590d\u5230\u5176\u539f\u6709\u7684\u7ed3\u6784\u548c\u751f\u7269\u529b\u5b66\u72b6\u6001\u3002<\/p>\n<p data-path-to-node=\"13\">\u5916\u79d1\u624b\u672f\u5c24\u5176\u662f\u5e26\u6709\u56fa\u6709\u98ce\u9669\uff0c\u5e76\u4e14\u53ef\u80fd\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\u9700\u8981\u8fdb\u884c\u7ffb\u4fee\u624b\u672f\u2014\u2014\u8fd9\u589e\u52a0\u4e86\u60a3\u8005\u7684\u4e34\u5e8a\u590d\u6742\u6027\u548c\u7ecf\u6d4e\u8d1f\u62c5\u3002\u8fd9\u79cd\u6301\u7eed\u5b58\u5728\u7684\u6cbb\u7597\u7a7a\u767d\u5c06\u5927\u91cf\u7684\u7814\u7a76\u6ce8\u610f\u529b\u5f15\u5411\u4e86\u518d\u751f\u65b9\u6cd5\uff0c\u5305\u62ec\u5e94\u7528\u80fd\u591f\u5728\u7ec6\u80de\u6c34\u5e73\u4e0a\u4fc3\u8fdb\u7ec4\u7ec7\u4fee\u590d\u7684\u5e72\u7ec6\u80de\u3002<\/p>\n\n<h2 class=\"wp-block-heading\" style=\"text-align: center;\"><br \/>\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5728\u5173\u8282\u4fee\u590d\u4e2d\u7684\u79d1\u5b66\u4f9d\u636e<\/h2>\n\n<figure><img decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/03\/6-1024x1017.jpeg\" alt=\"\" \/><\/figure>\n\n<p class=\"wp-block-paragraph\">\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08Mesenchymal Stem Cells, MSCs\uff09\u7531\u4e8e\u5176\u5145\u5206\u8868\u5f81\u7684\u514d\u75ab\u8c03\u8282\u7279\u6027\u548c\u5df2\u8bc1\u5b9e\u7684\u8de8\u80da\u5c42\u5206\u5316\u80fd\u529b\uff0c\u5728\u808c\u8089\u9aa8\u9abc\u533b\u5b66\u9886\u57df\u5f15\u8d77\u4e86\u6301\u7eed\u7684\u79d1\u5b66\u5174\u8da3\u3002\u4e0e\u80da\u80ce\u5e72\u7ec6\u80de\u4e0d\u540c\uff0cMSCs\u53ef\u4ee5\u6765\u6e90\u4e8e\u591a\u79cd\u6210\u4f53\u548c\u56f4\u4ea7\u671f\u7ec4\u7ec7\u2014\u2014\u5305\u62ec\u9aa8\u9ad3\u3001\u8102\u80aa\u7ec4\u7ec7\u548c\u8110\u5e26\u2014\u2014\u6bcf\u79cd\u6765\u6e90\u90fd\u4e3a\u4e34\u5e8a\u5e94\u7528\u63d0\u4f9b\u4e86\u4e0d\u540c\u7684\u5b9e\u8df5\u548c\u751f\u7269\u5b66\u8003\u91cf\u3002<\/p>\n\n<h3 class=\"wp-block-heading\" style=\"text-align: center;\"><br \/>\u4e3a\u4ec0\u4e48\u7814\u7a76\u4eba\u8110\u5e26MSCs<\/h3>\n\n<figure><img decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/03\/9-1024x683.jpg\" alt=\"\" \/><\/figure>\n\n<p class=\"wp-block-paragraph\" data-path-to-node=\"17\">\u6e90\u81ea\u4eba\u8110\u5e26\u7684\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08UC-MSCs\uff09\u5728\u518d\u751f\u533b\u5b66\u5e94\u7528\u4e2d\u5907\u53d7\u5173\u6ce8\u3002UC-MSCs\u662f\u5728\u8db3\u6708\u5206\u5a29\u540e\u4ece\u5e9f\u5f03\u7684\u8110\u5e26\u7ec4\u7ec7\u7684\u534e\u901a\u6c0f\u80f6\uff08Wharton&#8217;s jelly\uff09\u4e2d\u91c7\u96c6\u7684\uff0c\u5728\u4f26\u7406\u4e0a\u88ab\u8ba4\u4e3a\u662f\u6613\u4e8e\u6536\u96c6\u7684\uff0c\u5e76\u4e14\u5728\u5b9e\u9a8c\u5ba4\u6761\u4ef6\u4e0b\u8868\u73b0\u51fa\u826f\u597d\u7684\u589e\u6b96\u7279\u6027\u3002<\/p>\n<p 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src=\"https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/03\/1-1-1024x684.jpg\" alt=\"\" \/><\/figure>\n\n<p class=\"wp-block-paragraph\">\u901a\u8fc7\u81f4\u529b\u4e8e\u591a\u4e2d\u5fc3\u3001\u968f\u673a\u3001\u53cc\u76f2\u548c\u5e73\u884c\u5bf9\u7167\u7684\u4e8c\u671f\u8bbe\u8ba1\uff0c\u4e2d\u5c71\u5927\u5b66\u7684\u7814\u7a76\u56e2\u961f\u6b63\u5728\u5c06\u672c\u7814\u7a76\u5b9a\u4f4d\u4e3a\u751f\u6210\u65b9\u6cd5\u5b66\u4e0a\u7a33\u5065\u7684\u6570\u636e\uff0c\u56fd\u9645\u76d1\u7ba1\u673a\u6784\u3001\u4e34\u5e8a\u6307\u5357\u59d4\u5458\u4f1a\u548c\u7cfb\u7edf\u8bc4\u4ef7\u673a\u6784\u5c06\u6b64\u7c7b\u6570\u636e\u89c6\u4e3a\u5faa\u8bc1\u5b9e\u8df5\u6807\u51c6\u7684\u57fa\u7840\u3002<\/p>\n\n<h3 class=\"wp-block-heading\" style=\"text-align: center;\"><br \/>\u5bf9\u518d\u751f\u9aa8\u79d1\u5faa\u8bc1\u533b\u5b66\u7684\u8d21\u732e<\/h3>\n\n<p 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