{"id":24341,"date":"2026-04-14T13:21:35","date_gmt":"2026-04-14T05:21:35","guid":{"rendered":"https:\/\/stemcell-malaysia.com\/?page_id=24341"},"modified":"2026-04-15T09:34:14","modified_gmt":"2026-04-15T01:34:14","slug":"premature-ovarian-failure","status":"publish","type":"page","link":"https:\/\/stemcell-malaysia.com\/zh\/conditions\/premature-ovarian-failure\/","title":{"rendered":"\u5375\u5de2\u65e9\u8870\u5e72\u7ec6\u80de\u6cbb\u7597 | \u653e\u5f03\u81ea\u5df1\u7684\u5375\u5b50\u4e4b\u524d\uff0c\u4f60\u5e94\u8be5\u770b\u770b\u8fd9\u4e9b\u6570\u636e"},"content":{"rendered":"\n<h1 class=\"wp-block-heading has-text-align-center\">\u5375\u5de2\u65e9\u8870\u5e72\u7ec6\u80de\u6cbb\u7597 | \u653e\u5f03\u81ea\u5df1\u7684\u5375\u5b50\u4e4b\u524d\uff0c\u4f60\u5e94\u8be5\u770b\u770b\u8fd9\u4e9b\u6570\u636e<\/h1>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"450\" src=\"https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/04\/pexels-pachon-in-motion-426015731-15803844.webp\" alt=\"\u4e00\u4e2a\u7c89\u7ea2\u8272\u76843D\u5973\u6027\u7ef4\u7eb3\u65af\u7b26\u53f7\uff0c\u80cc\u666f\u662f\u98d8\u9038\u7684\u7d2b\u8272\u5e03\u6599\u3002\" class=\"wp-image-24315\" style=\"width:592px\" srcset=\"https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/04\/pexels-pachon-in-motion-426015731-15803844.webp 800w, https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/04\/pexels-pachon-in-motion-426015731-15803844-300x169.webp 300w, https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/04\/pexels-pachon-in-motion-426015731-15803844-768x432.webp 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><figcaption class=\"wp-element-caption\">\u5375\u5de2\u65e9\u8870\uff08POF\/POI\uff09\u5f71\u54cd\u7ea61%\u7684\u80b2\u9f84\u5973\u6027\u3002\u5927\u591a\u6570\u4eba\u5728\u786e\u8bca\u540e\uff0c\u53ea\u88ab\u544a\u77e5HRT\u548c\u4f9b\u5375\u4e24\u4e2a\u9009\u9879\u3002<\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">\u6708\u7ecf\u5df2\u7ecf\u4e09\u4e2a\u591a\u6708\u6ca1\u6765\u4e86\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u9a8c\u8840\u7ed3\u679c\u51fa\u6765\uff0c\u533b\u751f\u8bf4\u4fc3\u5375\u6ce1\u7d20\uff08FSH\uff09\u7684\u6570\u503c\u9ad8\u5f97\u50cf\u7edd\u7ecf\u540e\u3002\u7136\u540e\u4f60\u542c\u5230\u4e86&#8221;\u5375\u5de2\u65e9\u8870&#8221;\u8fd9\u56db\u4e2a\u5b57\uff0c\u4ee5\u53ca\u63a5\u4e0b\u6765\u7684\uff1a\u5148\u505a\u6fc0\u7d20\u66ff\u4ee3\u6cbb\u7597\uff0c\u5982\u679c\u60f3\u8981\u5b69\u5b50\uff0c\u8003\u8651\u4f9b\u5375\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u624d\u4e09\u5341\u5c81\u51fa\u5934\uff0c\u7528\u81ea\u5df1\u7684\u5375\u5b50\u751f\u5b69\u5b50\u8fd9\u4ef6\u4e8b\uff0c\u5c31\u8fd9\u6837\u7ed3\u675f\u4e86\u5417\uff1f<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5375\u5de2\u65e9\u8870\uff08POF\/POI\uff1aPremature Ovarian Failure \/ Insufficiency\uff09\u662f\u630740\u5c81\u4e4b\u524d\u5375\u5de2\u529f\u80fd\u663e\u8457\u4e0b\u964d\uff0c\u5bfc\u81f4\u95ed\u7ecf\u6216\u6708\u7ecf\u7d0a\u4e71\u7684\u75be\u75c5\u72b6\u6001\u3002\u5168\u7403\u7ea61%\u7684\u80b2\u9f84\u5973\u6027\u53d7\u5176\u5f71\u54cd\uff0c\u4ee5\u4e2d\u56fd\u5927\u9646\u7ea61.5\u4ebf\u540d20~39\u5c81\u80b2\u9f84\u5973\u6027\u4f30\u7b97\uff0c\u6f5c\u5728\u53d7\u5f71\u54cd\u4eba\u6570\u7ea6\u4e3a150\u4e07\u3002\u786e\u8bca\u540e\u7684\u81ea\u7136\u53d7\u5b55\u7387\u4ec5\u4e3a5~10%\uff0c\u800c\u8d85\u8fc790%\u7684\u75c5\u4f8b\u4e3a&#8221;\u7279\u53d1\u6027&#8221;\uff0c\u5373\u539f\u56e0\u4e0d\u660e\u3002<\/p>\n\n\n\n<p 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class=\"wp-block-paragraph\">\u5bf9\u4e8e\u6709\u751f\u80b2\u610f\u613f\u7684\u60a3\u8005\uff0c\u76ee\u524d\u6807\u51c6\u533b\u7597\u4f53\u7cfb\u4e3b\u8981\u63d0\u4f9b\u4f9b\u5375\u4f5c\u4e3a\u65b9\u6848\u3002\u6210\u529f\u7387\u9ad8\uff0c\u5bf9\u8bb8\u591a\u4eba\u6765\u8bf4\u662f\u73b0\u5b9e\u53ef\u884c\u7684\u9009\u62e9\u3002\u7136\u800c\uff0c&#8221;\u751f\u4e0b\u6709\u81ea\u5df1\u9057\u4f20\u57fa\u56e0\u7684\u5b69\u5b50&#8221;\u8fd9\u4e00\u613f\u671b\u662f\u975e\u5e38\u6df1\u5c42\u7684\u9700\u6c42\u3002\u4f7f\u7528\u81ea\u4f53\u5375\u5b50\u7684IVF\u5728\u5375\u5de2\u65e9\u8870\u786e\u7acb\u4e4b\u540e\u598a\u5a20\u7387\u6781\u4f4e\uff0c\u4fc3\u6392\u5375\u65b9\u6848\u4e0e\u5b89\u6170\u5242\u76f8\u6bd4\u4e5f\u672a\u663e\u793a\u51fa\u7edf\u8ba1\u5b66\u663e\u8457\u5dee\u5f02\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u6b63\u662f\u5728\u6807\u51c6\u6cbb\u7597\u65b9\u6848\u90fd\u5df2\u5c1d\u8bd5\u4e4b\u540e\uff0c\u4ecd\u7136\u62b1\u7740&#8221;\u6211\u7684\u5375\u5de2\u8fd8\u6709\u6ca1\u6709\u53ef\u80fd&#8221;\u8fd9\u4e2a\u95ee\u9898\u7684\u5973\u6027\uff0c\u5f00\u59cb\u5bfb\u627e\u5e72\u7ec6\u80de\u6cbb\u7597\u7684\u76f8\u5173\u4fe1\u606f\u3002<\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"aioseo-how-stem-cell-therapy-targets-the-biology-of-premature-ovarian-failure-21\"><mark style=\"background-color:#dce9f5\" class=\"has-inline-color has-black-color\">\u5e72\u7ec6\u80de\u6cbb\u7597\u4f5c\u7528\u4e8e\u5375\u5de2\u65e9\u8870\u7684\u4e09\u5927\u673a\u5236<\/mark><\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" width=\"799\" height=\"495\" src=\"https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/04\/MSC-Treatment-31.webp\" alt=\"\u5375\u5de2\u65e9\u8870\u5e72\u7ec6\u80de\u6cbb\u7597\u7684\u4e09\u5927\u673a\u5236\u793a\u610f\u56fe\uff1a\u5375\u5de2\u5185\u708e\u75c7\u8c03\u63a7\u3001\u4f11\u7720\u5375\u6ce1\u6fc0\u6d3b\u3001\u9897\u7c92\u7ec6\u80de\u4fdd\u62a4\" class=\"wp-image-24345\" style=\"width:592px\" srcset=\"https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/04\/MSC-Treatment-31.webp 799w, https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/04\/MSC-Treatment-31-300x186.webp 300w, https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/04\/MSC-Treatment-31-768x476.webp 768w\" sizes=\"(max-width: 799px) 100vw, 799px\" \/><figcaption class=\"wp-element-caption\">\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSC\uff09\u4e0d\u662f\u4ece\u5916\u90e8\u8865\u5145\u6fc0\u7d20\uff0c\u800c\u662f\u76f4\u63a5\u4f5c\u7528\u4e8e\u5375\u5de2\u7ec4\u7ec7\u5185\u90e8\u7684\u5fae\u73af\u5883\u3002<\/figcaption><\/figure>\n<\/div>\n\n\n<h3 class=\"wp-block-heading\" id=\"aioseo-mechanism-1-modulating-the-inflammatory-environment-inside-the-ovary-22\">\u673a\u5236\u4e00\uff1a\u8c03\u8282\u5375\u5de2\u5185\u7684\u708e\u75c7\u73af\u5883<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u5728\u81ea\u8eab\u514d\u75ab\u4ecb\u5bfc\u7684\u5375\u5de2\u65e9\u8870\u4e2d\uff0c\u5375\u5de2\u5c40\u90e8\u5904\u4e8e\u6162\u6027\u708e\u75c7\u72b6\u6001\u3002\u514d\u75ab\u7ec6\u80de\u91ca\u653e\u7684\u708e\u75c7\u56e0\u5b50\uff08\u7ec6\u80de\u56e0\u5b50\u2014\u2014\u7ec6\u80de\u95f4\u4f20\u9012\u4fe1\u53f7\u7684\u86cb\u767d\u8d28\u5206\u5b50\uff09\u6301\u7eed\u635f\u4f24\u5305\u88f9\u6bcf\u4e2a\u5375\u6ce1\u7684\u9897\u7c92\u7ec6\u80de\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u95f4\u5145\u8d28\u5e72\u7ec6\u80de\uff08MSC\uff1aMesenchymal Stem Cell\uff09\u80fd\u591f\u76f4\u63a5\u4f5c\u7528\u4e8e\u8fd9\u4e00\u708e\u75c7\u7684&#8221;\u6e90\u5934&#8221;\u3002\u5b83\u4e00\u65b9\u9762\u6291\u5236\u653b\u51fb\u6027T\u7ec6\u80de\u548c\u5de8\u566c\u7ec6\u80de\u7684\u6d3b\u6027\uff0c\u53e6\u4e00\u65b9\u9762\u4fc3\u8fdb\u8c03\u8282\u6027T\u7ec6\u80de\uff08Treg\uff09\u7684\u589e\u6b96\u2014\u2014Treg\u7684\u529f\u80fd\u672c\u8d28\u4e0a\u5c31\u662f\u544a\u8bc9\u5176\u4ed6\u514d\u75ab\u7ec6\u80de&#8221;\u505c\u4e0b\u6765&#8221;\u3002\u8fd9\u79cd\u53cc\u5411\u514d\u75ab\u8c03\u8282\u4f5c\u7528\uff0c\u5728\u7c7b\u98ce\u6e7f\u5173\u8282\u708e\u7b49\u5176\u4ed6\u81ea\u8eab\u514d\u75ab\u75c5\u7684MSC\u7814\u7a76\u4e2d\u4e5f\u5f97\u5230\u4e86\u4e00\u81f4\u8bc1\u5b9e\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">HRT\u662f\u4ece\u5916\u90e8\u8865\u5145\u6fc0\u7d20\uff0cMSC\u6cbb\u7597\u5219\u662f\u5c1d\u8bd5\u51cf\u5f31\u653b\u51fb\u5375\u5de2\u7684\u514d\u75ab\u53cd\u5e94\u672c\u8eab\u2014\u2014\u8fd9\u662f\u4e24\u79cd\u622a\u7136\u4e0d\u540c\u7684\u751f\u7269\u5b66\u5207\u5165\u70b9\u3002<\/p>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"aioseo-\u673a\u5236\u4e8c\u5524\u9192\u4f11\u7720\u4e2d\u7684\u5375\u6ce1-36\">\u673a\u5236\u4e8c\uff1a\u5524\u9192\u4f11\u7720\u4e2d\u7684\u5375\u6ce1<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u5373\u4fbf\u5df2\u786e\u8bca\u4e3a\u5375\u5de2\u65e9\u8870\uff0c\u5375\u5de2\u4e2d\u5f80\u5f80\u4ecd\u6709\u6b8b\u4f59\u5375\u6ce1\u3002MSC\u4f1a\u5206\u6ccc\u591a\u79cd\u751f\u957f\u56e0\u5b50\u2014\u2014\u5305\u62ecVEGF\uff08\u4fc3\u8fdb\u8840\u7ba1\u65b0\u751f\u7684\u86cb\u767d\u8d28\uff09\u3001HGF\uff08\u809d\u7ec6\u80de\u751f\u957f\u56e0\u5b50\uff09\u548cIGF-1\uff08\u80f0\u5c9b\u7d20\u6837\u751f\u957f\u56e0\u5b50\uff09\u2014\u2014\u4e3a\u4f11\u7720\u5375\u6ce1\u7684\u6d3b\u5316\u521b\u9020\u66f4\u6709\u5229\u7684\u5fae\u73af\u5883\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u9700\u8981\u5f3a\u8c03\u7684\u662f\uff1a\u5e72\u7ec6\u80de\u4e0d\u662f&#8221;\u521b\u9020&#8221;\u51fa\u65b0\u5375\u5b50\u3002\u5b83\u7684\u4f5c\u7528\u662f\u4e3a\u5df2\u5b58\u5728\u7684\u5375\u6ce1\u5efa\u7acb\u4e00\u4e2a\u66f4\u6709\u53ef\u80fd\u91cd\u65b0\u542f\u52a8\u7684\u751f\u7269\u5b66\u73af\u5883\u3002<\/p>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"aioseo-\u673a\u5236\u4e09\u4fdd\u62a4\u9897\u7c92\u7ec6\u80de-39\">\u673a\u5236\u4e09\uff1a\u4fdd\u62a4\u9897\u7c92\u7ec6\u80de<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u9897\u7c92\u7ec6\u80de\u662f\u5305\u7ed5\u5e76\u6ecb\u517b\u6bcf\u4e2a\u5375\u6ce1\u3001\u5206\u6ccc\u96cc\u6fc0\u7d20\u3001\u652f\u6301\u5375\u6bcd\u7ec6\u80de\u6210\u719f\u7684\u6838\u5fc3\u7ec6\u80de\u3002FSH\u6301\u7eed\u504f\u9ad8\uff0c\u90e8\u5206\u539f\u56e0\u6b63\u662f\u9897\u7c92\u7ec6\u80de\u529f\u80fd\u5931\u8c03\u6240\u81f4\u3002\u591a\u9879\u5b9e\u9a8c\u7814\u7a76\u8868\u660e\uff0cMSC\u80fd\u6291\u5236\u9897\u7c92\u7ec6\u80de\u7684\u51cb\u4ea1\uff08\u7a0b\u5e8f\u6027\u7ec6\u80de\u6b7b\u4ea1\uff09\u5e76\u7ef4\u6301\u5176\u529f\u80fd\u3002\u9897\u7c92\u7ec6\u80de\u5b58\u6d3b\uff0c\u96cc\u6fc0\u7d20\u751f\u6210\u5c31\u6709\u53ef\u80fd\u9010\u6b65\u6062\u590d\uff0cFSH\u4e0eLH\uff08\u9ec4\u4f53\u751f\u6210\u7d20\uff09\u7684\u5e73\u8861\u4e5f\u6709\u671b\u91cd\u5efa\u3002<\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"aioseo-what-the-clinical-trials-actually-show-numbers-not-promises-36\"><mark style=\"background-color:#dce9f5\" class=\"has-inline-color\">\u4e34\u5e8a\u6570\u636e\u8bf4\u660e\u7684\u6570\u5b57\uff1a\u6fc0\u7d20\u6307\u6807\u4e0e\u598a\u5a20\u7387<\/mark><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"aioseo-\u6fc0\u7d20\u6307\u6807\u53d8\u5316\u6765\u81ea\u591a\u9879\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6570\u636e-45\">\u6fc0\u7d20\u6307\u6807\u53d8\u5316\uff1a\u6765\u81ea\u591a\u9879\u4e34\u5e8a\u8bd5\u9a8c\u7684\u6570\u636e<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u5375\u5de2\u65e9\u8870\u5e72\u7ec6\u80de\u6cbb\u7597\u7684\u4e34\u5e8a\u8bc1\u636e\u4f53\u91cf\uff0c\u76ee\u524d\u5c1a\u4e0d\u53ca\u5fc3\u8870\u6216\u9aa8\u5173\u8282\u708e\u7b49\u9886\u57df\uff0c\u5c1a\u65e0\u5927\u89c4\u6a21\u2162\u671f\u968f\u673a\u5bf9\u7167\u8bd5\u9a8c\u3002\u4f46\u2160\/\u2161\u671f\u8bd5\u9a8c\u548c\u7cfb\u7edf\u7efc\u8ff0\u00b7\u5143\u5206\u6790\u7684\u6570\u636e\u5df2\u6709\u591a\u9879\u53d1\u8868\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u53d1\u8868\u4e8eRegenerative Therapy\uff082024\u5e74\uff09\u7684\u5143\u5206\u6790\u62a5\u544a\uff1a\u63a5\u53d7\u5e72\u7ec6\u80de\u79fb\u690d\u7684\u5375\u5de2\u65e9\u8870\u60a3\u8005\uff0cFSH\u6c34\u5e73\u76f8\u6bd4\u57fa\u7ebf\u51fa\u73b0\u7edf\u8ba1\u663e\u8457\u4e0b\u964d\uff0c\u96cc\u4e8c\u9187\uff08\u96cc\u6fc0\u7d20\u7684\u4e3b\u8981\u5f62\u5f0f\uff09\u51fa\u73b0\u7edf\u8ba1\u663e\u8457\u4e0a\u5347\u3002\u8d85\u58f0\u53ef\u89c1\u7684\u7aa6\u72b6\u5375\u6ce1\u8ba1\u6570\u4e5f\u6709\u663e\u8457\u6539\u5584\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u53d1\u8868\u4e8eFrontiers in Endocrinology\uff082023\u5e74\uff09\u7684Liu\u7b49\u7cfb\u7edf\u7efc\u8ff0\u00b7\u5143\u5206\u6790\uff08\u6db5\u76d637\u9879\u7814\u7a76\u30011,079\u53ea\u52a8\u7269\uff09\u8bc1\u5b9e\uff1aMSC\u6cbb\u7597\u4f7f\u96cc\u4e8c\u9187\uff08\u6548\u5e94\u91cfSMD 2.69\uff09\u3001FSH\uff08SMD 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id=\"aioseo-\u598a\u5a20\u7387\u7684\u8bda\u5b9e\u6570\u5b57-50\">\u598a\u5a20\u7387\u7684\u8bda\u5b9e\u6570\u5b57<\/h3>\n\n\n\n<p 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alt=\"\u5375\u5de2\u65e9\u8870\u6cbb\u7597\u4e2d\u81ea\u4f53\u5e72\u7ec6\u80de\uff08\u65e5\u672c\u7b49\u5730\uff09\u4e0e\u5f02\u4f53\u8110\u5e26\u6765\u6e90MSC\uff08\u9a6c\u6765\u897f\u4e9a\uff09\u7684\u7ec6\u80de\u7279\u6027\u5bf9\u6bd4\u56fe\" class=\"wp-image-24343\" style=\"aspect-ratio:0.9743846925391559;width:426px;height:auto\" srcset=\"https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/04\/SCMC-Article-3.webp 724w, https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/04\/SCMC-Article-3-296x300.webp 296w, https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/04\/SCMC-Article-3-700x710.webp 700w\" sizes=\"(max-width: 724px) 100vw, 724px\" \/><figcaption 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class=\"wp-block-paragraph\">\u6211\u4eec\u63d0\u4f9b\u514d\u8d39\u7ebf\u4e0a\u54a8\u8be2\u3002\u8bf7\u5e26\u4e0a\u6fc0\u7d20\u6570\u503c\u3001\u8d85\u58f0\u62a5\u544a\u548c\u4e0d\u5b55\u6cbb\u7597\u7ecf\u5386\u3002\u60a8\u4e0d\u9700\u8981\u5df2\u7ecf\u505a\u597d\u51b3\u5b9a\u3002\u6211\u4eec\u4f1a\u6839\u636e\u60a8\u7684\u4e34\u5e8a\u8d44\u6599\uff0c\u8bda\u5b9e\u544a\u77e5\u662f\u5426\u9002\u5408\u63a5\u53d7\u672c\u6cbb\u7597\uff0c\u4ee5\u53ca\u4e3a\u4ec0\u4e48\u3002<\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"aioseo-references-140\"><mark style=\"background-color:#dce9f5\" class=\"has-inline-color\">\u53c2\u8003\u6587\u732e<\/mark><\/h2>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Chon SJ, Umair Z, Yoon MS. &#8220;Premature ovarian insufficiency: past, present, and future.&#8221; Frontiers in Cell and Developmental Biology. 2021;9:672890. <a href=\"https:\/\/doi.org\/10.3389\/fcell.2021.672890\" target=\"_blank\" rel=\"noopener\" title=\"\">https:\/\/doi.org\/10.3389\/fcell.2021.672890<\/a><br><\/li>\n\n\n\n<li>Golezar S, Ramezani Tehrani F, Khazaei S, Ebadi A, Keshavarz Z. &#8220;The global prevalence of primary ovarian insufficiency and early menopause: a meta-analysis.&#8221; Climacteric. 2019;22(4):403\u2013411. <a href=\"https:\/\/doi.org\/10.1080\/13697137.2019.1574738\" target=\"_blank\" rel=\"noopener\" title=\"\">https:\/\/doi.org\/10.1080\/13697137.2019.1574738<\/a><br><\/li>\n\n\n\n<li>Shareghi-Oskoue O, Aghebati-Maleki L, Yousefi M. &#8220;Transplantation of human umbilical cord mesenchymal stem cells to treat premature ovarian failure.&#8221; Stem Cell Research and Therapy. 2021;12:454. <a href=\"https:\/\/doi.org\/10.1186\/s13287-021-02529-w\" target=\"_blank\" rel=\"noopener\" title=\"\">https:\/\/doi.org\/10.1186\/s13287-021-02529-w<\/a><br><\/li>\n\n\n\n<li>Liu R, Zhang X, Fan Z, Wang Y, Yao G, Yang B, et al. &#8220;Mesenchymal stem cells therapy improves ovarian function in premature ovarian failure: a systematic review and meta-analysis based on preclinical studies.&#8221; Frontiers in Endocrinology. 2023;14:1165574. <a href=\"https:\/\/doi.org\/10.3389\/fendo.2023.1165574\" target=\"_blank\" rel=\"noopener\" title=\"\">https:\/\/doi.org\/10.3389\/fendo.2023.1165574<\/a><br><\/li>\n\n\n\n<li>Zhang L et al. &#8220;Meta-analysis highlight the therapeutic potential of stem cells for premature ovarian failure.&#8221; Regenerative Therapy. 2024. <a href=\"https:\/\/doi.org\/10.1016\/j.reth.2024.07.002\" target=\"_blank\" rel=\"noopener\" title=\"\">https:\/\/doi.org\/10.1016\/j.reth.2024.07.002<\/a><br><\/li>\n\n\n\n<li>Webber L, Anderson RA, Davies M, Janse F, Vermeulen N. &#8220;HRT for women with premature ovarian insufficiency: a comprehensive review.&#8221; Human Reproduction Open. 2017;2017:hox007. <a href=\"https:\/\/doi.org\/10.1093\/hropen\/hox007\" target=\"_blank\" rel=\"noopener\" title=\"\">https:\/\/doi.org\/10.1093\/hropen\/hox007<\/a><br><\/li>\n\n\n\n<li>Sheikhansari G, Aghebati-Maleki L, Nouri M, Jadidi-Niaragh F, Yousefi M. &#8220;Current approaches for the treatment of premature ovarian failure.&#8221; Biomedicine and Pharmacotherapy. 2018;102:254\u2013262. <a href=\"https:\/\/doi.org\/10.1016\/j.biopha.2018.03.056\" target=\"_blank\" rel=\"noopener\" title=\"\">https:\/\/doi.org\/10.1016\/j.biopha.2018.03.056<\/a><br><\/li>\n\n\n\n<li>Gao M, Yu Z, Yao D, Qian Y, Wang Q, Jia R. &#8220;Mesenchymal stem cells therapy: a promising method for the treatment of uterine scars and premature ovarian failure.&#8221; Tissue and Cell. 2022;74:101676. <a href=\"https:\/\/doi.org\/10.1016\/j.tice.2021.101676\" target=\"_blank\" rel=\"noopener\" title=\"\">https:\/\/doi.org\/10.1016\/j.tice.2021.101676<\/a><\/li>\n<\/ol>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\t\t<div 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