{"id":22932,"date":"2026-03-10T16:03:34","date_gmt":"2026-03-10T08:03:34","guid":{"rendered":"https:\/\/stemcell-malaysia.com\/?p=22932"},"modified":"2026-07-17T19:26:54","modified_gmt":"2026-07-17T11:26:54","slug":"eli-lilly-pays-2-4-billion-for-orna-therapeutics-to-push-forward-next-generation-cell-therapy","status":"publish","type":"post","link":"https:\/\/stemcell-malaysia.com\/ja\/eli-lilly-pays-2-4-billion-for-orna-therapeutics-to-push-forward-next-generation-cell-therapy\/","title":{"rendered":"\u30a4\u30fc\u30e9\u30a4\u30ea\u30ea\u30fc\u3001\u6b21\u4e16\u4ee3\u7d30\u80de\u7642\u6cd5\u3092\u63a8\u9032\u3059\u308b\u305f\u3081\u30aa\u30eb\u30ca\u30fb\u30bb\u30e9\u30d4\u30e5\u30fc\u30c6\u30a3\u30af\u30b9\u306b24\u5104\u30c9\u30eb\u3092\u6295\u8cc7"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"22932\" class=\"elementor elementor-22932\" data-elementor-post-type=\"post\">\n\t\t\t\t        <section class=\"elementor-section elementor-top-section elementor-element elementor-element-1ad6e853 elementor-section-boxed elementor-section-height-default elementor-section-height-default pxl-row-scroll-none pxl-zoom-point-false pxl-section-overflow-visible pxl-section-fix-none pxl-bg-color-none pxl-section-overlay-none\" data-id=\"1ad6e853\" data-element_type=\"section\">\n\n                \n                <div class=\"elementor-container elementor-column-gap-default \">\n                <div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d81876 pxl-column-none pxl-column-overflow-hidden-no\" data-id=\"d81876\" data-element_type=\"column\">\r\n        <div class=\"elementor-widget-wrap elementor-element-populated\">\r\n                     \r\n        \t\t<div class=\"elementor-element elementor-element-412e5c15 elementor-widget elementor-widget-text-editor\" data-id=\"412e5c15\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t\n<h1 style=\"text-align: center;\">\u30a4\u30fc\u30e9\u30a4\u30ea\u30ea\u30fc\u3001\u6b21\u4e16\u4ee3\u7d30\u80de\u7642\u6cd5\u3092\u63a8\u9032\u3059\u308b\u305f\u3081\u30aa\u30eb\u30ca\u30fb\u30bb\u30e9\u30d4\u30e5\u30fc\u30c6\u30a3\u30af\u30b9\u306b24\u5104\u30c9\u30eb\u3092\u652f\u6255\u3046<\/h1>\n\n<figure><img decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/03\/pexels-artempodrez-5726796-1024x576.jpg\" alt=\"\" \/><\/figure>\n\n<p class=\"wp-block-paragraph\" style=\"text-align: center;\"><em>\u30a4\u30fc\u30e9\u30a4\u30ea\u30ea\u30fc\uff08Eli Lilly\uff09\u306f\u3001\u81ea\u5df1\u514d\u75ab\u75be\u60a3\uff08autoimmune diseases\uff09\u3092\u6cbb\u7642\u3059\u308b\u305f\u3081\u306e\u74b0\u72b6RNA\uff08circular RNA\uff09\u304a\u3088\u3073\u5e79\u7d30\u80de\uff08stem cells\uff09\u7814\u7a76\u3092\u7528\u3044\u305f\u751f\u4f53\u5185CAR-T\u7d30\u80de\u7642\u6cd5\uff08in vivo CAR-T cell 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class=\"wp-block-paragraph\">\u3082\u3057\u3001\u6570\u9031\u9593\u306b\u308f\u305f\u308b\u691c\u67fb\u5ba4\u3067\u306e\u624b\u9806\u3084\u5165\u9662\u306e\u5fc5\u8981\u306a\u3057\u306b\u3001\u3042\u306a\u305f\u306e\u4f53\u304c\u81ea\u3089\u3092\u6cbb\u7652\u3059\u308b\u3088\u3046\u306b\u6307\u793a\u3055\u308c\u308b\u3068\u3057\u305f\u3089\u3069\u3046\u3067\u3057\u3087\u3046\u304b\u3002\u305d\u308c\u304c\u30012026\u5e742\u67089\u65e5\u306b\u767a\u8868\u3055\u308c\u305f\u3001\u6700\u592724\u5104\u30c9\u30eb\u3067\u30aa\u30eb\u30ca\u30fb\u30bb\u30e9\u30d4\u30e5\u30fc\u30c6\u30a3\u30af\u30b9\u3092\u8cb7\u53ce\u3059\u308b\u3068\u3044\u3046\u30a4\u30fc\u30e9\u30a4\u30ea\u30ea\u30fc\u306e\u6c7a\u5b9a\u306e\u80cc\u5f8c\u306b\u3042\u308b\u4e2d\u5fc3\u7684\u306a\u8003\u3048\u3067\u3059\u3002\u3053\u306e\u53d6\u5f15\u306e\u4e2d\u5fc3\u306b\u3042\u308b\u306e\u306f\u3001\u64cd\u4f5c\u3055\u308c\u305fRNA\uff08engineered RNA\uff09\u5206\u5b50\u3092\u7528\u3044\u3066\u4f53\u5185\u304b\u3089\u81ea\u5206\u81ea\u8eab\u306e\u514d\u75ab\u7d30\u80de\uff08immune cells\uff09\u3092\u518d\u30d7\u30ed\u30b0\u30e9\u30df\u30f3\u30b0\u3059\u308b\u6280\u8853\u3067\u3042\u308a\u3001\u9032\u5316\u3057\u7d9a\u3051\u308b\u7d30\u80de\u7642\u6cd5\uff08cell therapy\uff09\u304a\u3088\u3073\u5e79\u7d30\u80de\u7814\u7a76\u306e\u5206\u91ce\u306b\u304a\u3051\u308b\u91cd\u8981\u306a\u524d\u9032\u3092\u8868\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n<h2 class=\"wp-block-heading\" style=\"text-align: center;\"><br \/>\u53d6\u5f15\u306e\u5185\u5bb9\u3068\u306f\u4f55\u304b\u3001\u305d\u3057\u3066\u306a\u305c\u305d\u308c\u304c\u91cd\u8981\u306a\u306e\u304b\uff1f<\/h2>\n\n<p class=\"wp-block-paragraph\" 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data-path-to-node=\"85\">\u3053\u306e\u52d5\u304d\u306f\u3001\u540c\u793e\u304c\u69cb\u7bc9\u3057\u3066\u304d\u305f\u30d1\u30bf\u30fc\u30f3\u306b\u5408\u81f4\u3059\u308b\u3082\u306e\u3067\u3059\u3002\u30a4\u30fc\u30e9\u30a4\u30ea\u30ea\u30fc\u306f\u3001\u30de\u30a6\u30f3\u30b8\u30e3\u30ed\uff08Mounjaro\uff09\u304a\u3088\u3073\u30bc\u30d7\u30d0\u30a6\u30f3\u30c9\uff08Zepbound\uff09\u306e\u30d6\u30e9\u30f3\u30c9\u540d\u3067\u8ca9\u58f2\u3055\u308c\u3066\u3044\u308b\u30c1\u30eb\u30bc\u30d1\u30c1\u30c9\uff08tirzepatide\uff09\u3092\u542b\u3080\u3001\u5927\u6210\u529f\u3092\u53ce\u3081\u305f\u4f53\u91cd\u7ba1\u7406\u85ac\u304b\u3089\u751f\u307f\u51fa\u3055\u308c\u305f\u53ce\u76ca\u3092\u3001\u907a\u4f1d\u5b50\u7de8\u96c6\uff08gene editing\uff09\u3084\u3001\u73fe\u5728\u306eRNA\u30d9\u30fc\u30b9\u306e\u7d30\u80de\u7642\u6cd5\uff08RNA-based cell therapy\uff09\u3092\u542b\u3080\u65b0\u8208\u306e\u533b\u7642\u5206\u91ce\u306b\u6295\u8cc7\u3057\u3066\u304d\u307e\u3057\u305f\u3002<\/p>\n<h2 style=\"text-align: center;\"><br \/>\u30aa\u30eb\u30ca\u30fb\u30bb\u30e9\u30d4\u30e5\u30fc\u30c6\u30a3\u30af\u30b9\u3068\u306f\u8ab0\u3067\u3001\u5f7c\u3089\u306f\u4f55\u3092\u69cb\u7bc9\u3057\u305f\u306e\u304b\uff1f<\/h2>\n\n<p class=\"wp-block-paragraph\" data-path-to-node=\"87\">\u30aa\u30eb\u30ca\u30fb\u30bb\u30e9\u30d4\u30e5\u30fc\u30c6\u30a3\u30af\u30b9\u306f\u3001\u74b0\u72b6RNA\u307e\u305f\u306foRNA\u3068\u547c\u3070\u308c\u308b\u65b0\u3057\u3044\u30bf\u30a4\u30d7\u306eRNA\u5206\u5b50\u3092\u958b\u767a\u3057\u305f\u30d0\u30a4\u30aa\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u4f01\u696d\u3067\u3059\u3002\u3053\u308c\u304c\u306a\u305c\u91cd\u8981\u306a\u306e\u304b\u3092\u7406\u89e3\u3059\u308b\u306b\u306f\u3001\u5f93\u6765\u306eRNA\u7642\u6cd5\u304c\u3069\u306e\u3088\u3046\u306b\u6a5f\u80fd\u3059\u308b\u304b\u3092\u5c11\u3057\u77e5\u308b\u3053\u3068\u304c\u5f79\u7acb\u3061\u307e\u3059\u3002<\/p>\n<p data-path-to-node=\"88\">COVID-19\u306e\u30d1\u30f3\u30c7\u30df\u30c3\u30af\u4e2d\u306b\u958b\u767a\u3055\u308c\u305fmRNA\u30ef\u30af\u30c1\u30f3\uff08mRNA vaccines\uff09\u306e\u3088\u3046\u306a\u3001RNA\u30d9\u30fc\u30b9\u306e\u85ac\u5264\u306e\u307b\u3068\u3093\u3069\u306f\u3001\u7dda\u72b6RNA\uff08linear RNA\uff09\u3067\u69cb\u6210\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u5206\u5b50\u306f2\u3064\u306e\u958b\u3044\u305f\u672b\u7aef\u3092\u6301\u3061\u3001\u4f53\u5185\u3067\u6bd4\u8f03\u7684\u65e9\u304f\u5206\u89e3\u3055\u308c\u307e\u3059\u3002\u5bfe\u7167\u7684\u306b\u3001\u30aa\u30eb\u30ca\u306e\u74b0\u72b6RNA\u306f\u958b\u3044\u305f\u672b\u7aef\u306e\u306a\u3044\u9589\u3058\u305f\u30eb\u30fc\u30d7\u3092\u5f62\u6210\u3057\u3001\u8457\u3057\u304f\u5b89\u5b9a\u6027\u304c\u9ad8\u304f\u306a\u308a\u307e\u3059\u3002\u7d30\u80de\u5185\u3067\u3088\u308a\u9577\u304f\u6301\u7d9a\u3057\u3001\u3088\u308a\u9577\u671f\u9593\u306b\u308f\u305f\u3063\u3066\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u7523\u751f\u3057\u3001\u4e00\u8cab\u3057\u305f\u88fd\u9020\u304c\u5bb9\u6613\u3067\u3059\u3002<\/p>\n\n<figure><img decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/03\/pexels-fayette-reynolds-m-s-181007507-11198493-1024x577.jpg\" alt=\"\" \/><\/figure>\n\n<p class=\"wp-block-paragraph\">\u30aa\u30eb\u30ca\u306f\u3001\u3053\u306e\u74b0\u72b6RNA\u3092\u8102\u8cea\u30ca\u30ce\u7c92\u5b50\uff08lipid nanoparticle, LNP\uff09\u3068\u547c\u3070\u308c\u308b\u9001\u9054\u30d3\u30d2\u30af\u30eb\u3068\u7d44\u307f\u5408\u308f\u305b\u307e\u3059\u3002\u3053\u308c\u306f\u672c\u8cea\u7684\u306b\u3001RNA\u3092\u4f53\u5185\u306e\u7279\u5b9a\u306e\u7d30\u80de\u306b\u904b\u3076\u3001\u5c0f\u3055\u306a\u8102\u80aa\u30d9\u30fc\u30b9\u306e\u30ab\u30d7\u30bb\u30eb\u3067\u3059\u3002\u74b0\u72b6RNA\u3068LNP\u306f\u4e00\u7dd2\u306b\u306a\u3063\u3066\u3001\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3001\u304c\u3093\uff08cancer\uff09\u3001\u907a\u4f1d\u6027\u75be\u60a3\uff08genetic disorders\uff09\u306a\u3069\u3001\u591a\u304f\u306e\u75be\u60a3\u9818\u57df\u5168\u4f53\u3067\u6f5c\u5728\u7684\u306b\u4f7f\u7528\u3067\u304d\u308b\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u306e\u57fa\u76e4\u3092\u5f62\u6210\u3057\u307e\u3059\u3002<\/p>\n\n<h2 class=\"wp-block-heading\" style=\"text-align: center;\"><br \/>\u4e3b\u8981\u306a\u533b\u85ac\u54c1\u5019\u88dc\uff1aORN-252<\/h2>\n\n<p class=\"wp-block-paragraph\">\u30aa\u30eb\u30ca\u306e\u6700\u3082\u9032\u3093\u3060\u30d7\u30ed\u30b0\u30e9\u30e0\u306fORN-252\u3067\u3059\u3002\u3053\u308c\u306f\u3001\u514d\u75ab\u7d30\u80de\u306e\u4e00\u7a2e\u3067\u3042\u308bB\u7d30\u80de\uff08B cells\uff09\u306e\u8868\u9762\u306b\u898b\u3089\u308c\u308bCD19\u3068\u547c\u3070\u308c\u308b\u30bf\u30f3\u30d1\u30af\u8cea\u3092\u6a19\u7684\u3068\u3059\u308b\u3001\u5b9f\u9a13\u7684\u306a\u751f\u4f53\u5185CAR-T\u7642\u6cd5\u3067\u3059\u3002ORN-252\u306f\u524d\u81e8\u5e8a\u8a66\u9a13\uff08preclinical testing\uff09\u3092\u5b8c\u4e86\u3057\u3066\u304a\u308a\u3001\u8cb7\u53ce\u767a\u8868\u306e\u6642\u70b9\u3067\u306f\u3001\u4eba\u9593\u306e\u60a3\u8005\u306b\u304a\u3051\u308b\u81e8\u5e8a\u8a66\u9a13\u306b\u5165\u308b\u6e96\u5099\u304c\u3067\u304d\u3066\u3044\u308b\u3068\u8aac\u660e\u3055\u308c\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n<h3 class=\"wp-block-heading\" style=\"text-align: center;\"><br \/>ORN-252\u306f\u5f93\u6765\u306eCAR-T\u7642\u6cd5\u3068\u3069\u3046\u9055\u3046\u306e\u304b\uff1f<\/h3>\n\n<figure>\n<p class=\"wp-block-paragraph\" data-path-to-node=\"93\">ORN-252\u304c\u63d0\u4f9b\u3059\u308b\u3082\u306e\u3092\u8a8d\u8b58\u3059\u308b\u305f\u3081\u306b\u306f\u3001\u6a19\u6e96\u7684\u306aCAR-T\u7642\u6cd5\u304c\u73fe\u5728\u3069\u306e\u3088\u3046\u306b\u6a5f\u80fd\u3057\u3066\u3044\u308b\u304b\u3092\u7406\u89e3\u3059\u308b\u3053\u3068\u304c\u5f79\u7acb\u3061\u307e\u3059\u3002\u5f93\u6765\u306e\u30d7\u30ed\u30bb\u30b9\u3067\u306f\u3001\u533b\u5e2b\u306f\u60a3\u8005\u306e\u8840\u6db2\u304b\u3089T\u7d30\u80de\uff08T cells\uff09\u3092\u62bd\u51fa\u3057\u3001\u5c02\u9580\u306e\u691c\u67fb\u5ba4\u306b\u9001\u3063\u3066\u6570\u9031\u9593\u304b\u3051\u3066\u907a\u4f1d\u5b50\u7684\u306b\u6539\u5909\u3057\u3001\u305d\u306e\u5f8c\u3001\u6539\u5909\u3055\u308c\u305f\u7d30\u80de\u3092\u60a3\u8005\u306b\u518d\u6ce8\u5165\u3057\u307e\u3059\u3002\u3053\u306e\u30d7\u30ed\u30bb\u30b9\u306f\u6642\u9593\u304c\u304b\u304b\u308a\u3001\u6280\u8853\u7684\u306b\u8907\u96d1\u3067\u3001\u975e\u5e38\u306b\u9ad8\u4fa1\u3067\u3042\u308a\u3001\u60a3\u8005\u4e00\u4eba\u5f53\u305f\u308a\u6570\u5341\u4e07\u30c9\u30eb\u306b\u9054\u3059\u308b\u3053\u3068\u304c\u3088\u304f\u3042\u308a\u307e\u3059\u3002<\/p>\n<p data-path-to-node=\"94\">ORN-252\u306f\u6839\u672c\u7684\u306b\u7570\u306a\u308b\u30a2\u30d7\u30ed\u30fc\u30c1\u3092\u3068\u308a\u307e\u3059\u3002\u7d30\u80de\u3092\u4f53\u5916\u306b\u53d6\u308a\u51fa\u3057\u3066\u5916\u90e8\u3067\u6539\u5909\u3059\u308b\u306e\u3067\u306f\u306a\u304f\u3001\u6cbb\u7642\u85ac\u3092\u60a3\u8005\u306b\u76f4\u63a5\u6ce8\u5c04\u3057\u307e\u3059\u3002LNP\u3092\u4ecb\u3057\u3066\u9001\u9054\u3055\u308c\u308b\u74b0\u72b6RNA\u306e\u30da\u30a4\u30ed\u30fc\u30c9\uff08payload\uff09\u306f\u3001\u60a3\u8005\u81ea\u8eab\u306eT\u7d30\u80de\u306b\u79fb\u52d5\u3057\u3001\u4f53\u5185\u3067\u305d\u308c\u3089\u3092CAR-T\u7d30\u80de\u306b\u306a\u308b\u3088\u3046\u306b\u518d\u30d7\u30ed\u30b0\u30e9\u30df\u30f3\u30b0\u3057\u307e\u3059\u3002\u751f\u4f53\u5185\u7d30\u80de\u518d\u30d7\u30ed\u30b0\u30e9\u30df\u30f3\u30b0\uff08in vivo cell reprogramming\uff09\u3068\u3057\u3066\u77e5\u3089\u308c\u308b\u3053\u306e\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u3001\u5f93\u6765\u306e\u7d30\u80de\u7642\u6cd5\u306b\u95a2\u9023\u3059\u308b\u9577\u3044\u88fd\u9020\u30d7\u30ed\u30bb\u30b9\u306a\u3057\u306b\u3001\u5916\u6765\u306e\u74b0\u5883\u3067\u6295\u4e0e\u3067\u304d\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<img decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/03\/pexels-gustavo-fring-8770717-1024x683.jpg\" alt=\"\" \/><\/figure>\n\n<h3 class=\"wp-block-heading\" style=\"text-align: center;\"><br \/>\u3069\u306e\u3088\u3046\u306a\u75be\u60a3\u3092\u6cbb\u7642\u3067\u304d\u308b\u306e\u304b\uff1f<\/h3>\n\n<p class=\"wp-block-paragraph\">ORN-252\u306f\u3001B\u7d30\u80de\u4e3b\u5c0e\u578b\u306e\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3001\u3059\u306a\u308f\u3061\u514d\u75ab\u7cfb\u304c\u8aa4\u3063\u3066\u4f53\u81ea\u8eab\u306e\u7d44\u7e54\u3092\u653b\u6483\u3057\u3066\u3057\u307e\u3046\u72b6\u614b\u3092\u6cbb\u7642\u3059\u308b\u305f\u3081\u306b\u958b\u767a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u4f8b\u3068\u3057\u3066\u306f\u3001\u5168\u8eab\u6027\u30a8\u30ea\u30c6\u30de\u30c8\u30fc\u30c7\u30b9\uff08systemic lupus erythematosus, SLE\uff09\u3084\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\uff08rheumatoid arthritis\uff09\u304c\u3042\u308a\u3001\u3069\u3061\u3089\u3082\u7570\u5e38\u306aB\u7d30\u80de\u306e\u6d3b\u52d5\u3092\u4f34\u3044\u307e\u3059\u3002 CAR-T\u7d30\u80de\u3092\u4f7f\u7528\u3057\u3066\u3053\u308c\u3089\u306e\u554f\u984c\u306e\u3042\u308bB\u7d30\u80de\u3092\u9078\u629e\u7684\u306b\u6392\u9664\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001ORN-252\u306f\u75be\u60a3\u306e\u30d7\u30ed\u30bb\u30b9\u3092\u305d\u306e\u767a\u751f\u6e90\u3067\u906e\u65ad\u3059\u308b\u3053\u3068\u3092\u76ee\u6307\u3057\u3066\u3044\u307e\u3059\u3002\u4e00\u90e8\u306e\u7814\u7a76\u8005\u306f\u3001\u3053\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u304c\u6f5c\u5728\u7684\u306a\u9577\u671f\u7684\u306a\u514d\u75ab\u7cfb\u306e\u30ea\u30bb\u30c3\u30c8\u3092\u63d0\u4f9b\u3059\u308b\u3082\u306e\u3068\u3057\u3066\u8aac\u660e\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u3053\u308c\u306f\u81e8\u5e8a\u8a66\u9a13\u3092\u901a\u3058\u3066\u78ba\u8a8d\u3055\u308c\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n<h2 class=\"wp-block-heading\" style=\"text-align: center;\"><br \/>\u30a4\u30fc\u30e9\u30a4\u30ea\u30ea\u30fc\u306f\u306a\u305c\u4eca\u3053\u306e\u52d5\u304d\u3092\u3057\u3066\u3044\u308b\u306e\u304b\uff1f<\/h2>\n\n<h3 class=\"wp-block-heading\" style=\"text-align: center;\">\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u5e02\u5834<\/h3>\n\n<p class=\"wp-block-paragraph\" data-path-to-node=\"99\">\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306f\u4e16\u754c\u4e2d\u306e\u4f55\u5104\u4eba\u3082\u306e\u4eba\u3005\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u3066\u304a\u308a\u3001\u73fe\u4ee3\u533b\u5b66\u306b\u304a\u3044\u3066\u6e80\u305f\u3055\u308c\u3066\u3044\u306a\u3044\u533b\u7642\u30cb\u30fc\u30ba\u304c\u6700\u3082\u5927\u304d\u3044\u5206\u91ce\u306e1\u3064\u3067\u3059\u3002\u30e2\u30ce\u30af\u30ed\u30fc\u30ca\u30eb\u6297\u4f53\uff08monoclonal antibodies\uff09\u3084\u514d\u75ab\u6291\u5236\u5264\uff08immunosuppressive drugs\uff09\u3092\u542b\u3080\u73fe\u5728\u306e\u6cbb\u7642\u6cd5\u306f\u3001\u75c7\u72b6\u3092\u7ba1\u7406\u3057\u3001\u75be\u60a3\u306e\u9032\u884c\u3092\u9045\u3089\u305b\u308b\u306e\u306b\u5f79\u7acb\u3061\u307e\u3059\u304c\u3001\u6839\u672c\u7684\u306a\u514d\u75ab\u6a5f\u80fd\u4e0d\u5168\u3092\u6c38\u7d9a\u7684\u306a\u65b9\u6cd5\u3067\u89e3\u6c7a\u3059\u308b\u3053\u3068\u306f\u3081\u3063\u305f\u306b\u3042\u308a\u307e\u305b\u3093\u3002\u60a3\u8005\u306f\u3057\u3070\u3057\u3070\u751f\u6daf\u306b\u308f\u305f\u308b\u6cbb\u7642\u3092\u5fc5\u8981\u3068\u3057\u3001\u6642\u9593\u306e\u7d4c\u904e\u3068\u3068\u3082\u306b\u53cd\u5fdc\u304c\u4f4e\u4e0b\u3059\u308b\u306e\u3092\u7d4c\u9a13\u3059\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p data-path-to-node=\"100\">ORN-252\u306e\u3088\u3046\u306a\u751f\u4f53\u5185\u7d30\u80de\u7642\u6cd5\u306f\u3001\u30e1\u30ab\u30cb\u30ba\u30e0\u7684\u306b\u7570\u306a\u308b\u9078\u629e\u80a2\u3092\u63d0\u4f9b\u3057\u3001\u3088\u308a\u6301\u7d9a\u7684\u306a\u7d50\u679c\u3092\u3082\u305f\u3089\u3059\u53ef\u80fd\u6027\u3092\u79d8\u3081\u3066\u3044\u307e\u3059\u3002\u3053\u306e\u305f\u3081\u3001\u5f93\u6765\u306e\u751f\u7269\u5b66\u7684\u88fd\u5264\uff08biologics\uff09\u306b\u7d9a\u304f\u6b21\u4e16\u4ee3\u306e\u6cbb\u7642\u6cd5\u3092\u6c42\u3081\u3066\u3044\u308b\u5927\u624b\u88fd\u85ac\u4f1a\u793e\u306b\u3068\u3063\u3066\u3001\u81ea\u5df1\u514d\u75ab\u5206\u91ce\u306f\u307e\u3059\u307e\u3059\u9b45\u529b\u7684\u306a\u3082\u306e\u3068\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n<h3 class=\"wp-block-heading\" style=\"text-align: center;\">\u88fd\u54c1\u3067\u306f\u306a\u304f\u3001\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0<\/h3>\n\n<p class=\"wp-block-paragraph\" data-path-to-node=\"102\">\u30a4\u30fc\u30e9\u30a4\u30ea\u30ea\u30fc\u306f\u5358\u306b1\u3064\u306e\u85ac\u5264\u3092\u8cb7\u53ce\u3057\u3066\u3044\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002ORN-252\u3092\u652f\u3048\u308boRNA-LNP\u751f\u4f53\u5185\u518d\u30d7\u30ed\u30b0\u30e9\u30df\u30f3\u30b0\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u306f\u3001\u5e83\u304f\u9069\u7528\u3067\u304d\u308b\u3088\u3046\u306b\u8a2d\u8a08\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u7406\u8ad6\u7684\u306b\u306f\u3001\u540c\u3058\u6280\u8853\u7684\u57fa\u76e4\u3092\u9069\u5fdc\u3055\u305b\u3066\u3001\u816b\u760d\u5b66\uff08oncology\uff09\u3001\u5e0c\u5c11\u907a\u4f1d\u6027\u75be\u60a3\u3001\u304a\u3088\u3073\u6a19\u7684\u3092\u7d5e\u3063\u305f\u7d30\u80de\u306e\u518d\u30d7\u30ed\u30b0\u30e9\u30df\u30f3\u30b0\u304c\u6709\u76ca\u3068\u306a\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u4ed6\u306e\u9818\u57df\u3067\u306e\u6cbb\u7642\u6cd5\u3092\u958b\u767a\u3059\u308b\u3053\u3068\u304c\u3067\u304d\u307e\u3059\u3002\u3053\u308c\u306b\u306f\u3001RNA\u30c4\u30fc\u30eb\u304c\u7d30\u80de\u306e\u6319\u52d5\u3084\u5206\u5316\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u305f\u3081\u306b\u307e\u3059\u307e\u3059\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u3001\u5e79\u7d30\u80de\u7814\u7a76\u306b\u96a3\u63a5\u3059\u308b\u30a2\u30d7\u30ea\u30b1\u30fc\u30b7\u30e7\u30f3\u304c\u542b\u307e\u308c\u307e\u3059\u3002<\/p>\n<p data-path-to-node=\"103\">\u524d\u81e8\u5e8a\u3067\u306e\u691c\u8a3c\u5f8c\u3001\u5927\u898f\u6a21\u306a\u81e8\u5e8a\u8a66\u9a13\u306e\u524d\u306b\u3001\u3053\u306e\u6bb5\u968e\u3067\u30aa\u30eb\u30ca\u3092\u8cb7\u53ce\u3059\u308b\u3053\u3068\u306b\u3088\u308a\u3001\u30a4\u30fc\u30e9\u30a4\u30ea\u30ea\u30fc\u306f\u521d\u671f\u6bb5\u968e\u306e\u79d1\u5b66\u7684\u767a\u898b\u3068\u3044\u3046\u6700\u3082\u30ea\u30b9\u30af\u306e\u9ad8\u3044\u6bb5\u968e\u3092\u907f\u3051\u306a\u304c\u3089\u3001\u6210\u719f\u3057\u305f\u30d7\u30e9\u30c3\u30c8\u30d5\u30a9\u30fc\u30e0\u3078\u306e\u30a2\u30af\u30bb\u30b9\u3092\u7372\u5f97\u3057\u307e\u3059\u3002<\/p>\n\n<h2 class=\"wp-block-heading\" style=\"text-align: center;\"><br \/>\u3053\u308c\u306f\u3088\u308a\u5e83\u7bc4\u306a\u696d\u754c\u306e\u69cb\u56f3\u306b\u3069\u3046\u9069\u5408\u3059\u308b\u306e\u304b\uff1f<\/h2>\n\n<p class=\"wp-block-paragraph\" 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