{"id":22741,"date":"2026-03-09T12:33:22","date_gmt":"2026-03-09T04:33:22","guid":{"rendered":"https:\/\/stemcell-malaysia.com\/?p=22741"},"modified":"2026-07-19T12:45:43","modified_gmt":"2026-07-19T04:45:43","slug":"navigating-the-regulatory-and-clinical-landscape-of-stem-cells-in-ovarian-cancer","status":"publish","type":"post","link":"https:\/\/stemcell-malaysia.com\/ko\/navigating-the-regulatory-and-clinical-landscape-of-stem-cells-in-ovarian-cancer\/","title":{"rendered":"\ub09c\uc18c\uc554 \uc904\uae30\uc138\ud3ec\uc758 \uaddc\uc81c \ubc0f \uc784\uc0c1 \ud658\uacbd \ud0d0\uc0c9"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"22741\" class=\"elementor elementor-22741\" data-elementor-post-type=\"post\">\n\t\t\t\t        <section class=\"elementor-section elementor-top-section elementor-element elementor-element-3f668a96 elementor-section-boxed elementor-section-height-default elementor-section-height-default pxl-row-scroll-none pxl-zoom-point-false pxl-section-overflow-visible pxl-section-fix-none pxl-bg-color-none pxl-section-overlay-none\" data-id=\"3f668a96\" data-element_type=\"section\">\n\n                \n                <div class=\"elementor-container elementor-column-gap-default \">\n                <div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7c3da457 pxl-column-none pxl-column-overflow-hidden-no\" data-id=\"7c3da457\" data-element_type=\"column\">\r\n        <div class=\"elementor-widget-wrap elementor-element-populated\">\r\n                     \r\n        \t\t<div class=\"elementor-element elementor-element-31383f96 elementor-widget elementor-widget-text-editor\" data-id=\"31383f96\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t\n<h1 style=\"text-align: center;\">\ub09c\uc18c\uc554 \uc904\uae30\uc138\ud3ec\uc758 \uaddc\uc81c \ubc0f \uc784\uc0c1 \ud658\uacbd \ud0d0\uc0c9<\/h1>\n\n<figure><img decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/03\/Screenshot-2026-03-09-at-11.42.44-AM-1024x745.png\" alt=\"\" \/><\/figure>\n\n<p class=\"wp-block-paragraph\" style=\"text-align: center;\"><em>\uc548\uc804\uc131, \uaddc\uc815 \uc900\uc218 \ubc0f \ud658\uc790 \uc608\ud6c4\uc5d0 \uc911\uc810\uc744 \ub450\uace0 \uc7ac\ubc1c\uc131 \ub09c\uc18c\uc554\uc5d0 \ub300\ud55c \uc904\uae30\uc138\ud3ec \uc720\ub798 \uc790\uc5f0\uc0b4\ud574(Natural Killer, NK) \uc138\ud3ec\uc758 \uc784\uc0c1 \uc5f0\uad6c\ub97c \ud0d0\uc0c9\ud569\ub2c8\ub2e4.<br \/><br \/><\/em><\/p>\n\n<p class=\"wp-block-paragraph\">\uc7ac\ubc1c\uc131 \uc0c1\ud53c\uc131 \ub09c\uc18c\uc554\uc740 \ud754\ud788 \ub192\uc740 \uc7ac\ubc1c\ub960\uacfc \ud45c\uc900 \ud654\ud559\uc694\ubc95 \ud504\ub85c\ud1a0\ucf5c \uc774\ud6c4 \uc81c\ud55c\uc801\uc778 \uc7a5\uae30 \uce58\ub8cc \uc635\uc158\uc774 \ud2b9\uc9d5\uc73c\ub85c \ub098\ud0c0\ub098\uba70, \uc774\ub294 \uc911\ub300\ud55c \uc784\uc0c1\uc801 \uacfc\uc81c\ub97c \uc81c\uc2dc\ud569\ub2c8\ub2e4. 2026\ub144 \u2018\ubd80\uc778\uc885\uc591\ud559(Gynecologic Oncology)\u2019\uc9c0\uc5d0 \ubc1c\ud45c\ub41c \ucd5c\uadfc \uc784\uc0c1 \uc5f0\uad6c\ub294 \uc774\ub7ec\ud55c \uce58\ub8cc\uc801 \uacf5\ubc31\uc744 \ud574\uc18c\ud558\uae30 \uc704\ud574 \uc81c\ub300\ud608 \uc904\uae30\uc138\ud3ec\uc5d0\uc11c \uc720\ub798\ud55c NK \uc138\ud3ec\ub97c \ubcf5\uac15\ub0b4 \uc8fc\uc785\uc744 \ud1b5\ud574 \ud22c\uc5ec\ud558\ub294 \ubc29\ubc95\uc758 \uc548\uc804\uc131\uacfc \ud0c0\ub2f9\uc131\uc744 \ud3c9\uac00\ud569\ub2c8\ub2e4. \ub124\ub35c\ub780\ub4dc \ub77c\ub4dc\ubc14\uc6b0\ub4dc \ub300\ud559 \ubcd1\uc6d0(Radboud University Medical Center)\uc774 \uc554\ud53c\uc544 \ubcd1\uc6d0(Amfia Hospital)\uacfc \ud611\ub825\ud558\uc5ec \uc8fc\ub3c4\ud55c INTRO-01 \uc784\uc0c1 1\uc0c1 \uc2dc\ud5d8\uc740 \uc774 \uc138\ud3ec \uc694\ubc95\uc758 \ub0b4\uc57d\uc131 \ubc0f \ucd08\uae30 \uc784\uc0c1 \ubc18\uc751\uc5d0 \uad00\ud55c \uc911\uc694\ud55c \uc608\ube44 \ub370\uc774\ud130\ub97c \uc81c\uacf5\ud569\ub2c8\ub2e4.<\/p>\n\n<h2 class=\"wp-block-heading\" style=\"text-align: center;\"><br \/><br \/>\uc904\uae30\uc138\ud3ec \uc720\ub798 NK \uc694\ubc95\uc758 \uc784\uc0c1\uc801 \uadfc\uac70<\/h2>\n\n<p class=\"wp-block-paragraph\" data-path-to-node=\"42\">\uc5ed\uc0ac\uc801\uc73c\ub85c \uc7ac\ubc1c\uc131 \ub09c\uc18c\uc554\uc758 \uad00\ub9ac\ub294 \ubc31\uae08 \uae30\ubc18 \ud654\ud559\uc694\ubc95\uacfc PARP \uc5b5\uc81c\uc81c\uc5d0 \ud06c\uac8c \uc758\uc874\ud574 \uc654\uc2b5\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \uc7ac\ubc1c \ud658\uc790\uc758 \ub192\uc740 \uc7ac\ubc1c\ub960\uacfc \uc57d 2\ub144\uc758 \uc911\uc559 \uc0dd\uc874 \uae30\uac04\uc740 \uc0c8\ub85c\uc6b4 \uce58\ub8cc \uc591\uc2dd\uc758 \ud544\uc694\uc131\uc744 \uac15\uc870\ud569\ub2c8\ub2e4. \uc885\uc591\ud559 \uc784\uc0c1 \uc5f0\uad6c\uc758 \ub354 \ub113\uc740 \ud658\uacbd\uc5d0\uc11c \uba74\uc5ed\uc694\ubc95, \ud2b9\ud788 \uc138\ud3ec \uae30\ubc18 \uc694\ubc95\uc740 \ud070 \uad00\uc2ec\uc744 \ub04c\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<p data-path-to-node=\"43\">\ud0a4\uba54\ub77c \ud56d\uc6d0 \uc218\uc6a9\uccb4 T\uc138\ud3ec(Chimeric Antigen Receptor T-cell, CAR-T) \uc694\ubc95\uc774 \ud2b9\uc815 \ud608\uc561 \uc545\uc131 \uc885\uc591\uc5d0\uc11c \ud6a8\ub2a5\uc744 \uc785\uc99d\ud588\uc9c0\ub9cc, \uc0c1\ud53c\uc131 \ub09c\uc18c\uc554\uacfc \uac19\uc740 \uace0\ud615\uc554\uc5d0 \ub300\ud55c \uc801\uc6a9\uc740 \ub69c\ub837\ud55c \ubbf8\uc138\ud658\uacbd \ubc0f \ud45c\uc801\ud654 \uacfc\uc81c\uc5d0 \uc9c1\uba74\ud574 \uc788\uc2b5\ub2c8\ub2e4. \uacb0\uacfc\uc801\uc73c\ub85c NK \uc138\ud3ec\ub294 \uace0\ud615\uc554 \uc5f0\uad6c\uc758 \uc8fc\uc694 \ucd08\uc810\uc73c\ub85c \ubd80\uc0c1\ud588\uc2b5\ub2c8\ub2e4. NK \uc138\ud3ec\ub294 \uc120\ucc9c \uba74\uc5ed \uccb4\uacc4\uc758 \ud575\uc2ec \uad6c\uc131 \uc694\uc18c\ub85c \uae30\ub2a5\ud558\uba70, \uc774\uc804\uc758 \ud56d\uc6d0 \ubbfc\uac10\ud654 \uc5c6\uc774\ub3c4 \uc774\uc0c1 \uc138\ud3ec\ub97c \uc2dd\ubcc4\ud558\uace0 \uc81c\uac70\ud558\ub294 \ub3d9\uc2dc\uc5d0 \uac74\uac15\ud55c \uc870\uc9c1\uc740 \uc77c\ubc18\uc801\uc73c\ub85c \ubcf4\uc874\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n<p data-path-to-node=\"44\">\ub610\ud55c \ub3d9\uc885 NK \uc138\ud3ec, \ud2b9\ud788 \uc81c\ub300\ud608 \uc904\uae30\uc138\ud3ec\uc5d0\uc11c \uc720\ub798\ud55c \uc138\ud3ec\uc758 \ud65c\uc6a9\uc740 \uc790\uac00 \uc694\ubc95\uacfc \uad00\ub828\ub41c \uc5ec\ub7ec \ubb3c\ub958\uc801 \ubc0f \uc784\uc0c1\uc801 \uc7a5\ubcbd\uc744 \ud574\uacb0\ud569\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ub3d9\uc885 \uc81c\ud488\uc740 \uba74\uc5ed \uc5b5\uc81c \ud654\ud559\uc694\ubc95\uc73c\ub85c \uc9d1\uc911\uc801\uc778 \uc0ac\uc804 \uce58\ub8cc\ub97c \ubc1b\uc740 \ud658\uc790\ub85c\ubd80\ud130 \uae30\ub2a5\uc801 \uba74\uc5ed \uc138\ud3ec\ub97c \uc218\ud655\ud574\uc57c \ud558\ub294 \uacfc\uc81c\ub97c \uc81c\uac70\ud569\ub2c8\ub2e4. \ub610\ud55c \uc5c4\uaca9\ud55c \uae00\ub85c\ubc8c \uaddc\uc815 \uc900\uc218 \ud45c\uc900\uc5d0 \ub9de\ucdb0 \uc138\ud3ec \uc81c\ud488\uc758 \ud45c\uc900\ud654\ub418\uace0 \ud655\uc7a5 \uac00\ub2a5\ud55c \uc81c\uc870\ub97c \uac00\ub2a5\ud558\uac8c \ud558\uba70, \uae30\uc131\ud488(off-the-shelf) \ud615\ud0dc\uc758 \uac00\uc6a9\uc131\uc744 \ucd09\uc9c4\ud569\ub2c8\ub2e4.<\/p>\n\n<h2 class=\"wp-block-heading\" style=\"text-align: center;\"><br \/><br \/>\ubcf5\uac15\ub0b4 \ud22c\uc5ec: \uad6d\uc18c \uc804\ub2ec \uac15\ud654<\/h2>\n\n<p class=\"wp-block-paragraph\" data-path-to-node=\"46\">\uc9c4\ud589\uc131 \ub09c\uc18c\uc554\uc758 \uacb0\uc815\uc801 \ud2b9\uc9d5\uc740 \uad11\ubc94\uc704\ud55c \ubcf5\ub9c9 \ud30c\uc885 \uacbd\ud5a5\uc785\ub2c8\ub2e4. \uc774\ub7ec\ud55c \ubcd1\ub9ac\ub97c \uc778\uc2dd\ud558\uc5ec INTRO-01 \uc2dc\ud5d8\uc758 \uc5f0\uad6c\ud300\uc740 \uc804\uc2e0 \uc815\ub9e5 \ud22c\uc5ec \ub300\uc2e0 \ubcf5\uac15\ub0b4 \uc8fc\uc785\uc744 \uc804\ub7b5\uc801\uc73c\ub85c \ud65c\uc6a9\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n<p data-path-to-node=\"47\">\uc774 \uad6d\uc18c \uc804\ub2ec \uba54\ucee4\ub2c8\uc998\uc740 \ubcf5\uac15\ub0b4 \ud654\ud559\uc694\ubc95 \ubc0f \uc628\uc5f4 \ubcf5\uac15\ub0b4 \ud654\ud559\uc694\ubc95(Hyperthermic Intraperitoneal Chemotherapy, HIPEC)\uc758 \uae30\ubcf8 \uc6d0\ub9ac\uc640 \uc720\uc0ac\ud558\uac8c \ubd80\uc778\uc885\uc591\ud559\uc5d0\uc11c \uc798 \ud655\ub9bd\ub41c \uac1c\ub150\uc785\ub2c8\ub2e4. \uc904\uae30\uc138\ud3ec \uc720\ub798 NK \uc81c\ud488\uc744 \ubcf5\uac15\uc5d0 \uc9c1\uc811 \ud22c\uc5ec\ud568\uc73c\ub85c\uc368 \uc784\uc0c1\uc758\ub294 \uc885\uc591 \ubcd1\ubcc0 \ubd80\uc704\uc5d0 \uc815\ud655\ud788 \uce58\ub8cc\uc81c\uc758 \uad6d\uc18c \ub18d\ub3c4\ub97c \ucd5c\ub300\ud654\ud558\ub294 \uac83\uc744 \ubaa9\ud45c\ub85c \ud569\ub2c8\ub2e4. \uc774\ub860\uc801\uc73c\ub85c \uc774 \uc811\uadfc\ubc95\uc740 \uc885\uc591 \ubbf8\uc138\ud658\uacbd \ub0b4\uc5d0\uc11c \uc774\ud399\ud130 \uc138\ud3ec\uc758 \uccb4\ub958 \uc2dc\uac04\uc744 \uc5f0\uc7a5\ud558\ub294 \ub3d9\uc2dc\uc5d0 \uc804\uc2e0 \ub3c5\uc131 \ubc0f \ud45c\uc801 \uc678(off-target) \ud6a8\uacfc\uc758 \uc704\ud5d8\uc744 \uc644\ud654\ud569\ub2c8\ub2e4.<\/p>\n<p>\u00a0<\/p>\n\n<figure><img decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/03\/2-3.jpg\" alt=\"\" \/><\/figure>\n\n<h2 class=\"wp-block-heading\" style=\"text-align: center;\"><br \/>\uc784\uc0c1 1\uc0c1 \uc2dc\ud5d8 \ud504\ub85c\ud1a0\ucf5c \ubc0f \uaddc\uc81c \uc900\uc218<\/h2>\n\n<p class=\"wp-block-paragraph\">INTRO-01 \uc784\uc0c1 \uc2dc\ud5d8\uc740 \uc8fc\ub85c \ub3c5\uc810\uc801\uc778 NK \uc138\ud3ec \uc81c\ud488\uc778 RNK001\uc758 \uc548\uc804\uc131 \ud504\ub85c\ud30c\uc77c\uacfc \ud0c0\ub2f9\uc131\uc744 \ud3c9\uac00\ud558\uae30 \uc704\ud574 \uc124\uacc4\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc5c4\uaca9\ud55c \uc724\ub9ac \uac80\ud1a0\uc640 \uc9c0\uc18d\uc801\uc778 \uc548\uc804 \ubaa8\ub2c8\ud130\ub9c1 \ud558\uc5d0 \uc6b4\uc601\ub41c \uc774 \uc5f0\uad6c\ub294 \ucd08\uae30\uc5d0 \uc0c1\ud53c\uc131 \ub09c\uc18c\uc554\uc774 \ub450 \ubc88\uc9f8\ub85c \uc7ac\ubc1c\ud558\uace0 CA125 \uc885\uc591 \ud45c\uc9c0\uc790\uac00 \uc0c1\uc2b9\ud55c 12\uba85\uc758 \ud658\uc790\ub97c \ub4f1\ub85d\ud560 \uacc4\ud68d\uc774\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n\n<h3 class=\"wp-block-heading\" style=\"text-align: center;\"><br \/>\ud658\uc790 \ucf54\ud638\ud2b8 \ubc0f \ud22c\uc5ec \ub9e4\uac1c\ubcc0\uc218<\/h3>\n\n<p class=\"wp-block-paragraph\" data-path-to-node=\"51\">\ud504\ub85c\ud1a0\ucf5c\uc740 \ucc38\uac00\uc790\ub97c \ub450 \uac1c\uc758 \ubcc4\uac1c \ucf54\ud638\ud2b8\ub85c \uacc4\uce35\ud654\ud558\uc5ec \uc0ac\uc804 \ub9bc\ud504\uad6c \uace0\uac08 \ud654\ud559\uc694\ubc95 \uc720\ubb34\uc5d0 \ub530\ub978 \uac1c\uc785\uc744 \ud3c9\uac00\ud588\uc2b5\ub2c8\ub2e4. 6\uba85\uc758 \ud658\uc790\ub85c \uad6c\uc131\ub41c \uccab \ubc88\uc9f8 \ucf54\ud638\ud2b8\ub294 \uc900\ube44 \ud654\ud559\uc694\ubc95 \uc5c6\uc774 RNK001\uc758 \uc9c1\uc811 \ubcf5\uac15\ub0b4 \uc8fc\uc785\uc744 \ubc1b\uc558\uc2b5\ub2c8\ub2e4. \ub450 \ubc88\uc9f8 \ucf54\ud638\ud2b8\ub294 \uc8fc\uc785 \uc804\uc5d0 \ub3d9\uc885 \uc138\ud3ec\uc5d0 \ub300\ud55c \uc219\uc8fc\uc758 \uba74\uc5ed \uac70\ubd80 \ubc18\uc751\uc744 \uc644\ud654\ud558\uae30 \uc704\ud55c \uc138\ud3ec \uc694\ubc95\uc758 \ud45c\uc900 \uad00\ud589\uc778 \uc0ac\uc774\ud074\ub85c\ud3ec\uc2a4\ud30c\ub9c8\uc774\ub4dc(cyclophosphamide)\uc640 \ud50c\ub8e8\ub2e4\ub77c\ube48(fludarabine)\uc73c\ub85c \uad6c\uc131\ub41c \uc57d\ud55c \ub9bc\ud504\uad6c \uace0\uac08 \uc694\ubc95\uc744 \ubc1b\ub3c4\ub85d \uc9c0\uc815\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \ud654\ud559\uc694\ubc95\uc774 \uc5c6\ub294 \uc811\uadfc\ubc95\uc744 \uc120\ud638\ud558\ub294 \ud658\uc790\uc758 \uc758\ud5a5\uc73c\ub85c \uc778\ud574 \uc774 \ub450 \ubc88\uc9f8 \ucf54\ud638\ud2b8\uc5d0\uc11c\ub294 \ub2e8 \ud55c \uba85\uc758 \ud658\uc790\ub9cc\uc774 \ub4f1\ub85d\ub418\uc5b4 \uce58\ub8cc\ub97c \uc644\ub8cc\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n<p data-path-to-node=\"52\">\uad81\uadf9\uc801\uc73c\ub85c 7\uba85\uc758 \ud658\uc790\uac00 \uc131\uacf5\uc801\uc73c\ub85c \ubcf5\uac15\ub0b4 \uac1c\uc785\uc744 \ubc1b\uc558\uc2b5\ub2c8\ub2e4. \ud22c\uc5ec \uc6a9\ub7c9\uc740 1.2~3.0 \u00d7 10\u2079\uac1c\uc758 NK \uc138\ud3ec \ubc94\uc704\uc600\uc2b5\ub2c8\ub2e4. \uc8fc\uc785\ub41c \uc138\ud3ec\uc758 \uc0dd\uccb4 \ub0b4(in vivo) \uc9c0\uc18d\uc131\uacfc \ud65c\uc131\ud654\ub97c \uc9c0\uc6d0\ud558\uae30 \uc704\ud574 7\uba85 \uc911 6\uba85\uc758 \ud658\uc790\ub294 \uc778\ud130\ub8e8\ud0a8-2(Interleukin-2, IL-2)\uc758 \ub3d9\uc2dc \ubcf5\uac15\ub0b4 \uc8fc\uc785\ub3c4 \ubc1b\uc558\uc2b5\ub2c8\ub2e4. \ud22c\uc5ec\ub294 \ubcf5\uac15\uacbd\uc73c\ub85c \ubc30\uce58\ub41c \ubcf5\uac15\ub0b4 \ud3ec\ud2b8\ub97c \ud1b5\ud574 \ucd09\uc9c4\ub418\uc5c8\uc73c\uba70, \uae30\ubcf8 \ud3c9\uac00\uc5d0\uc11c \ubcf5\uac15\uc561\uc758 \uc801\uc808\ud55c \ud655\uc0b0 \ub2a5\ub825\uc774 \ud655\uc778\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc808\ucc28 \ub2e8\uacc4\ub294 \ud3ec\ud2b8 \ud3d0\uc0c9\uc774\ub098 \uae09\uc131 \uc8fc\uc785 \ubc18\uc751\uacfc \uac19\uc740 \ud569\ubcd1\uc99d \uc5c6\uc774 \uc644\ub8cc\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n\n<h3 class=\"wp-block-heading\" style=\"text-align: center;\"><br \/>GMP \uc900\uc218 \uc81c\uc870<\/h3>\n\n<p class=\"wp-block-paragraph\">\ubcf8 \uc5f0\uad6c\uc5d0\uc11c \ud65c\uc6a9\ub41c RNK001 \uc81c\ud488\uc740 \ucca8\ub2e8\uc7ac\uc0dd\uc758\ub8cc\uc81c\ud488(Advanced Therapy Medicinal Products, ATMPs)\uc5d0\uc11c \uac15\ub825\ud55c \uaddc\uc81c \ud504\ub808\uc784\uc6cc\ud06c\uc758 \uc911\uc694\uc131\uc744 \uac15\uc870\ud569\ub2c8\ub2e4. \ub3d9\uc885 NK \uc138\ud3ec\ub294 \uc6b0\uc218 \uc758\uc57d\ud488 \uc81c\uc870 \ubc0f \ud488\uc9c8 \uad00\ub9ac \uae30\uc900(Good Manufacturing Practice, GMP)\uc744 \uc5c4\uaca9\ud788 \uc900\uc218\ud558\uc5ec \uc81c\ub300\ud608 \uc870\ud608 \uc904\uae30\uc138\ud3ec\uc5d0\uc11c \uccb4\uc678(in vitro)\ub85c \uc99d\ud3ed\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ud488\uc9c8 \uad00\ub9ac \uce21\uc815 \uacb0\uacfc, CD56+CD3- NK \uc138\ud3ec\uc758 \ud3c9\uade0 \uc21c\ub3c4\ub294 90%\uc600\uc73c\uba70 \uc138\ud3ec \uc0dd\uc874\uc728\uc740 99%\uc600\uc2b5\ub2c8\ub2e4. \ubaa8\ub4e0 \ubc30\uce58\ub294 \uc778\uac04 \uc784\uc0c1 \uc801\uc6a9\uc5d0 \ud544\uc694\ud55c \uaddc\uc815 \uc900\uc218 \uc694\uac74\uc744 \ucda9\uc871\ud558\uba70 \ubbf8\uc0dd\ubb3c \uc624\uc5fc \ubc0f \ub0b4\ub3c5\uc18c \ud55c\uacc4\uc5d0 \ub300\ud55c \uc5c4\uaca9\ud55c \ud14c\uc2a4\ud2b8\ub97c \ud1b5\uacfc\ud588\uc2b5\ub2c8\ub2e4.<br \/><br \/><\/p>\n\n<figure><img decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/03\/3-1-1024x701.webp\" alt=\"\" \/><\/figure>\n\n<h2 class=\"wp-block-heading\" style=\"text-align: center;\"><br \/><br \/>\uc548\uc804\uc131 \ud504\ub85c\ud30c\uc77c \ubc0f \uc608\ube44 \uc784\uc0c1 \uad00\ucc30<\/h2>\n\n<p class=\"wp-block-paragraph\">\uc784\uc0c1 1\uc0c1 \uc5f0\uad6c\ub85c\uc11c \uc77c\ucc28 \ud3c9\uac00\ubcc0\uc218\ub294 \uc548\uc804\uc131 \ubc0f \ub0b4\uc57d\uc131\uc5d0 \ub300\ud55c \ud3c9\uac00\uc600\uc2b5\ub2c8\ub2e4. \ub370\uc774\ud130\uc5d0 \ub530\ub974\uba74 RNK001 \uac1c\uc785\uc740 \uc77c\ubc18\uc801\uc73c\ub85c \ub0b4\uc57d\uc131\uc774 \uc6b0\uc218\ud588\uc73c\uba70, \uc2ec\uac01\ud55c \uc6a9\ub7c9 \uc81c\ud55c \ub3c5\uc131\uc774 \uc5c6\ub294 \uad00\ub9ac \uac00\ub2a5\ud55c \uc548\uc804\uc131 \ud504\ub85c\ud30c\uc77c\uc744 \uc785\uc99d\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n\n<h3 class=\"wp-block-heading\" style=\"text-align: center;\"><br \/>\uc774\uc0c1\ubc18\uc751 \ud3c9\uac00<\/h3>\n\n<p class=\"wp-block-paragraph\">\uc911\uc694\ud55c \uc810\uc740, 7\uba85\uc758 \ud658\uc790 \uc911 \ub204\uad6c\ub3c4 \ub3d9\uc885 \uc138\ud3ec \uc694\ubc95\uacfc \uad00\ub828\ub41c \uac00\uc7a5 \uc911\uc694\ud558\uace0 \uc7a0\uc7ac\uc801\uc73c\ub85c \uc0dd\uba85\uc744 \uc704\ud611\ud560 \uc218 \uc788\ub294 \ud569\ubcd1\uc99d\uc778 \uc774\uc2dd\ud3b8\ub300\uc219\uc8fc\ubcd1(Graft-versus-host disease, GVHD) \ub610\ub294 \uc0ac\uc774\ud1a0\uce74\uc778 \ubc29\ucd9c \uc99d\ud6c4\uad70(Cytokine release syndrome, CRS)\uc744 \ubc1c\uc0dd\uc2dc\ud0a4\uc9c0 \uc54a\uc558\ub2e4\ub294 \uac83\uc785\ub2c8\ub2e4. 3\ub4f1\uae09 \uc774\uc0c1\ubc18\uc751\uc740 2\uac74\uc73c\ub85c \uc81c\ud55c\ub418\uc5c8\uc2b5\ub2c8\ub2e4: 2\uc8fc \uc774\ub0b4\uc5d0 \uc790\uc5f0\uc801\uc73c\ub85c \uc18c\uc2e4\ub41c \uc77c\uacfc\uc131 \uac04 \ud6a8\uc18c \uc0c1\uc2b9 1\uac74, \uadf8\ub9ac\uace0 \uc7a5\ud3d0\uc0c9 1\uac74\uc774\uc5c8\uc2b5\ub2c8\ub2e4. \ud6c4\uc790\ub294 NK \uc138\ud3ec \uc8fc\uc785\uacfc \uad00\ub828\ub41c \ub3c5\uc131\uc774 \uc544\ub2c8\ub77c \uae30\uc800 \uc9c8\ud658 \uc9c4\ud589\uc758 \uacb0\uacfc\ub85c \uc784\uc0c1\uc801\uc73c\ub85c \ud3c9\uac00\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ubcf4\uc870\uc801\uc778 IL-2 \uc694\ubc95\uc744 \ubc1b\uc740 \ud658\uc790\ub294 \ubc1c\uc5f4 \ubc0f \uc624\ud55c\uacfc \uac19\uc774 \uc608\uc0c1 \uac00\ub2a5\ud55c \ub0ae\uc740 \ub4f1\uae09\uc758 \ubc18\uc751\uc744 \ubcf4\uc600\uc73c\uba70, \uc774\ub294 \uc544\uc138\ud2b8\uc544\ubbf8\ub178\ud39c(acetaminophen)\uacfc \uac19\uc740 \ud45c\uc900 \ud574\uc5f4\uc81c\ub85c \uc801\uc808\ud558\uac8c \uad00\ub9ac\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n\n<h3 class=\"wp-block-heading\" style=\"text-align: center;\"><br \/>\uc885\uc591 \ud45c\uc9c0\uc790 \ubc18\uc751 \ubc0f \uc0dd\uc874 \ub370\uc774\ud130<\/h3>\n\n<p class=\"wp-block-paragraph\" data-path-to-node=\"60\">\uc784\uc0c1 1\uc0c1 \uc2dc\ud5d8\uc5d0\uc11c \ud6a8\ub2a5\uc740 \uc774\ucc28 \ud3c9\uac00\ubcc0\uc218\uc9c0\ub9cc, \uc608\ube44 \uad00\ucc30 \ub370\uc774\ud130\ub294 \uc0dd\ubb3c\ud559\uc801 \ud65c\uc131\uc758 \uce21\uc815 \uac00\ub2a5\ud55c \uc9c0\ud45c\ub97c \uc81c\uacf5\ud588\uc2b5\ub2c8\ub2e4. \uce58\ub8cc \uc804 \ubaa8\ub4e0 \ub4f1\ub85d \ud658\uc790\ub294 \uc720\uc758\ud558\uac8c \uc0c1\uc2b9\ub41c CA125 \uc218\uce58\ub97c \ubcf4\uc600\uc2b5\ub2c8\ub2e4. \uc8fc\uc785 14\uc77c \ud6c4, 7\uba85\uc758 \ud658\uc790 \uc911 5\uba85\uc740 CA125\uc5d0\uc11c 20%~53% \uac10\uc18c\uc5d0 \uc774\ub974\ub294 \uc815\ub7c9\ud654 \uac00\ub2a5\ud55c \uac10\uc18c\ub97c \uc785\uc99d\ud588\uc2b5\ub2c8\ub2e4.<\/p>\n<p data-path-to-node=\"61\">\uc8fc\ubaa9\ud560 \ub9cc\ud55c \ud55c \uc0ac\ub840(\ud658\uc790 INTRO-07)\ub294 \ub2e8\uc77c \uc8fc\uc785 \ud6c4 9\uac1c\uc6d4\uc758 \ubb34\uc9c4\ud589 \uc0dd\uc874 \uae30\uac04(Progression-free survival, PFS)\uc744 \ub2ec\uc131\ud588\uc2b5\ub2c8\ub2e4. \uc774 \ud658\uc790\uc758 \uc601\uc0c1 \uc9c4\ub2e8 \uacb0\uacfc, \ubcf5\ubd80 \ubcd1\ubcc0\uc774 63%(38mm\uc5d0\uc11c 14mm\ub85c) \uac10\uc18c\ud558\uace0 \uac04 \uc804\uc774\uac00 49%(37mm\uc5d0\uc11c 19mm\ub85c) \uac10\uc18c\ud55c \uac83\uc73c\ub85c \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. \ub610\ud55c \uc774 \ud658\uc790\ub294 \uc8fc\uc785 \ud6c4 42\uac1c\uc6d4\uae4c\uc9c0 \uc5f0\uc7a5\ub41c \uc804\uccb4 \uc0dd\uc874 \uae30\uac04(Overall survival, OS)\uc744 \ubcf4\uc600\uc73c\uba70, 2025\ub144 \ub9d0 \uae30\uc900\uc73c\ub85c \ucd94\uc801 \uad00\ucc30\uc774 \uc9c4\ud589 \uc911\uc785\ub2c8\ub2e4. 7\uba85\uc758 \ud658\uc790\ub85c \uad6c\uc131\ub41c \uc804\uccb4 \uce58\ub8cc \ucf54\ud638\ud2b8\uc5d0\uc11c \ud3c9\uade0 \uc804\uccb4 \uc0dd\uc874 \uae30\uac04\uc740 18\uac1c\uc6d4\ub85c \uacc4\uc0b0\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ucd94\uac00\ub85c, \uc57d\ub3d9\ud559\uc801 \uc0d8\ud50c\ub9c1\uc740 \ubcf5\uac15 \ub0b4 RNK001 \uc138\ud3ec\uc758 \uc77c\uacfc\uc131 \uc0dd\uc874\uc744 \ub098\ud0c0\ub0c8\uc73c\uba70, IL-2 \ud22c\uc5ec\uac00 \uad11\ubc94\uc704\ud55c \uc804\uc2e0 \uba74\uc5ed \ud65c\uc131\ud654\ub97c \uc790\uadf9\ud588\ub2e4\ub294 \uc99d\uac70\ub97c \ubcf4\uc5ec\uc8fc\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n<p>\u00a0<\/p>\n\n<figure><img decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/03\/4-1024x576.jpeg\" alt=\"\" \/><\/figure>\n\n<h2 class=\"wp-block-heading\" style=\"text-align: center;\"><br \/><br \/>\uc804\ub7b5\uc801 \ucd5c\uc801\ud654 \ubc0f \ud5a5\ud6c4 \uc784\uc0c1 \ubc29\ud5a5<\/h2>\n\n<p class=\"wp-block-paragraph\">INTRO-01 \uc2dc\ud5d8\uc740 \ubcf5\uac15\ub0b4 \ub3d9\uc885 NK \uc138\ud3ec \uc694\ubc95\uc758 \ud0c0\ub2f9\uc131\uc744 \ub4b7\ubc1b\uce68\ud558\ub294 \uae30\ucd08\uc801\uc778 \uc99d\uac70\ub97c \uc81c\uacf5\ud558\uc9c0\ub9cc, \uc5f0\uad6c \ub9e4\uac1c\ubcc0\uc218\ub294 \uc18c\uaddc\ubaa8 \ud45c\ubcf8 \ud06c\uae30\uc640 \uc8fc\ub85c \ub2e8\uc77c \uc8fc\uc785 \ud504\ub85c\ud1a0\ucf5c\ub85c \uc778\ud574 \ubcf8\uc9c8\uc801\uc73c\ub85c \uc81c\ud55c\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \ub300\ubd80\ubd84\uc758 \ud658\uc790\ub294 \uc8fc\uc785 \ud6c4 \uc57d 28\uc77c\uacbd\uc5d0 CA125 \uc218\uce58\uc758 \ubc18\ub4f1\uacfc \ud6c4\uc18d\uc801\uc778 \uc9c8\ubcd1 \uc9c4\ud589\uc744 \uacbd\ud5d8\ud588\uc2b5\ub2c8\ub2e4. \uc784\uc0c1 \uc5f0\uad6c \ud30c\uc774\ud504\ub77c\uc778 \ub0b4\uc5d0\uc11c \uc774 \uce58\ub8cc \uc591\uc2dd\uc744 \ubc1c\uc804\uc2dc\ud0a4\ub824\uba74 \uc5ec\ub7ec \ud504\ub85c\ud1a0\ucf5c \ucd5c\uc801\ud654\uac00 \ud544\uc694\ud569\ub2c8\ub2e4.<\/p>\n\n<h3 class=\"wp-block-heading\" style=\"text-align: center;\"><br \/>\ub2e4\uc911 \ud22c\uc5ec \ubc0f \uc0ac\uc774\ud1a0\uce74\uc778 \ub300\uccb4<\/h3>\n\n<p class=\"wp-block-paragraph\">\ud5a5\ud6c4 \uc784\uc0c1 \ud504\ub808\uc784\uc6cc\ud06c\ub294 \ubcf5\ub9c9 \ubbf8\uc138\ud658\uacbd \ub0b4\uc5d0\uc11c NK \uc138\ud3ec\uc758 \uce58\ub8cc \ub18d\ub3c4\ub97c \uc720\uc9c0\ud558\uae30 \uc704\ud574 \ub2e4\uc911 \ud22c\uc5ec \uc694\ubc95\uc744 \ud3c9\uac00\ud560 \uac00\ub2a5\uc131\uc774 \ub192\uc2b5\ub2c8\ub2e4. \ub610\ud55c IL-2\uc5d0\uc11c IL-15 \ub610\ub294 \uadf8 \uc288\ud37c\uc791\uc6a9\uc81c(\uc608: N-803)\uc640 \uac19\uc740 \ub300\uccb4 \uc0ac\uc774\ud1a0\uce74\uc778\uc73c\ub85c \uc804\ud658\ud558\ub294 \uac83\uc740 \ub9e4\uc6b0 \uae30\ub300\ub418\ub294 \uac1c\uc120 \uc0ac\ud56d\uc785\ub2c8\ub2e4. IL-15\ub294 \uc870\uc808 T\uc138\ud3ec(Regulatory T cells, Tregs)\ub97c \ub3d9\uc2dc\uc5d0 \uc790\uadf9\ud558\uc9c0 \uc54a\uc73c\uba74\uc11c NK \uc138\ud3ec \ubc0f \uae30\uc5b5 T\uc138\ud3ec\ub97c \ud2b9\uc774\uc801\uc73c\ub85c \ud65c\uc131\ud654\ud558\uc5ec, \uc7a0\uc7ac\uc801\uc73c\ub85c \ud56d\uc885\uc591 \ubc18\uc751\uc744 \uac15\ud654\ud558\uba74\uc11c \uc804\uc2e0 \ubd80\uc791\uc6a9\uc744 \uc904\uc77c \uc218 \uc788\ub294 \uc57d\ub9ac\ud559\uc801 \uc774\uc810\uc744 \uc81c\uacf5\ud569\ub2c8\ub2e4.<\/p>\n\n<h3 class=\"wp-block-heading\" style=\"text-align: center;\"><br \/>CAR-NK \uc5d4\uc9c0\ub2c8\uc5b4\ub9c1 \ubc0f \ubcd1\uc6a9 \uc694\ubc95<\/h3>\n\n<p class=\"wp-block-paragraph\" data-path-to-node=\"67\">\uc720\uc804 \uacf5\ud559\uc758 \ubc1c\uc804\uc740 \uc774\ub7ec\ud55c \uc904\uae30\uc138\ud3ec \uacf5\uae09\uc6d0\uc5d0\uc11c \ud0a4\uba54\ub77c \ud56d\uc6d0 \uc218\uc6a9\uccb4(Chimeric Antigen Receptor, CAR)-NK \uc138\ud3ec\ub97c \uac1c\ubc1c\ud560 \uae30\ud68c\ub97c \uc81c\uacf5\ud569\ub2c8\ub2e4. NK \uc138\ud3ec\uac00 \ud2b9\uc815 \ub09c\uc18c\uc554 \ud56d\uc6d0(\uc608: EpCAM, FOLR1 \ub610\ub294 MUC1)\uc744 \ud45c\uc801\uc73c\ub85c \ud558\ub294 \uc218\uc6a9\uccb4\ub97c \ubc1c\ud604\ud558\ub3c4\ub85d \uc870\uc791\ud568\uc73c\ub85c\uc368 \uc5f0\uad6c\uc6d0\ub4e4\uc740 \uc885\uc591 \uc778\uc2dd \ubc0f \ud45c\uc801\ud654\ub41c \uc138\ud3ec \ub3c5\uc131\uc744 \uac15\ud654\ud558\ub294 \uac83\uc744 \ubaa9\ud45c\ub85c \ud569\ub2c8\ub2e4.<\/p>\n<p data-path-to-node=\"68\">\ucd94\uac00\uc801\uc73c\ub85c, \ud45c\uc900 \uce58\ub8cc\ubc95, \ud2b9\ud788 \ubc31\uae08 \uae30\ubc18 \ud654\ud559\uc694\ubc95\uacfc\uc758 \uc2dc\ub108\uc9c0 \ud6a8\uacfc\uac00 \uc788\ub294 \ubcd1\uc6a9\uc744 \uc870\uc0ac\ud558\ub294 \uac83\uc740 \uc911\uc694\ud55c \ub2e4\uc74c \ub2e8\uacc4\ub85c \ub0a8\uc544 \uc788\uc2b5\ub2c8\ub2e4. \uc804\uc784\uc0c1 \ub370\uc774\ud130\ub294 \ud2b9\uc815 \ud654\ud559\uc694\ubc95\uc81c\uac00 \uba74\uc5ed \uc5b5\uc81c \uc138\ud3ec\ub97c \uace0\uac08\uc2dc\ud0b4\uc73c\ub85c\uc368 \uc885\uc591 \ubbf8\uc138\ud658\uacbd\uc744 \uae0d\uc815\uc801\uc73c\ub85c \uc870\uc808\ud558\uc5ec \uc774\ub860\uc801\uc73c\ub85c \uc8fc\uc785\ub41c NK \uc138\ud3ec\uac00 \uc0dd\ucc29\ud558\uace0 \uce58\ub8cc \ud6a8\uacfc\ub97c \ubc1c\ud718\ud560 \uc218 \uc788\ub294 \ub354 \uc801\ud569\ud55c \ud658\uacbd\uc744 \uc870\uc131\ud560 \uc218 \uc788\uc74c\uc744 \uc2dc\uc0ac\ud569\ub2c8\ub2e4.<\/p>\n<p data-path-to-node=\"69\">RNK001 \ubc0f \uc720\uc0ac\ud55c \uc904\uae30\uc138\ud3ec \uc720\ub798 \uc694\ubc95\uc774 \uc784\uc0c1 2\uc0c1 \ubc0f 3\uc0c1 \uc2dc\ud5d8\uc73c\ub85c \uc9c4\ud589\ub418\ub824\uba74 \uae00\ub85c\ubc8c \uaddc\uc815 \uc900\uc218 \ud45c\uc900\uc5d0 \ub300\ud55c \uc5c4\uaca9\ud55c \uc900\uc218\uc640 \uc9c0\uc18d\uc801\uc778 \uc724\ub9ac \uac80\ud1a0\uac00 \ud544\uc694\ud569\ub2c8\ub2e4. \ucf54\ud638\ud2b8 \uaddc\ubaa8\ub97c \ud655\ub300\ud558\uace0 \ub9bc\ud504\uad6c \uace0\uac08 \uc804\ub7b5\uc744 \uacf5\uc2dd\uc801\uc73c\ub85c \ube44\uad50\ud558\ub294 \uac83\uc740 \uc9c4\ud589\uc131 \uc0c1\ud53c\uc131 \ub09c\uc18c\uc554 \uad00\ub9ac\uc5d0 \uc788\uc5b4 \ub3d9\uc885 NK \uc138\ud3ec \uc694\ubc95\uc758 \uc784\uc0c1\uc801 \uc720\uc6a9\uc131\uc744 \uba85\ud655\ud558\uac8c \ud655\ub9bd\ud558\ub294 \ud544\uc218\uc801\uc778 \ub2e8\uacc4\uac00 \ub420 \uac83\uc785\ub2c8\ub2e4.<\/p>\n<h2 style=\"text-align: center;\"><br \/><br \/>\uacb0\ub860<\/h2>\n\n<p class=\"wp-block-paragraph\" data-path-to-node=\"71\">INTRO-01 \uc784\uc0c1 1\uc0c1 \uc2dc\ud5d8\uc740 \uc7ac\ubc1c\uc131 \uc0c1\ud53c\uc131 \ub09c\uc18c\uc554 \uce58\ub8cc\ub97c \uc704\ud574 \uc81c\ub300\ud608 \uc904\uae30\uc138\ud3ec \uc720\ub798 NK \uc138\ud3ec\ub97c \ud65c\uc6a9\ud558\ub294 \uac83\uc758 \uc548\uc804\uc131\uacfc \ud0c0\ub2f9\uc131\uc744 \ub4b7\ubc1b\uce68\ud558\ub294 \uae30\ucd08\uc801\uc778 \uc99d\uac70\ub97c \uc81c\uacf5\ud569\ub2c8\ub2e4. \uc774 \uc5f0\uad6c\ub294 \uad00\ub9ac \uac00\ub2a5\ud55c \ub3c5\uc131 \ud504\ub85c\ud30c\uc77c\uacfc \uad6d\uc18c \ubcf5\uac15\ub0b4 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