{"id":24600,"date":"2026-04-27T14:05:27","date_gmt":"2026-04-27T06:05:27","guid":{"rendered":"https:\/\/stemcell-malaysia.com\/?page_id=24600"},"modified":"2026-04-27T14:05:29","modified_gmt":"2026-04-27T06:05:29","slug":"mild-cognitive-impairment","status":"publish","type":"page","link":"https:\/\/stemcell-malaysia.com\/zh\/conditions\/mild-cognitive-impairment\/","title":{"rendered":"\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u5e72\u7ec6\u80de\u7597\u6cd5 | \u8ba4\u77e5\u80fd\u529b\u4e0b\u964d\u80fd\u5426\u5728\u6f14\u53d8\u4e3a\u75f4\u5446\u75c7\u4e4b\u524d\u88ab\u51cf\u7f13\uff1f"},"content":{"rendered":"\n

\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u5e72\u7ec6\u80de\u7597\u6cd5 | \u8ba4\u77e5\u80fd\u529b\u4e0b\u964d\u80fd\u5426\u5728\u6f14\u53d8\u4e3a\u75f4\u5446\u75c7\u4e4b\u524d\u88ab\u51cf\u7f13\uff1f<\/h1>\n\n\n
\n
\"\u4e00\u5e45\u672a\u6765\u4e3b\u4e49\u7684
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\u4f60\u66fe\u7ecf\u5728\u542c\u5230\u540d\u5b57\u7684\u90a3\u4e00\u523b\u5c31\u80fd\u8bb0\u4f4f\u5b83\u4eec\u3002\u73b0\u5728\u5374\u51fa\u73b0\u4e86\u7a7a\u767d\u2014\u2014\u60f3\u8981\u60f3\u8d77\u4ec0\u4e48\uff0c\u5374\u4e0d\u518d\u50cf\u4ee5\u524d\u90a3\u6837\u8fc5\u901f\u3002<\/p>\n\n\n\n

\u4f60\u786e\u4fe1\u81ea\u5df1\u5df2\u7ecf\u8bb0\u4f4f\u7684\u8d2d\u7269\u6e05\u5355\uff0c\u5728\u5230\u8fbe\u5546\u5e97\u65f6\u5374\u5fd8\u5f97\u4e00\u5e72\u4e8c\u51c0\u3002\u4e0a\u5468\u9884\u7ea6\u7684\u4f1a\u8bae\u51fa\u73b0\u5728\u4f60\u7684\u65e5\u5386\u4e0a\uff0c\u4f46\u4f60\u5b8c\u5168\u4e0d\u8bb0\u5f97\u66fe\u5b89\u6392\u8fc7\u5b83\u3002\u4f60\u53d1\u73b0\u81ea\u5df1\u8bdd\u8bf4\u5230\u4e00\u534a\uff0c\u5374\u5728\u7b49\u5f85\u4e00\u4e2a\u66fe\u7ecf\u53ef\u4ee5\u6beb\u4e0d\u8d39\u529b\u5c31\u60f3\u8d77\u6765\u7684\u8bcd\u3002<\/p>\n\n\n\n

\u8fd9\u4e9b\u65f6\u523b\u6700\u521d\u53ef\u80fd\u53ea\u662f\u5076\u5c14\u53d1\u751f\u3002\u5982\u679c\u4f60\u6b63\u5728\u9605\u8bfb\u8fd9\u7bc7\u6587\u7ae0\uff0c\u5b83\u4eec\u53ef\u80fd\u8ba9\u4f60\u89c9\u5f97\u4e0d\u518d\u53ea\u662f\u5076\u7136\u4e86\u3002<\/p>\n\n\n\n

\u5982\u679c\u533b\u751f\u544a\u8bc9\u4f60\u60a3\u6709\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\uff08Mild Cognitive Impairment, MCI\uff09\uff0c\u4f60\u6240\u9762\u4e34\u7684\u8fd9\u4e2a\u8bca\u65ad\u5f80\u5f80\u4f34\u968f\u7740\u6781\u5c11\u7684\u4e34\u5e8a\u6307\u5bfc\u3002\u4f60\u5f88\u53ef\u80fd\u88ab\u544a\u77e5\u8981\u591a\u953b\u70bc\u3001\u5065\u5eb7\u996e\u98df\u3001\u4fdd\u6301\u5927\u8111\u6d3b\u8dc3\uff0c\u7136\u540e\u4e00\u5e74\u540e\u518d\u6765\u590d\u8bca\u3002\u4f60\u6ca1\u6709\u88ab\u544a\u77e5\u7684\u662f\uff0c\u9664\u4e86\u76d1\u6d4b\u4e4b\u5916\uff0c\u533b\u5b66\u5b9e\u9645\u4e0a\u80fd\u505a\u4e9b\u4ec0\u4e48\u6765\u51cf\u7f13\u4f60\u5927\u8111\u5185\u90e8\u6b63\u5728\u53d1\u751f\u7684\u4e8b\u60c5\u3002<\/p>\n\n\n\n

\u6839\u636e\u5168\u7403\u75be\u75c5\u8d1f\u62c5\u7814\u7a76\uff08Global Burden of Disease study\uff09\uff0c\u622a\u81f3 2019 \u5e74\uff0c\u5168\u7403\u4f30\u8ba1\u6709 6880 \u4e07\u4eba\u60a3\u6709\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\uff08MCI\uff09\u3002\u5176\u4e2d\uff0c\u5927\u7ea6 10% \u5230 15% \u7684\u4eba\u6bcf\u5e74\u4f1a\u53d1\u5c55\u4e3a\u75f4\u5446\u75c7\u3002\u5728\u60a3\u6709\u9057\u5fd8\u578b\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\uff08Amnestic MCI\uff0c\u4ee5\u8bb0\u5fc6\u529b\u51cf\u9000\u4e3a\u4e3b\u8981\u7279\u5f81\u7684\u4e9a\u578b\uff09\u7684\u4eba\u7fa4\u4e2d\uff0c\u5982\u679c\u6ca1\u6709\u91c7\u53d6\u4efb\u4f55\u6539\u53d8\u75c5\u7a0b\u8f68\u8ff9\u7684\u63aa\u65bd\uff0c\u5927\u7ea6\u4e00\u534a\u7684\u4eba\u5c06\u5728\u4e94\u5e74\u5185\u53d1\u5c55\u4e3a\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\uff08Alzheimer’s disease\uff09\u3002<\/p>\n\n\n\n

\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u5e72\u7ec6\u80de\u7597\u6cd5\u662f\u76ee\u524d\u6d3b\u8dc3\u7684\u4e34\u5e8a\u7814\u7a76\u9886\u57df\u3002\u5b83\u4e0d\u662f\u6cbb\u6108\u65b9\u6cd5\uff0c\u6211\u4eec\u4e5f\u4e0d\u4f1a\u6697\u793a\u5b83\u662f\u3002\u4f46\u5b83\u662f\u4e00\u79cd\u5728\u751f\u7269\u5b66\u4e0a\u8fde\u8d2f\u7684\u65b9\u6cd5\uff0c\u5e76\u62e5\u6709\u8d8a\u6765\u8d8a\u591a\u7ecf\u8fc7\u540c\u884c\u8bc4\u5ba1\u7684\u8bc1\u636e\u652f\u6301\u2014\u2014\u800c\u4e14\uff0c\u5bf9\u4e8e\u5927\u591a\u6570 MCI \u60a3\u8005\u6765\u8bf4\uff0c\u4ed6\u4eec\u4ece\u672a\u542c\u8fc7\u4e34\u5e8a\u56e2\u961f\u7528\u5177\u4f53\u7684\u6570\u636e\u3001\u8bda\u5b9e\u5730\u8ba8\u8bba\u8fc7\u8fd9\u79cd\u65b9\u6cd5\uff0c\u4e00\u4e2a\u4e5f\u4f1a\u5728\u7b54\u6848\u662f\u5426\u5b9a\u65f6\u5766\u8bda\u76f8\u544a\u7684\u56e2\u961f\u3002<\/p>\n\n\n\n

\u6211\u4eec\u7684\u603b\u90e8\u8bbe\u5728\u9a6c\u6765\u897f\u4e9a\u3002\u6211\u4eec\u7684\u56e2\u961f\u5728\u518d\u751f\u533b\u5b66\u9886\u57df\u5de5\u4f5c\u4e86\u4e03\u5e74\u591a\uff0c\u4f7f\u7528\u540c\u79cd\u5f02\u4f53\uff08\u4f9b\u4f53\u6765\u6e90\uff09\u8110\u5e26\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08Mesenchymal Stem Cells, MSCs\uff09\u6cbb\u7597\u4e86 200 \u591a\u540d\u60a3\u6709\u5404\u79cd\u75be\u75c5\u7684\u60a3\u8005\u3002\u672c\u6587\u5c06\u4ecb\u7ecd\u4e34\u5e8a\u8bc1\u636e\u663e\u793a\u4e86\u4ec0\u4e48\uff0c\u672a\u663e\u793a\u4ec0\u4e48\uff0c\u4ee5\u53ca\u8c01\u662f\u2014\u2014\u8c01\u53c8\u4e0d\u662f\u2014\u2014\u8fd9\u79cd\u65b9\u6cd5\u7684\u73b0\u5b9e\u5019\u9009\u4eba\u3002<\/p>\n\n\n\n

<\/div>\n\n\n\n

\u76ee\u5f55<\/mark><\/h2>\n\n\n
  1. \u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u671f\u95f4\u5927\u8111\u5185\u90e8\u53d1\u751f\u4e86\u4ec0\u4e48<\/a>
    1. \u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u4e2d\u8bb0\u5fc6\u529b\u4e27\u5931\u7684\u751f\u7269\u5b66\u673a\u5236<\/a><\/li>
    2. \u4e3a\u4ec0\u4e48\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u7684\u5927\u8111\u65e0\u6cd5\u81ea\u6211\u4fee\u590d<\/a><\/li><\/ol><\/li>
    3. \u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u6807\u51c6\u62a4\u7406\u4e2d\u7684\u7a7a\u767d<\/a>
      1. \u4f20\u7edf\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u6cbb\u7597\u80fd\u505a\u4ec0\u4e48\u548c\u4e0d\u80fd\u505a\u4ec0\u4e48<\/a><\/li>
      2. \u4e3a\u4ec0\u4e48\u201c\u89c2\u5bdf\u548c\u7b49\u5f85\u201d\u8ba9\u8bb8\u591a\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u60a3\u8005\u611f\u5230\u4e0d\u8db3<\/a><\/li><\/ol><\/li>
      3. \u4e34\u5e8a\u8bc1\u636e\u5bf9\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u5e72\u7ec6\u80de\u7597\u6cd5\u6709\u4f55\u542f\u793a<\/a>
        1. \u5173\u4e8e MSCs \u7597\u6cd5\u6cbb\u7597\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u548c\u8ba4\u77e5\u80fd\u529b\u4e0b\u964d\u7684\u5173\u952e\u4e34\u5e8a\u7814\u7a76<\/a><\/li>
        2. \u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u60a3\u8005\u63a5\u53d7\u5e72\u7ec6\u80de\u7597\u6cd5\u540e\u7684\u73b0\u5b9e\u6539\u5584\u60c5\u51b5<\/a><\/li><\/ol><\/li>
        3. \u5e72\u7ec6\u80de\u5982\u4f55\u5e94\u5bf9\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u7684\u751f\u7269\u5b66\u673a\u5236<\/a>
          1. MSCs \u7597\u6cd5\u5728\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u4e2d\u7684\u4e09\u79cd\u751f\u7269\u5b66\u673a\u5236<\/a><\/li>
          2. \u4e3a\u4ec0\u4e48\u9a6c\u6765\u897f\u4e9a\u4f7f\u7528\u540c\u79cd\u5f02\u4f53\u8110\u5e26\u884d\u751f MSCs \u6cbb\u7597\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d<\/a><\/li><\/ol><\/li>
          3. \u8c01\u662f\u2014\u2014\u8c01\u53c8\u4e0d\u662f\u2014\u2014\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u5e72\u7ec6\u80de\u7597\u6cd5\u7684\u5408\u9002\u5019\u9009\u4eba<\/a>
            1. \u5f80\u5f80\u5bf9 MSCs \u6cbb\u7597\u53cd\u5e94\u66f4\u597d\u7684\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u7c7b\u578b<\/a><\/li>
            2. \u4ec0\u4e48\u65f6\u5019\u5e72\u7ec6\u80de\u7597\u6cd5\u4e0d\u662f\u6cbb\u7597\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u7684\u6b63\u786e\u9014\u5f84<\/a><\/li><\/ol><\/li>
            3. \u4e00\u4f4d\u60a3\u8005\u5728\u9a6c\u6765\u897f\u4e9a\u63a5\u53d7\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u5e72\u7ec6\u80de\u7597\u6cd5\u7684\u7ecf\u5386<\/a>
              1. \u5728\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u671f\u95f4\uff0c\u5728\u60c5\u51b5\u53d8\u5f97\u66f4\u7cdf\u4e4b\u524d\u91c7\u53d6\u884c\u52a8\u7684\u51b3\u5b9a<\/a><\/li>
              2. \u63a5\u53d7\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u5e72\u7ec6\u80de\u6cbb\u7597\u540e\u6539\u53d8\u4e86\u4ec0\u4e48\u2014\u2014\u4ee5\u53ca\u6ca1\u6709\u6539\u53d8\u4ec0\u4e48<\/a><\/li>
              3. \u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u5e72\u7ec6\u80de\u6cbb\u7597\u540e\u7684\u6062\u590d\u548c\u968f\u8bbf<\/a><\/li><\/ol><\/li>
              4. \u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u5e72\u7ec6\u80de\u7597\u6cd5\u7684\u771f\u5b9e\u98ce\u9669\u4e0e\u5c40\u9650\u6027<\/a>
                1. \u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u7684\u5df2\u77e5\u526f\u4f5c\u7528\u548c\u5b89\u5168\u6570\u636e<\/a><\/li>
                2. \u5e72\u7ec6\u80de\u7597\u6cd5\u4e0d\u80fd\u4e3a\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u505a\u4ec0\u4e48<\/a><\/li><\/ol><\/li>
                3. \u5173\u4e8e\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u5e72\u7ec6\u80de\u7597\u6cd5\u7684\u5e38\u89c1\u95ee\u9898<\/a><\/li>
                4. \u5982\u679c\u60a8\u60a3\u6709\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\uff0c\u4e0b\u4e00\u6b65\u8be5\u600e\u4e48\u505a\uff1f<\/a><\/li>
                5. \u53c2\u8003<\/a><\/li><\/ol><\/div>\n\n\n
                  <\/div>\n\n\n\n

                  \u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u671f\u95f4\u5927\u8111\u5185\u90e8\u53d1\u751f\u4e86\u4ec0\u4e48<\/mark><\/h2>\n\n\n\n

                  \u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u4e2d\u8bb0\u5fc6\u529b\u4e27\u5931\u7684\u751f\u7269\u5b66\u673a\u5236<\/h3>\n\n\n\n

                  \u5927\u8111\u5305\u542b\u5927\u7ea6 860 \u4ebf\u4e2a\u795e\u7ecf\u5143\u2014\u2014\u8fd9\u4e9b\u795e\u7ecf\u7ec6\u80de\u901a\u8fc7\u5e9e\u5927\u7684\u7535\u5316\u5b66\u4fe1\u53f7\u7f51\u7edc\u8fdb\u884c\u4ea4\u6d41\u3002\u8fd9\u4e9b\u795e\u7ecf\u5143\u5728\u79f0\u4e3a\u7a81\u89e6\u7684\u8fde\u63a5\u5904\u76f8\u8fde\uff0c\u5728\u4e00\u4e2a\u7ec6\u80de\u91ca\u653e\u5316\u5b66\u4fe1\u4f7f\uff08\u795e\u7ecf\u9012\u8d28\uff09\u7a7f\u8fc7\u5fae\u5c0f\u7684\u95f4\u9699\u5e76\u6fc0\u6d3b\u4e0b\u4e00\u4e2a\u7ec6\u80de\u3002\u8fd9\u5c31\u662f\u8bb0\u5fc6\u5f62\u6210\u3001\u5b58\u50a8\u548c\u63d0\u53d6\u7684\u65b9\u5f0f\u3002<\/p>\n\n\n\n

                  \u5728\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u4e2d\uff0c\u8fd9\u4e2a\u8fc7\u7a0b\u5f00\u59cb\u5728\u7279\u5b9a\u533a\u57df\u51fa\u73b0\u6545\u969c\u3002\u6d77\u9a6c\u4f53\u2014\u2014\u5927\u8111\u5f62\u6210\u65b0\u8bb0\u5fc6\u7684\u4e3b\u8981\u7ed3\u6784\u2014\u2014\u901a\u5e38\u662f\u6700\u65e9\u53d7\u5f71\u54cd\u7684\u533a\u57df\u3002\u6d77\u9a6c\u4f53\u53ca\u5176\u5468\u56f4\u7684\u795e\u7ecf\u5143\u5f00\u59cb\u5931\u53bb\u8fde\u63a5\u3001\u840e\u7f29\uff0c\u5e76\u5728\u67d0\u4e9b\u60c5\u51b5\u4e0b\u6b7b\u4ea1\uff0c\u8fd9\u65e9\u5728\u5168\u9762\u75f4\u5446\u75c7\u53d1\u5c55\u4e4b\u524d\u5c31\u5df2\u7ecf\u53d1\u751f\u4e86\u3002<\/p>\n\n\n\n

                  \u6709\u4e24\u4e2a\u8fc7\u7a0b\u662f\u8fd9\u79cd\u6545\u969c\u7684\u6838\u5fc3\uff0c\u5e76\u4e14\u8fd9\u4e24\u4e2a\u8fc7\u7a0b\u5728\u751f\u7269\u5b66\u4e0a\u4e0e\u5e72\u7ec6\u80de\u7597\u6cd5\u65e8\u5728\u53d1\u6325\u4f5c\u7528\u7684\u65b9\u5f0f\u5bc6\u5207\u76f8\u5173\u3002<\/p>\n\n\n\n

                  \u7b2c\u4e00\u4e2a\u662f\u795e\u7ecf\u708e\u75c7\uff08Neuroinflammation\uff09\u2014\u2014\u5927\u8111\u5185\u90e8\u7684\u6162\u6027\u708e\u75c7\u3002\u5927\u8111\u6709\u81ea\u8eab\u7684\u514d\u75ab\u7ec6\u80de\uff0c\u79f0\u4e3a\u5c0f\u80f6\u8d28\u7ec6\u80de\uff08Microglia\uff09\uff0c\u5176\u6b63\u5e38\u4f5c\u7528\u662f\u4fdd\u62a4\u795e\u7ecf\u5143\u514d\u53d7\u611f\u67d3\u5e76\u6e05\u9664\u7ec6\u80de\u788e\u7247\u3002\u5728 MCI \u4e2d\uff0c\u8fd9\u4e9b\u5c0f\u80f6\u8d28\u7ec6\u80de\u4ece\u4fdd\u62a4\u89d2\u8272\u8f6c\u53d8\u4e3a\u7834\u574f\u89d2\u8272\uff0c\u91ca\u653e\u51fa\u708e\u75c7\u5206\u5b50\uff0c\u635f\u5bb3\u4e86\u5b83\u4eec\u672c\u5e94\u4fdd\u62a4\u7684\u795e\u7ecf\u5143\u3002\u8fd9\u4e0d\u662f\u77ed\u6682\u7684\u514d\u75ab\u53cd\u5e94\u2014\u2014\u5b83\u662f\u4e00\u79cd\u6301\u7eed\u7684\u3001\u4f4e\u7a0b\u5ea6\u7684\u201c\u71c3\u70e7\u201d\uff0c\u63a8\u52a8\u7740\u8ba4\u77e5\u80fd\u529b\u7684\u4e0b\u964d\u3002<\/p>\n\n\n\n

                  \u7b2c\u4e8c\u4e2a\u662f\u795e\u7ecf\u8425\u517b\u652f\u6301\u7684\u4e27\u5931\u3002\u795e\u7ecf\u5143\u4fdd\u6301\u5065\u5eb7\u90e8\u5206\u662f\u901a\u8fc7\u79f0\u4e3a\u795e\u7ecf\u8425\u517b\u56e0\u5b50\u7684\u86cb\u767d\u8d28\u7684\u4f5c\u7528\u3002\u5176\u4e2d\u6700\u91cd\u8981\u7684\u662f\u8111\u6e90\u6027\u795e\u7ecf\u8425\u517b\u56e0\u5b50\uff08Brain-Derived Neurotrophic Factor, BDNF\uff09\uff0c\u5b83\u53ef\u4ee5\u88ab\u8ba4\u4e3a\u662f\u5927\u8111\u7ec6\u80de\u7684\u201c\u80a5\u6599\u201d\u3002BDNF \u652f\u6301\u795e\u7ecf\u5143\u5b58\u6d3b\uff0c\u9f13\u52b1\u7ef4\u6301\u7a81\u89e6\u8fde\u63a5\uff0c\u5e76\u4fdd\u62a4\u8bb0\u5fc6\u6240\u4f9d\u8d56\u7684\u8ba4\u77e5\u7075\u6d3b\u6027\u3002\u5728 MCI \u4e2d\uff0c\u6d77\u9a6c\u4f53\u53ca\u5176\u5468\u56f4\u533a\u57df\u7684 BDNF \u6c34\u5e73\u59cb\u7ec8\u4f4e\u4e8e\u540c\u9f84\u7684\u8ba4\u77e5\u6b63\u5e38\u6210\u5e74\u4eba\u3002<\/p>\n\n\n\n

                  \u8fd9\u4e24\u4e2a\u8fc7\u7a0b\u2014\u2014\u795e\u7ecf\u708e\u75c7\u548c\u795e\u7ecf\u8425\u517b\u5265\u593a\u2014\u2014\u6b63\u662f MSCs \u7597\u6cd5\u65e8\u5728\u89e3\u51b3\u7684\u9776\u70b9\u3002<\/p>\n\n\n\n

                  <\/div>\n\n\n\n

                  \u4e3a\u4ec0\u4e48\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u7684\u5927\u8111\u65e0\u6cd5\u81ea\u6211\u4fee\u590d<\/h3>\n\n\n\n

                  \u809d\u810f\u5728\u53d7\u635f\u540e\u53ef\u4ee5\u518d\u751f\u5176\u5927\u90e8\u5206\uff0c\u76ae\u80a4\u53ef\u4ee5\u5728\u51e0\u5929\u5185\u6108\u5408\u53ef\u89c1\u7684\u4f24\u53e3\uff0c\u4e0e\u6b64\u4e0d\u540c\uff0c\u6210\u5e74\u4eba\u7684\u5927\u8111\u51e0\u4e4e\u6ca1\u6709\u80fd\u529b\u66ff\u6362\u5df2\u7ecf\u4e22\u5931\u7684\u795e\u7ecf\u5143\u3002<\/p>\n\n\n\n

                  \u8fd9\u662f MCI \u7684\u6838\u5fc3\u751f\u7269\u5b66\u73b0\u5b9e\u3002\u5df2\u7ecf\u6b7b\u4ea1\u7684\u795e\u7ecf\u5143\u4e0d\u4f1a\u590d\u6d3b\u3002\u5df2\u7ecf\u88ab\u5207\u65ad\u7684\u8fde\u63a5\u4e0d\u4f1a\u81ea\u53d1\u5730\u91cd\u65b0\u5f62\u6210\u3002<\/p>\n\n\n\n

                  \u5927\u8111\u6240\u80fd\u505a\u7684\u2014\u2014\u5728\u6b63\u786e\u7684\u751f\u7269\u5b66\u652f\u6301\u4e0b\u2014\u2014\u662f\u4fdd\u62a4\u6b8b\u5b58\u7684\u795e\u7ecf\u5143\uff0c\u7ef4\u6301\u4ecd\u7136\u5b8c\u597d\u7684\u8fde\u63a5\uff0c\u5e76\u51cf\u7f13\u8fdb\u4e00\u6b65\u635f\u4f24\u7d2f\u79ef\u7684\u901f\u5ea6\u3002<\/p>\n\n\n\n

                  \u8fd9\u79cd\u6709\u9650\u4f46\u771f\u5b9e\u7684\u7a97\u53e3\u671f\uff0c\u4f7f\u5f97 MCI \u6210\u4e3a\u6bd4\u5df2\u786e\u8bca\u7684\u665a\u671f\u75f4\u5446\u75c7\u66f4\u6709\u5e0c\u671b\u7684\u5e72\u7ec6\u80de\u7597\u6cd5\u9776\u70b9\u3002\u5728\u4e25\u91cd\u7684\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u4e2d\uff0c\u7ed3\u6784\u6027\u635f\u4f24\u5982\u6b64\u5e7f\u6cdb\uff0c\u4ee5\u81f3\u4e8e\u5e72\u9884\u7684\u751f\u7269\u5b66\u7a7a\u95f4\u53d7\u5230\u4e25\u91cd\u9650\u5236\u3002\u5728 MCI \u4e2d\uff0c\u4ecd\u7136\u5b58\u5728\u5927\u91cf\u5b58\u6d3b\u7684\u795e\u7ecf\u7ec4\u7ec7\u3002\u4e34\u5e8a\u95ee\u9898\u5728\u4e8e\uff0c\u662f\u5426\u53ef\u4ee5\u5728\u66f4\u591a\u7ec4\u7ec7\u4e22\u5931\u4e4b\u524d\u652f\u6301\u548c\u4fdd\u62a4\u8fd9\u4e9b\u7ec4\u7ec7\u2014\u2014\u4ee5\u53ca\u8fd9\u6837\u505a\u662f\u5426\u5bf9\u8eab\u5904\u8be5\u5927\u8111\u4e2d\u7684\u4eba\u4ea7\u751f\u6709\u610f\u4e49\u7684\u6539\u53d8\u3002<\/p>\n\n\n\n

                  <\/div>\n\n\n\n

                  \u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u6807\u51c6\u62a4\u7406\u4e2d\u7684\u7a7a\u767d<\/mark><\/h2>\n\n\n\n

                  \u4f20\u7edf\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u6cbb\u7597\u80fd\u505a\u4ec0\u4e48\u548c\u4e0d\u80fd\u505a\u4ec0\u4e48<\/h3>\n\n\n\n

                  \u76ee\u524d\u6ca1\u6709\u6279\u51c6\u7528\u4e8e\u6cbb\u7597\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u7684\u836f\u7269\u3002\u8fd9\u4e0d\u662f\u533b\u5b66\u754c\u5ffd\u89c6\u7684\u7a7a\u767d\u2014\u2014\u5b83\u53cd\u6620\u4e86\u4f17\u591a\u5927\u578b\u4e34\u5e8a\u8bd5\u9a8c\u7684\u7ed3\u679c\u3002<\/p>\n\n\n\n

                  \u6279\u51c6\u7528\u4e8e\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7684\u836f\u7269\u2014\u2014\u4f8b\u5982\u589e\u52a0\u795e\u7ecf\u9012\u8d28\u4e59\u9170\u80c6\u78b1\u53ef\u7528\u6027\u7684\u80c6\u78b1\u916f\u9176\u6291\u5236\u5242\uff08Cholinesterase inhibitors\uff09\u591a\u5948\u54cc\u9f50\uff08Donepezil\uff09\u548c\u5361\u5df4\u62c9\u6c40\uff08Rivastigmine\uff09\uff0c\u4ee5\u53ca\u8c03\u8282\u4e0d\u540c\u4fe1\u53f7\u901a\u8def\u7684\u7f8e\u91d1\u521a\uff08Memantine\uff09\u2014\u2014\u5df2\u7ecf\u5728 MCI \u4eba\u7fa4\u4e2d\u8fdb\u884c\u4e86\u7814\u7a76\u3002\u8fd9\u4e9b\u836f\u7269\u90fd\u6ca1\u6709\u8bc1\u660e\u80fd\u591f\u663e\u8457\u964d\u4f4e\u8fdb\u5c55\u4e3a\u75f4\u5446\u75c7\u7684\u98ce\u9669\uff0c\u6216\u5728\u5904\u4e8e MCI \u9636\u6bb5\u7684\u4eba\u7fa4\u4e2d\u5b9e\u73b0\u8ba4\u77e5\u8bc4\u5206\u7684\u6301\u7eed\u6539\u5584\u3002<\/p>\n\n\n\n

                  \u56e0\u6b64\uff0c\u5927\u591a\u6570\u795e\u7ecf\u79d1\u533b\u751f\u548c\u8001\u5e74\u75c5\u5b66\u5bb6\u9075\u5faa\u7684\u6307\u5357\u5efa\u8bae\uff1a\u7ba1\u7406\u5fc3\u8840\u7ba1\u5371\u9669\u56e0\u7d20\uff08\u8840\u538b\u3001\u80c6\u56fa\u9187\u3001\u8840\u7cd6\uff09\uff0c\u6bcf\u5468\u8fdb\u884c 150 \u5206\u949f\u6216\u66f4\u957f\u65f6\u95f4\u7684\u6709\u6c27\u8fd0\u52a8\uff0c\u53c2\u4e0e\u8ba4\u77e5\u6d3b\u52a8\u548c\u7cbe\u795e\u523a\u6fc0\uff0c\u4fdd\u6301\u5145\u8db3\u7684\u7761\u7720\uff0c\u4ee5\u53ca\u5b9a\u671f\u76d1\u6d4b\u2014\u2014\u901a\u5e38\u662f\u6bcf\u5e74\u6216\u6bcf\u534a\u5e74\u8fdb\u884c\u4e00\u6b21\u795e\u7ecf\u5fc3\u7406\u5b66\u8bc4\u4f30\u3002<\/p>\n\n\n\n

                  \u8fd9\u4e9b\u5efa\u8bae\u662f\u771f\u6b63\u57fa\u4e8e\u8bc1\u636e\u7684\u3002\u5fc3\u8840\u7ba1\u5065\u5eb7\u4e0e\u5927\u8111\u5065\u5eb7\u5bc6\u5207\u76f8\u5173\uff0c\u6162\u6027\u8840\u7ba1\u75be\u75c5\u662f\u8ba4\u77e5\u80fd\u529b\u4e0b\u964d\u6700\u5f3a\u7684\u53ef\u6539\u53d8\u98ce\u9669\u56e0\u7d20\u4e4b\u4e00\u3002\u5728\u591a\u9879\u968f\u673a\u8bd5\u9a8c\u4e2d\uff0c\u6709\u6c27\u8fd0\u52a8\u5df2\u88ab\u8bc1\u660e\u53ef\u4ee5\u589e\u52a0\u9ad8\u98ce\u9669\u4eba\u7fa4\u7684\u6d77\u9a6c\u4f53\u4f53\u79ef\u5e76\u51cf\u7f13\u8ba4\u77e5\u80fd\u529b\u9000\u5316\u3002\u6211\u4eec\u7edd\u4e0d\u8f7b\u89c6\u8fd9\u4e9b\u751f\u6d3b\u65b9\u5f0f\u56e0\u7d20\uff0c\u5e76\u5c06\u5b83\u4eec\u89c6\u4e3a\u4efb\u4f55\u989d\u5916\u5e72\u9884\u7684\u5fc5\u8981\u57fa\u7840\u3002<\/p>\n\n\n\n

                  \u8fd9\u79cd\u65b9\u6cd5\u7684\u5c40\u9650\u6027\u5728\u4e8e\u7ed3\u6784\u6027\u7684\u3002\u8fd9\u4e9b\u5efa\u8bae\u662f\u5728\u7ba1\u7406\u98ce\u9669\u3002\u5b83\u4eec\u5e76\u6ca1\u6709\u89e3\u51b3\u63a8\u52a8\u75c5\u60c5\u5b9e\u65f6\u53d1\u5c55\u7684\u6d3b\u8dc3\u751f\u7269\u5b66\u8fc7\u7a0b\u2014\u2014\u795e\u7ecf\u708e\u75c7\u3001\u7a81\u89e6\u9000\u5316\u3001\u795e\u7ecf\u8425\u517b\u4e0b\u964d\u3002\u5bf9\u4e8e\u90a3\u4e9b\u5c3d\u7ba1\u4f18\u5316\u4e86\u751f\u6d3b\u65b9\u5f0f\u4f46 MCI \u4ecd\u5728\u8fdb\u5c55\u7684\u60a3\u8005\u6765\u8bf4\uff0c\u533b\u5b66\u5728\u751f\u7269\u5b66\u4e0a\u8fd8\u80fd\u505a\u4e9b\u4ec0\u4e48\u7684\u95ee\u9898\u53d8\u5f97\u7d27\u8feb\u8d77\u6765\uff0c\u800c\u8fd9\u662f\u6807\u51c6\u4e34\u5e8a\u53cd\u5e94\u672a\u80fd\u627f\u8ba4\u7684\u3002<\/p>\n\n\n\n

                  <\/div>\n\n\n\n

                  \u4e3a\u4ec0\u4e48\u201c\u89c2\u5bdf\u548c\u7b49\u5f85\u201d\u8ba9\u8bb8\u591a\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u60a3\u8005\u611f\u5230\u4e0d\u8db3<\/h3>\n\n\n\n

                  \u201c\u76d1\u6d4b\u5e76\u4e00\u5e74\u540e\u518d\u6765\u201d\u7684\u5efa\u8bae\u5728\u4e34\u5e8a\u4e0a\u662f\u7ad9\u5f97\u4f4f\u811a\u7684\uff0c\u4f46\u5728\u60c5\u611f\u4e0a\u5374\u4ee5\u4e00\u79cd\u7279\u5b9a\u7684\u65b9\u5f0f\u8ba9\u4eba\u96be\u4ee5\u63a5\u53d7\u3002<\/p>\n\n\n\n

                  \u5bf9\u5927\u591a\u6570\u60a3\u8005\u6765\u8bf4\uff0cMCI \u5177\u6709\u65b9\u5411\u6027\u3002\u5b83\u4e0d\u4f1a\u4fdd\u6301\u4e0d\u53d8\u3002\u53d8\u5316\u7684\u901f\u5ea6\u5404\u4e0d\u76f8\u540c\u2014\u2014\u5c11\u6570 MCI \u60a3\u8005\u5728\u4e94\u5e74\u5185\u4e0d\u4f1a\u53d1\u5c55\u4e3a\u75f4\u5446\u75c7\u2014\u2014\u4f46\u5bf9\u4e8e\u90a3\u4e9b\u6b63\u5728\u8fdb\u5c55\u7684\u60a3\u8005\u6765\u8bf4\uff0c\u6bcf\u4e00\u5e74\u90fd\u4ee3\u8868\u7740\u65e0\u6cd5\u6062\u590d\u7684\u5b9e\u9645\u8ba4\u77e5\u9886\u57df\u7684\u4e27\u5931\u3002<\/p>\n\n\n\n

                  \u53d8\u5f97\u8d8a\u6765\u8d8a\u96be\u505a\u51fa\u7684\u51b3\u5b9a\uff0c\u8d8a\u6765\u8d8a\u96be\u8ddf\u4e0a\u7684\u5bf9\u8bdd\uff0c\u5f00\u59cb\u9700\u8981\u66f4\u591a\u52aa\u529b\u624d\u80fd\u7ef4\u6301\u7684\u72ec\u7acb\u6027\u2014\u2014\u8fd9\u4e9b\u7d2f\u79ef\u8d77\u6765\uff0c\u5bf9\u6b63\u5728\u7ecf\u5386\u8fd9\u4e9b\u7684\u4eba\u4ee5\u53ca\u4ed6\u4eec\u5468\u56f4\u7684\u4eba\u6765\u8bf4\uff0c\u6709\u7740\u6df1\u523b\u7684\u5f71\u54cd\u3002<\/p>\n\n\n\n

                  \u6765\u5230\u6211\u4eec\u8bca\u6240\u7684\u60a3\u8005\u5e76\u4e0d\u662f\u653e\u5f03\u751f\u6d3b\u65b9\u5f0f\u7ba1\u7406\u7684\u4eba\u3002\u4ed6\u4eec\u901a\u5e38\u662f\u5df2\u7ecf\u505a\u4e86\u6240\u6709\u88ab\u544a\u77e5\u8981\u505a\u7684\u4e8b\u60c5\uff0c\u5374\u773c\u7741\u7741\u770b\u7740\u81ea\u5df1\u7684\u8ba4\u77e5\u80fd\u529b\u7ee7\u7eed\u6539\u53d8\u7684\u4eba\u3002\u4ed6\u4eec\u60f3\u77e5\u9053\u533b\u5b66\u662f\u5426\u80fd\u63d0\u4f9b\u66f4\u591a\u5e2e\u52a9\u2014\u2014\u5177\u4f53\u6765\u8bf4\uff0c\u662f\u9488\u5bf9\u8ba4\u77e5\u8870\u9000\u7684\u751f\u7269\u5b66\u673a\u5236\uff0c\u800c\u4e0d\u4ec5\u4ec5\u662f\u5176\u540e\u679c\u8fdb\u884c\u5e72\u9884\u7684\u65b9\u6cd5\u3002<\/p>\n\n\n\n

                  <\/div>\n\n\n\n

                  \u4e34\u5e8a\u8bc1\u636e\u5bf9\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u5e72\u7ec6\u80de\u7597\u6cd5\u6709\u4f55\u542f\u793a<\/mark><\/h2>\n\n\n
                  \n
                  \"\u56fe\u8868\u663e\u793a\u4e86\u63a5\u53d7\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u6cbb\u7597\u7684\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u60a3\u8005\u4e0e\u5b89\u6170\u5242\u7ec4\u5728
                  \u5728\u5df2\u53d1\u8868\u7684 I\/IIa \u671f\u8bd5\u9a8c\u4e2d\uff0c\u4e0e\u5b89\u6170\u5242\u7ec4\u76f8\u6bd4\uff0c\u9488\u5bf9\u8f7b\u5ea6\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u548c\u9057\u5fd8\u578b\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u4eba\u7fa4\u7684 MSCs \u7597\u6cd5\u964d\u4f4e\u4e86\u7b80\u6613\u7cbe\u795e\u72b6\u6001\u68c0\u67e5\uff08Mini-Mental State Examination, MMSE\uff09\u548c\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u8bc4\u4f30\u91cf\u8868\u8ba4\u77e5\u5b50\u91cf\u8868\uff08Alzheimer’s Disease Assessment Scale Cognitive subscale, ADAS-Cog\uff09\u7684\u4e0b\u964d\u901f\u5ea6\u3002\u5728 12 \u81f3 24 \u4e2a\u6708\u7684\u968f\u8bbf\u4e2d\uff0c\u8fd9\u79cd\u76ca\u5904\u6bd4 6 \u4e2a\u6708\u65f6\u66f4\u4e3a\u660e\u663e\u3002<\/figcaption><\/figure>\n<\/div>\n\n\n

                  \u5173\u4e8e MSCs \u7597\u6cd5\u6cbb\u7597\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u548c\u8ba4\u77e5\u80fd\u529b\u4e0b\u964d\u7684\u5173\u952e\u4e34\u5e8a\u7814\u7a76<\/h3>\n\n\n\n

                  \u5728\u5217\u51fa\u6570\u636e\u4e4b\u524d\uff0c\u5fc5\u987b\u8bf4\u660e\u4e00\u4e2a\u91cd\u8981\u7684\u900f\u660e\u5ea6\u95ee\u9898\uff1a\u5173\u4e8e\u4eba\u7c7b\u53d7\u8bd5\u8005\u63a5\u53d7 MSCs \u7597\u6cd5\u7684\u6700\u4e25\u8c28\u3001\u5df2\u53d1\u8868\u7684\u4e34\u5e8a\u7814\u7a76\uff0c\u4e3b\u8981\u662f\u5728\u8f7b\u5ea6\u81f3\u4e2d\u5ea6\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u4eba\u7fa4\u4e2d\u8fdb\u884c\u7684\uff0c\u800c\u4e0d\u662f\u4e13\u95e8\u9488\u5bf9 MCI\u3002\u8fd9\u503c\u5f97\u660e\u786e\u6307\u51fa\u3002\u9057\u5fd8\u578b\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\uff08Amnestic MCI\uff09\u2014\u2014\u4ee5\u8bb0\u5fc6\u4e3a\u4e2d\u5fc3\u7684\u4e9a\u578b\u2014\u2014\u73b0\u5728\u88ab\u7814\u7a76\u4eba\u5458\u5e7f\u6cdb\u8ba4\u4e3a\u662f\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u8fde\u7eed\u7edf\u4e00\u4f53\u7684\u6700\u65e9\u4e34\u5e8a\u9636\u6bb5\uff0c\u5e76\u4e14\u5176\u751f\u7269\u5b66\u673a\u5236\u5b58\u5728\u5927\u91cf\u91cd\u53e0\u3002\u4f46\u8fd9\u4e9b\u4eba\u7fa4\u5e76\u4e0d\u5b8c\u5168\u76f8\u540c\uff0c\u8bc1\u636e\u5728\u6240\u6709\u60c5\u51b5\u4e0b\u662f\u63a8\u65ad\u5f97\u51fa\u7684\uff0c\u800c\u4e0d\u662f\u76f4\u63a5\u9002\u7528\u7684\u3002<\/p>\n\n\n\n

                  \u5728\u5efa\u7acb\u8fd9\u4e00\u80cc\u666f\u4e4b\u540e\uff0c\u4ee5\u4e0b\u662f\u5df2\u516c\u5e03\u7684\u6570\u636e\u6240\u663e\u793a\u7684\u3002<\/p>\n\n\n\n

                  \u6700\u4e25\u8c28\u7684\u5df2\u5b8c\u6210\u8bd5\u9a8c\u4e4b\u4e00\u662f NEUROSTEM \u7814\u7a76\uff0c\u8fd9\u662f\u7531 Kwon \u53ca\u5176\u540c\u4e8b\u5728\u97e9\u56fd\u8fdb\u884c\u7684\u4e00\u9879 I\/IIa \u671f\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\uff0c\u53d1\u8868\u5728 2021 \u5e74\u7684\u300a\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7814\u7a76\u4e0e\u6cbb\u7597\u300b\uff08Alzheimer’s Research and Therapy\uff09\u4e0a\u3002\u8be5\u8bd5\u9a8c\u62db\u52df\u4e86 45 \u540d\u8f7b\u5ea6\u81f3\u4e2d\u5ea6\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u60a3\u8005\uff0c\u5e76\u65bd\u7528\u4e86\u4e24\u79cd\u5242\u91cf\u7684\u8110\u5e26\u8840\u884d\u751f\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff0c\u540c\u65f6\u4e0e\u5b89\u6170\u5242\u7ec4\u8fdb\u884c\u4e86\u6bd4\u8f83\u3002\u4e24\u4e2a\u5242\u91cf\u7ec4\u90fd\u8fbe\u5230\u4e86\u4e3b\u8981\u7684\u5b89\u5168\u7ec8\u70b9\uff1a\u6ca1\u6709\u4e25\u91cd\u7684\u4e0d\u826f\u4e8b\u4ef6\u5f52\u56e0\u4e8e\u5e72\u7ec6\u80de\u3002\u5728\u8f83\u9ad8\u5242\u91cf\u7ec4\u4e2d\uff0cADAS-Cog\uff08\u4e00\u79cd\u5728\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\u5e7f\u6cdb\u4f7f\u7528\u7684\u6807\u51c6\u5316\u8bb0\u5fc6\u3001\u8bed\u8a00\u548c\u6ce8\u610f\u529b\u6d4b\u8bd5\uff09\u7684\u4e0b\u964d\u901f\u5ea6\u5728 24 \u4e2a\u6708\u65f6\u660e\u663e\u6162\u4e8e\u5b89\u6170\u5242\u7ec4\u3002<\/p>\n\n\n\n

                  Oh \u53ca\u5176\u540c\u4e8b\uff082015 \u5e74\uff09\u5728\u300a\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u6742\u5fd7\u300b\uff08Journal of Alzheimer’s Disease\uff09\u4e0a\u53d1\u8868\u7684\u4e00\u9879 I \u671f\u7814\u7a76\uff0c\u4f7f\u7528\u8f83\u65e9\u7684 NEUROSTEM \u961f\u5217\uff0c\u62db\u52df\u4e86 9 \u540d\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u60a3\u8005\uff0c\u5e76\u5c06\u4eba\u7c7b\u795e\u7ecf\u5e72\u7ec6\u80de\u76f4\u63a5\u53cd\u590d\u8f93\u6ce8\u5230\u5927\u8111\u8111\u810a\u6db2\u7a7a\u95f4\u3002\u5728 24 \u4e2a\u6708\u5185\uff0c\u4e0e\u672a\u6cbb\u7597\u4eba\u7fa4\u7684\u9884\u671f\u4e0b\u964d\u901f\u5ea6\u76f8\u6bd4\uff0c9 \u540d\u60a3\u8005\u4e2d\u6709 4 \u540d\u5728 MMSE\uff08\u4e00\u79cd 30 \u5206\u5236\u91cf\u8868\uff0c\u5206\u6570\u9ad8\u4e8e 24 \u5206\u901a\u5e38\u8868\u793a\u8ba4\u77e5\u6b63\u5e38\uff09\u4e0a\u8868\u73b0\u51fa\u7a33\u5b9a\u6216\u9002\u5ea6\u6539\u5584\u3002\u6ca1\u6709\u8bb0\u5f55\u5230\u4e25\u91cd\u7684\u6cbb\u7597\u76f8\u5173\u4e0d\u826f\u4e8b\u4ef6\u3002<\/p>\n\n\n\n

                  \u5bf9\u4e8e\u9759\u8109\u7ed9\u836f\u9014\u5f84\u2014\u2014\u8fd9\u662f\u9a6c\u6765\u897f\u4e9a\u91c7\u7528\u7684\u65b9\u6cd5\uff0c\u907f\u514d\u4e86\u76f4\u63a5\u8fdb\u884c\u5927\u8111\u6216\u810a\u9ad3\u6ce8\u5c04\u2014\u20142023 \u5e74\u53d1\u8868\u5728\u300a\u8870\u8001\u795e\u7ecf\u79d1\u5b66\u524d\u6cbf\u300b\uff08Frontiers in Aging Neuroscience\uff09\u4e0a\u7684\u4e00\u9879\u7814\u7a76\u62db\u52df\u4e86 40 \u540d\u60a3\u6709\u8f7b\u5ea6\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u6216\u9057\u5fd8\u578b\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u7684\u60a3\u8005\uff0c\u5e76\u5c06\u9759\u8109\u8f93\u6ce8\u8110\u5e26\u884d\u751f MSCs \u4e0e\u5b89\u6170\u5242\u8fdb\u884c\u4e86\u6bd4\u8f83\u3002\u5728 12 \u4e2a\u6708\u65f6\uff0c\u6cbb\u7597\u7ec4\u663e\u793a\u51fa MMSE \u4e0b\u964d\u901f\u5ea6\u663e\u8457\u51cf\u7f13\uff0c\u540c\u65f6\u8111\u810a\u6db2\u4e2d\u767d\u7ec6\u80de\u4ecb\u7d20-6\uff08Interleukin-6\uff0c\u4e00\u79cd\u4fc3\u8fdb\u708e\u75c7\u7684\u5316\u5b66\u4fe1\u4f7f\uff0c\u5728\u795e\u7ecf\u9000\u884c\u6027\u75c5\u53d8\u4e2d\u6301\u7eed\u5347\u9ad8\uff09\u7684\u6c34\u5e73\u964d\u4f4e\u3002\u8fd9\u79cd\u5f71\u54cd\u5728 MCI \u4e9a\u7ec4\u4e2d\u6bd4\u5728\u8f7b\u5ea6\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u4e9a\u7ec4\u4e2d\u66f4\u4e3a\u660e\u663e\u2014\u2014\u8fd9\u4e00\u53d1\u73b0\u4e0e\u751f\u7269\u5b66\u9884\u6d4b\u4e00\u81f4\uff1a\u5728\u53d7\u635f\u8f83\u5c0f\u7684\u795e\u7ecf\u73af\u5883\u4e2d\u53ca\u65e9\u5e72\u9884\uff0c\u4f1a\u4ea7\u751f\u66f4\u660e\u663e\u7684\u76ca\u5904\u3002<\/p>\n\n\n\n

                  <\/div>\n\n\n\n

                  \u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u60a3\u8005\u63a5\u53d7\u5e72\u7ec6\u80de\u7597\u6cd5\u540e\u7684\u73b0\u5b9e\u6539\u5584\u60c5\u51b5<\/h3>\n\n\n\n

                  \u6211\u4eec\u5e0c\u671b\u51c6\u786e\u8bf4\u660e\u8fd9\u4e9b\u7ed3\u679c\u5728\u5b9e\u9645\u64cd\u4f5c\u4e2d\u610f\u5473\u7740\u4ec0\u4e48\uff0c\u56e0\u4e3a\u9009\u62e9\u6027\u5730\u62a5\u544a\u6700\u4f73\u7ed3\u679c\u5bf9\u60a3\u8005\u662f\u771f\u6b63\u7684\u4e0d\u8d1f\u8d23\u4efb\u3002<\/p>\n\n\n\n

                  \u5728\u672a\u63a5\u53d7\u6cbb\u7597\u7684\u9057\u5fd8\u578b MCI \u548c\u65e9\u671f\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u4eba\u7fa4\u4e2d\uff0cMMSE \u5206\u6570\u901a\u5e38\u6bcf\u5e74\u4e0b\u964d\u7ea6 2 \u5230 4 \u5206\u3002\u5728\u6700\u76f8\u5173\u5df2\u53d1\u8868\u8bd5\u9a8c\u7684\u6cbb\u7597\u7ec4\u4e2d\uff0c\u8fd9\u79cd\u4e0b\u964d\u901f\u5ea6\u51cf\u7f13\u4e86\u2014\u2014\u5728\u4e00\u4e9b\u7814\u7a76\u4e2d\u964d\u81f3\u6bcf\u5e74\u4e0d\u5230 1 \u5206\uff0c\u5728\u5176\u4ed6\u7814\u7a76\u4e2d\u5728 12 \u81f3 24 \u4e2a\u6708\u5185\u63a5\u8fd1\u7a33\u5b9a\u3002<\/p>\n\n\n\n

                  \u8fd9\u4e0d\u662f\u9006\u8f6c\u3002\u8fd9\u662f\u51cf\u7f13\u3002<\/p>\n\n\n\n

                  \u5bf9\u4e8e\u8bb8\u591a\u60a3\u8005\u6765\u8bf4\uff0c\u51cf\u7f13\u6b63\u662f\u91cd\u8981\u7684\u610f\u4e49\u6240\u5728\uff1a\u7ef4\u6301\u7ba1\u7406\u65e5\u5e38\u8d22\u52a1\u3001\u8ddf\u4e0a\u590d\u6742\u5bf9\u8bdd\u3001\u7ee7\u7eed\u5728\u804c\u4e1a\u4e0a\u505a\u51fa\u8d21\u732e\u3001\u4fdd\u6301\u5c45\u5bb6\u72ec\u7acb\u7684\u8ba4\u77e5\u80fd\u529b\u3002\u6bcf\u5e74\u4e0b\u964d 3 \u5206\u548c\u6bcf\u5e74\u4e0b\u964d 0.5 \u5206\u4e4b\u95f4\u7684\u533a\u522b\uff0c\u5728\u4e94\u5e74\u5185\u8861\u91cf\uff0c\u5c31\u662f\u4e00\u4e2a\u529f\u80fd\u6b63\u5e38\u7684\u65e5\u5e38\u751f\u6d3b\u548c\u4e00\u4e2a\u53d7\u5230\u4e25\u91cd\u635f\u5bb3\u7684\u65e5\u5e38\u751f\u6d3b\u4e4b\u95f4\u7684\u533a\u522b\u3002<\/p>\n\n\n\n

                  MCI \u7684\u5e72\u7ec6\u80de\u7597\u6cd5\u5728\u540c\u884c\u8bc4\u5ba1\u7684\u8bd5\u9a8c\u4e2d\u5c1a\u672a\u8bc1\u660e\u80fd\u591f\u6062\u590d\u6cbb\u7597\u524d\u4e22\u5931\u7684\u8bb0\u5fc6\u3002\u62b1\u7740\u627e\u56de\u5df2\u7ecf\u9057\u5fd8\u4e8b\u7269\u671f\u671b\u8fdb\u5165\u8fd9\u4e00\u8fc7\u7a0b\u7684\u60a3\u8005\uff0c\u5176\u6846\u67b6\u662f\u4e0d\u5207\u5b9e\u9645\u7684\u3002\u62b1\u7740\u5e0c\u671b\u4fdd\u7559\u66f4\u591a\u4ed6\u4eec\u4ecd\u7136\u62e5\u6709\u7684\u4e1c\u897f\u2014\u2014\u5e76\u51cf\u7f13\u4ed6\u4eec\u7ee7\u7eed\u5931\u53bb\u8fd9\u4e9b\u4e1c\u897f\u7684\u901f\u5ea6\u2014\u2014\u800c\u8fdb\u5165\u7684\u60a3\u8005\uff0c\u5176\u6846\u67b6\u662f\u73b0\u6709\u8bc1\u636e\u6240\u652f\u6301\u7684\u3002<\/p>\n\n\n\n

                  \u5728\u6211\u4eec\u7684\u9879\u76ee\u4e2d\u63a5\u53d7\u6cbb\u7597\u7684 MCI \u60a3\u8005\u4e2d\uff0c\u6709\u76f8\u5f53\u4e00\u90e8\u5206\u6ca1\u6709\u8868\u73b0\u51fa\u53ef\u6d4b\u91cf\u7684\u53d8\u5316\u3002\u6839\u636e\u73b0\u6709\u7684\u8bd5\u9a8c\u6570\u636e\u548c\u6211\u4eec\u4e03\u5e74\u7684\u4e34\u5e8a\u7ecf\u9a8c\uff0c\u6211\u4eec\u4f30\u8ba1\u5927\u7ea6 30% \u5230 40% \u63a5\u53d7 MSCs \u7597\u6cd5\u7684 MCI \u60a3\u8005\u5728 12 \u5230 24 \u4e2a\u6708\u7684\u65f6\u95f4\u5185\u8868\u73b0\u51fa\u67d0\u79cd\u7a0b\u5ea6\u7684\u53ef\u6d4b\u91cf\u7a33\u5b9a\u6216\u4e0b\u964d\u51cf\u7f13\u3002\u5176\u4f59 60% \u5230 70% \u7684\u4eba\u8868\u73b0\u51fa\u6709\u9650\u6216\u6ca1\u6709\u660e\u663e\u7684\u76ca\u5904\u3002\u6211\u4eec\u76ee\u524d\u8fd8\u65e0\u6cd5\u5728\u6cbb\u7597\u524d\u53ef\u9760\u5730\u9884\u6d4b\u8c01\u4f1a\u5c5e\u4e8e\u54ea\u4e2a\u7fa4\u4f53\u2014\u2014\u5c3d\u7ba1\u4e0b\u9762\u7684\u5019\u9009\u4eba\u6807\u51c6\u63d0\u4f9b\u4e86\u6709\u610f\u4e49\u7684\u6307\u5bfc\uff0c\u5e76\u4e14\u6211\u4eec\u5c06\u5728\u4efb\u4f55\u54a8\u8be2\u4e2d\u516c\u5f00\u8ba8\u8bba\u8fd9\u4e00\u70b9\u3002<\/p>\n\n\n\n

                  <\/div>\n\n\n\n

                  \u5e72\u7ec6\u80de\u5982\u4f55\u5e94\u5bf9\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u7684\u751f\u7269\u5b66\u673a\u5236<\/mark><\/h2>\n\n\n
                  \n
                  \"\u79d1\u5b66\u793a\u610f\u56fe\u5c55\u793a\u4e86\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u7597\u6cd5\u6cbb\u7597\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u7684\u4e09\u79cd\u673a\u5236\uff1a\u51cf\u8f7b\u795e\u7ecf\u708e\u75c7\u3001\u63d0\u4f9b\u8111\u6e90\u6027\u795e\u7ecf\u8425\u517b\u56e0\u5b50\uff08BDNF\uff09\u652f\u6301\u4ee5\u53ca\u4fdd\u62a4\u7a81\u89e6\u8fde\u63a5\u3002\"
                  \u95f4\u5145\u8d28\u5e72\u7ec6\u80de\u5728\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u4e2d\u901a\u8fc7\u4e09\u4e2a\u91cd\u53e0\u7684\u751f\u7269\u5b66\u9014\u5f84\u53d1\u6325\u4f5c\u7528\uff1a\u5e73\u606f\u8fc7\u5ea6\u6d3b\u8dc3\u7684\u795e\u7ecf\u708e\u75c7\uff0c\u6062\u590d\u73b0\u6709\u795e\u7ecf\u5143\u7684\u795e\u7ecf\u7ecf\u8425\u517b\u652f\u6301\uff0c\u4ee5\u53ca\u6539\u5584\u704c\u6ce8\u4e0d\u8db3\u8111\u7ec4\u7ec7\u7684\u8840\u7ba1\u4f9b\u5e94\u3002<\/figcaption><\/figure>\n<\/div>\n\n\n

                  MSCs \u7597\u6cd5\u5728\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u4e2d\u7684\u4e09\u79cd\u751f\u7269\u5b66\u673a\u5236<\/h3>\n\n\n\n

                  \u5728\u8fd9\u79cd\u60c5\u51b5\u4e0b\uff0cMSCs \u4e0d\u4f1a\u66ff\u6362\u4e22\u5931\u7684\u795e\u7ecf\u5143\u3002\u5e72\u7ec6\u80de\u53ef\u4ee5\u901a\u8fc7\u8f6c\u5316\u4e3a\u65b0\u795e\u7ecf\u5143\u6765\u76f4\u63a5\u518d\u751f\u5927\u8111\u7ec4\u7ec7\u7684\u7406\u8bba\uff0c\u5728\u8fc7\u53bb\u4e8c\u5341\u5e74\u7684\u7814\u7a76\u4e2d\u9010\u6e10\u5f97\u5230\u6f84\u6e05\uff1a\u867d\u7136 MSCs \u5728\u5b9e\u9a8c\u5ba4\u6761\u4ef6\u4e0b\u53ef\u4ee5\u5206\u5316\u6210\u5404\u79cd\u7ec6\u80de\u7c7b\u578b\uff0c\u4f46\u8fd9\u5e76\u6ca1\u6709\u5728\u53d7\u635f\u7684\u4eba\u7c7b\u5927\u8111\u4f53\u5185\u6709\u610f\u4e49\u5730\u53d1\u751f\u3002<\/p>\n\n\n\n

                  \u8bc1\u636e\u6240\u652f\u6301\u7684\u662f\u4e00\u5957\u95f4\u63a5\u4f46\u5728\u751f\u7269\u5b66\u4e0a\u5177\u6709\u91cd\u5927\u610f\u4e49\u7684\u673a\u5236\uff0c\u8fd9\u4e9b\u673a\u5236\u76f4\u63a5\u9488\u5bf9\u63a8\u52a8 MCI \u8fdb\u5c55\u7684\u8fc7\u7a0b\u3002<\/p>\n\n\n\n

                  \u7b2c\u4e00\u4e2a\u673a\u5236\u662f\u795e\u7ecf\u708e\u75c7\u8c03\u8282\u3002\u5f53\u901a\u8fc7\u9759\u8109\u9014\u5f84\u65bd\u7528 MSCs \u65f6\uff0c\u4e00\u90e8\u5206\u4f1a\u5411\u6d3b\u8dc3\u7684\u708e\u75c7\u90e8\u4f4d\u8fc1\u79fb\u2014\u2014\u88ab\u53d7\u635f\u7ec4\u7ec7\u91ca\u653e\u7684\u5316\u5b66\u4fe1\u53f7\u6240\u5438\u5f15\u2014\u2014\u5e76\u5f00\u59cb\u91ca\u653e\u6297\u708e\u4fe1\u53f7\u5206\u5b50\u3002\u5728\u5927\u8111\u4e2d\uff0c\u8fd9\u610f\u5473\u7740\u5e72\u9884\u6d77\u9a6c\u4f53\u53ca\u5176\u5468\u56f4\u533a\u57df\u91ca\u653e\u7834\u574f\u6027\u708e\u75c7\u86cb\u767d\u7684\u8fc7\u5ea6\u6d3b\u8dc3\u7684\u5c0f\u80f6\u8d28\u7ec6\u80de\u3002MSCs \u91ca\u653e\u7ec6\u80de\u56e0\u5b50\uff08\u8c03\u8282\u514d\u75ab\u7ec6\u80de\u884c\u4e3a\u7684\u5206\u5b50\u4fe1\u4f7f\uff09\uff0c\u4fc3\u4f7f\u5c0f\u80f6\u8d28\u7ec6\u80de\u4ece\u5176\u7834\u574f\u6027\u7684\u201cM1\u201d\u72b6\u6001\u8f6c\u53d8\u4e3a\u4fdd\u62a4\u7ec4\u7ec7\u7684\u201cM2\u201d\u72b6\u6001\u3002\u5728\u5df2\u53d1\u8868\u7684\u5b9e\u9a8c\u5ba4\u548c\u52a8\u7269\u6a21\u578b\u7814\u7a76\u4e2d\uff0c\u8fd9\u79cd\u8f6c\u53d8\u5df2\u88ab\u8bc1\u660e\u53ef\u4ee5\u964d\u4f4e\u53d1\u708e\u8111\u7ec4\u7ec7\u4e2d\u7684\u795e\u7ecf\u5143\u6b7b\u4ea1\u7387\u3002\u5728\u4e0a\u8ff0\u4eba\u4f53\u8bd5\u9a8c\u4e2d\uff0c\u5b83\u5bf9\u5e94\u4e8e\u5305\u62ec\u767d\u7ec6\u80de\u4ecb\u7d20-6\u5728\u5185\u7684\u8111\u810a\u6db2\u708e\u75c7\u6807\u5fd7\u7269\u6c34\u5e73\u7684\u964d\u4f4e\u3002<\/p>\n\n\n\n

                  \u7b2c\u4e8c\u4e2a\u673a\u5236\u662f\u795e\u7ecf\u8425\u517b\u56e0\u5b50\u652f\u6301\u3002MSCs \u5206\u6ccc BDNF\u2014\u2014\u6709\u6c27\u8fd0\u52a8\u81ea\u7136\u589e\u52a0\u7684\u540c\u4e00\u79cd\u86cb\u767d\u8d28\u2014\u2014\u4ee5\u53ca\u5176\u4ed6\u751f\u957f\u56e0\u5b50\uff0c\u5305\u62ec\u795e\u7ecf\u751f\u957f\u56e0\u5b50\uff08Nerve Growth Factor, NGF\uff09\u548c\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff08Vascular Endothelial Growth Factor, VEGF\uff09\u3002\u8fd9\u4e9b\u5206\u5b50\u652f\u6301\u73b0\u6709\u795e\u7ecf\u5143\u7684\u5b58\u6d3b\uff0c\u9f13\u52b1\u7ef4\u6301\u7a81\u89e6\u8fde\u63a5\uff0c\u5e76\u4fc3\u8fdb\u6210\u4eba\u5927\u8111\u4fdd\u7559\u7684\u6709\u9650\u795e\u7ecf\u53ef\u5851\u6027\u3002\u628a\u5b83\u60f3\u8c61\u6210\u6062\u590d\u795e\u7ecf\u5143\u4fdd\u6301\u529f\u80fd\u6240\u9700\u7684\u571f\u58e4\u6761\u4ef6\u2014\u2014\u4e0d\u662f\u5728\u7530\u5730\u91cc\u6dfb\u52a0\u65b0\u7684\u795e\u7ecf\u5143\uff0c\u800c\u662f\u8ba9\u5df2\u7ecf\u5728\u90a3\u91cc\u7684\u795e\u7ecf\u5143\u5f97\u5230\u66f4\u597d\u7684\u652f\u6301\uff0c\u5b58\u6d3b\u5f97\u66f4\u4e45\u3002<\/p>\n\n\n\n

                  \u7b2c\u4e09\u4e2a\u673a\u5236\u662f\u8840\u7ba1\u652f\u6301\u3002\u8ba4\u77e5\u80fd\u529b\u4e0b\u964d\u2014\u2014\u7279\u522b\u662f\u8840\u7ba1\u6027 MCI\uff0c\u7531\u5927\u8111\u957f\u671f\u8840\u6db2\u4f9b\u5e94\u4e0d\u8db3\u9a71\u52a8\u2014\u2014\u4e0e\u5fae\u8840\u7ba1\u75be\u75c5\u5bc6\u5207\u76f8\u5173\uff1a\u4e3a\u795e\u7ecf\u5143\u8f93\u9001\u6c27\u6c14\u548c\u8461\u8404\u7cd6\u7684\u5c0f\u8840\u7ba1\u53d7\u635f\u4e14\u529f\u80fd\u4e0d\u5168\u3002MSCs \u4fc3\u8fdb\u8840\u7ba1\u751f\u6210\uff08Angiogenesis\uff0c\u65b0\u5c0f\u8840\u7ba1\u7684\u5f62\u6210\uff09\uff0c\u5e76\u6539\u5584\u53d1\u708e\u7ec4\u7ec7\u7684\u5fae\u8840\u7ba1\u529f\u80fd\u3002\u8fd9\u4e0e\u5728\u7f3a\u8840\u6027\u5fc3\u529b\u8870\u7aed\u4e2d\u89c2\u5bdf\u5230\u7684\u673a\u5236\u76f8\u540c\uff0c\u5e72\u7ec6\u80de\u53ef\u4ee5\u6539\u5584\u704c\u6ce8\u4e0d\u8db3\u4f46\u5b58\u6d3b\u7684\u5fc3\u808c\u7ec4\u7ec7\u7684\u8840\u6db2\u4f9b\u5e94\u2014\u2014\u73b0\u5728\u5e94\u7528\u4e8e\u5927\u8111\u4e2d\u7c7b\u4f3c\u7684\u95ee\u9898\u3002MCI \u5177\u6709\u663e\u8457\u8840\u7ba1\u75c5\u53d8\u56e0\u7d20\u7684\u60a3\u8005\u53ef\u80fd\u7279\u522b\u53d7\u76ca\u4e8e\u8fd9\u4e00\u9014\u5f84\u3002<\/p>\n\n\n\n

                  <\/div>\n\n\n\n

                  \u4e3a\u4ec0\u4e48\u9a6c\u6765\u897f\u4e9a\u4f7f\u7528\u540c\u79cd\u5f02\u4f53\u8110\u5e26\u884d\u751f MSCs \u6cbb\u7597\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d<\/h3>\n\n\n\n

                  \u6cbb\u7597\u4e2d\u6240\u4f7f\u7528\u7ec6\u80de\u7684\u6765\u6e90\u4e0d\u662f\u4e00\u4e2a\u6b21\u8981\u7684\u6280\u672f\u7ec6\u8282\u2014\u2014\u5b83\u76f4\u63a5\u5173\u7cfb\u5230\u80fd\u591f\u8fbe\u5230\u7684\u751f\u7269\u5b66\u6548\u679c\u3002<\/p>\n\n\n\n

                  \u5728\u65e5\u672c\uff0c\u518d\u751f\u533b\u5b66\u7684\u76d1\u7ba1\u6846\u67b6\u4ee5\u81ea\u4f53\u7ec6\u80de\u4f7f\u7528\uff08Autologous cell use\uff09\u4e3a\u4e2d\u5fc3\uff1a\u4ece\u60a3\u8005\u81ea\u8eab\u4f53\u5185\u91c7\u96c6\u7684\u7ec6\u80de\uff0c\u901a\u5e38\u6765\u81ea\u9aa8\u9ad3\u6216\u8102\u80aa\u7ec4\u7ec7\u3002\u5176\u4f18\u52bf\u5728\u4e8e\u65e0\u9700\u62c5\u5fc3\u4efb\u4f55\u514d\u75ab\u6392\u65a5\u95ee\u9898\u3002\u663e\u8457\u7684\u5c40\u9650\u6027\u2014\u2014\u7279\u522b\u662f\u5bf9\u4e8e\u60a3\u6709 MCI \u7684\u8001\u5e74\u4eba\u2014\u2014\u5728\u4e8e\u5e72\u7ec6\u80de\u7684\u8d28\u91cf\u4f1a\u968f\u7740\u5e74\u9f84\u7684\u589e\u957f\u800c\u5927\u5e45\u4e0b\u964d\u3002\u4e00\u540d 72 \u5c81\u7684\u60a3\u8005\u4f7f\u7528\u81ea\u8eab\u7684 MSCs \u8fdb\u884c\u6cbb\u7597\uff0c\u4e0e\u6765\u81ea\u5e74\u8f7b\u5065\u5eb7\u4f9b\u4f53\u7684\u7ec6\u80de\u76f8\u6bd4\uff0c\u63a5\u53d7\u7684\u7ec6\u80de\u5176\u589e\u6b96\u80fd\u529b\u660e\u663e\u964d\u4f4e\uff0cBDNF \u5206\u6ccc\u66f4\u5c11\uff0c\u6297\u708e\u6d3b\u6027\u51cf\u5f31\u3002\u65e8\u5728\u89e3\u51b3\u4e0e\u5e74\u9f84\u76f8\u5173\u7684\u795e\u7ecf\u9000\u884c\u6027\u75c5\u53d8\u7684\u6cbb\u7597\uff0c\u5b9e\u9645\u4e0a\u53d7\u5230\u4e86\u5b83\u8bd5\u56fe\u5bf9\u6297\u7684\u76f8\u540c\u8870\u8001\u8fc7\u7a0b\u5728\u751f\u7269\u5b66\u4e0a\u7684\u9650\u5236\u3002<\/p>\n\n\n\n

                  \u9a6c\u6765\u897f\u4e9a\u4f7f\u7528\u7684\u540c\u79cd\u5f02\u4f53\u8110\u5e26\u884d\u751f MSCs \u6765\u6e90\u4e8e\u5065\u5eb7\u6bcd\u4eb2\u5728\u5206\u5a29\u65f6\u6350\u8d60\u7684\u8110\u5e26\u7ec4\u7ec7\u3002\u4ece\u751f\u7269\u5b66\u89d2\u5ea6\u6765\u770b\uff0c\u8fd9\u4e9b\u7ec6\u80de\u662f\u5e74\u8f7b\u7684\u2014\u2014\u63d0\u53d6\u81ea\u65b0\u751f\u513f\u7ec4\u7ec7\uff0c\u800c\u4e0d\u662f\u5904\u4e8e\u6162\u6027\u708e\u75c7\u538b\u529b\u4e0b\u7684 70 \u5c81\u8eaf\u4f53\u2014\u2014\u5e76\u4e14\u5728\u5b9e\u9a8c\u5ba4\u5bf9\u6bd4\u4e2d\u5df2\u663e\u793a\uff0c\u5176\u5206\u6ccc\u7684 BDNF\u3001NGF \u548c\u6297\u708e\u7ec6\u80de\u56e0\u5b50\u6c34\u5e73\u660e\u663e\u9ad8\u4e8e\u6765\u81ea\u6210\u5e74\u4f9b\u4f53\u7684\u540c\u9f84\u81ea\u4f53 MSCs\u3002\u5b83\u4eec\u5728\u6807\u51c6\u5316\u3001\u53d7\u8d28\u91cf\u63a7\u5236\u7684\u5236\u5242\u4e2d\u751f\u4ea7\uff0c\u8fd9\u610f\u5473\u7740\u5728\u6bcf\u6b21\u6cbb\u7597\u524d\u90fd\u4f1a\u9a8c\u8bc1\u7ec6\u80de\u6d3b\u529b\u548c\u6548\u529b\u3002\u56e0\u4e3a\u8110\u5e26 MSCs \u8868\u8fbe\u5f15\u53d1\u514d\u75ab\u6392\u65a5\u7684\u8868\u9762\u86cb\u767d\u6c34\u5e73\u975e\u5e38\u4f4e\uff0c\u6240\u4ee5\u4e25\u91cd\u7684\u6392\u65a5\u53cd\u5e94\u5728\u4e34\u5e8a\u5b9e\u8df5\u4e2d\u6781\u5176\u7f55\u89c1\u3002<\/p>\n\n\n\n

                  \u5bf9\u4e8e\u4e00\u79cd\u6cbb\u7597\u76ee\u6807\u76f4\u63a5\u53d6\u51b3\u4e8e\u7ec6\u80de\u63d0\u4f9b\u7684\u795e\u7ecf\u8425\u517b\u548c\u6297\u708e\u4fe1\u53f7\u7684\u8d28\u91cf\u548c\u6548\u529b\u7684\u75be\u75c5\uff0c\u5e74\u8f7b\u4f9b\u4f53\u7ec6\u80de\u4e0e\u8001\u5e74\u60a3\u8005\u81ea\u8eab\u8870\u8001\u7ec6\u80de\u4e4b\u95f4\u7684\u751f\u7269\u5b66\u5dee\u5f02\u5e76\u975e\u5076\u7136\u2014\u2014\u5b83\u76f4\u63a5\u51b3\u5b9a\u4e86\u5e72\u9884\u662f\u5426\u80fd\u8fbe\u5230\u6709\u610f\u4e49\u7684\u6548\u679c\u9608\u503c\u3002<\/p>\n\n\n\n

                  <\/div>\n\n\n\n

                  \u8c01\u662f\u2014\u2014\u8c01\u53c8\u4e0d\u662f\u2014\u2014\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u5e72\u7ec6\u80de\u7597\u6cd5\u7684\u5408\u9002\u5019\u9009\u4eba<\/mark><\/h2>\n\n\n\n

                  \u5f80\u5f80\u5bf9 MSCs \u6cbb\u7597\u53cd\u5e94\u66f4\u597d\u7684\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u7c7b\u578b<\/h3>\n\n\n\n

                  \u5e76\u975e\u6bcf\u4e2a\u88ab\u8bca\u65ad\u4e3a MCI \u7684\u4eba\u90fd\u662f MSCs \u7597\u6cd5\u7684\u5408\u9002\u5019\u9009\u4eba\uff0c\u6211\u4eec\u4f1a\u4ed4\u7ec6\u8bc4\u4f30\u8fd9\u4e00\u70b9\u2014\u2014\u5305\u62ec\u5728\u6211\u4eec\u8ba4\u4e3a\u8bc1\u636e\u4e0d\u652f\u6301\u4ed6\u4eec\u7279\u5b9a\u60c5\u51b5\u4e0b\u7684\u6cbb\u7597\u65f6\uff0c\u613f\u610f\u660e\u786e\u5730\u544a\u8bc9\u60a3\u8005\u3002<\/p>\n\n\n\n

                  \u5728\u4e34\u5e8a\u6570\u636e\u548c\u6211\u4eec\u81ea\u8eab\u7684\u60a3\u8005\u7ecf\u9a8c\u4e2d\uff0c\u8868\u73b0\u51fa\u6700\u4e00\u81f4\u76ca\u5904\u7684\u60a3\u8005\u7279\u5f81\u5305\u62ec\uff1a<\/p>\n\n\n\n

                  \u8bca\u65ad\u662f\u6700\u8fd1\u7684\uff0c\u4e14\u635f\u4f24\u7a0b\u5ea6\u4e3a\u8f7b\u5ea6\u81f3\u4e2d\u5ea6\uff1a\u8ba4\u77e5\u6d4b\u8bd5\u5c06\u60a3\u8005\u7f6e\u4e8e\u8868\u660e\u4ecd\u6709\u6709\u610f\u4e49\u8ba4\u77e5\u50a8\u5907\u7684\u8303\u56f4\u5185\u2014\u2014\u901a\u5e38 MMSE \u5f97\u5206\u4e3a 24 \u81f3 28 \u5206\uff08\u6ee1\u5206 30 \u5206\uff09\uff0c\u6216\u8499\u7279\u5229\u5c14\u8ba4\u77e5\u8bc4\u4f30\uff08Montreal Cognitive Assessment, MoCA\uff09\u5f97\u5206\u4e3a 19 \u81f3 25 \u5206\uff08\u6ee1\u5206 30 \u5206\uff09\u3002\u8870\u9000\u662f\u6e10\u8fdb\u7684\uff0c\u4f46\u5c1a\u672a\u8fbe\u5230\u4e25\u91cd\u635f\u5bb3\u65e5\u5e38\u72ec\u7acb\u529f\u80fd\u7684\u9636\u6bb5\u3002<\/p>\n\n\n\n

                  \u8111\u90e8 MRI \u663e\u793a\u6d77\u9a6c\u4f53\u840e\u7f29\uff0c\u8fd9\u4e0e\u65e9\u671f\u795e\u7ecf\u9000\u884c\u6027\u6539\u53d8\u4e00\u81f4\uff0c\u4f46\u6ca1\u6709\u4e2d\u91cd\u5ea6\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u7279\u5f81\u6027\u7684\u5e7f\u6cdb\u76ae\u8d28\u840e\u7f29\u3002\u6362\u53e5\u8bdd\u8bf4\uff0c\u4ecd\u7136\u6709\u5927\u91cf\u5b58\u6d3b\u7684\u795e\u7ecf\u7ed3\u6784\u3002<\/p>\n\n\n\n

                  \u708e\u75c7\u6807\u5fd7\u7269\u2014\u2014\u5305\u62ec C\u53cd\u5e94\u86cb\u767d\uff08C-reactive protein, CRP\uff0c\u4e00\u79cd\u8861\u91cf\u6d3b\u52a8\u6027\u708e\u75c7\u7684\u5168\u8eab\u6307\u6807\uff09\uff0c\u4ee5\u53ca\u5728\u53ef\u884c\u60c5\u51b5\u4e0b\u7684\u8111\u810a\u6db2\u6807\u5fd7\u7269\uff0c\u5982\u5347\u9ad8\u7684 tau \u86cb\u767d\u6216 p-tau \u86cb\u767d\u2014\u2014\u8868\u660e\u5b58\u5728\u6d3b\u8dc3\u7684\u795e\u7ecf\u708e\u75c7\u8fc7\u7a0b\uff0cMSCs \u7597\u6cd5\u7684\u6297\u708e\u673a\u5236\u53ef\u4ee5\u5bf9\u6b64\u4ea7\u751f\u6709\u610f\u4e49\u7684\u5e72\u9884\u3002\u88ab\u8bc1\u660e\u60a3\u6709\u795e\u7ecf\u708e\u75c7\u5347\u9ad8\u7684\u60a3\u8005\uff0c\u4f3c\u4e4e\u6bd4\u8ba4\u77e5\u80fd\u529b\u4e0b\u964d\u4e3b\u8981\u662f\u7531\u4e8e\u7ed3\u6784\u6216\u7eaf\u4ee3\u8c22\u539f\u56e0\u5f15\u8d77\u7684\u60a3\u8005\u53cd\u5e94\u66f4\u4e00\u81f4\u3002<\/p>\n\n\n\n

                  \u5b58\u5728\u8840\u7ba1\u5371\u9669\u56e0\u7d20\u2014\u2014\u9ad8\u8840\u538b\u3001\u7cd6\u5c3f\u75c5\u6216\u5728 MRI \u4e0a\u53ef\u89c1\u7684\u5fae\u8840\u7ba1\u75be\u75c5\u2014\u2014\u4f46\u6b63\u5728\u5f97\u5230\u79ef\u6781\u7ba1\u7406\u3002\u5728\u8fd9\u4e9b\u60a3\u8005\u4e2d\uff0cMSCs \u7597\u6cd5\u7684\u8840\u7ba1\u652f\u6301\u673a\u5236\u53ef\u80fd\u4f1a\u63d0\u4f9b\u8d85\u51fa\u795e\u7ecf\u708e\u75c7\u9014\u5f84\u7684\u76ca\u5904\uff0c\u4f7f\u5176\u6210\u4e3a\u9488\u5bf9\u5176\u7279\u5b9a\u75be\u75c5\u60c5\u51b5\u7684\u66f4\u5168\u9762\u7684\u751f\u7269\u5b66\u5e72\u9884\u3002<\/p>\n\n\n\n

                  \u60a3\u8005\u75c5\u60c5\u7a33\u5b9a\uff0c\u6ca1\u6709\u6d3b\u52a8\u6027\u6076\u6027\u80bf\u7624\u3001\u5168\u8eab\u6027\u611f\u67d3\u6216\u672a\u63a7\u5236\u7684\u4ee3\u8c22\u6027\u75be\u75c5\uff0c\u5e76\u4e14\u6ca1\u6709\u670d\u7528\u663e\u8457\u6291\u5236\u514d\u75ab\u529f\u80fd\u7684\u836f\u7269\u3002<\/p>\n\n\n\n

                  <\/div>\n\n\n\n

                  \u4ec0\u4e48\u65f6\u5019\u5e72\u7ec6\u80de\u7597\u6cd5\u4e0d\u662f\u6cbb\u7597\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u7684\u6b63\u786e\u9014\u5f84<\/h3>\n\n\n\n

                  \u5728\u67d0\u4e9b\u4e34\u5e8a\u60c5\u51b5\u4e0b\uff0c\u6211\u4eec\u4f1a\u660e\u786e\u5efa\u8bae\u4e0d\u8981\u7ee7\u7eed\u8fdb\u884c\u2014\u2014\u8fd9\u91cc\u7684\u660e\u786e\u5e76\u4e0d\u4ee3\u8868\u4ee4\u4eba\u6c14\u9981\uff1b\u5b83\u662f\u8bda\u4fe1\u505a\u51fa\u51b3\u5b9a\u7684\u57fa\u7840\u3002<\/p>\n\n\n\n

                  \u5df2\u7ecf\u4ece MCI \u8fdb\u5c55\u4e3a\u8f7b\u5ea6\u75f4\u5446\u75c7\u7684\u60a3\u8005\u2014\u2014\u7279\u522b\u662f\u90a3\u4e9b MMSE \u5f97\u5206\u4f4e\u4e8e 20 \u5206\u7684\u60a3\u8005\u2014\u2014\u6b63\u5728\u9762\u5bf9\u53d7\u635f\u66f4\u4e25\u91cd\u7684\u795e\u7ecf\u57fa\u7840\u3002\u5728\u8fd9\u4e2a\u9636\u6bb5\uff0c\u8bc1\u660e MSCs \u76ca\u5904\u7684\u8bc1\u636e\u8f83\u5f31\uff0c\u53ef\u7528\u7684\u751f\u7269\u5b66\u7a7a\u95f4\u53d7\u5230\u66f4\u591a\u9650\u5236\u3002\u5c31\u50cf\u5728\u7c7b\u98ce\u6e7f\u6027\u5173\u8282\u708e\u4e2d\u2014\u2014\u5f53\u708e\u75c7\u6d3b\u8dc3\u4f46\u5173\u8282\u7834\u574f\u5c1a\u672a\u8fbe\u5230\u665a\u671f\u65f6\uff0cMSCs \u7597\u6cd5\u6700\u6709\u6548\u2014\u2014\u5728\u5e7f\u6cdb\u7684\u795e\u7ecf\u4e22\u5931\u53d1\u751f\u4e4b\u524d\uff0c\u8ba4\u77e5\u80fd\u529b\u4e0b\u964d\u7684\u5e72\u7ec6\u80de\u7597\u6cd5\u4f3c\u4e4e\u6700\u6709\u7528\u3002<\/p>\n\n\n\n

                  \u5176\u8ba4\u77e5\u75c7\u72b6\u4e3b\u8981\u662f\u7531\u53ef\u7ea0\u6b63\u7684\u6f5c\u5728\u539f\u56e0\u9a71\u52a8\u7684\u60a3\u8005\u2014\u2014\u672a\u786e\u8bca\u7684\u7532\u72b6\u817a\u529f\u80fd\u969c\u788d\u3001\u7ef4\u751f\u7d20 B12 \u7f3a\u4e4f\u75c7\u3001\u672a\u6cbb\u7597\u7684\u6291\u90c1\u75c7\uff08\u5728\u8ba4\u77e5\u6d4b\u8bd5\u4e2d\u4f1a\u663e\u8457\u6a21\u4eff MCI\uff09\u6216\u836f\u7269\u526f\u4f5c\u7528\u2014\u2014\u5728\u8003\u8651\u4efb\u4f55\u989d\u5916\u5e72\u9884\u4e4b\u524d\uff0c\u5e94\u786e\u5b9a\u5e76\u89e3\u51b3\u8fd9\u4e9b\u539f\u56e0\u3002\u7528\u5e72\u7ec6\u80de\u6cbb\u7597\u4e0e B12 \u7f3a\u4e4f\u76f8\u5173\u7684\u8ba4\u77e5\u80fd\u529b\u4e0b\u964d\uff0c\u4e0d\u662f\u5bf9\u751f\u7269\u5e72\u9884\u9002\u5f53\u6216\u5177\u6709\u6210\u672c\u6548\u76ca\u7684\u4f7f\u7528\u3002<\/p>\n\n\n\n

                  \u9700\u8981\u5feb\u901f\u7f13\u89e3\u7684\u60a3\u8005\u2014\u2014\u4ed6\u4eec\u7684\u8ba4\u77e5\u53d8\u5316\u9020\u6210\u4e86\u76f4\u63a5\u7684\u5b89\u5168\u95ee\u9898\uff0c\u6216\u8005\u4ed6\u4eec\u7684\u804c\u4e1a\u6216\u4e2a\u4eba\u60c5\u51b5\u9700\u8981\u5feb\u901f\u89e3\u51b3\u2014\u2014\u4e0e\u8fd9\u79cd\u7597\u6cd5\u975e\u5e38\u4e0d\u5339\u914d\uff0c\u56e0\u4e3a\u8fd9\u79cd\u7597\u6cd5\u7684\u6548\u679c\uff08\u5982\u679c\u51fa\u73b0\u7684\u8bdd\uff09\u4f1a\u5728\u4e09\u5230\u5341\u4e8c\u4e2a\u6708\u5185\u9010\u6e10\u663e\u73b0\u3002<\/p>\n\n\n\n

                  \u9700\u8981\u4fdd\u969c\u7684\u60a3\u8005\u2014\u2014\u786e\u5b9a\u4ed6\u4eec\u7684\u8ba4\u77e5\u80fd\u529b\u4e0d\u4f1a\u8fdb\u4e00\u6b65\u4e0b\u964d\u2014\u2014\u5728\u8fd9\u91cc\u6216\u4efb\u4f55\u5730\u65b9\u90fd\u627e\u4e0d\u5230\u8fd9\u79cd\u4fdd\u969c\u3002MCI \u5e72\u7ec6\u80de\u7597\u6cd5\u4e0d\u662f\u4e00\u79cd\u4fdd\u8bc1\u3002\u5b83\u662f\u4e00\u79cd\u57fa\u4e8e\u751f\u7269\u5b66\u57fa\u7840\u7684\u5e72\u9884\u63aa\u65bd\uff0c\u6709\u8bc1\u636e\u8868\u660e\u5bf9\u4e00\u90e8\u5206\u60a3\u8005\u6709\u76ca\uff0c\u5bf9\u4e8e\u54ea\u4e9b\u4eba\u4f1a\u6709\u53cd\u5e94\u5b58\u5728\u8bda\u5b9e\u7684\u4e0d\u786e\u5b9a\u6027\uff0c\u5e76\u4e14\u6709\u76f8\u5f53\u6bd4\u4f8b\u7684\u65e0\u53cd\u5e94\u8005\u3002\u6211\u4eec\u4f1a\u5728\u6bcf\u6b21\u521d\u6b65\u54a8\u8be2\u4e2d\u5411\u6bcf\u4f4d\u60a3\u8005\u6e05\u695a\u5730\u5448\u73b0\u8fd9\u4e00\u73b0\u5b9e\u3002<\/p>\n\n\n\n

                  <\/div>\n\n\n\n

                  \u4e00\u4f4d\u60a3\u8005\u5728\u9a6c\u6765\u897f\u4e9a\u63a5\u53d7\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u5e72\u7ec6\u80de\u7597\u6cd5\u7684\u7ecf\u5386<\/mark><\/h2>\n\n\n\n

                  \u5728\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u671f\u95f4\uff0c\u5728\u60c5\u51b5\u53d8\u5f97\u66f4\u7cdf\u4e4b\u524d\u91c7\u53d6\u884c\u52a8\u7684\u51b3\u5b9a<\/h3>\n\n\n\n

                  \u4e00\u4f4d\u516d\u5341\u591a\u5c81\u7684\u5973\u6027\u3002\u5979\u66fe\u662f\u4e00\u540d\u8d22\u52a1\u5206\u6790\u5e08\uff0c\u5728\u804c\u4e1a\u751f\u6daf\u4e2d\u66fe\u4ee5\u7cbe\u786e\u7ba1\u7406\u5c42\u5c42\u590d\u6742\u6027\u800c\u81ea\u8c6a\u3002\u5728\u5927\u7ea6\u4e24\u5e74\u7684\u65f6\u95f4\u91cc\uff0c\u5979\u6ce8\u610f\u5230\u4e86\u4e00\u4e9b\u5979\u6700\u521d\u5f52\u56e0\u4e8e\u5de5\u4f5c\u538b\u529b\u7684\u53d8\u5316\uff1a\u68c0\u7d22\u540d\u5b57\u9700\u8981\u66f4\u957f\u7684\u65f6\u95f4\uff0c\u8fd1\u671f\u5bf9\u8bdd\u4e2d\u7684\u7ec6\u8282\u5728\u88ab\u5199\u4e0b\u6765\u4e4b\u524d\u5c31\u6e9c\u8d70\u4e86\uff0c\u5728\u4f1a\u8bae\u4e2d\u8ddf\u8e2a\u591a\u4e2a\u540c\u65f6\u8fdb\u884c\u7684\u7ebf\u7d22\u539f\u672c\u4e0d\u8d39\u5439\u7070\u4e4b\u529b\uff0c\u73b0\u5728\u5374\u9700\u8981\u4ed8\u51fa\u52aa\u529b\u3002<\/p>\n\n\n\n

                  \u795e\u7ecf\u5fc3\u7406\u5b66\u6d4b\u8bd5\u5c06\u5979\u76f4\u63a5\u5f52\u5165\u9057\u5fd8\u578b MCI \u8303\u56f4\u2014\u2014\u7279\u5b9a\u4e8e\u8bb0\u5fc6\u7684\u4e0b\u964d\uff0c\u800c\u5176\u4ed6\u8ba4\u77e5\u529f\u80fd\u6ca1\u6709\u660e\u663e\u53d7\u635f\u3002\u5979\u7684 MRI \u663e\u793a\u8f7b\u5ea6\u53cc\u4fa7\u6d77\u9a6c\u4f53\u4f53\u79ef\u7f29\u5c0f\uff0c\u4e0e\u65e9\u671f\u795e\u7ecf\u9000\u884c\u6027\u6539\u53d8\u4e00\u81f4\u3002\u5979\u7684\u795e\u7ecf\u79d1\u533b\u751f\u786e\u8ba4\u6ca1\u6709\u53ef\u9006\u539f\u56e0\uff0c\u5e76\u5efa\u8bae\u6bcf\u5e74\u8fdb\u884c\u76d1\u6d4b\uff0c\u540c\u65f6\u8fdb\u884c\u6709\u6c27\u8fd0\u52a8\u548c\u8ba4\u77e5\u953b\u70bc\u3002<\/p>\n\n\n\n

                  \u5979\u6765\u5230\u6211\u4eec\u8bca\u6240\uff0c\u5e76\u4e0d\u662f\u56e0\u4e3a\u5979\u7684\u8ba4\u77e5\u529f\u80fd\u4e25\u91cd\u53d7\u635f\uff0c\u6070\u6070\u662f\u56e0\u4e3a\u8fd8\u6ca1\u6709\u3002\u5979\u6e05\u695a\u5730\u660e\u767d\uff0c\u5e72\u9884\u8d8a\u65e9\u652f\u6301\u795e\u7ecf\u73af\u5883\uff0c\u80fd\u591f\u4fdd\u62a4\u7684\u4e1c\u897f\u5c31\u8d8a\u591a\u3002\u5979\u5728\u7b2c\u4e00\u6b21\u54a8\u8be2\u524d\u56de\u987e\u4e86\u5df2\u53d1\u8868\u7684\u8bd5\u9a8c\u6570\u636e\uff0c\u5e76\u5e26\u7740\u5173\u4e8e\u8bc1\u636e\u663e\u793a\u4e86\u4ec0\u4e48\u548c\u6ca1\u6709\u663e\u793a\u4ec0\u4e48\u7684\u5177\u4f53\u3001\u6280\u672f\u6027\u95ee\u9898\u524d\u6765\u3002\u5979\u4e0d\u662f\u5728\u5bfb\u627e\u627f\u8bfa\u3002\u5979\u662f\u5728\u5bfb\u627e\u4e00\u6b21\u7b26\u5408\u751f\u7269\u5b66\u4e8b\u5b9e\u7684\u8bda\u5b9e\u5bf9\u8bdd\u3002<\/p>\n\n\n\n

                  \u5728\u63a5\u53d7\u5979\u8fdb\u884c\u6cbb\u7597\u4e4b\u524d\uff0c\u6211\u4eec\u56de\u987e\u4e86\u5979\u7684\u795e\u7ecf\u5fc3\u7406\u5b66\u8bc4\u4f30\u3001\u5979\u7684 MRI\u3001\u5979\u7684\u708e\u75c7\u6807\u5fd7\u7269\u4ee5\u53ca\u5979\u5b8c\u6574\u7684\u7528\u836f\u53f2\u3002\u5979\u7b26\u5408 MSCs \u7597\u6cd5\u5177\u6709\u751f\u7269\u5b66\u4e0a\u5408\u7406\u4e14\u6709\u8bc1\u636e\u652f\u6301\u7684\u60a3\u8005\u6863\u6848\u3002<\/p>\n\n\n\n

                  <\/div>\n\n\n\n

                  \u63a5\u53d7\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u5e72\u7ec6\u80de\u6cbb\u7597\u540e\u6539\u53d8\u4e86\u4ec0\u4e48\u2014\u2014\u4ee5\u53ca\u6ca1\u6709\u6539\u53d8\u4ec0\u4e48<\/h3>\n\n\n\n

                  \u5728\u9759\u8109\u8f93\u6ce8 MSCs \u540e\u7684\u524d\u516b\u5468\uff0c\u5979\u6ca1\u6709\u53d1\u73b0\u4efb\u4f55\u53ef\u8bc6\u522b\u7684\u53d8\u5316\u3002\u8fd9\u662f\u9884\u671f\u7684\u6f5c\u4f0f\u671f\uff0c\u5e76\u4e14\u5979\u5df2\u88ab\u660e\u786e\u544a\u77e5\u8981\u505a\u597d\u51c6\u5907\u3002<\/p>\n\n\n\n

                  \u5230\u7b2c\u4e09\u4e2a\u6708\uff0c\u5979\u63cf\u8ff0\u4e86\u4e00\u4e9b\u5979\u53d1\u73b0\u5f88\u96be\u8868\u8fbe\u7684\u4e8b\u60c5\uff1a\u5979\u6240\u8c13\u7684\u201c\u8ba4\u77e5\u52aa\u529b\u201d\u51cf\u5c11\u4e86\u3002\u90a3\u4e9b\u66fe\u7ecf\u9700\u8981\u660e\u663e\u8111\u529b\u7684\u4efb\u52a1\u2014\u2014\u8ddf\u4e0a\u590d\u6742\u7684\u5bf9\u8bdd\u3001\u8bb0\u4f4f\u4e00\u7cfb\u5217\u6307\u4ee4\u3001\u56de\u5fc6\u8d77\u6700\u8fd1\u542c\u5230\u7684\u540d\u5b57\u2014\u2014\u611f\u89c9\u4e0d\u90a3\u4e48\u8d39\u529b\u4e86\u3002\u5e76\u975e\u6beb\u4e0d\u8d39\u529b\u3002\u53ea\u662f\u7a0d\u5fae\u6ca1\u90a3\u4e48\u96be\u4e86\u3002<\/p>\n\n\n\n

                  \u5728\u516d\u4e2a\u6708\u7684\u8282\u70b9\uff0c\u5979\u7684\u795e\u7ecf\u5fc3\u7406\u5b66\u590d\u67e5\u663e\u793a\uff0c\u5728\u6240\u6709\u6d4b\u8bd5\u9886\u57df\u7684\u5206\u6570\u90fd\u4fdd\u6301\u7a33\u5b9a\u3002\u4e0e\u57fa\u7ebf\u76f8\u6bd4\u6ca1\u6709\u53ef\u6d4b\u91cf\u7684\u4e0b\u964d\u3002\u8fd9\u4e0e\u5982\u679c\u6ca1\u6709\u5e72\u9884\u5728\u7edf\u8ba1\u5b66\u4e0a\u9884\u671f\u6bcf\u5e74\u5927\u7ea6\u4e0b\u964d 2 \u5206\u7684 MMSE \u5f62\u6210\u4e86\u9c9c\u660e\u7684\u5bf9\u6bd4\u3002\u5979\u81ea\u6211\u62a5\u544a\u5728\u65e5\u5e38\u8ba4\u77e5\u4efb\u52a1\u4e2d\u7684\u4fe1\u5fc3\u6709\u6240\u63d0\u9ad8\u3002\u5979\u7684\u7761\u7720\u8d28\u91cf\u6709\u6240\u6539\u5584\u2014\u2014\u5979\u5c06\u5176\u90e8\u5206\u5f52\u56e0\u4e8e\u5bf9\u8bca\u65ad\u8f68\u8ff9\u7684\u7126\u8651\u51cf\u5c11\u3002<\/p>\n\n\n\n

                  \u5341\u4e8c\u4e2a\u6708\u65f6\uff0c\u60c5\u51b5\u4fdd\u6301\u7a33\u5b9a\u3002\u5979\u5e76\u6ca1\u6709\u7ecf\u5386\u5bf9\u8fc7\u53bb\u4e24\u5e74\u6240\u6ce8\u610f\u5230\u8bb0\u5fc6\u53d8\u5316\u7684\u9006\u8f6c\u3002\u5979\u5bf9\u6b64\u770b\u5f97\u5f88\u6e05\u695a\uff1a\u5979\u6709\u65f6\u4ecd\u7136\u9700\u8981\u5bfb\u627e\u8bcd\u8bed\uff0c\u4ecd\u7136\u53d1\u73b0\u6709\u4e9b\u540d\u5b57\u6bd4\u4ee5\u524d\u66f4\u96be\u68c0\u7d22\u3002\u6539\u53d8\u7684\u662f\u8f68\u8ff9\u2014\u2014\u8fd9\u662f\u4e00\u79cd\u4e8b\u60c5\u5904\u4e8e\u7a33\u5b9a\u72b6\u6001\u800c\u4e0d\u662f\u7ee7\u7eed\u6076\u5316\u7684\u611f\u89c9\u3002<\/p>\n\n\n\n

                  \u5979\u5c06\u7ee7\u7eed\u6bcf\u5e74\u8fdb\u884c\u76d1\u6d4b\uff0c\u5e76\u4e14\u6ca1\u6709\u6392\u9664\u6839\u636e\u540e\u7eed\u8bc4\u4f30\u7ed3\u679c\u8fdb\u884c\u7b2c\u4e8c\u6b21\u8f93\u6ce8\u7684\u53ef\u80fd\u6027\u3002<\/p>\n\n\n\n

                  \u8fd9\u4efd\u53d9\u8ff0\u5df2\u7ecf\u7ecf\u8fc7\u60a3\u8005\u540c\u610f\u8fdb\u884c\u533f\u540d\u5904\u7406\u3002\u4e2a\u4f53\u7ed3\u679c\u5dee\u5f02\u5f88\u5927\u4e14\u65e0\u6cd5\u4fdd\u8bc1\u3002\u8fd9\u6bb5\u7ecf\u5386\u5e76\u4e0d\u4ee3\u8868\u6240\u6709\u60a3\u8005\u90fd\u4f1a\u7ecf\u5386\u7684\u60c5\u51b5\u3002<\/p>\n\n\n\n

                  <\/div>\n\n\n\n

                  \u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u5e72\u7ec6\u80de\u6cbb\u7597\u540e\u7684\u6062\u590d\u548c\u968f\u8bbf<\/h3>\n\n\n\n

                  \u9759\u8109 MSCs \u8f93\u6ce8\u7684\u6062\u590d\u5bf9\u8eab\u4f53\u8981\u6c42\u4e0d\u9ad8\u3002\u5927\u591a\u6570\u60a3\u8005\u5728\u624b\u672f\u540e\u4e24\u5230\u4e09\u5929\u5185\u5373\u53ef\u8212\u9002\u5730\u4e58\u8f66\u56de\u5bb6\u3002\u6062\u590d\u6b63\u5e38\u7684\u65e5\u5e38\u6d3b\u52a8\u901a\u5e38\u5728\u7b2c\u4e00\u5468\u5185\u3002<\/p>\n\n\n\n

                  \u6cbb\u7597\u540e\u9636\u6bb5\u6700\u91cd\u8981\u7684\u4e00\u70b9\u662f\u5bf9\u65f6\u95f4\u8868\u7684\u8010\u5fc3\u3002\u4e0d\u540c\u4e8e\u6025\u6027\u6cbb\u7597\u2014\u2014\u51e0\u5c0f\u65f6\u5185\u8d77\u6548\u7684\u6b62\u75db\u836f\uff0c\u51e0\u5929\u5185\u6d88\u708e\u7684\u76ae\u8d28\u7c7b\u56fa\u9187\u6ce8\u5c04\u2014\u2014MSCs \u7597\u6cd5\u901a\u8fc7\u7f13\u6162\u7684\u751f\u7269\u5b66\u8fc7\u7a0b\u53d1\u6325\u4f5c\u7528\uff1a\u5411\u708e\u75c7\u90e8\u4f4d\u8fc1\u79fb\u3001\u6301\u7eed\u7684\u795e\u7ecf\u8425\u517b\u56e0\u5b50\u5206\u6ccc\u3001\u6e10\u8fdb\u7684\u5c0f\u80f6\u8d28\u7ec6\u80de\u8c03\u8282\u3002\u8fd9\u4e9b\u8fc7\u7a0b\u9700\u8981\u6570\u5468\u5230\u6570\u6708\u7684\u65f6\u95f4\u624d\u80fd\u4ea7\u751f\u60a3\u8005\u6216\u6b63\u5f0f\u6d4b\u8bd5\u80fd\u591f\u68c0\u6d4b\u5230\u7684\u6548\u679c\u3002<\/p>\n\n\n\n

                  \u90a3\u4e9b\u62b1\u7740\u5728\u524d\u56db\u5468\u5185\u5c31\u4f1a\u51fa\u73b0\u6709\u610f\u4e49\u6539\u53d8\u671f\u671b\u5230\u6765\u7684\u60a3\u8005\u5c06\u4f1a\u611f\u5230\u6cae\u4e27\uff0c\u8fd9\u79cd\u6cae\u4e27\u53ef\u80fd\u4f1a\u5bfc\u81f4\u4e00\u4e2a\u4e0d\u51c6\u786e\u7684\u65e9\u671f\u7ed3\u8bba\uff1a\u6cbb\u7597\u4e0d\u8d77\u4f5c\u7528\u3002\u7406\u89e3\u65f6\u95f4\u8868\u7684\u60a3\u8005\u2014\u2014\u5e76\u4e14\u6709\u4e00\u4e2a\u7ed3\u6784\u5316\u7684\u968f\u8bbf\u8ba1\u5212\uff0c\u5305\u62ec\u5ba2\u89c2\u7684 6 \u4e2a\u6708\u590d\u67e5\u2014\u2014\u80fd\u66f4\u597d\u5730\u516c\u5e73\u8bc4\u4f30\u4ed6\u4eec\u7684\u53cd\u5e94\u3002<\/p>\n\n\n\n

                  <\/div>\n\n\n\n

                  \u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u5e72\u7ec6\u80de\u7597\u6cd5\u7684\u771f\u5b9e\u98ce\u9669\u4e0e\u5c40\u9650\u6027<\/mark><\/h2>\n\n\n\n

                  \u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u7684\u5df2\u77e5\u526f\u4f5c\u7528\u548c\u5b89\u5168\u6570\u636e<\/h3>\n\n\n\n

                  \u5728\u5df2\u53d1\u8868\u7684\u4e34\u5e8a\u8bd5\u9a8c\u548c\u6211\u4eec\u7684\u4e34\u5e8a\u7ecf\u9a8c\u4e2d\uff0c\u9759\u8109\u540c\u79cd\u5f02\u4f53 MSCs \u7597\u6cd5\u7684\u5b89\u5168\u6027\u7279\u5f81\u5bf9\u4e8e\u9759\u8109\u7ed9\u836f\u9014\u5f84\u59cb\u7ec8\u662f\u6709\u5229\u7684\u3002\u8fd9\u4e00\u70b9\u503c\u5f97\u660e\u786e\u6307\u51fa\uff0c\u4e5f\u503c\u5f97\u653e\u5728\u80cc\u666f\u4e2d\u8003\u8651\uff1a\u9a6c\u6765\u897f\u4e9a\u91c7\u7528\u7684\u9759\u8109\u6ce8\u5c04\u65b9\u6cd5\u7684\u98ce\u9669\u7279\u5f81\u4e0e\u901a\u8fc7\u5c06\u7ec6\u80de\u76f4\u63a5\u6ce8\u5c04\u5230\u5927\u8111\u6216\u8111\u810a\u6db2\u7a7a\u95f4\u7684\u8bd5\u9a8c\u660e\u663e\u4e0d\u540c\u2014\u2014\u540e\u8005\u6211\u4eec\u4e0d\u4f7f\u7528\uff0c\u56e0\u4e3a\u8fd9\u79cd\u65b9\u6cd5\u4f34\u968f\u66f4\u9ad8\u7684\u7a0b\u5e8f\u98ce\u9669\u3002<\/p>\n\n\n\n

                  \u5728\u9759\u8109\u6ce8\u5c04 MSCs \u540e\uff0c\u6700\u5e38\u62a5\u544a\u7684\u5f71\u54cd\u662f\u8f7b\u5fae\u4e14\u81ea\u9650\u6027\u7684\u3002\u8f93\u6ce8\u540e 24 \u5230 48 \u5c0f\u65f6\u5185\u7684\u4f4e\u70e7\u2014\u2014\u5927\u7ea6 15% \u5230 20% \u7684\u60a3\u8005\u62a5\u544a\u2014\u2014\u53cd\u6620\u4e86\u514d\u75ab\u7cfb\u7edf\u5bf9\u4f9b\u4f53\u7ec6\u80de\u7684\u8bc6\u522b\uff0c\u5e76\u975e\u611f\u67d3\u3002\u8f93\u6ce8\u540e\u4e00\u5230\u4e09\u5929\u51fa\u73b0\u77ed\u6682\u7684\u75b2\u52b3\u5f88\u5e38\u89c1\u3002\u62a5\u544a\u4e86\u5728\u6700\u521d\u7684 48 \u5c0f\u65f6\u5185\u5076\u5c14\u51fa\u73b0\u8f7b\u5fae\u5934\u75db\u3002\u5728\u7edd\u5927\u591a\u6570\u60c5\u51b5\u4e0b\uff0c\u8fd9\u4e9b\u5f71\u54cd\u65e0\u9700\u533b\u7597\u5e72\u9884\u5373\u53ef\u81ea\u884c\u6d88\u9000\u3002<\/p>\n\n\n\n

                  \u5728\u6d89\u53ca\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u6216 MCI \u4eba\u7fa4\u8fdb\u884c\u9759\u8109\u7ed9\u836f\u7684\u5df2\u53d1\u8868\u4e34\u5e8a\u8bd5\u9a8c\u4e2d\uff0c\u6ca1\u6709\u89c2\u5bdf\u5230\u76f4\u63a5\u5f52\u56e0\u4e8e\u9759\u8109 MSCs \u8f93\u6ce8\u7684\u4e25\u91cd\u4e0d\u826f\u4e8b\u4ef6\u2014\u2014\u5305\u62ec\u4e2d\u98ce\u3001\u80bf\u7624\u5f62\u6210\u6216\u4e25\u91cd\u7684\u514d\u75ab\u6392\u65a5\u53cd\u5e94\u3002<\/p>\n\n\n\n

                  \u5bf9\u4e8e\u53ef\u80fd\u5b58\u5728\u5fc3\u8840\u7ba1\u8106\u5f31\u6027\u7684\u8001\u5e74\u4eba\uff0c\u6cbb\u7597\u524d\u7684\u5fc3\u8840\u7ba1\u7b5b\u67e5\u662f\u6211\u4eec\u6807\u51c6\u8d44\u683c\u5ba1\u67e5\u7684\u4e00\u90e8\u5206\u3002\u5bf9\u4e8e\u60a3\u6709\u91cd\u5927\u5fc3\u810f\u75be\u75c5\u7684\u60a3\u8005\uff0c\u5728\u63a8\u8350\u4efb\u4f55\u8f93\u6ce8\u4e4b\u524d\u90fd\u8981\u8fdb\u884c\u5355\u72ec\u8bc4\u4f30\u3002<\/p>\n\n\n\n

                  <\/div>\n\n\n\n

                  \u5e72\u7ec6\u80de\u7597\u6cd5\u4e0d\u80fd\u4e3a\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u505a\u4ec0\u4e48<\/h3>\n\n\n\n

                  \u8fd9\u4e00\u8282\u548c\u672c\u6587\u7684\u5176\u4ed6\u4efb\u4f55\u90e8\u5206\u4e00\u6837\u91cd\u8981\u3002<\/p>\n\n\n\n

                  MSCs \u7597\u6cd5\u4e0d\u80fd\u6062\u590d\u5df2\u7ecf\u4e22\u5931\u7684\u8bb0\u5fc6\u3002\u5df2\u7ecf\u6b7b\u4ea1\u7684\u795e\u7ecf\u5143\u4e0d\u4f1a\u901a\u8fc7\u8fd9\u79cd\u5e72\u9884\u518d\u751f\u3002\u5df2\u7ecf\u6c38\u4e45\u5207\u65ad\u7684\u8fde\u63a5\u65e0\u6cd5\u91cd\u65b0\u5f62\u6210\u3002\u8be5\u6cbb\u7597\u9488\u5bf9\u7684\u662f\u5e78\u5b58\u795e\u7ecf\u5143\u5468\u56f4\u7684\u7ec6\u80de\u73af\u5883\u2014\u2014\u51cf\u7f13\u6301\u7eed\u7684\u635f\u4f24\uff0c\u800c\u4e0d\u662f\u9006\u8f6c\u5df2\u7ecf\u7d2f\u79ef\u7684\u635f\u4f24\u3002<\/p>\n\n\n\n

                  MSCs \u7597\u6cd5\u4e0d\u80fd\u6700\u7ec8\u9632\u6b62\u75c5\u60c5\u8fdb\u5c55\u4e3a\u75f4\u5446\u75c7\u3002\u5373\u4f7f\u5728\u5bf9\u6cbb\u7597\u6709\u53cd\u5e94\u7684\u60a3\u8005\u4e2d\uff0cMCI \u7684\u6f5c\u5728\u751f\u7269\u5b66\u8fc7\u7a0b\u2014\u2014\u5f53\u7531\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u75c5\u7406\u9a71\u52a8\u65f6\u2014\u2014\u4e5f\u4e0d\u4f1a\u88ab\u4e00\u6b21\u8f93\u6ce8\u6240\u6251\u706d\u3002\u8be5\u6cbb\u7597\u53ef\u80fd\u4f1a\u51cf\u7f13\u5b83\u4eec\u3002\u5b83\u4e0d\u80fd\u4fdd\u8bc1\u963b\u6b62\u5b83\u4eec\u3002<\/p>\n\n\n\n

                  \u76ee\u524d\u5173\u4e8e\u8fd9\u4e00\u9002\u5e94\u75c7\u7684\u957f\u671f\u7ed3\u679c\u6570\u636e\u5c1a\u672a\u4ee5\u5df2\u53d1\u8868\u7684\u5f62\u5f0f\u5b58\u5728\u3002\u5728\u6700\u76f8\u5173\u4eba\u4f53\u8bd5\u9a8c\u4e2d\uff0c\u6700\u957f\u7684\u968f\u8bbf\u671f\u4e3a\u4e24\u5230\u4e09\u5e74\u3002\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\uff0c\u91cd\u590d\u8f93\u6ce8\u662f\u5426\u6709\u76ca\uff0c\u6cbb\u7597\u4e4b\u95f4\u7684\u6700\u4f73\u95f4\u9694\u662f\u591a\u5c11\uff0c\u4ee5\u53ca\u4efb\u4f55\u5f71\u54cd\u7684\u6301\u4e45\u6027\u5982\u4f55\uff0c\u4ecd\u7136\u662f\u60ac\u800c\u672a\u51b3\u7684\u4e34\u5e8a\u95ee\u9898\u3002<\/p>\n\n\n\n

                  \u5728\u6cbb\u7597\u524d\uff0c\u6ca1\u6709\u4efb\u4f55\u751f\u7269\u6807\u5fd7\u7269\u80fd\u591f\u53ef\u9760\u5730\u9884\u6d4b\u54ea\u4e9b MCI \u60a3\u8005\u4f1a\u6709\u53cd\u5e94\uff0c\u54ea\u4e9b\u6ca1\u6709\u3002\u6211\u4eec\u7684\u6cbb\u7597\u524d\u8bc4\u4f30\u63d0\u4f9b\u4e86\u6700\u4f73\u53ef\u7528\u6307\u5bfc\u2014\u2014\u5e76\u4e14\u6211\u4eec\u5c06\u6839\u636e\u4e34\u5e8a\u60c5\u51b5\u5206\u4eab\u6211\u4eec\u8bda\u5b9e\u7684\u5224\u65ad\u2014\u2014\u4f46\u8fd9\u79cd\u4e0d\u786e\u5b9a\u6027\u662f\u8be5\u8fc7\u7a0b\u56fa\u6709\u7684\u3002<\/p>\n\n\n\n

                  \u8fd9\u4e9b\u9650\u5236\u5e76\u4e0d\u662f\u9a73\u56de\u73b0\u6709\u8bc1\u636e\u7684\u7406\u7531\u3002\u5b83\u4eec\u662f\u5fc5\u987b\u9605\u8bfb\u8be5\u8bc1\u636e\u2014\u2014\u4ee5\u53ca\u5fc5\u987b\u505a\u51fa\u4efb\u4f55\u5173\u4e8e\u6cbb\u7597\u7684\u51b3\u5b9a\u2014\u2014\u7684\u771f\u5b9e\u80cc\u666f\u3002<\/p>\n\n\n\n

                  <\/div>\n\n\n\n

                  \u5173\u4e8e\u8f7b\u5ea6\u8ba4\u77e5\u969c\u788d\u5e72\u7ec6\u80de\u7597\u6cd5\u7684\u5e38\u89c1\u95ee\u9898<\/mark><\/h2>\n\n\n\n
                  \n
                  \n