{"id":25276,"date":"2026-05-20T08:42:38","date_gmt":"2026-05-20T00:42:38","guid":{"rendered":"https:\/\/stemcell-malaysia.com\/?page_id=25276"},"modified":"2026-05-20T08:42:40","modified_gmt":"2026-05-20T00:42:40","slug":"psoriasis","status":"publish","type":"page","link":"https:\/\/stemcell-malaysia.com\/ko\/conditions\/psoriasis\/","title":{"rendered":"\uac74\uc120 \uc904\uae30\uc138\ud3ec \uce58\ub8cc\uff5c\uc0dd\ubb3c\ud559\uc801 \uc81c\uc81c \ucd94\uac00 \uc5c6\uc774 \uba74\uc5ed \ud3ed\uc8fc \uc790\uccb4\ub97c \uc7a0\uc7ac\uc6b8 \uc218 \uc788\uc744\uae4c"},"content":{"rendered":"\n

\uac74\uc120 \uc904\uae30\uc138\ud3ec \uce58\ub8cc\uff5c\uc0dd\ubb3c\ud559\uc801 \uc81c\uc81c \ucd94\uac00 \uc5c6\uc774 \uba74\uc5ed \ud3ed\uc8fc \uc790\uccb4\ub97c \uc7a0\uc7ac\uc6b8 \uc218 \uc788\uc744\uae4c<\/h1>\n\n\n
\n
\"\ub9cc\uc131
\ud55c\uad6d\uc5d0\ub294 \uc57d 17\ub9cc \uba85\uc758 \uc9c4\ub2e8 \uac74\uc120 \ud658\uc790\uac00 \ub4f1\ub85d\ub418\uc5b4 \uc788\uc73c\uba70, \ub204\ub77d \ud658\uc790\uae4c\uc9c0 \ud3ec\ud568\ud558\uba74 \ucd5c\ub300 50\ub9cc \uba85\uc73c\ub85c \ucd94\uc815\ub41c\ub2e4. \uc0b0\uc815\ud2b9\ub840 \uc81c\ub3c4\uc5d0\ub3c4 \uc57d\uc744 \ubc14\uafd4\uac00\uba70 \uc0b4\uc544\uac00\ub294 \ud658\uc790\ub294 \uc801\uc9c0 \uc54a\ub2e4.<\/figcaption><\/figure>\n<\/div>\n\n\n

\uc624\ub298\ub3c4 \uae34\ud314 \uc154\uce20\ub97c \uace8\ub790\uc2b5\ub2c8\ub2e4. \ub354\uc6b4 \uc5ec\ub984\uc5d0\ub3c4 \ud314\uafc8\uce58 \uc548\ucabd\uc758 \ubd89\uc740 \ubc18\uc810\uacfc \uc740\ubc31\uc0c9 \uc778\uc124\uc774 \ubcf4\uc774\uc9c0 \uc54a\ub3c4\ub85d \uc18c\ub9e4\ub97c \ub0b4\ub9ac\ub294 \uac83\uc774 \uc774\ubbf8 \uc2b5\uad00\uc774 \ub41c \uc9c0 \uc624\ub798\uc785\ub2c8\ub2e4. \ubc18\ub144 \uc804\uc5d0 \ubc14\uafbc \uc0dd\ubb3c\ud559\uc801 \uc81c\uc81c\ub294 \ucc98\uc74c \uba87 \uc8fc \ub3d9\uc548 \ud53c\ubd80\ub97c \uac70\uc758 \uc644\uc804\ud788 \uae68\ub057\ud558\uac8c \ub9cc\ub4e4\uc5b4 \uc8fc\uc5c8\uc2b5\ub2c8\ub2e4. \uadf8\ub7f0\ub370 \ucd5c\uadfc \ub450\ud53c, \ud5c8\ub9ac \uc544\ub798, \uc815\uac15\uc774\uc5d0 \ucc9c\ucc9c\ud788 \ub2e4\uc2dc \ubc18\uc810\uc774 \uc62c\ub77c\uc624\uae30 \uc2dc\uc791\ud588\uc2b5\ub2c8\ub2e4. \ub2e4\uc74c \uc9c4\ub8cc \ub54c \ub2f4\ub2f9 \uc758\uc0ac\ub85c\ubd80\ud130 “\ub2e4\uc74c \uc57d\uc744 \uc0dd\uac01\ud574 \ubd05\uc2dc\ub2e4”\ub77c\ub294 \ub9d0\uc744 \ub4e4\uc744 \uac83 \uac19\uc544 \ub9c8\uc74c\uc758 \uc900\ube44\ub97c \ud558\uace0 \uc788\ub294 \uc790\uc2e0\uc744 \ubc1c\uacac\ud569\ub2c8\ub2e4.<\/p>\n\n\n\n

\uc774 \ud328\ud134\uc774 \uc775\uc219\ud558\ub2e4\uba74 \uacb0\ucf54 \ud63c\uc790\uac00 \uc544\ub2d9\ub2c8\ub2e4. \ud55c\uad6d\uc5d0\uc11c\ub294 \uac74\uac15\ubcf4\ud5d8\uc2ec\uc0ac\ud3c9\uac00\uc6d0\uc5d0 \ub4f1\ub85d\ub41c \uac74\uc120 \ud658\uc790\uac00 \uc57d 17\ub9cc \uba85, \ub204\ub77d\ub41c \ud658\uc790\uae4c\uc9c0 \ud3ec\ud568\ud558\uba74 \ucd5c\ub300 50\ub9cc \uba85\uc73c\ub85c \ucd94\uc815\ub429\ub2c8\ub2e4. \uc138\uacc4 \uc804\uccb4\ub85c\ub294 \uc778\uad6c\uc758 \uc57d 3%\uc5d0 \ud574\ub2f9\ud558\ub294 \uc57d 1\uc5b5 2500\ub9cc \uba85\uc774 \uac74\uc120\uacfc \ud568\uaed8 \uc0b4\uace0 \uc788\uc2b5\ub2c8\ub2e4. \ud55c\uad6d\uc5d0\uc11c\ub294 \uc0b0\uc815\ud2b9\ub840 \uc81c\ub3c4 \ub3c4\uc785 \uc774\ud6c4 \uc911\uc99d \ud658\uc790\uc758 \uce58\ub8cc \ube44\uc6a9 \ubd80\ub2f4\uc774 \uc77c\ubd80 \uc644\ud654\ub418\uc5c8\uc9c0\ub9cc, \ud55c\uad6d\uac74\uc120\ud611\ud68c \uc870\uc0ac\uc5d0 \ub530\ub974\uba74 \uc5ec\uc804\ud788 \ud658\uc790\uc758 \uc57d 19%\ub9cc\uc774 \uc0dd\ubb3c\ud559\uc801 \uc81c\uc81c\ub97c \ucc98\ubc29\ubc1b\uace0 \uc788\uc73c\uba70, \uc911\uc99d \ud658\uc790 \uc911\uc5d0\uc11c\ub3c4 \uc57d 40%\uc5d0 \uadf8\uce69\ub2c8\ub2e4.<\/p>\n\n\n\n

\uc9c0\ub09c \uc218\uc2ed \ub144\uac04 \uac74\uc120 \uce58\ub8cc\ub294 \uadf9\uc801\uc73c\ub85c \ubc1c\uc804\ud588\uc2b5\ub2c8\ub2e4. IL-17, IL-23 \uc5b5\uc81c\uc81c\ub85c PASI 90, \uc2ec\uc9c0\uc5b4 PASI 100(\ud53c\ubd80\uac00 \uac70\uc758 \uc644\uc804\ud788 \uae68\ub057\ud574\uc9c4 \uc0c1\ud0dc)\uc5d0 \ub3c4\ub2ec\ud558\ub294 \ud658\uc790\uac00 \ub4dc\ubb3c\uc9c0 \uc54a\uac8c \ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uadf8\ub7ec\ub098 \ud6a8\uacfc\uc758 \uc9c0\uc18d\uc131\uc774\ub77c\ub294 \ubb38\uc81c\uac00 \ub0a8\uc544 \uc788\uc2b5\ub2c8\ub2e4. \ud56d\uc57d\ubb3c \ud56d\uccb4 \ud615\uc131, \ub2e4\ub978 \uc5fc\uc99d \uacbd\ub85c\uc758 \uc6b0\ud68c \ub4f1\uc73c\ub85c \uc778\ud574 \uc2dc\uac04\uc774 \uc9c0\ub098\uba70 \ud6a8\uacfc\uac00 \uac10\uc18c\ud558\ub294 ‘\uc774\ucc28 \ubb34\ud6a8’\uac00 \uc77c\uc815 \ube44\uc728\ub85c \ubc1c\uc0dd\ud569\ub2c8\ub2e4.<\/p>\n\n\n\n

\uc774 \uae00\uc740 \uc774\ubbf8 \uc5ec\ub7ec \ucc28\ub840 \uc57d\uc744 \ubc14\uafb8\uc5b4 \ubcf4\uc2e0 \ubd84, \ud639\uc740 \ubd80\uc791\uc6a9\uc73c\ub85c \ub2e4\ub978 \uc120\ud0dd\uc9c0\ub97c \ucc3e\uace0 \uacc4\uc2e0 \ubd84\uc744 \uc704\ud574 \uc4f0\uc5ec\uc84c\uc2b5\ub2c8\ub2e4. \uac74\uc120\uc5d0 \ub300\ud55c \uc904\uae30\uc138\ud3ec \uce58\ub8cc\uac00 \uacfc\ud559\uc801\uc73c\ub85c \uc5b4\ub514\uae4c\uc9c0 \uac80\uc99d\ub418\uc5b4 \uc788\ub294\uc9c0, \ub204\uad6c\uc5d0\uac8c \uc758\ubbf8\uac00 \uc788\uace0 \ub204\uad6c\uc5d0\uac8c \uc758\ubbf8\uac00 \uc801\uc740\uc9c0, \uadf8\ub9ac\uace0 \uc194\uc9c1\ud788 \uc5b4\ub514\uc5d0 \ud55c\uacc4\uac00 \uc788\ub294\uc9c0\ub97c \uad11\uace0 \uc5c6\uc774 \uc124\uba85\ud569\ub2c8\ub2e4. \uc800\ud76c\ub294 \ub9d0\ub808\uc774\uc2dc\uc544\uc5d0\uc11c 7\ub144 \uc774\uc0c1, 200\uba85\uc744 \ub118\ub294 \ud658\uc790\ubd84\uaed8 \ub3d9\uc885 \uc81c\ub300 \uc720\ub798 \uc911\uac04\uc5fd \uc904\uae30\uc138\ud3ec(MSC) \uce58\ub8cc\ub97c \uc9c4\ud589\ud574 \uc654\uc2b5\ub2c8\ub2e4. \uac74\uc120\uc774 “\uc644\uce58”\ub41c\ub2e4\uace0 \ub9d0\uc500\ub4dc\ub9ac\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4. \uadf8\uac83\uc744 \ubcf4\uc7a5\ud558\ub294 \uc784\uc0c1\uc801 \uadfc\uac70\ub294 \ud604\uc7ac \uc5c6\uc73c\uba70, \ubcf4\uc7a5\ud558\ub294 \uc2dc\uc124\uc774 \uc788\ub2e4\uba74 \uc815\uc9c1\ud558\uc9c0 \uc54a\uc740 \uac83\uc785\ub2c8\ub2e4. \uc800\ud76c\uac00 \ud560 \uc218 \uc788\ub294 \uac83\uc740 \ud604\uc7ac\uae4c\uc9c0 \ubb34\uc5c7\uc774 \ubc1d\ud600\uc84c\uace0 \ubb34\uc5c7\uc774 \ubc1d\ud600\uc9c0\uc9c0 \uc54a\uc558\ub294\uc9c0\ub97c \uc194\uc9c1\ud558\uac8c \uc804\ud558\ub294 \uc77c\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n

<\/div>\n\n\n\n

\ubaa9\ucc28<\/mark><\/h2>\n\n\n
  1. \uac74\uc120\uc774 \uc644\ud654\ub41c \ud6c4\uc5d0\ub3c4 \ub2e4\uc2dc \ub3cc\uc544\uc624\ub294 \uc774\uc720<\/a>
      <\/ol><\/li>
    1. \ud604\uc7ac\uc758 \uac74\uc120 \uce58\ub8cc\uac00 \ud55c\uacc4\uc5d0 \ubd80\ub52a\ud788\ub294 \uc9c0\uc810<\/a>
        <\/ol><\/li>
      1. \uac74\uc120 \uc904\uae30\uc138\ud3ec \uce58\ub8cc\ub97c \ub4b7\ubc1b\uce68\ud558\ub294 \uc784\uc0c1 \ub370\uc774\ud130<\/a>
          <\/ol><\/li>
        1. \uc904\uae30\uc138\ud3ec \uce58\ub8cc\uac00 \uac74\uc120 \uba74\uc5ed \ub8e8\ud504\uc5d0 \uc791\uc6a9\ud558\ub294 \ubc29\uc2dd<\/a>
            <\/ol><\/li>
          1. \uac74\uc120 \uc904\uae30\uc138\ud3ec \uce58\ub8cc\uac00 \uc801\ud569\ud55c \uc0ac\ub78c\uacfc \uc801\ud569\ud558\uc9c0 \uc54a\uc740 \uc0ac\ub78c<\/a>
              <\/ol><\/li>
            1. \uac74\uc120 \uc904\uae30\uc138\ud3ec \uce58\ub8cc\ub97c \ubc1b\uc740 \ud658\uc790\uc758 \uacbd\uacfc<\/a>
                <\/ol><\/li>
              1. \uac74\uc120 \uc904\uae30\uc138\ud3ec \uce58\ub8cc\uc758 \uc815\uc9c1\ud55c \uc704\ud5d8\uacfc \ud55c\uacc4<\/a>
                  <\/ol><\/li>
                1. \uac74\uc120 \uc904\uae30\uc138\ud3ec \uce58\ub8cc\uc5d0 \uad00\ud55c \uc790\uc8fc \ubb3b\ub294 \uc9c8\ubb38<\/a><\/li>
                2. \ub2e4\uc74c \ub2e8\uacc4<\/a><\/li>
                3. \ucc38\uace0\ubb38\ud5cc<\/a><\/li><\/ol><\/div>\n\n\n
                  <\/div>\n\n\n\n

                  \uac74\uc120\uc774 \uc644\ud654\ub41c \ud6c4\uc5d0\ub3c4 \ub2e4\uc2dc \ub3cc\uc544\uc624\ub294 \uc774\uc720<\/mark><\/h2>\n\n\n\n

                  \uac74\uc120\uc744 \uc77c\uc73c\ud0a4\ub294 \uba74\uc5ed \uc2dc\uc2a4\ud15c\uc758 \uc624\uc791\ub3d9<\/h3>\n\n\n\n

                  \uac74\uc120\uc740 \ud53c\ubd80 \ud45c\uba74\uc5d0 \uc99d\uc0c1\uc774 \ub098\ud0c0\ub098\uae30 \ub54c\ubb38\uc5d0 ‘\ud53c\ubd80\ubcd1’\uc73c\ub85c \uc5ec\uaca8\uc9c0\uc9c0\ub9cc, \ubcf8\uc9c8\uc740 \uba74\uc5ed \uc2dc\uc2a4\ud15c\uc758 \uc624\uc791\ub3d9\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n

                  \uac74\uac15\ud55c \uc0ac\ub78c\uc758 \ubab8\uc5d0\uc11c\ub294 T \ub9bc\ud504\uad6c(\uba74\uc5ed\uc138\ud3ec\uc758 \uc77c\uc885\uc774\uc790 \uc6b0\ub9ac \ubab8\uc758 \ubc29\uc5b4 \ubd80\ub300)\uac00 \ubc15\ud14c\ub9ac\uc544, \ubc14\uc774\ub7ec\uc2a4 \uac19\uc740 \uc2e4\uc81c \uc704\ud611\uc744 \ucc3e\uc544 \uc804\uc2e0\uc744 \uc21c\ucc30\ud569\ub2c8\ub2e4. \uadf8\ub7f0\ub370 \uac74\uc120\uc5d0\uc11c\ub294 \uc774 T \ub9bc\ud504\uad6c \uc911\uc5d0\uc11c\ub3c4 \ud2b9\ud788 Th17 \uc138\ud3ec\ub77c\ub294 \uadf8\ub8f9\uc774 \uc790\uae30 \uc790\uc2e0\uc758 \ud53c\ubd80\ub97c ‘\uc801’\uc73c\ub85c \uc624\uc778\ud569\ub2c8\ub2e4. \uc624\uc778\ub41c Th17 \uc138\ud3ec\ub294 \ud53c\ubd80 \ud45c\uce35\uc73c\ub85c \ubaa8\uc5ec\ub4e4\uc5b4 IL-17, IL-23, TNF-\u03b1(\uc885\uc591\uad34\uc0ac\uc778\uc790 \uc54c\ud30c)\ub77c\ub294 \uc5fc\uc99d\uc131 \uc0ac\uc774\ud1a0\uce74\uc778(\uba74\uc5ed\uc138\ud3ec \uac04 \uc18c\ud1b5\uc6a9 \ud654\ud559 \ubb3c\uc9c8)\uc744 \ubc29\ucd9c\ud569\ub2c8\ub2e4. \uc774\ub7ec\ud55c \uc2e0\ud638\ub97c \ubc1b\uc740 \ud53c\ubd80\ub294 \ubcf4\ud1b5 28\uc77c \uac78\ub9ac\ub294 \uc138\ud3ec \uad50\uccb4 \uc8fc\uae30\ub97c 3~5\uc77c\ub85c \ub2e8\ucd95\ud574 \ubc84\ub9ac\uace0, \uacb0\uacfc\uc801\uc73c\ub85c \ubd89\uac8c \ubd80\ud480\uace0 \uc740\ubc31\uc0c9 \uc778\uc124\uc774 \ubd99\uc740 \uadf8 \ud2b9\uc720\uc758 \uac74\uc120 \ubcd1\ubcc0\uc774 \ub9cc\ub4e4\uc5b4\uc9d1\ub2c8\ub2e4.<\/p>\n\n\n\n

                  \uc5ec\uae30\uc11c \uc911\uc694\ud55c \uc810\uc740, \ubcd1\ubcc0\uc774 \uc0ac\ub77c\uc9c4 \ud6c4\uc5d0\ub3c4 \uadf8 \ub4a4\uc5d0 \uc788\ub294 \uba74\uc5ed \uc774\uc0c1 \uc790\uccb4\ub294 \uc0ac\ub77c\uc9c0\uc9c0 \uc54a\ub294\ub2e4\ub294 \uac83\uc785\ub2c8\ub2e4. \uce58\ub8cc\ub85c \ud53c\ubd80\uac00 \uae68\ub057\ud574 \ubcf4\uc5ec\ub3c4 Th17 \uc138\ud3ec\ub294 \ubab8 \uc548\uc5d0 \uacc4\uc18d \ub0a8\uc544 \uc788\uace0, \uc5b8\uc81c\ub4e0 \uc7ac\ud65c\uc131\ud654\ub420 \uc900\ube44\uac00 \ub418\uc5b4 \uc788\uc2b5\ub2c8\ub2e4. \uac74\uc120\uc774 ‘\ub9cc\uc131, \uc7ac\ubc1c\uc131’\uc73c\ub85c \ubd84\ub958\ub418\ub294 \uc774\uc720\ub294 \uc7ac\ubc1c\ud558\ub294 \uc131\uc9c8\uc774 \ud53c\ubd80\uac00 \uc544\ub2c8\ub77c \uba74\uc5ed \uc2dc\uc2a4\ud15c \uc790\uccb4\uc5d0 \ub0b4\uc7a5\ub418\uc5b4 \uc788\uae30 \ub54c\ubb38\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n

                  <\/div>\n\n\n\n

                  \uce58\ub8cc\ub85c \uae68\ub057\ud574\uc9c4 \ud53c\ubd80\uac00 \ub2e4\uc2dc \ub098\ube60\uc9c0\ub294 \uc774\uc720<\/h3>\n\n\n\n

                  \uac74\uc120\uc744 \uc624\ub798 \uc553\uc544 \uc624\uc2e0 \ubd84\uc774\ub77c\uba74 \ub204\uad6c\ub098 \uacaa\ub294 \ud328\ud134\uc774 \uc788\uc2b5\ub2c8\ub2e4. \uc5b4\ub5a4 \uce58\ub8cc\ub97c \uc2dc\uc791\ud558\uba74 \ud53c\ubd80\uac00 \uae68\ub057\ud574\uc9c0\uace0, \uc7a0\uc2dc \ud3c9\uc628\ud55c \uc2dc\uae30\uac00 \uc774\uc5b4\uc9c0\ub2e4\uac00, \uc5b4\ub290 \ub0a0 \ub2e4\uc2dc \ud314\uafc8\uce58\ub098 \ubb34\ub98e\uc5d0 \ubd89\uc740 \ubc18\uc810\uc774 \uc62c\ub77c\uc624\uae30 \uc2dc\uc791\ud569\ub2c8\ub2e4. \uacc4\uae30\uac00 \ubd84\uba85\ud55c \uacbd\uc6b0(\uac15\ud55c \uc2a4\ud2b8\ub808\uc2a4, \uac10\uc5fc, \uc57d \uc911\ub2e8 \ub4f1)\ub3c4 \uc788\uace0, \uc544\ubb34 \uc804\uc870 \uc5c6\uc774 \ub3cc\uc544\uc624\ub294 \uacbd\uc6b0\ub3c4 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n

                  \uc774 \ud328\ud134\uc774 \ubc18\ubcf5\ub418\ub294 \uc774\uc720\ub294 \ud604\uc7ac \uac74\uc120 \uce58\ub8cc\uc758 \uc791\uc6a9 \uae30\uc804\uc5d0 \uc788\uc2b5\ub2c8\ub2e4. \uc0dd\ubb3c\ud559\uc801 \uc81c\uc81c\ub97c \ud3ec\ud568\ud55c \ud604\uc7ac \uc8fc\ub958 \uce58\ub8cc\uc758 \ub300\ubd80\ubd84\uc740 “\ud2b9\uc815 \uc5fc\uc99d \uc2e0\ud638\ub97c \ucc28\ub2e8”\ud558\ub294 \ud558\ub958\uc5d0\uc11c\uc758 \uac1c\uc785\uc785\ub2c8\ub2e4. \uc2a4\ud53c\ucee4\uc758 \uc74c\ub7c9\uc740 \ub0ae\ucd94\uace0 \uc788\uc9c0\ub9cc, \uc2a4\ud53c\ucee4\uc5d0 \ub300\uace0 \ub9c8\uc774\ud06c\ub85c \ub9d0\ud558\uace0 \uc788\ub294 \uc138\ud3ec \uc790\uccb4\uc5d0\ub294 \uc544\ubb34\uac83\ub3c4 \ud558\uc9c0 \uc54a\ub294 \uc0c1\ud0dc\uc640 \uac19\uc2b5\ub2c8\ub2e4. \ud53c\ubd80\uac00 \uae68\ub057\ud574\uc9c4 \ub3d9\uc548\uc5d0\ub3c4 Th17 \uc138\ud3ec\ub294 \ud3ed\uc8fc\ud560 \uc900\ube44\ub97c \ub9c8\uce5c \ucc44 \ubab8\uc18d\uc5d0 \ub0a8\uc544 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n

                  \uc774 \uc0dd\ubb3c\ud559\uc801 \uc0ac\uc2e4\uc774\uc57c\ub9d0\ub85c \uac74\uc120\uc774\ub77c\ub294 \ubcd1\uc758 \ud589\ub3d9 \uc591\uc2dd\uc758 \uadfc\ubcf8\uc5d0 \uc788\uc73c\uba70, \ub610\ud55c “\ud558\ub958\ub97c \ucc28\ub2e8\ud558\ub294 \uac83”\uc774 \uc544\ub2c8\ub77c “\uc0c1\ub958\uc758 \uba74\uc5ed \ud3ed\uc8fc \uc790\uccb4\ub97c \uc870\uc815\ud558\ub294 \uac83”\uc774\ub77c\ub294 \uc811\uadfc\ubc95\uc774 \uc5f0\uad6c\uc758 \ucd08\uc810\uc774 \ub418\uc5b4 \uc788\ub294 \uc774\uc720\uc774\uae30\ub3c4 \ud569\ub2c8\ub2e4.<\/p>\n\n\n\n

                  <\/div>\n\n\n\n

                  \ud604\uc7ac\uc758 \uac74\uc120 \uce58\ub8cc\uac00 \ud55c\uacc4\uc5d0 \ubd80\ub52a\ud788\ub294 \uc9c0\uc810<\/mark><\/h2>\n\n\n\n

                  \uc678\uc6a9\uc81c\ubd80\ud130 \uc0dd\ubb3c\ud559\uc801 \uc81c\uc81c\uae4c\uc9c0\uc758 \ud45c\uc900 \ub2e8\uacc4<\/h3>\n\n\n\n

                  \uc0c8\ub85c \uac74\uc120\uc744 \uc9c4\ub2e8\ubc1b\uc73c\uc2e0 \ubd84\ub4e4\uc758 \uce58\ub8cc\ub294 \ubcf4\ud1b5 \uc678\uc6a9\uc81c\ubd80\ud130 \uc2dc\uc791\ub429\ub2c8\ub2e4. \uc2a4\ud14c\ub85c\uc774\ub4dc \uc5f0\uace0, \ube44\ud0c0\ubbfc D \uc720\ub3c4\uccb4, \ubcf4\uc2b5\uc81c \ub4f1\uc740 \uacbd\uc99d\uc758 \uacbd\uc6b0 \ucda9\ubd84\ud788 \uc870\uc808\ub420 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uc911\ub4f1\ub3c4\ub85c \uc9c4\ud589\ub418\uba74 \uad11\uc120 \uce58\ub8cc(\uc790\uc678\uc120 \uc694\ubc95), \uba54\ud1a0\ud2b8\ub809\uc138\uc774\ud2b8, \uc0ac\uc774\ud074\ub85c\uc2a4\ud3ec\ub9b0, \ub808\ud2f0\ub178\uc774\ub4dc \ub4f1\uc758 \uacbd\uad6c\uc57d\uc774 \uc120\ud0dd\uc9c0\uc5d0 \ucd94\uac00\ub429\ub2c8\ub2e4. \uc774\ub4e4\uc740 \ud6a8\uacfc\uac00 \uc788\uc9c0\ub9cc \uc7a5\uae30 \uc0ac\uc6a9\uc5d0\ub294 \uc8fc\uc758\uac00 \ud544\uc694\ud569\ub2c8\ub2e4. \uba54\ud1a0\ud2b8\ub809\uc138\uc774\ud2b8\ub294 \uc815\uae30\uc801\uc778 \uac04 \uae30\ub2a5 \uac80\uc0ac\uac00 \ud544\uc218\uc774\uace0, \uc0ac\uc774\ud074\ub85c\uc2a4\ud3ec\ub9b0\uc740 \uc2e0\uc7a5 \uae30\ub2a5\uacfc \ud608\uc555\uc5d0 \ubbf8\uce58\ub294 \uc601\ud5a5\uc744, \uc7a5\uae30\uac04\uc758 \uad11\uc120 \uce58\ub8cc\ub294 \ud53c\ubd80\uc554 \uc704\ud5d8\uc744 \uac01\uac01 \uace0\ub824\ud574\uc57c \ud569\ub2c8\ub2e4.<\/p>\n\n\n\n

                  \uc911\ub4f1\ub3c4~\uc911\uc99d\uc73c\ub85c \uae30\uc874 \uce58\ub8cc\uac00 \uc798 \ub4e3\uc9c0 \uc54a\uac8c \ub41c \uacbd\uc6b0\uc5d0 \ub4f1\uc7a5\ud558\ub294 \uac83\uc774 \uc0dd\ubb3c\ud559\uc801 \uc81c\uc81c\uc785\ub2c8\ub2e4. TNF-\u03b1 \uc5b5\uc81c\uc81c(\uc778\ud50c\ub9ad\uc2dc\ub9d9, \uc544\ub2ec\ub9ac\ubb34\ub9d9, \uc5d0\ud0c0\ub108\uc149\ud2b8), IL-12\/23 \uc5b5\uc81c\uc81c(\uc6b0\uc2a4\ud14c\ud0a4\ub204\ub9d9), IL-17 \uc5b5\uc81c\uc81c(\uc138\ucfe0\ud0a4\ub204\ub9d9, \uc775\uc138\ud0a4\uc8fc\ub9d9), IL-23 \uc5b5\uc81c\uc81c(\uad6c\uc140\ucfe0\ub9d9, \ub9ac\uc0b0\ud0a4\uc8fc\ub9d9) \ub4f1 \ud2b9\uc815 \uc5fc\uc99d \uacbd\ub85c\ub97c \uc815\ubc00 \ud0c0\uaca9\ud558\ub294 \uc57d\ub4e4\uc774 \ucc28\ub840\ub85c \uac1c\ubc1c\ub418\uc5b4 \uc654\uc2b5\ub2c8\ub2e4. \ud6a8\uacfc\uac00 \uc788\ub294 \ud658\uc790\uc5d0\uc11c\ub294 \ud53c\ubd80\uac00 \uac70\uc758 \uc644\uc804\ud788 \uae68\ub057\ud574\uc9c0\uace0 \uc0b6\uc758 \uc9c8\uc774 \uadf9\uc801\uc73c\ub85c \uac1c\uc120\ub429\ub2c8\ub2e4.<\/p>\n\n\n\n

                  \ub2e4\ub9cc \uc5ec\uae30\uc5d0 \uc9c0\uc18d\uc131\uc758 \ubb38\uc81c\uac00 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n

                  <\/div>\n\n\n\n

                  \uc0dd\ubb3c\ud559\uc801 \uc81c\uc81c\uac00 \ub4e3\uc9c0 \uc54a\uac8c \ub418\ub294 \uc774\ucc28 \ubb34\ud6a8\uc758 \ud604\uc2e4<\/h3>\n\n\n\n

                  \uc0dd\ubb3c\ud559\uc801 \uc81c\uc81c\uc758 \uc7a5\uae30 \uce58\ub8cc\ub97c \ubd84\uc11d\ud55c \uc5ec\ub7ec \uc5f0\uad6c\uc5d0\uc11c \uc2dc\uac04\uc774 \uc9c0\ub098\uba70 \ud6a8\uacfc\uac00 \uac10\uc18c\ud558\ub294 \ud328\ud134\uc774 \ubc18\ubcf5\uc801\uc73c\ub85c \ubcf4\uace0\ub418\uc5b4 \uc788\uc2b5\ub2c8\ub2e4. Journal of Dermatological Treatment\uc9c0\uc5d0 \uac8c\uc7ac\ub41c \ud6c4\ud5a5\uc801 \uc5f0\uad6c\uc5d0\uc11c\ub294, \uc0dd\ubb3c\ud559\uc801 \uc81c\uc81c\uac00 \uc774\ucc28 \ubb34\ud6a8\ub85c \uc778\ud55c \uc911\ub2e8\uc728\uc774 24.2%\ub85c \uae30\uc874 \uc804\uc2e0 \uce58\ub8cc(9.3%)\ubcf4\ub2e4 \uba85\ubc31\ud788 \ub192\ub2e4\ub294 \uacb0\uacfc\uac00 \uc81c\uc2dc\ub418\uc5c8\uc2b5\ub2c8\ub2e4. <\/p>\n\n\n\n

                  \uc774\uc720\ub294 \ub450 \uac00\uc9c0\uc785\ub2c8\ub2e4. \uccab\uc9f8, \ud658\uc790\uc758 \uba74\uc5ed \uc2dc\uc2a4\ud15c\uc774 \uc0dd\ubb3c\ud559\uc801 \uc81c\uc81c \uc790\uccb4\ub97c ‘\uc774\ubb3c’\ub85c \uc778\uc2dd\ud558\uace0 \uc911\ud654 \ud56d\uccb4(\ud56d\uc57d\ubb3c \ud56d\uccb4)\ub97c \ub9cc\ub4e4\uc5b4 \ubc84\ub9ac\ub294 \uac83. \ub458\uc9f8, \ud558\ub098\uc758 \uacbd\ub85c\ub97c \ucc28\ub2e8\ud574\ub3c4 \ud3ed\uc8fc\ud558\ub294 \uba74\uc5ed\uc138\ud3ec\uac00 \ub2e4\ub978 \uc5fc\uc99d \uacbd\ub85c\ub97c \ucc3e\uc544 \uc9c8\ubcd1\uc744 \uc720\uc9c0\ud574 \ubc84\ub9ac\ub294 \uac83. \uc57d\uc740 \ub3c4\uad6c \ud558\ub098\ub97c \ube7c\uc557\uace0 \uc788\uc9c0\ub9cc, \ud3ed\uc8fc\ud558\ub294 \uc138\ud3ec \uc790\uccb4\ub294 \uc5ec\uc804\ud788 \uadf8\uacf3\uc5d0 \uc788\ub294 \uac83\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n

                  \uccab \ubc88\uc9f8 \uc0dd\ubb3c\ud559\uc801 \uc81c\uc81c\uac00 \ub4e3\uc9c0 \uc54a\uac8c \ub418\uba74 \ub450 \ubc88\uc9f8 \uc57d\uc758 \uc751\ub2f5\ub960\uc740 \ub2e4\uc18c \ub5a8\uc5b4\uc9c0\ub294 \uacbd\ud5a5\uc774 \uc788\uc2b5\ub2c8\ub2e4. \uac74\uc120\uc131 \uad00\uc808\uc5fc\uc744 \ub300\uc0c1\uc73c\ub85c \ud55c 2025\ub144 \uc5f0\uad6c\uc5d0\uc11c\ub294, \ucd08\uae30\uc5d0 \ubc18\uc751\ud55c 264\uba85 \uc911 94\uba85(35.6%)\uc774 \uc911\uc559\uac12 2.7\ub144\uc5d0 \uc774\ucc28\uc801\uc778 \uc0dd\ubb3c\uc81c\uc81c \ubb34\ud6a8\ub97c \uacbd\ud5d8\ud588\ub2e4\uace0 \ubcf4\uace0\ub418\uc5c8\uc2b5\ub2c8\ub2e4. <\/p>\n\n\n\n

                  \ub9ce\uc740 \ud658\uc790\ubd84\uc774 \uc5b4\ub290 \ub0a0 \uac11\uc790\uae30 \uadf9\uc801\uc73c\ub85c \uc545\ud654\ub418\uae30\ubcf4\ub2e4\ub294 ‘\uc9c0\uce58\uac8c’ \ub429\ub2c8\ub2e4. \uc57d \uad50\uccb4\uc5d0 \uc9c0\uce58\uace0, \ub2e4\uc74c \uc57d\uc774 \ub4e4\uc744\uc9c0\ub97c 12\uc8fc \ub3d9\uc548 \uae30\ub2e4\ub9ac\ub294 \ub370 \uc9c0\uce58\uace0, \ub204\uc801\ub418\ub294 \ubaa8\ub2c8\ud130\ub9c1\uacfc \ube44\uc6a9\uc5d0 \uc9c0\uce58\uac8c \ub429\ub2c8\ub2e4. \ud55c\uad6d \ud658\uc790\ubd84\ub4e4\uc758 \uacbd\uc6b0 \uc0b0\uc815\ud2b9\ub840\ub97c \ubc1b\uace0 \uc788\uc5b4\ub3c4 \uce58\ub8cc \ube44\uc6a9 \ubd80\ub2f4\uc740 \uacb0\ucf54 \uac00\ubccd\uc9c0 \uc54a\ub2e4\ub294 \ubcf4\uace0\uac00 \ud55c\uad6d\uac74\uc120\ud611\ud68c \uc870\uc0ac\uc5d0\uc11c \ud655\uc778\ub429\ub2c8\ub2e4. \uc5ec\uae30\uc5d0\uc11c “\uadfc\ubcf8\uc801\uc73c\ub85c \ub2e4\ub978 \uba54\ucee4\ub2c8\uc998\uc744 \uac00\uc9c4 \uc811\uadfc\ubc95\uc740 \uc5c6\ub294\uac00”\ub77c\ub294 \uc9c8\ubb38\uc774 \uc0dd\uae41\ub2c8\ub2e4.<\/p>\n\n\n\n

                  <\/div>\n\n\n\n

                  \uac74\uc120 \uc904\uae30\uc138\ud3ec \uce58\ub8cc\ub97c \ub4b7\ubc1b\uce68\ud558\ub294 \uc784\uc0c1 \ub370\uc774\ud130<\/mark><\/h2>\n\n\n
                  \n
                  \"Cheng
                  heng 2022 phase 1\/2a \uc784\uc0c1\uc2dc\ud5d8\uc5d0\uc11c \uac74\uc120 \ud658\uc790 17\uba85 \uc911 47.1%(8\uba85)\uac00 \uc81c\ub300 \uc720\ub798 MSC \uc815\ub9e5 \uc8fc\uc785 \ud6c4 PASI \uc810\uc218 40% \uc774\uc0c1 \uac1c\uc120\uc744 \ub2ec\uc131\ud588\ub2e4. \ub0a8\ub140 \uac04 \uc751\ub2f5\ub960 \ucc28\uc774\uac00 \uad00\ucc30\ub418\uc5c8\ub2e4.<\/figcaption><\/figure>\n<\/div>\n\n\n

                  \ub3d9\uc885 \uc81c\ub300 \uc720\ub798 MSC\uc5d0 \uad00\ud55c \uc8fc\uc694 \uc784\uc0c1 \uc5f0\uad6c<\/h3>\n\n\n\n

                  \uac74\uc120\uc5d0 \ub300\ud55c \uc904\uae30\uc138\ud3ec \uce58\ub8cc\uc758 \uadfc\uac70\ub294 \ud655\ub9bd\ub41c \uc0dd\ubb3c\ud559\uc801 \uc81c\uc81c\uc5d0 \ube44\ud574 \uc5ed\uc0ac\uac00 \uc9e7\uc9c0\ub9cc, \uad11\uace0\uc131 \uae00\uc774 \uc2dc\uc0ac\ud558\ub294 \uac83\ubcf4\ub2e4 \uad6c\uccb4\uc801\uc774\uace0, \ub610\ud55c \uac00\uc7a5 \uc5f4\uad11\uc801\uc778 \uc8fc\uc7a5\uc774 \uc2dc\uc0ac\ud558\ub294 \uac83\ubcf4\ub2e4 \uc2e0\uc911\ud55c \uac83\uc774 \uc2e4\uc0c1\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n

                  \uac00\uc7a5 \uc9c1\uc811\uc801\uc73c\ub85c \uad00\ub828\ub41c \uc5f0\uad6c\ub294 Cheng \ub4f1\uc774 2022\ub144 Signal Transduction and Targeted Therapy\uc9c0\uc5d0 \ubc1c\ud45c\ud55c phase 1\/2a \ub2e8\uc77c\uad70 \uc2dc\ud5d8\uc785\ub2c8\ub2e4. \uc774 \uc2dc\ud5d8\uc5d0\uc11c\ub294 \uac74\uc120 \ud658\uc790 17\uba85\uc5d0\uac8c \uc778\uac04 \uc81c\ub300 \uc720\ub798 \uc911\uac04\uc5fd \uc904\uae30\uc138\ud3ec(MSC)\ub97c \uc815\ub9e5 \uc8fc\uc785\ud558\uace0 \uc548\uc804\uc131\uacfc \ud6a8\ub2a5\uc744 6\uac1c\uc6d4\uc5d0 \uac78\uccd0 \ud3c9\uac00\ud588\uc2b5\ub2c8\ub2e4. \ud3c9\uac00 \uc9c0\ud45c\ub294 PASI(\uac74\uc120\uc758 \uc911\uc99d\ub3c4\ub97c \ub098\ud0c0\ub0b4\ub294 \uad6d\uc81c \ud45c\uc900 \uc810\uc218), PGA(\uc758\uc0ac\uc5d0 \uc758\ud55c \uc804\uc2e0 \ud3c9\uac00), \uac80\uc0ac \uc218\uce58 \ub4f1\uc785\ub2c8\ub2e4. <\/p>\n\n\n\n

                  \uacb0\uacfc\ub294 \uc2e0\uc911\ud558\uac8c \ubcf4\uace0\ub418\uc5c8\uc2b5\ub2c8\ub2e4. 17\uba85 \uc911 8\uba85(47.1%)\uc774 PASI \uc810\uc218\uc5d0\uc11c 40% \uc774\uc0c1\uc758 \uac1c\uc120\uc744 \ub2ec\uc131\ud588\uace0, 3\uba85(17.6%)\uc774 PGA\uc5d0\uc11c “\ubcd1\ubcc0 \uc5c6\uc74c \ub610\ub294 \ucd5c\uc18c\ud55c\uc758 \uc9c8\ud658”\uc73c\ub85c \ud3c9\uac00\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc11c\ube0c\uadf8\ub8f9 \ubd84\uc11d\uc5d0\uc11c\ub294 \uc911\uc694\ud55c \uacbd\ud5a5\ub3c4 \uae30\ub85d\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc720\ud6a8\uc728\uc740 \ub0a8\uc131\uc5d0\uc11c 25%(2\/8), \uc5ec\uc131\uc5d0\uc11c 66.7%(6\/9)\uc600\uc2b5\ub2c8\ub2e4. \uce58\ub8cc \uc911 \ubc0f 6\uac1c\uc6d4 \ucd94\uc801 \uae30\uac04 \ub3d9\uc548 \uba85\ubc31\ud55c \ubd80\uc791\uc6a9\uc740 \uad00\ucc30\ub418\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4. <\/p>\n\n\n\n

                  \ub2e4\ub978 \uc5f0\uad6c\ub85c Yao \ub4f1\uc774 2021\ub144 Annals of Translational Medicine\uc9c0\uc5d0 \ubc1c\ud45c\ud55c \ub2e8\uc77c\uad70 \uc2dc\ud5d8\uc5d0\uc11c\ub294 \uc911\ub4f1\ub3c4~\uc911\uc99d \uac74\uc120 \ud658\uc790 7\uba85\uc5d0\uac8c \uc9c0\ubc29 \uc720\ub798 MSC \uc815\ub9e5 \uc8fc\uc785\uc744 \uc2dc\ud589\ud588\uc2b5\ub2c8\ub2e4. PASI, \uce68\ubc94 \uccb4\ud45c\uba74\uc801, VAS, DLQI(\ud53c\ubd80\uacfc \uc0b6\uc758 \uc9c8 \uc9c0\ud45c)\ub97c \ud3c9\uac00\ud55c \uacb0\uacfc, \uc9c0\ubc29 \uc720\ub798 MSC \uc815\ub9e5 \ub0b4 \ud22c\uc5ec\ub294 \uc548\uc804\ud558\uba70 \uac74\uc120 \ud658\uc790\uc5d0\uac8c \uce58\ub8cc \uc120\ud0dd\uc9c0\uac00 \ub420 \uc218 \uc788\ub2e4\uace0 \uacb0\ub860\uc9c0\uc5b4\uc84c\uc2b5\ub2c8\ub2e4. <\/p>\n\n\n\n

                  Bajouri \ub4f1\uc774 2023\ub144 Cell Journal\uc9c0\uc5d0 \ubc1c\ud45c\ud55c phase I \uc2dc\ud5d8\uc5d0\uc11c\ub294 \ub3d9\uc885 \uc9c0\ubc29 \uc720\ub798 MSC\ub97c \uac74\uc120 \ubcd1\ubcc0\uc5d0 \uc9c1\uc811 \ud53c\ud558 \uc8fc\uc0ac\ud558\ub294 \ub2e4\ub978 \ud22c\uc5ec \ubc29\uc2dd\uc744 5\uba85\uc758 \ud658\uc790\uc5d0\uc11c \ud3c9\uac00\ud588\uc73c\uba70, \uc548\uc804\uc131\uc774 \uc8fc\ub41c \uc18c\uacac\uc73c\ub85c \ud655\uc778\ub418\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n

                  <\/div>\n\n\n\n

                  \uc218\uce58\uac00 \uac74\uc120 \ud658\uc790\uc5d0\uac8c \uc758\ubbf8\ud558\ub294 \uac83<\/h3>\n\n\n\n

                  \uc774 \uc22b\uc790\ub4e4\uc774 \uc2e4\uc81c \ud658\uc790 \uacbd\ud5d8\uc73c\ub85c \uc5b4\ub5bb\uac8c \ubc88\uc5ed\ub418\ub294\uc9c0 \ubd84\uba85\ud788 \uc124\uba85\ub4dc\ub9ac\uace0\uc790 \ud569\ub2c8\ub2e4.<\/p>\n\n\n\n

                  PASI 40% \uac1c\uc120\uc774\ub77c\ub294 \uac83\uc740 ‘\uc911\ub4f1\ub3c4~\uc911\uc99d\uc758 \uad11\ubc94\uc704\ud55c \uc9c8\ud658’\uc5d0\uc11c ‘\uba74\uc801\uc774 \uc791\uc544\uc9c0\uace0 \uc5fc\uc99d\ub3c4 \uac00\ub77c\uc549\uc740 \uc0c1\ud0dc’\ub85c\uc758 \ubcc0\ud654\uc5d0 \ud574\ub2f9\ud569\ub2c8\ub2e4. \uc774\ub294 \uc0dd\ubb3c\ud559\uc801 \uc81c\uc81c \uc784\uc0c1\uc2dc\ud5d8\uc5d0\uc11c \ubaa9\ud45c\ub85c \ud558\ub294 PASI 75(75% \uac1c\uc120)\ub098 PASI 90\uc5d0\ub294 \ubbf8\uce58\uc9c0 \ubabb\ud569\ub2c8\ub2e4. Cheng \uc2dc\ud5d8\uc5d0\uc11c 17\uba85 \uc911 3\uba85\uc774 PGA\uc5d0\uc11c \uac70\uc758 \ubcd1\ubcc0 \uc5c6\ub294 \uc0c1\ud0dc\uc5d0 \ub3c4\ub2ec\ud588\uc9c0\ub9cc, \uc751\ub2f5\uc790\uc758 \ub2e4\uc218\ub294 \ubd80\ubd84\uc801 \uac1c\uc120\uc5d0 \uadf8\ucce4\uace0 \uc644\uc804\ud55c \ud53c\ubd80 \ud074\ub9ac\uc5b4\ub7f0\uc2a4\ub294 \uc544\ub2c8\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n

                  \ub0a8\ub140 \ucc28\uc774\ub294 \ubb34\uc2dc\ud560 \uc218 \uc5c6\uc2b5\ub2c8\ub2e4. \uc751\ub2f5\ub960\uc774 \uc5ec\uc131 66.7%, \ub0a8\uc131 25%\ub77c\ub294 \ucc28\uc774\uc758 \uc774\uc720\ub294 \uc544\uc9c1 \uc644\uc804\ud788 \uaddc\uba85\ub418\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4. \ud638\ub974\ubaac\uc5d0 \uc758\ud55c \uba74\uc5ed \uc870\uc808 \ucc28\uc774, \uae30\uc800 \uc9c8\ud658 \ud2b9\uc131\uc758 \ucc28\uc774, \uae30\ud0c0 \ubbf8\ud655\uc778 \uc694\uc778\uc774 \uad00\uc5ec\ud558\uace0 \uc788\uc744 \uac00\ub2a5\uc131\uc774 \uc788\uc2b5\ub2c8\ub2e4. \uc2e4\ubb34\uc801 \uc758\ubbf8\ub294 \ud604\uc7ac \ub370\uc774\ud130\uc5d0\uc11c \ub0a8\uc131 \ud658\uc790\uc640 \uc5ec\uc131 \ud658\uc790\uc5d0 \uac19\uc740 \uc608\uce21\uc744 \uc138\uc6b8 \uc218 \uc5c6\ub2e4\ub294 \uac83\uc785\ub2c8\ub2e4. \uc800\ud76c\ub294 \uce58\ub8cc \uac80\ud1a0 \ub2e8\uacc4\uc5d0\uc11c \uc774 \uc0ac\uc2e4\uc744 \ubc18\ub4dc\uc2dc \ud658\uc790\ubd84\uaed8 \uacf5\uac1c\ud569\ub2c8\ub2e4.<\/p>\n\n\n\n

                  \ub9c8\ucc2c\uac00\uc9c0\ub85c \uc911\uc694\ud55c \uac83\uc740 \uc544\uc9c1 \uc785\uc99d\ub418\uc9c0 \uc54a\uc740 \uc0ac\ud56d\uc785\ub2c8\ub2e4. \ud604\uc2dc\uc810\uc5d0 2\ub144, 3\ub144, 5\ub144\uc758 \uc7a5\uae30\uc5d0 \uac78\uccd0 \ud6a8\uacfc\uac00 \uc720\uc9c0\ub418\ub294 \uac83\uc744 \ubcf4\uc5ec\uc8fc\ub294 \ub300\uaddc\ubaa8 \ubb34\uc791\uc704 \ub300\uc870 \uc2dc\ud5d8\uc740 \uc5c6\uc2b5\ub2c8\ub2e4. \uc7ac\ud22c\uc5ec\uac00 \ud544\uc694\ud55c\uc9c0, \ud544\uc694\ud558\ub2e4\uba74 \uc5b4\ub5a4 \uac04\uaca9\uc73c\ub85c \ud574\uc57c \ud558\ub294\uc9c0\uc5d0 \ub300\ud55c \ub2f5\ub3c4 \ub098\uc640 \uc788\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4. \uc5f0\uad6c\ub294 \uc804\uc9c4\ud558\uace0 \uc788\uc9c0\ub9cc \uc804\uccb4\uc801\uc778 \uadf8\ub9bc\uc740 \uc544\uc9c1 \uc644\uc131\ub418\uc9c0 \uc54a\uc558\ub2e4\ub294 \uac83\uc744 \uc544\uc2dc\uace0 \uac80\ud1a0\ud574 \uc8fc\uc2dc\uae30 \ubc14\ub78d\ub2c8\ub2e4.<\/p>\n\n\n\n

                  <\/div>\n\n\n\n

                  \uc904\uae30\uc138\ud3ec \uce58\ub8cc\uac00 \uac74\uc120 \uba74\uc5ed \ub8e8\ud504\uc5d0 \uc791\uc6a9\ud558\ub294 \ubc29\uc2dd<\/mark><\/h2>\n\n\n
                  \n
                  \"\uac74\uc120
                  \ub3d9\uc885 \uc911\uac04\uc5fd \uc904\uae30\uc138\ud3ec\ub294 \ud558\ub958\uc758 \uc5fc\uc99d \uc2e0\ud638\uac00 \uc544\ub2c8\ub77c \uadf8 \uc0c1\ub958\uc5d0 \uc788\ub294 \uba74\uc5ed\uc138\ud3ec \uc790\uccb4\uc5d0 \uc791\uc6a9\ud558\ub294 \uc138 \uac00\uc9c0 \uacbd\ub85c\ub85c \uac74\uc120\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce5c\ub2e4.<\/figcaption><\/figure>\n<\/div>\n\n\n

                  \uac74\uc120 \uc904\uae30\uc138\ud3ec \uce58\ub8cc\uc758 \uc138 \uac00\uc9c0 \uc791\uc6a9 \uae30\uc804<\/h3>\n\n\n\n

                  \uc911\uac04\uc5fd \uc904\uae30\uc138\ud3ec(MSC)\ub294 \uc0dd\ubb3c\ud559\uc801 \uc81c\uc81c\uc640\ub294 \ub2e4\ub978 \uac01\ub3c4\uc5d0\uc11c \uac74\uc120\uc5d0 \uc791\uc6a9\ud569\ub2c8\ub2e4. \uc0dd\ubb3c\ud559\uc801 \uc81c\uc81c\ub294 \ud2b9\uc815 \uc5fc\uc99d \uc2e0\ud638\ub97c \ud558\ub098\uc529 \ucc28\ub2e8\ud558\uc9c0\ub9cc, MSC\ub294 \uadf8 \uc2e0\ud638\ub97c \ub0b4\uace0 \uc788\ub294 \uba74\uc5ed\uc138\ud3ec \uc790\uccb4\uc640 \ub300\ud654\ud569\ub2c8\ub2e4.<\/p>\n\n\n\n

                  \uccab \ubc88\uc9f8 \uc791\uc6a9 \uae30\uc804\uc740 \ubcd1\uc6d0\uc131 \uba74\uc5ed\uc138\ud3ec\uc758 \uc9c1\uc811\uc801 \uc5b5\uc81c\uc785\ub2c8\ub2e4. 2022\ub144 Cell and Tissue Research\uc9c0\uc5d0 \uac8c\uc7ac\ub41c \uc5f0\uad6c\uc5d0\uc11c\ub294 \uc778\uac04 \uc81c\ub300 \uc720\ub798 MSC\uac00 IL-17 \uc0dd\uc0b0 \u03b3\u03b4 T \uc138\ud3ec\ub97c \uc5b5\uc81c\ud55c\ub2e4\ub294 \uc0ac\uc2e4\uc774 \uac74\uc120 \uc720\uc0ac \uc5fc\uc99d \ubaa8\ub378\uc5d0\uc11c \uc785\uc99d\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc774\ub4e4\uc740 \uc5ec\ub7ec \uc0dd\ubb3c\ud559\uc801 \uc81c\uc81c\ub97c \uc870\ud569\ud574\uc57c \ube44\ub85c\uc18c \uac1c\ubcc4\uc801\uc73c\ub85c \ucc28\ub2e8\ud560 \uc218 \uc788\ub294 \uc5fc\uc99d \uc2e0\ud638 \ub300\ubd80\ubd84\uc744 \ub9cc\ub4e4\uc5b4\ub0b4\ub294 \uc138\ud3ec \uadf8\ub8f9\uc785\ub2c8\ub2e4. MSC\ub294 \uc774 \uc0c1\ub958\uc758 \uc138\ud3ec\uc5d0 \uc791\uc6a9\ud568\uc73c\ub85c\uc368 \uc5ec\ub7ec \uc5fc\uc99d \ub9e4\uac1c\uccb4\uc758 \uc0dd\uc0b0\uc744 \ub3d9\uc2dc\uc5d0 \uc870\uc808\ud569\ub2c8\ub2e4. <\/p>\n\n\n\n

                  \ub450 \ubc88\uc9f8 \uc791\uc6a9 \uae30\uc804\uc740 \uc870\uc808 T \uc138\ud3ec(Treg)\uc758 \uc99d\uac00\uc785\ub2c8\ub2e4. 2026\ub144 Frontiers in Immunology\uc9c0\uc5d0 \ubc1c\ud45c\ub41c \ubcc4\ub3c4 \uc5f0\uad6c\uc5d0\uc11c\ub294 \uc81c\ub300 \uc720\ub798 MSC \ud22c\uc5ec\uac00 \ub9d0\ucd08\ud608\uc5d0\uc11c \uc870\uc808 T \uc138\ud3ec(Treg)\uc640 CD4+ \uba54\ubaa8\ub9ac T \uc138\ud3ec\uc758 \ube48\ub3c4\ub97c \uc99d\uac00\uc2dc\ud0a4\uace0 Th17 \uc138\ud3ec\uc640 CD4+ \ub098\uc774\ube0c T \uc138\ud3ec\ub97c \uac10\uc18c\uc2dc\ud0a8\ub2e4\ub294 \uc0ac\uc2e4\uc774 \uc77c\ubd80 \uac74\uc120 \ud658\uc790\uc5d0\uc11c \uad00\ucc30\ub418\uc5c8\uc2b5\ub2c8\ub2e4. Treg\ub294 \uba74\uc5ed \uc2dc\uc2a4\ud15c \uc790\uccb4\uc758 ‘\ube0c\ub808\uc774\ud06c \uc5ed\ud560’\uc744 \ud558\uba70, \ub2e4\ub978 \uba74\uc5ed\uc138\ud3ec\uc5d0\uac8c “\ub354 \uc774\uc0c1 \uacf5\uaca9\ud558\uc9c0 \ub9d0\ub77c”\uace0 \uc804\ub2ec\ud558\ub294 \uc5ed\ud560\uc744 \ud569\ub2c8\ub2e4. \uac74\uc120\uc5d0\uc11c\ub294 \uc774 \uade0\ud615\uc774 \uacf5\uaca9 \uce21\uc73c\ub85c \uce58\uc6b0\uccd0 \uc788\ub294\ub370, MSC \uce58\ub8cc\ub294 \uc774\ub97c \uc911\ub9bd \ucabd\uc73c\ub85c \ub2e4\uc18c \ub418\ub3cc\ub9b4 \uc218 \uc788\ub294 \uac00\ub2a5\uc131\uc774 \uc788\uc2b5\ub2c8\ub2e4. \uc774\ub294 \ub958\ub9c8\ud2f0\uc2a4 \uad00\uc808\uc5fc\uc758 \uc904\uae30\uc138\ud3ec \uce58\ub8cc\uc5d0\uc11c\ub3c4 \uc5f0\uad6c\ub418\uace0 \uc788\ub294 \ub3d9\uc77c\ud55c Treg \uc870\uc808 \uba54\ucee4\ub2c8\uc998\uc774\uba70, \uc5ec\ub7ec \uc790\uac00\uba74\uc5ed \uc9c8\ud658\uc5d0 \uacf5\ud1b5\ub418\ub294 \uba74\uc5ed\ud559\uc801 \ub17c\ub9ac\uc785\ub2c8\ub2e4. <\/p>\n\n\n\n

                  \uc138 \ubc88\uc9f8 \uc791\uc6a9 \uae30\uc804\uc740 \uc5fc\uc99d\uc131 \uc0ac\uc774\ud1a0\uce74\uc778 \ud658\uacbd\uc758 \uac10\uc18c\uc785\ub2c8\ub2e4. MSC\ub294 \uad6d\uc18c \ubc0f \uc804\uc2e0\uc5d0\uc11c TNF-\u03b1, IL-17, IL-23\uc758 \uc0dd\uc0b0\uc744 \uc5b5\uc81c\ud558\ub294 \uc2e0\ud638 \ubd84\uc790\ub97c \ubd84\ube44\ud569\ub2c8\ub2e4. \uc0dd\ubb3c\ud559\uc801 \uc81c\uc81c\uc640\uc758 \ucc28\uc774\ub294, \uc0ac\uc774\ud1a0\uce74\uc778 \uc790\uccb4\ub97c \uc57d\ubb3c\ub85c \uacb0\ud569\ud574 \ucc28\ub2e8\ud558\ub294 \uac83\uc774 \uc544\ub2c8\ub77c \uc0dd\uc0b0 \uc138\ud3ec\uc758 \ud65c\uc131\uc744 \uc870\uc815\ud55c\ub2e4\ub294 \uc810\uc785\ub2c8\ub2e4. MSC\uc758 \ud6a8\uacfc\uac00 (\uc57d\ucc98\ub7fc \uba70\uce60 \ub9cc\uc5d0) \uc989\ud6a8\uc131\uc774 \uc544\ub2c8\ub77c \uc218 \uc8fc\uc5d0\uc11c \uc218 \uac1c\uc6d4\uc5d0 \uac78\uccd0 \uc810\uc9c4\uc801\uc73c\ub85c \ub098\ud0c0\ub098\ub294 \uc774\uc720\uac00 \uc5ec\uae30\uc5d0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n

                  \uc774 \uc791\uc6a9\ub4e4\uc774 \ud558\uc9c0 \uc54a\ub294 \uac83\uc5d0 \ub300\ud574\uc11c\ub3c4 \uc815\uc9c1\ud558\uac8c \ub9d0\uc500\ub4dc\ub9b4 \ud544\uc694\uac00 \uc788\uc2b5\ub2c8\ub2e4. MSC\ub294 \uac74\uc120\uc758 \uc720\uc804\uc801 \uc18c\uc778\uc744 \uc5c6\uc560\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4. HLA \ud0c0\uc785\uc744 \ubc14\uafb8\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4. \uc601\uad6c\uc801\uc778 \ud53c\ubd80 \ud074\ub9ac\uc5b4\ub7f0\uc2a4\ub97c \ubcf4\uc7a5\ud558\ub294 \uac83\ub3c4 \uc544\ub2d9\ub2c8\ub2e4. \ud604\uc7ac\uc758 \uadfc\uac70\uac00 \ubcf4\uc5ec\uc8fc\ub294 \uac83\uc740 \uc5b4\ub5a4 \uae30\uac04 \ub3d9\uc548 \uc77c\ubd80 \ud658\uc790\uc5d0\uc11c \uba74\uc5ed \ud658\uacbd\uc744 \uc5fc\uc99d\uc774 \uc801\uc740 \ubc29\ud5a5\uc73c\ub85c \uc774\ub3d9\uc2dc\ud0ac \uac00\ub2a5\uc131\uc774 \uc788\ub2e4\ub294 \uac83\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n

                  <\/div>\n\n\n\n

                  \uc65c \ub3d9\uc885 \uc81c\ub300 \uc720\ub798 MSC\ub97c \uac74\uc120 \uce58\ub8cc\uc5d0 \uc0ac\uc6a9\ud558\ub294\uac00<\/h3>\n\n\n\n

                  \uc904\uae30\uc138\ud3ec \uce58\ub8cc\uc5d0\uc11c \uc0ac\uc6a9\ud558\ub294 \uc138\ud3ec\uc758 \uc885\ub958\ub294 \uc0dd\ubb3c\ud559\uc801\uc73c\ub85c \ubb34\uc5c7\uc774 \uac00\ub2a5\ud55c\uc9c0\ub97c \uc88c\uc6b0\ud569\ub2c8\ub2e4. \ud06c\uac8c \uc790\uac00(\ud658\uc790 \ubcf8\uc778\uc758 \uace8\uc218\ub098 \uc9c0\ubc29\uc5d0\uc11c \ucc44\ucde8\ud558\ub294 \uc138\ud3ec)\uc640 \ub3d9\uc885(\uac74\uac15\ud55c \uae30\uc99d\uc790\uc758 \uc81c\ub300 \uc870\uc9c1 \ub4f1\uc5d0\uc11c \uc5bb\ub294 \uc138\ud3ec)\uc758 \ub450 \uac00\uc9c0 \uc811\uadfc\ubc95\uc774 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n

                  \uc77c\ubcf8\uc758 \uc7ac\uc0dd\uc758\ub8cc \ub4f1 \uc548\uc804\uc131 \ud655\ubcf4\ubc95\uc758 \ud604\ud589 \uccb4\uacc4\uc5d0\uc11c\ub294 \uc8fc\ub85c \uc790\uac00 MSC\ub97c \uc774\uc6a9\ud55c \uce58\ub8cc\uac00 \uc2dc\ud589\ub429\ub2c8\ub2e4. \ud658\uc790\uc5d0\uac8c\uc11c \ucc44\ucde8\ud558\uc5ec \ubc30\uc591\ud558\uace0 \ub2e4\uc2dc \uc8fc\uc785\ud558\uae30 \ub54c\ubb38\uc5d0 \uac70\ubd80 \ubc18\uc751 \uc704\ud5d8\uc774 \uc5c6\ub2e4\ub294 \uc810\uc774 \uc7a5\uc810\uc785\ub2c8\ub2e4. \ub2e4\ub9cc \uac74\uc120\uacfc \uac19\uc740 \uc790\uac00\uba74\uc5ed \uc9c8\ud658\uc5d0\uc11c\ub294 \ubb38\uc81c\uac00 \uc788\uc2b5\ub2c8\ub2e4. \ud658\uc790\uc758 \ubab8 \uc548\uc5d0\uc11c \ub9cc\uc131\uc801\uc778 \uba74\uc5ed \uc774\uc0c1\uc5d0 \ub178\ucd9c\ub418\uc5b4 \uc628 \uc138\ud3ec\ub97c \uaebc\ub0b4 \ub2e4\uc2dc \uc8fc\uc785\ud588\uc744 \ub54c, \uadf8 \uc138\ud3ec\uac00 ‘\uc815\uc0c1\uc801\uc778 \uba74\uc5ed \uc870\uc808’\uc744 \uc81c\ub300\ub85c \ud560 \uc218 \uc788\ub294\uc9c0\uc5d0 \ub300\ud55c \uc9c8\ubb38\uc774 \uc544\uc9c1 \uc644\uc804\ud788 \uacb0\ub860\ub098\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n

                  \uc800\ud76c\uac00 \ub9d0\ub808\uc774\uc2dc\uc544\uc5d0\uc11c \uc81c\uacf5\ud558\ub294 \uce58\ub8cc\ub294 \ub3d9\uc885 \uc81c\ub300 \uc720\ub798 MSC\ub97c \uc0ac\uc6a9\ud569\ub2c8\ub2e4. \uc774 \uc138\ud3ec\ub4e4\uc740 \uac74\uac15\ud55c \uc2e0\uc0dd\uc544 \ucd9c\uc0b0 \uc2dc \ub3d9\uc758\ub97c \ubc1b\uc544 \uae30\uc99d\ub41c \uc81c\ub300 \uc870\uc9c1\uc5d0\uc11c \uc5bb\uc5b4\uc9c4 \uac83\uc785\ub2c8\ub2e4. \uc0dd\ubb3c\ud559\uc801\uc73c\ub85c \uc80a\uace0, \uc544\uc9c1 \uc218\uc2ed \ub144\uc5d0 \uac78\uce5c \uba74\uc5ed\uc801\u00b7\uc57d\ub9ac\uc801 \ub178\ucd9c\uc744 \ubc1b\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4. \ubc30\uce58\ubcc4\ub85c \ud488\uc9c8\uc744 \ud655\uc778\ud558\uace0 \ud22c\uc5ec\ub7c9\uc744 \ud45c\uc900\ud654\ud560 \uc218 \uc788\uc2b5\ub2c8\ub2e4. \uac74\uc120 \ud658\uc790\ubd84\uaed8 \uacb0\uc815\uc801\uc778 \uac83\uc740, \uc774 \uc138\ud3ec\ub4e4\uc774 “\ud658\uc790\ubd84\uc758 \ud3ed\uc8fc\ud55c \uba74\uc5ed \ud658\uacbd \ubc14\uae65\uc5d0\uc11c” \uac74\uac15\ud55c \uba74\uc5ed \uc870\uc808 \uc2e0\ud638\ub97c \ub4e4\uc5ec\uc628\ub2e4\ub294 \uc810\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n

                  \ub3d9\uc885 \uc81c\ub300 \uc720\ub798 MSC\ub294 \uba74\uc5ed\uc6d0\uc131\uc774 \ub0ae\uace0(\uac70\ubd80 \ubc18\uc751\uc758 \ubc29\uc544\uc1e0\uac00 \ub418\ub294 \ud45c\uba74 \ubd84\uc790 \ubc1c\ud604\uc774 \uc801\uc74c), \uc9c0\uae08\uae4c\uc9c0\uc758 \uc784\uc0c1\uc2dc\ud5d8\uc5d0\uc11c \uc911\ub300\ud55c \uac70\ubd80 \ubc18\uc751\uc740 \ubcf4\uace0\ub418\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n

                  <\/div>\n\n\n\n

                  \uac74\uc120 \uc904\uae30\uc138\ud3ec \uce58\ub8cc\uac00 \uc801\ud569\ud55c \uc0ac\ub78c\uacfc \uc801\ud569\ud558\uc9c0 \uc54a\uc740 \uc0ac\ub78c<\/mark><\/h2>\n\n\n\n

                  \uc904\uae30\uc138\ud3ec \uce58\ub8cc\ub97c \uac80\ud1a0\ud560 \uac00\uce58\uac00 \uc788\ub294 \uac74\uc120 \ud658\uc790\uc758 \ud504\ub85c\ud544<\/h3>\n\n\n\n

                  \uc9c0\uae08\uae4c\uc9c0\uc758 \uc784\uc0c1\uc2dc\ud5d8 \ub370\uc774\ud130\uc640 \uc800\ud76c\uc758 \uc784\uc0c1 \uacbd\ud5d8\uc5d0\uc11c \uac74\uc120 \uc904\uae30\uc138\ud3ec \uce58\ub8cc\uac00 \ub354 \uc758\ubbf8\ub97c \uac16\ub294 \ud658\uc790\uc0c1\uc774 \ubcf4\uc785\ub2c8\ub2e4. \ud655\uc9c4\ub41c \uc911\ub4f1\ub3c4~\uc911\uc99d \uac74\uc120\uc73c\ub85c \uc678\uc6a9\uc81c\uc640 \uc804\uc2e0 \uc694\ubc95\uc73c\ub85c\ub294 \ucda9\ubd84\ud788 \uc870\uc808\ub418\uc9c0 \uc54a\uac8c \ub41c \ubd84. \ud55c \uac00\uc9c0 \uc774\uc0c1\uc758 \uc0dd\ubb3c\ud559\uc801 \uc81c\uc81c\ub97c \uc2dc\ub3c4\ud588\uc73c\ub098 \ud6a8\uacfc\uac00 \ub5a8\uc5b4\uc9c0\uace0 \uc788\uac70\ub098, \ud604\uc7ac \uce58\ub8cc\uc758 \ubd80\uc791\uc6a9\uc774 \uc77c\uc0c1\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\uace0 \uc788\ub294 \ubd84. \uccab \ubc88\uc9f8 \uc120\ud0dd\uc9c0\ub85c\uc11c\uac00 \uc544\ub2c8\ub77c \uc5b4\ub290 \ub2e8\uacc4\ub97c \uac70\uce5c \ud6c4\uc5d0 \ub2e4\uc74c \uac80\ud1a0 \uc7ac\ub8cc\ub97c \ucc3e\uace0 \uacc4\uc2e0 \ubd84. \ud53c\ubd80\uacfc\ub098 \ub958\ub9c8\ud2f0\uc2a4\ub0b4\uacfc\uc5d0\uc11c\uc758 \ud1b5\uc0c1 \uc9c4\ub8cc\ub97c \uacc4\uc18d\ud558\ub294 \uac83\uc744 \uc804\uc81c\ub85c \uac80\ud1a0\ud558\ub294 \ubd84.<\/p>\n\n\n\n

                  \uc774\ud658 \uae30\uac04\uc774 \uadf8\ub2e4\uc9c0 \uae38\uc9c0 \uc54a\uace0 \ubcd1\ubcc0 \ubc94\uc704\uac00 \uadf9\ub2e8\uc801\uc73c\ub85c \ub113\uc9c0 \uc54a\uc740 \ubd84\uc774 \uc751\ub2f5\ub960\uc774 \ub2e4\uc18c \ub192\uc740 \uacbd\ud5a5\uc774 \uc788\ub294 \uac83\uc73c\ub85c \ubcf4\uc774\ub098, \uc774\ub294 \ubc1c\ud45c \ub370\uc774\ud130\uc5d0\uc11c \uc544\uc9c1 \ud655\uc815\uc801\uc774\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4. \uc784\uc2e0 \uc911\u00b7\uac00\uae4c\uc6b4 \uc2dc\uae30\uc5d0 \uc784\uc2e0 \uc608\uc815\uc774 \uc5c6\uc73c\uba70 \ud65c\ub3d9\uc131 \uac10\uc5fc\uc99d\uc774\ub098 \uc545\uc131 \uc885\uc591\uc744 \uc553\uace0 \uc788\uc9c0 \uc54a\uc740 \ubd84\uc774 \uc784\uc0c1\uc801\uc73c\ub85c \ud3c9\uac00 \ub300\uc0c1\uc774 \ub429\ub2c8\ub2e4.<\/p>\n\n\n\n

                  \uac74\uc120\uacfc \uac74\uc120\uc131 \uad00\uc808\uc5fc(\ud53c\ubd80 \uc99d\uc0c1\uc5d0 \ub354\ud574 \uad00\uc808\uc758 \ubd80\uc885\uacfc \ud1b5\uc99d\uc774 \uc788\ub294 \uc0c1\ud0dc)\uc744 \ud568\uaed8 \uac00\uc9c4 \uacbd\uc6b0, \ud53c\ubd80 \uc99d\uc0c1\uc5d0 \uc791\uc6a9\ud558\ub294 \uba74\uc5ed \uc870\uc808 \uc791\uc6a9\uc774 \uad00\uc808\uc758 \uc5fc\uc99d\uc5d0\ub3c4 \uc791\uc6a9\ud560 \uac00\ub2a5\uc131\uc774 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n

                  <\/div>\n\n\n\n

                  \uac74\uc120 \uc904\uae30\uc138\ud3ec \uce58\ub8cc\uac00 \uc801\ud569\ud558\uc9c0 \uc54a\uc740 \uc0c1\ud669<\/h3>\n\n\n\n

                  \uac74\uc120 \uc904\uae30\uc138\ud3ec \uce58\ub8cc\ub97c \uad8c\ud558\uc9c0 \uc54a\ub294 \uc0c1\ud669\uc5d0 \ub300\ud574\uc11c\ub3c4 \uba85\ud655\ud788 \ub9d0\uc500\ub4dc\ub9bd\ub2c8\ub2e4.<\/p>\n\n\n\n

                  \ud604\uc7ac\uc758 \uce58\ub8cc\ub85c \uac74\uc120\uc774 \ucda9\ubd84\ud788 \uc870\uc808\ub418\uace0 \uc788\uace0 \ubd80\uc791\uc6a9\ub3c4 \ud5c8\uc6a9 \ubc94\uc704\uc778 \ubd84\uc740, \uc2dc\uac04\u00b7\uc774\ub3d9\u00b7\ube44\uc6a9 \ubd80\ub2f4\uc744 \uc0dd\uac01\ud558\uba74 \uc5bb\uc744 \uac83\uc774 \uc801\uc744 \uac00\ub2a5\uc131\uc774 \uc788\uc2b5\ub2c8\ub2e4. \uc800\ud76c\ub294 \ucd08\uae30 \uc0c1\ub2f4\uc5d0\uc11c \uadf8\ub807\uac8c \ud310\ub2e8\ub418\ub294 \uacbd\uc6b0 \ubd84\uba85\ud788 \ub9d0\uc500\ub4dc\ub9bd\ub2c8\ub2e4.<\/p>\n\n\n\n

                  \ud65c\ub3d9\uc131\u00b7\uc870\uc808\ub418\uc9c0 \uc54a\ub294 \uac10\uc5fc\uc99d(\uc801\uc808\ud788 \uc2a4\ud06c\ub9ac\ub2dd\u00b7\uad00\ub9ac\ub418\uc9c0 \uc54a\uc740 \uc7a0\ubcf5 \uacb0\ud575 \ud3ec\ud568)\uc774 \uc788\ub294 \ubd84\uc740 MSC \uce58\ub8cc\ub97c \ubc1b\uc73c\uc154\uc11c\ub294 \uc548 \ub429\ub2c8\ub2e4. \uc784\uc2e0 \uc911\u00b7\uac00\uae4c\uc6b4 \uc2dc\uae30\uc5d0 \uc784\uc2e0 \uc608\uc815\uc778 \ubd84, \ud65c\ub3d9\uc131 \uc545\uc131 \uc885\uc591\uc774 \uc788\ub294 \ubd84\ub3c4 \ub300\uc0c1\uc5d0\uc11c \uc81c\uc678\ub429\ub2c8\ub2e4. \uc2ec\ud55c \uc870\uc808 \ubd88\ub7c9\uc758 \ub3d9\ubc18 \uc9c8\ud658(\ud2b9\ud788 \uac04 \uae30\ub2a5, \uc2e0\uc7a5 \uae30\ub2a5, \ud608\uad6c \uc218\uc5d0 \uc601\ud5a5\uc744 \ubbf8\uce58\ub294 \ubcd1\ud0dc)\uc774 \uc788\ub294 \uacbd\uc6b0\ub294 \uce58\ub8cc \uc804 \uad00\ub9ac \ub610\ub294 \ube44\uc801\uc751 \ud310\ub2e8\uc774 \ud544\uc694\ud569\ub2c8\ub2e4.<\/p>\n\n\n\n

                  \ud655\uc2e4\ud55c \ud53c\ubd80 \ud074\ub9ac\uc5b4\ub7f0\uc2a4\ub97c \uae30\ub300\ud558\uc2dc\ub294 \ubd84, \ud53c\ubd80\uacfc \uce58\ub8cc\ub97c \uadf8\ub9cc\ub458 \uc218 \uc788\ub2e4\uace0 \uc0dd\uac01\ud558\uc2dc\ub294 \ubd84\uaed8\ub294, \ub370\uc774\ud130\uac00 \uadf8\uac83\uc744 \uc9c0\uc9c0\ud558\uc9c0 \uc54a\ub294\ub2e4\ub294 \uc0ac\uc2e4\uc744 \uc194\uc9c1\ud788 \uc804\ud569\ub2c8\ub2e4. \uce58\ub8cc \ud6c4\uc5d0 \uc2e4\ub9dd\ud558\uc2dc\ub294 \uac83\ubcf4\ub2e4 \uc0c1\ub2f4 \ub2e8\uacc4\uc5d0\uc11c \uc5b4\ub824\uc6b4 \uc774\uc57c\uae30\ub97c \ud558\ub294 \ud3b8\uc774 \ub354 \uc815\uc9c1\ud558\ub2e4\uace0 \uc0dd\uac01\ud569\ub2c8\ub2e4.<\/p>\n\n\n\n

                  \ub0a8\uc131 \ud658\uc790\ubd84\uaed8\ub294 Cheng 2022 \uc2dc\ud5d8\uc5d0\uc11c\uc758 \ub0a8\ub140 \ucc28\uc774\ub97c \ubc18\ub4dc\uc2dc \uc54c\ub824\ub4dc\ub9bd\ub2c8\ub2e4. \ub0a8\uc131 \ud658\uc790\ubd84\uaed8 \uce58\ub8cc\ub97c \uad8c\ud558\uc9c0 \uc54a\ub294\ub2e4\ub294 \uc758\ubbf8\ub294 \uc544\ub2d9\ub2c8\ub2e4. \ub9ce\uc740 \ub0a8\uc131 \ud658\uc790\ubd84\uaed8 \uc815\ub2f9\ud55c \uc784\uc0c1\uc801 \uac80\ud1a0 \uc774\uc720\uac00 \uc788\uc2b5\ub2c8\ub2e4. \ub2e4\ub9cc \ubc1c\ud45c \ub370\uc774\ud130\uc5d0 \ub9de\ucdb0 \uae30\ub300\uce58\ub97c \uc870\uc815\ud574 \uc8fc\uc2dc\uae30 \uc704\ud574 \uc194\uc9c1\ud788 \ub9d0\uc500\ub4dc\ub9bd\ub2c8\ub2e4.<\/p>\n\n\n\n

                  <\/div>\n\n\n\n

                  \uac74\uc120 \uc904\uae30\uc138\ud3ec \uce58\ub8cc\ub97c \ubc1b\uc740 \ud658\uc790\uc758 \uacbd\uacfc<\/mark><\/h2>\n\n\n\n

                  \uce58\ub8cc\ub97c \uc120\ud0dd\ud558\uae30\uae4c\uc9c0\uc758 \uacfc\uc815<\/h3>\n\n\n\n

                  40\ub300 \ud6c4\ubc18\uc758 \uc5ec\uc131. \ub9cc\uc131 \ud310\uc0c1 \uac74\uc120 \uc9c4\ub2e8 \ud6c4 14\ub144. \ucc98\uc74c 3~4\ub144\uc740 \uc678\uc6a9 \uc2a4\ud14c\ub85c\uc774\ub4dc\ub85c \uc5b4\ub290 \uc815\ub3c4 \uc870\uc808\ub418\uc5c8\uc9c0\ub9cc, \uc810\ucc28 \uc678\uc6a9\uc73c\ub85c\ub294 \ub530\ub77c\uc7a1\uc744 \uc218 \uc5c6\uac8c \ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uba54\ud1a0\ud2b8\ub809\uc138\uc774\ud2b8\ub97c \uc0ac\uc6a9\ud558\ub2e4\uac00 TNF-\u03b1 \uc5b5\uc81c\uc81c\ub97c \uc2dc\uc791(\uc57d 2\ub144 \ud6a8\uacfc \ud6c4 \uc774\ucc28 \ubb34\ud6a8), \uc774\ud6c4 IL-17 \uc5b5\uc81c\uc81c\ub85c \uc804\ud658(\uc720\uc0ac\ud55c \ud328\ud134, \ucd08\uae30\uc5d0 \uac15\ud558\uac8c \ud6a8\uacfc \ud6c4 18\uac1c\uc6d4 \uc815\ub3c4\uc5d0 \ubcd1\ubcc0\uc774 \uc11c\uc11c\ud788 \ub3cc\uc544\uc634), \uc138 \ubc88\uc9f8 \uc0dd\ubb3c\ud559\uc801 \uc81c\uc81c\ub85c \ubc14\uafbc \uc9c0 10\uac1c\uc6d4\uc774 \uc9c0\ub09c \uc2dc\uc810\uc774\uc5c8\uc2b5\ub2c8\ub2e4. \uc7ac\uc9c4\ud560 \ub54c\ub9c8\ub2e4 \ub450\ud53c\u00b7\uc815\uac15\uc774\u00b7\ud5c8\ub9ac \uc544\ub798\ub85c \ubcd1\ubcc0\uc774 \ub3cc\uc544\uc624\uae30 \uc2dc\uc791\ud558\ub294 \uac83\uc744 \uc9c1\uc811 \ud655\uc778\ud558\uace0 \uacc4\uc168\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n

                  PASI \uc810\uc218\ub294 \uc911\ub4f1\ub3c4 \ubc94\uc704. \uc870\uc808\uc740 \ub418\uace0 \uc788\uc9c0\ub9cc 18~24\uac1c\uc6d4\ub9c8\ub2e4 \uc57d\uc744 \ubc14\uafd4\uac00\ub294 \ud328\ud134\uc5d0 \uc9c0\ucce4\ub2e4\ub294 \ub9d0\uc500\uc774\uc5c8\uc2b5\ub2c8\ub2e4. \ud55c\uad6d\uc5d0\uc11c \uc0b0\uc815\ud2b9\ub840\ub97c \ubc1b\uace0 \uacc4\uc168\uc9c0\ub9cc, \uadf8 \uc548\uc5d0\uc11c\ub3c4 \uc0dd\ubb3c\ud559\uc801 \uc81c\uc81c\uc758 \ube44\uc6a9 \ubd80\ub2f4\uc740 \uacb0\ucf54 \uac00\ubccd\uc9c0 \uc54a\ub2e4\uace0 \ud558\uc168\uc2b5\ub2c8\ub2e4. \ub3c4\ud56d \uc804 \uc628\ub77c\uc778 \uc0c1\ub2f4\uc5d0\uc11c \uc800\ud76c\ub294 \ubcd1\ub825\u00b7\ucd5c\uadfc\uc758 \uac80\uc0ac\u00b7\uacfc\uac70\uc758 \uce58\ub8cc \uc751\ub2f5\uc744 \ud655\uc778\ud558\uace0, \ub370\uc774\ud130\uac00 \ubcf4\uc5ec\uc8fc\ub294 \uac83\uc744 \uc815\uc9c1\ud558\uac8c \ub9d0\uc500\ub4dc\ub838\uc2b5\ub2c8\ub2e4. \uc5ec\uc131\uc774\ub77c\ub294 \ud504\ub85c\ud544\uc740 \uc751\ub2f5\ub960\uc774 \ub192\uc740 \uad70\uc5d0 \ud574\ub2f9\ud558\uc9c0\ub9cc, \uadf8\ub798\ub3c4 \uc2dc\ud5d8 \ucc38\uac00\uc790\uc758 \uc57d \uc808\ubc18\uc740 \uc758\ubbf8 \uc788\ub294 PASI \uac1c\uc120\uc5d0 \uc774\ub974\uc9c0 \uc54a\ub294\ub2e4\ub294 \uc0ac\uc2e4\uae4c\uc9c0 \ud3ec\ud568\ud574\uc11c.<\/p>\n\n\n\n

                  2024\ub144 \uc911\ubc18\uc5d0 \ub9d0\ub808\uc774\uc2dc\uc544\uc5d0 \uc624\uc154\uc11c \ub3d9\uc885 \uc81c\ub300 \uc720\ub798 MSC \uc815\ub9e5 \uc8fc\uc785\uc744 \ubc1b\uc73c\uc168\uc2b5\ub2c8\ub2e4. \uae30\uc874 \uc0dd\ubb3c\ud559\uc801 \uc81c\uc81c\ub294 \uce58\ub8cc \uc911\uc5d0\ub3c4 \uacc4\uc18d\ud574 \uc8fc\uc2ed\uc2dc\uc624. \uc57d\uc758 \uc870\uc815\uc740 \uc800\ud76c\uc758 \ud310\ub2e8\uc774 \uc544\ub2c8\ub77c \ub2f4\ub2f9 \uc758\uc0ac\uc758 \ud310\ub2e8\uc5d0 \ub9e1\uaca8\uc57c \ud558\uae30 \ub54c\ubb38\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n

                  <\/div>\n\n\n\n

                  \uce58\ub8cc \ud6c4 6\uac1c\uc6d4 \ub3d9\uc548\uc758 \uacbd\uacfc<\/h3>\n\n\n\n

                  \ucc98\uc74c 6\uc8fc\ub294 \uc544\ubb34\ub7f0 \ubcc0\ud654\uac00 \uc5c6\uc5c8\uc2b5\ub2c8\ub2e4. \uc0ac\uc804\uc5d0 “\ucd08\uae30\uc5d0\ub294 \ubcc0\ud654\uac00 \ubcf4\uc774\uc9c0 \uc54a\ub294 \uacbd\uc6b0\uac00 \ub9ce\ub2e4”\uace0 \ub9d0\uc500\ub4dc\ub838\uc9c0\ub9cc, \ud6c4\uc5d0 \ub3cc\uc544\ubcf4\uba74 \ubcf8\uc778\ub3c4 \uc774 \uae30\uac04\uc740 \ub9c8\uc74c\uc774 \uac00\ub77c\uc549\uc558\ub2e4\uace0 \ud569\ub2c8\ub2e4. 3\uac1c\uc6d4\uc9f8\uc5d0 \ub450\ud53c \ubcd1\ubcc0\uc774 \uc605\uc5b4\uc9c0\uae30 \uc2dc\uc791\ud588\uc2b5\ub2c8\ub2e4. \uc0ac\ub77c\uc9c4 \uac83\uc740 \uc544\ub2c8\uc9c0\ub9cc \uc778\uc124\uc774 \ub208\uc5d0 \ub744\uac8c \uc904\uace0 \uadf8 \uc544\ub798\uc758 \ubd89\uc740 \uae30\uac00 \ubd80\ub4dc\ub7ec\uc6cc\uc84c\uc2b5\ub2c8\ub2e4. 4\uac1c\uc6d4\uc9f8\uc5d0 \uac00\uc7a5 \uc644\uace0\ud588\ub358 \uc815\uac15\uc774 \ubcd1\ubcc0\uc5d0 \uba87 \ub144 \ub9cc\uc5d0 \ub208\uc5d0 \ubcf4\uc774\ub294 \uac1c\uc120\uc774 \ub098\ud0c0\ub0ac\uc2b5\ub2c8\ub2e4. 6\uac1c\uc6d4 \uc2dc\uc810\uc758 \ud3c9\uac00\uc5d0\uc11c PASI \uc810\uc218\uac00 \uae30\uc900\uc120\uc5d0\uc11c \uc57d 45% \uac1c\uc120\ub418\uc5c8\uc2b5\ub2c8\ub2e4. \uc644\uc804 \ud074\ub9ac\uc5b4\ub7f0\uc2a4\ub294 \uc544\ub2c8\uace0 \ubcd1\ubcc0\uc740 \ub0a8\uc544 \uc788\uc5c8\uc9c0\ub9cc, \uba74\uc801\ub3c4 \uc791\uc544\uc9c0\uace0 \uc5fc\uc99d\ub3c4 \uac00\ub77c\uc549\uc544 \uc788\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n

                  \uc0dd\ubb3c\ud559\uc801 \uc81c\uc81c\ub294 \uac19\uc740 \uc6a9\ub7c9\uc73c\ub85c \uacc4\uc18d. \ub2f4\ub2f9 \uc758\uc0ac\uc640\uc758 \uc0c1\ub2f4 \uc704\uc5d0 \uc57d\uc758 \uc870\uc815\uc740 \ud558\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4. \uadf8\ub140\uc5d0\uac8c \ub2ec\ub77c\uc9c4 \uac83\uc740 \uad6c\uccb4\uc801\uc778 \uc77c\uc0c1\uc774\uc5c8\uc2b5\ub2c8\ub2e4. \uba87 \ub144 \ub9cc\uc5d0 \uc5ec\ub984\uc5d0 \ubc18\ud314\uc744 \uc785\uc744 \uc218 \uc788\uc5c8\uc2b5\ub2c8\ub2e4. \uc544\uce68\uc5d0 \uad6d\uc18c \uc678\uc6a9\uc5d0 \uac78\ub9ac\ub294 \uc2dc\uac04\uc774 \ud655\uc2e4\ud788 \uc9e7\uc544\uc84c\uc2b5\ub2c8\ub2e4. \ubcf8\uc778\uc740 “\ud074\ub9ac\uc5b4\ub7f0\uc2a4\ub294 \uc544\ub2c8\uc9c0\ub9cc \uc774\ubbf8 \uae30\ub300\ud558\ub294 \uac83\uc744 \uadf8\ub9cc\ub450\uc5c8\ub358 \ubc29\ud5a5\uc73c\ub85c\uc758 \ubd84\uba85\ud55c \ubcc0\ud654”\ub77c\uace0 \ud45c\ud604\ud558\uc168\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n

                  \uacc4\uc18d\ud574\uc11c \uacbd\uacfc \uad00\ucc30\uc744 \uc9c4\ud589\ud558\uace0 \uc788\uc2b5\ub2c8\ub2e4. 12\uac1c\uc6d4 \uc774\ud6c4\uc5d0\ub3c4 \ud6a8\uacfc\uac00 \uc720\uc9c0\ub418\ub294\uc9c0\ub294 \uc55e\uc73c\ub85c\uc758 \ucd94\uc801\uc5d0\uc11c \ubcf4\uc774\uac8c \ub429\ub2c8\ub2e4. \uc9c0\uae08 \ub2e8\uacc4\uc5d0\uc11c\ub294 \uc544\uc9c1 \ubaa8\ub985\ub2c8\ub2e4.<\/p>\n\n\n\n

                  \uc774\ub294 \ud658\uc790\ubd84\uc758 \ub3d9\uc758\ub97c \uc5bb\uc740 \uc775\uba85\uc758 \uacbd\uacfc \uae30\ub85d\uc785\ub2c8\ub2e4. \uac1c\uc778\ucc28\uac00 \ud06c\uace0, \ubc1c\ud45c \ub370\uc774\ud130\uc5d0\uc11c\ub3c4 \uc77c\uc815 \uc218\uc758 \ubd84\uc774 \uc758\ubbf8 \uc788\ub294 \uac1c\uc120\uc5d0 \uc774\ub974\uc9c0 \ubabb\ud558\ub294 \uac83\uc73c\ub85c \ub098\ud0c0\ub098 \uc788\uc2b5\ub2c8\ub2e4. \uc774 \uacbd\ud5d8\uc774 \ubaa8\ub4e0 \ubd84\uaed8 \ud574\ub2f9\ub418\ub294 \uac83\uc740 \uc544\ub2d9\ub2c8\ub2e4.<\/em><\/p>\n\n\n\n

                  <\/div>\n\n\n\n

                  \uce58\ub8cc \ud6c4 \ud68c\ubcf5\uacfc \ud754\ud55c \uacbd\uacfc<\/h3>\n\n\n\n

                  \uc815\ub9e5 \ub0b4 MSC \uc8fc\uc785 \ud6c4\uc758 \ud68c\ubcf5\uc740 \ub2e4\ub978 \ucc98\uce58\uc5d0 \ube44\ud574 \ub9e4\uc6b0 \ubd80\ub4dc\ub7fd\uc2b5\ub2c8\ub2e4. \ub9ce\uc740 \ubd84\uc774 24\uc2dc\uac04 \uc774\ub0b4\uc5d0 \ud1b5\uc0c1\uc758 \uc77c\uc0c1 \ud65c\ub3d9\uc73c\ub85c \ub3cc\uc544\uac11\ub2c8\ub2e4. \ud22c\uc5ec \ud6c4 24~48\uc2dc\uac04 \uc774\ub0b4\uc758 \uacbd\ubbf8\ud55c \ubc1c\uc5f4\uc774\ub098 \uad8c\ud0dc\uac10\uc774 \ubcf4\uace0\ub418\uae30\ub3c4 \ud558\uc9c0\ub9cc, \uba74\uc5ed \uc2dc\uc2a4\ud15c\uc758 \ubc18\uc751\uc73c\ub85c \uc5ec\uaca8\uc9c0\uba70 \ubcf4\ud1b5 \uc790\uc5f0\ud788 \uac1c\uc120\ub429\ub2c8\ub2e4.<\/p>\n\n\n\n

                  \ud68c\ubcf5\uc5d0 \ub300\ud574 \uac00\uc7a5 \uc911\uc694\ud55c \uac83\uc740 ‘\uc11c\ub450\ub974\uc9c0 \uc54a\ub294 \uac83’\uc785\ub2c8\ub2e4. \uc678\uc6a9 \uc2a4\ud14c\ub85c\uc774\ub4dc\ub098 \uc0dd\ubb3c\ud559\uc801 \uc81c\uc81c\ucc98\ub7fc \uba70\uce60 \ub9cc\uc5d0 \ub208\uc5d0 \ubcf4\uc774\ub294 \ubcc0\ud654\uac00 \uc788\ub294 \uac83\uc774 \uc544\ub2c8\ub77c, MSC\ub294 \uc138\ud3ec \uc774\ub3d9\uacfc \uba74\uc5ed \ud658\uacbd\uc758 \uc870\uc815\uc774\ub77c\ub294 \ucc9c\ucc9c\ud788 \uc9c4\ud589\ub418\ub294 \uc0dd\ubb3c\ud559\uc801 \ud504\ub85c\uc138\uc2a4\ub97c \ud1b5\ud574 \uc791\uc6a9\ud569\ub2c8\ub2e4. \uc784\uc0c1\uc2dc\ud5d8\uc5d0\uc11c\uc758 \uc751\ub2f5\uc790\ub294 \ubcf4\ud1b5 8~16\uc8fc\uc5d0 \ubcc0\ud654\ub97c \ub290\ub07c\uae30 \uc2dc\uc791\ud558\uba70, 6\uac1c\uc6d4\uc758 \ucd94\uc801 \uae30\uac04 \ub3d9\uc548 \ud6a8\uacfc\uac00 \uc9c4\uc804\ub429\ub2c8\ub2e4. \ucc98\uc74c 1\uac1c\uc6d4\uc5d0 \ub208\uc5d0 \ubcf4\uc774\ub294 \ubcc0\ud654\ub97c \uae30\ub300\ud558\uba74 \ud6a8\uacfc\uac00 \uc5c6\ub2e4\uace0 \uc870\uae30 \ud310\ub2e8\ud574 \ubc84\ub9ac\uae30 \uc27d\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n

                  <\/div>\n\n\n\n

                  \uac74\uc120 \uc904\uae30\uc138\ud3ec \uce58\ub8cc\uc758 \uc815\uc9c1\ud55c \uc704\ud5d8\uacfc \ud55c\uacc4<\/mark><\/h2>\n\n\n\n

                  \uc784\uc0c1\uc2dc\ud5d8\uc5d0\uc11c \ubcf4\uace0\ub41c \ubd80\uc791\uc6a9<\/h3>\n\n\n\n

                  \ubc1c\ud45c\ub41c MSC \uce58\ub8cc\uc758 \uc548\uc804\uc131 \ud504\ub85c\ud544\uc740 \ub300\uccb4\ub85c \uc591\ud638\ud558\uc9c0\ub9cc, 2\ub144 \uc774\uc0c1\uc758 \uc7a5\uae30 \ub370\uc774\ud130\ub294 \uc544\uc9c1 \ud55c\uc815\uc801\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n

                  \ub2e8\uae30\uc801\uc778 \ubd80\uc791\uc6a9\uc73c\ub85c \uac00\uc7a5 \ud754\ud788 \ubcf4\uace0\ub418\ub294 \uac83\uc740 \uc815\ub9e5 \uc8fc\uc785 \ud6c4 24~48\uc2dc\uac04\uc758 \uacbd\ubbf8\ud55c \ubc1c\uc5f4, \uc804\uc2e0 \uad8c\ud0dc\uac10, \ub4dc\ubb3c\uac8c \uacbd\ubbf8\ud55c \ub450\ud1b5\uc785\ub2c8\ub2e4. \ud1b5\uc0c1\uc801\uc73c\ub85c \uc790\uc5f0\ud788 \uac00\ub77c\uc549\uc2b5\ub2c8\ub2e4. Cheng 2022 \uc2dc\ud5d8\uc758 17\uba85\uc5d0\uc11c\ub294 \uce58\ub8cc \ubc0f 6\uac1c\uc6d4 \ucd94\uc801 \uae30\uac04 \ub3d9\uc548 \uba85\ubc31\ud55c \ubd80\uc791\uc6a9\uc774 \uad00\ucc30\ub418\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4. Yao 2021 \uc2dc\ud5d8\uc758 7\uba85\uc5d0\uc11c\ub3c4 \uc911\ub300\ud55c \uc720\ud574 \uc0ac\uc0c1\uc740 \ubcf4\uace0\ub418\uc9c0 \uc54a\uc558\uc2b5\ub2c8\ub2e4. Bajouri 2023\uc758 \ud53c\ud558 \ud22c\uc5ec \uc2dc\ud5d8\uc5d0\uc11c\ub3c4 \uc911\ub300\ud55c \ubd80\uc791\uc6a9\uc740 \uc5c6\uc5c8\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n

                  MSC \uce58\ub8cc\uc5d0 \ud2b9\uc774\uc801\uc778 \uc774\ub860\uc0c1\uc758 \uc704\ud5d8\uc73c\ub85c\ub294 \ubc18\ubcf5 \ud22c\uc5ec\uc5d0 \uc758\ud55c \uae30\uc99d\uc790 \uc138\ud3ec\uc5d0 \ub300\ud55c \uba74\uc5ed \uac10\uc791 \uac00\ub2a5\uc131, \uba74\uc5ed \uc870\uc808\uc774 \uc774\ud615\uc131 \uc138\ud3ec\uc5d0 \ub300\ud55c \uac10\uc2dc \uae30\ub2a5\uc5d0 \ubbf8\uce58\ub294 \ubbf8\ud655\uc815 \uc601\ud5a5, \ud604\uc7ac\uc758 \ucd94\uc801 \uae30\uac04(\uc218 \uac1c\uc6d4~2\ub144 \uc815\ub3c4)\uc744 \ub118\ub294 \uc7a5\uae30 \uc601\ud5a5 \ub4f1\uc774 \uc788\uc2b5\ub2c8\ub2e4. \uce58\ub8cc \uc804\uc5d0 \ubc18\ub4dc\uc2dc \uc774\ub97c \uc124\uba85\ub4dc\ub9ac\uace0 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n

                  \uc0dd\ubb3c\ud559\uc801 \uc81c\uc81c\ub97c \uacc4\uc18d\ud558\uba74\uc11c MSC \uce58\ub8cc\ub97c \ubc1b\ub294 \uacbd\uc6b0, \uc591\ucabd\uc758 \uba74\uc5ed \uc870\uc808 \uc791\uc6a9\uc774 \uacb9\uce58\ub294 \uac83\uc5d0 \uc758\ud55c \uac10\uc5fc\uc99d \ucde8\uc57d\uc131\uc744 \uc758\uc2dd\ud560 \ud544\uc694\uac00 \uc788\uc2b5\ub2c8\ub2e4. \uc800\ud76c\ub294 \uae30\uc874 \uc57d\uc758 \uc911\uc9c0\ub97c \uc694\uad6c\ud558\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4. \uadf8\uac83\uc740 \ub2f4\ub2f9 \uc758\uc0ac\uc758 \ud310\ub2e8\uc774\uba70 \uc800\ud76c\uac00 \uc77c\ubc29\uc801\uc73c\ub85c \uacb0\uc815\ud558\ub294 \uac83\uc774 \uc544\ub2d9\ub2c8\ub2e4. \ub2e4\ub9cc \uc774 \ubcf5\ud569\uc801\uc778 \uba74\uc5ed \uc870\uc808 \uc0c1\ud0dc\ub97c \uc194\uc9c1\ud788 \uc54c\ub824\ub4dc\ub9bd\ub2c8\ub2e4.<\/p>\n\n\n\n

                  <\/div>\n\n\n\n

                  \uac74\uc120 \uc904\uae30\uc138\ud3ec \uce58\ub8cc\uac00 \ud560 \uc218 \uc5c6\ub294 \uac83<\/h3>\n\n\n\n

                  \uacbd\uacc4\uc120\uc744 \uba85\ud655\ud788 \ub9d0\uc500\ub4dc\ub9bd\ub2c8\ub2e4.<\/p>\n\n\n\n

                  MSC \uce58\ub8cc\ub294 \uac74\uc120\uc758 \uc720\uc804\uc801\u00b7\uba74\uc5ed\ud559\uc801 \uc18c\uc778\uc744 \uc5c6\uc560\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4. HLA-C*06:02\uc758 \uad00\ub828, Th17\uc758 \uc6b0\uc704\uc131 \uacbd\ud5a5, \ub354 \ub113\uc740 \uba74\uc5ed \uc18c\uc778\uc740 \uae30\uc99d\uc790 \uc138\ud3ec\uc758 \ud22c\uc5ec\ub85c \ubc14\ub00c\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4. \ubcc0\ud654\ud560 \uac00\ub2a5\uc131\uc774 \uc788\ub294 \uac83\uc740 \uc5b4\ub5a4 \uc2dc\uae30\uc758 \uba74\uc5ed\uc138\ud3ec \ud65c\uc131 \uc0c1\ud0dc\uc785\ub2c8\ub2e4.<\/p>\n\n\n\n

                  MSC \uce58\ub8cc\ub294 \ud53c\ubd80 \ud074\ub9ac\uc5b4\ub7f0\uc2a4\ub97c \ubcf4\uc7a5\ud558\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4. Cheng 2022 \ub370\uc774\ud130\uc5d0 \uae30\ubc18\ud558\uba74 \uc57d \uc808\ubc18\uc758 \ud658\uc790\ubd84\uc740 PASI 40% \uac1c\uc120\uc758 \uc5ed\uce58\uc5d0 \ub2ff\uc9c0 \ubabb\ud588\uace0, \uc57d 80%\uc758 \ubd84\uc774 PGA\uc5d0\uc11c “\ubcd1\ubcc0 \uc5c6\uc74c\/\ucd5c\uc18c\ud55c”\uc758 \uc0c1\ud0dc\uc5d0\ub294 \ub2ff\uc9c0 \ubabb\ud588\uc2b5\ub2c8\ub2e4. \uc0ac\uc804\uc5d0 \uc5b4\ub290 \uad70\uc5d0 \ub4e4\uc5b4\uac08\uc9c0 \ud655\uc2e4\ud788 \uc608\uce21\ud560 \uc218 \uc5c6\uc2b5\ub2c8\ub2e4(\uc131\ubcc4\uc774 \ud558\ub098\uc758 \ubcc0\uc218\uac00 \ub420 \uac00\ub2a5\uc131\uc740 \uc788\uc2b5\ub2c8\ub2e4).<\/p>\n\n\n\n

                  MSC \uce58\ub8cc\ub294 \ud53c\ubd80\uacfc \uce58\ub8cc\uc758 \ub300\uccb4\uac00 \uc544\ub2d9\ub2c8\ub2e4. \uce58\ub8cc \ud6c4\uc5d0\ub3c4 \uc9c8\ud658\uc758 \ubaa8\ub2c8\ud130\ub9c1, \ud50c\ub808\uc5b4 \uad00\ub9ac, \ub9ce\uc740 \uacbd\uc6b0 \uae30\uc874 \uc57d\uc758 \uacc4\uc18d\uc774 \ud544\uc694\ud569\ub2c8\ub2e4. \ud53c\ubd80\uacfc\uc640\uc758 \uc7a5\uae30\uc801 \uad00\uacc4\uc5d0\uc11c \uc5bb\uc744 \uc218 \uc788\ub294 \uc9c0\uc18d\uc801 \ubaa8\ub2c8\ud130\ub9c1\uc744 \ub300\uccb4\ud558\ub294 \uac83\uc774 \uc544\ub2c8\ub77c \uadf8 \uc606\uc5d0\uc11c \uba74\uc5ed\uc758 \uc774\uc0c1\uc5d0 \uc791\uc6a9\ud558\ub294 \uac83\uc774\ub77c\uace0 \uc0dd\uac01\ud574 \uc8fc\uc2ed\uc2dc\uc624.<\/p>\n\n\n\n

                  MSC \uce58\ub8cc\ub294 \ube60\ub974\uac8c \ub4e3\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4. \ud2b9\uc815 \uc774\ubca4\ud2b8\uc5d0 \ub9de\ucd98 \uae09\uc18d\ud55c \ud074\ub9ac\uc5b4\ub7f0\uc2a4\ub098 \uac15\ud55c \uc2ec\ub9ac\uc801 \uae34\uae09\uc131\uc744 \uac00\uc9c0\uc2e0 \ubd84\uaed8\ub294 \uc218\uac1c\uc6d4 \ub2e8\uc704\uc758 \ud0c0\uc784\ub77c\uc778\uc774 \ub9de\uc9c0 \uc54a\uc2b5\ub2c8\ub2e4. \uc678\uc6a9, \uad11\uc120 \uce58\ub8cc, \ub2e8\uae30\uac04\uc758 \uc804\uc2e0 \uce58\ub8cc\uac00 \ub354 \uc801\ud569\ud55c \uc0c1\ud669\ub3c4 \uc788\uc2b5\ub2c8\ub2e4.<\/p>\n\n\n\n

                  \uadf8\ub9ac\uace0 \ud604\uc2dc\uc810\uc5d0 \uc7a5\uae30 \ucd94\uc801\uc774 \uc788\ub294 \ub300\uaddc\ubaa8 phase III \ubb34\uc791\uc704 \ub300\uc870 \uc2dc\ud5d8\uc740 \uc544\uc9c1 \uc5c6\uc2b5\ub2c8\ub2e4. \uadfc\uac70\uc758 \ud1a0\ub300\ub294 phase 1\/2a \uaddc\ubaa8\uc774\uba70 \ucd94\uc801 \uae30\uac04\uc740 \ud1b5\uc0c1 \uc218\uac1c\uc6d4~1\ub144\uc785\ub2c8\ub2e4. \uc774\ub294 \uc815\uc9c1\ud788 \uacf5\uac1c\ud569\ub2c8\ub2e4. \uc5f0\uad6c\ub294 \uc804\uc9c4\ud558\uace0 \uc788\uc9c0\ub9cc \ud655\ub9bd\ub41c \uce58\ub8cc\uc640 \uac19\uc740 \uadfc\uac70\uc758 \uae4a\uc774\uc5d0\ub294 \uc544\uc9c1 \ub3c4\ub2ec\ud558\uc9c0 \ubabb\ud588\uc2b5\ub2c8\ub2e4.shed treatments sit in terms of evidence depth.<\/p>\n\n\n\n

                  <\/div>\n\n\n\n

                  \uac74\uc120 \uc904\uae30\uc138\ud3ec \uce58\ub8cc\uc5d0 \uad00\ud55c \uc790\uc8fc \ubb3b\ub294 \uc9c8\ubb38<\/mark><\/h2>\n\n\n\n
                  \n
                  \n