{"id":22905,"date":"2026-03-10T14:23:49","date_gmt":"2026-03-10T06:23:49","guid":{"rendered":"https:\/\/stemcell-malaysia.com\/?p=22905"},"modified":"2026-07-17T19:26:55","modified_gmt":"2026-07-17T11:26:55","slug":"stem-cell-therapy-for-premature-ovarian-failure-what-a-phase-i-trial-found","status":"publish","type":"post","link":"https:\/\/stemcell-malaysia.com\/ja\/stem-cell-therapy-for-premature-ovarian-failure-what-a-phase-i-trial-found\/","title":{"rendered":"\u65e9\u767a\u5375\u5de3\u4e0d\u5168\u306b\u5bfe\u3059\u308b\u5e79\u7d30\u80de\u6cbb\u7642\uff1a\u7b2cI\u76f8\u8a66\u9a13\u304b\u3089\u5f97\u3089\u308c\u305f\u77e5\u898b"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"22905\" class=\"elementor elementor-22905\" data-elementor-post-type=\"post\">\n\t\t\t\t        <section class=\"elementor-section elementor-top-section elementor-element elementor-element-8867ad elementor-section-boxed elementor-section-height-default 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center;\">\u65e9\u767a\u5375\u5de3\u4e0d\u5168\u306b\u5bfe\u3059\u308b\u5e79\u7d30\u80de\u6cbb\u7642\uff1a\u7b2cI\u76f8\u8a66\u9a13\u304b\u3089\u5f97\u3089\u308c\u305f\u77e5\u898b<\/h1>\n\n<figure><img decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/03\/pexels-mart-production-7088487-1024x683.jpg\" alt=\"\" \/><\/figure>\n\n<p class=\"wp-block-paragraph\" style=\"text-align: center;\"><em>\u7b2cI\u76f8\u8a66\u9a13\u306f\u3001\u65e9\u767a\u5375\u5de3\u4e0d\u5168\uff08Premature Ovarian Failure, POF\uff09\u306e\u5973\u602735\u540d\u3092\u5bfe\u8c61\u306b\u5e79\u7d30\u80de\u3092\u30c6\u30b9\u30c8\u3057\u3001\u4e00\u90e8\u306e\u60a3\u8005\u306b\u304a\u3044\u3066\u30db\u30eb\u30e2\u30f3\u72b6\u614b\u306e\u6539\u5584\u3068\u6708\u7d4c\u306e\u56de\u5fa9\u3092\u5831\u544a\u3057\u307e\u3057\u305f\u3002<\/em><\/p>\n\n<h1 class=\"wp-block-heading\" style=\"text-align: center;\"><br 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data-path-to-node=\"110\">\u5e79\u7d30\u80de\u306f\u3001POF\u3092\u62b1\u3048\u3066\u751f\u304d\u308b\u5973\u6027\u305f\u3061\u306b\u524d\u9032\u3059\u308b\u305f\u3081\u306e\u65b0\u305f\u306a\u9053\u3092\u63d0\u4f9b\u3067\u304d\u308b\u3067\u3057\u3087\u3046\u304b\u3002\u591a\u304f\u306e\u60a3\u8005\u306b\u3068\u3063\u3066\u3001\u73fe\u5728\u306e\u6cbb\u7642\u9078\u629e\u80a2\u306f\u75c7\u72b6\u306b\u5bfe\u51e6\u3059\u308b\u3082\u306e\u306e\u3001\u5375\u5de3\u6a5f\u80fd\u3084\u751f\u6b96\u80fd\u529b\u3092\u56de\u5fa9\u3055\u305b\u308b\u306b\u306f\u81f3\u308a\u307e\u305b\u3093\u3002\u6700\u8fd1\u5b8c\u4e86\u3057\u305f\u7b2cI\u76f8\u81e8\u5e8a\u8a66\u9a13\u3067\u306f\u3001\u80ce\u76e4\u7d44\u7e54\u306b\u7531\u6765\u3059\u308b\u5e79\u7d30\u80de\u306e\u4e00\u7a2e\u3067\u3042\u308b\u30d2\u30c8\u7f8a\u819c\u4e0a\u76ae\u7d30\u80de\uff08Human Amniotic Epithelial Cells, hAECs\uff09\u304c\u3001\u3053\u306e\u75be\u60a3\u3092\u6301\u3064\u5973\u6027\u306b\u6709\u610f\u7fa9\u306a\u5909\u5316\u3092\u3082\u305f\u3089\u3059\u3053\u3068\u304c\u3067\u304d\u308b\u304b\u3069\u3046\u304b\u3092\u8abf\u67fb\u3057\u307e\u3057\u305f\u3002<\/p>\n<p 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\/>\u65e9\u767a\u5375\u5de3\u4e0d\u5168\u3068\u306f\u4f55\u304b\uff1f<\/h2>\n\n<figure><img decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/03\/pexels-moose-photos-170195-1036620-1024x684.jpg\" alt=\"\" \/><\/figure>\n\n<p class=\"wp-block-paragraph\" data-path-to-node=\"113\"><span class=\"citation-9 citation-end-9\">POF\uff08\u539f\u767a\u6027\u5375\u5de3\u4e0d\u5168\uff08Primary Ovarian Insufficiency, POI\uff09\u3068\u3082\u547c\u3070\u308c\u307e\u3059\uff09\u306f\u3001\u5973\u6027\u304c40\u6b73\u306b\u9054\u3059\u308b\u524d\u306b\u5375\u5de3\u304c\u6b63\u5e38\u306b\u6a5f\u80fd\u3057\u306a\u304f\u306a\u308b\u75be\u60a3\u3067\u3059\u3002\u81ea\u7136\u306a\u9589\u7d4c\u3068\u306f\u7570\u306a\u308a\u3001POF\u306f10\u4ee3\u3068\u3044\u3046\u65e9\u3044\u6642\u671f\u306b\u8d77\u3053\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u3001\u591a\u304f\u306e\u5834\u5408\u4e88\u671f\u3057\u306a\u3044\u3082\u306e\u3067\u3042\u308a\u3001\u60a3\u8005\u306f\u5341\u5206\u306a\u6e96\u5099\u3084\u660e\u78ba\u306a\u6cbb\u7642\u9078\u629e\u80a2\u304c\u306a\u3044\u72b6\u614b\u306b\u53d6\u308a\u6b8b\u3055\u308c\u307e\u3059\u3002<\/span><\/p>\n<p data-path-to-node=\"114\">\u3053\u306e\u75be\u60a3\u306f\u3001\u4e16\u754c\u4e2d\u306e\u5973\u6027\u306e\u7d043.5%\u306b\u5f71\u97ff\u3092\u53ca\u307c\u3057\u3066\u3044\u308b\u3068\u63a8\u5b9a\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u3001\u30bf\u30fc\u30ca\u30fc\u75c7\u5019\u7fa4\uff08Turner syndrome\uff09\u306a\u3069\u306e\u907a\u4f1d\u7684\u8981\u56e0\u3001\u74b0\u5883\u66dd\u9732\u3001\u307e\u305f\u306f\u5316\u5b66\u7642\u6cd5\u3084\u653e\u5c04\u7dda\u7642\u6cd5\u306a\u3069\u306e\u533b\u7642\u7684\u6cbb\u7642\u306e\u526f\u4f5c\u7528\u306b\u3088\u3063\u3066\u5f15\u304d\u8d77\u3053\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002\u3057\u304b\u3057\u306a\u304c\u3089\u3001\u591a\u304f\u306e\u5834\u5408\u3001\u7279\u5b9a\u53ef\u80fd\u306a\u539f\u56e0\u306f\u898b\u3064\u304b\u308a\u307e\u305b\u3093\u3002<\/p>\n<p data-path-to-node=\"115\">\u5375\u5de3\u306f\u4e8c\u91cd\u306e\u5f79\u5272\u3092\u679c\u305f\u3057\u307e\u3059\u3002\u6708\u7d4c\u5468\u671f\u3092\u8abf\u7bc0\u3057\u3001\u5e83\u7bc4\u306a\u8eab\u4f53\u6a5f\u80fd\u306b\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u6027\u30db\u30eb\u30e2\u30f3\uff08\u4e3b\u306b\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u3068\u30d7\u30ed\u30b2\u30b9\u30c6\u30ed\u30f3\uff09\u3092\u7523\u751f\u3057\u307e\u3059\u3002\u5375\u5de3\u6a5f\u80fd\u304c\u82e5\u304f\u3057\u3066\u4f4e\u4e0b\u3059\u308b\u3068\u3001\u305d\u306e\u5f71\u97ff\u306f\u751f\u6b96\u306b\u95a2\u3059\u308b\u5065\u5eb7\u3092\u306f\u308b\u304b\u306b\u8d85\u3048\u3066\u53ca\u3076\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n<h3 class=\"wp-block-heading\" style=\"text-align: center;\"><br \/>\u75c7\u72b6\u3068\u5065\u5eb7\u3078\u306e\u5f71\u97ff<\/h3>\n\n<p class=\"wp-block-paragraph\" data-path-to-node=\"117\">POF\u306e\u6700\u3082\u8a8d\u8b58\u3057\u3084\u3059\u3044\u75c7\u72b6\u306f\u6708\u7d4c\u306e\u4e0d\u9806\u3084\u7121\u6708\u7d4c\u3067\u3059\u304c\u3001\u3088\u308a\u5e83\u7bc4\u306a\u30db\u30eb\u30e2\u30f3\u306e\u5f71\u97ff\u306b\u3088\u308a\u3001\u65e5\u5e38\u751f\u6d3b\u306b\u5927\u304d\u306a\u5f71\u97ff\u3092\u4e0e\u3048\u308b\u53ef\u80fd\u6027\u306e\u3042\u308b\u4e00\u9023\u306e\u75c7\u72b6\u304c\u751f\u3058\u307e\u3059\u3002\u3053\u308c\u3089\u306b\u306f\u3001\u307b\u3066\u308a\u3084\u5bdd\u6c57\u3001\u7761\u7720\u969c\u5bb3\u3001\u8a18\u61b6\u56f0\u96e3\u3001\u3044\u3089\u3044\u3089\u3001\u81a3\u306e\u4e7e\u71e5\u3001\u6027\u6b32\u4f4e\u4e0b\u3001\u6027\u4ea4\u75db\u304c\u542b\u307e\u308c\u307e\u3059\u3002\u9577\u671f\u7684\u306b\u306f\u3001\u4f4e\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u5024\u306f\u9aa8\u7c97\u9b06\u75c7\u3084\u5fc3\u8840\u7ba1\u75be\u60a3\u306e\u30ea\u30b9\u30af\u3092\u9ad8\u3081\u307e\u3059\u3002<\/p>\n<p data-path-to-node=\"118\">\u751f\u6b96\u80fd\u529b\u3082\u5f71\u97ff\u3092\u53d7\u3051\u3001\u60a3\u8005\u306f\u75be\u60a3\u304c\u3044\u3064\u767a\u75c7\u3059\u308b\u304b\u306b\u5fdc\u3058\u3066\u3001\u539f\u767a\u6027\u307e\u305f\u306f\u7d9a\u767a\u6027\u306e\u4e0d\u598a\u75c7\u3092\u7d4c\u9a13\u3057\u307e\u3059\u3002\u598a\u5a20\u3092\u671b\u3093\u3067\u3044\u305f\u5973\u6027\u306b\u3068\u3063\u3066\u3001POF\u306e\u8a3a\u65ad\u306f\u7279\u306b\u82e6\u75db\u3092\u4f34\u3046\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<h3 style=\"text-align: center;\"><br \/>\u3069\u306e\u3088\u3046\u306b\u8a3a\u65ad\u3055\u308c\u308b\u304b\uff1f<\/h3>\n\n<p class=\"wp-block-paragraph\">40\u6b73\u672a\u6e80\u306e\u5973\u6027\u306e\u8a3a\u65ad\u306f\u3001\u6b21\u306e3\u3064\u306e\u57fa\u6e96\u306b\u57fa\u3065\u3044\u3066\u3044\u307e\u3059\u3002\u5c11\u306a\u304f\u3068\u30824\u301c6\u30f6\u6708\u306e\u6708\u7d4c\u306e\u6b20\u5982\u307e\u305f\u306f\u5e0c\u767a\u30014\u9031\u9593\u4ee5\u4e0a\u306e\u9593\u9694\u3092\u7a7a\u3051\u3066\u63a1\u53d6\u3055\u308c\u305f2\u56de\u306e\u5225\u3005\u306e\u8840\u6db2\u691c\u67fb\u3067\u78ba\u8a8d\u3055\u308c\u305f40 IU\/L\u3092\u8d85\u3048\u308b\u5375\u80de\u523a\u6fc0\u30db\u30eb\u30e2\u30f3\uff08Follicle-Stimulating Hormone, FSH\uff09\u5024\u3001\u305d\u3057\u3066\u66f4\u5e74\u671f\u69d8\u75c7\u72b6\u3092\u4f34\u3046\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u5024\u306e\u4f4e\u4e0b\u3067\u3059\u3002<\/p>\n\n<h2 class=\"wp-block-heading\" style=\"text-align: center;\"><br \/>\u73fe\u5728\u306e\u6cbb\u7642\u3068\u305d\u306e\u9650\u754c<\/h2>\n\n<figure><img decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/03\/pexels-freestockpro-4309557-1024x683.jpg\" alt=\"\" \/><\/figure>\n\n<p class=\"wp-block-paragraph\" data-path-to-node=\"122\">POF\u3092\u7ba1\u7406\u3059\u308b\u305f\u3081\u306e\u6a19\u6e96\u7684\u306a\u30a2\u30d7\u30ed\u30fc\u30c1\u306f\u30db\u30eb\u30e2\u30f3\u88dc\u5145\u7642\u6cd5\uff08Hormone Replacement Therapy, 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class=\"wp-block-paragraph\">\u5b50\u5bae\u5185\u819c\u306e\u539a\u3055\uff08\u5b50\u5bae\u306e\u53d7\u5bb9\u6027\u3068\u30a8\u30b9\u30c8\u30ed\u30b2\u30f3\u6d3b\u6027\u306e\u91cd\u8981\u306a\u30de\u30fc\u30ab\u30fc\uff09\u306f\u3001\u6cbb\u7642\u5f8c1\u30f6\u6708\u304a\u3088\u30735\u30f6\u6708\u3067\u6709\u610f\u306b\u5897\u52a0\u3057\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u51e6\u7f6e\u306e1\u30f6\u6708\u5f8c\u306b\u5de6\u5375\u5de3\u306e\u7d71\u8a08\u7684\u306b\u6709\u610f\u306a\u80a5\u5927\u304c\u89b3\u5bdf\u3055\u308c\uff08p = 0.041\uff09\u3001\u3053\u308c\u306f\u5375\u80de\u6d3b\u52d5\u306e\u6539\u5584\u307e\u305f\u306f\u7d44\u7e54\u704c\u6d41\u306e\u5f37\u5316\u3092\u53cd\u6620\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n<h3 class=\"wp-block-heading\" style=\"text-align: center;\"><br \/>\u751f\u6d3b\u306e\u8cea\uff08QOL\uff09<\/h3>\n\n<p class=\"wp-block-paragraph\">\u66f4\u5e74\u671f\u75c7\u72b6\u306e\u8ca0\u62c5\u306f\u3001\u8840\u7ba1\u904b\u52d5\u3001\u8eab\u4f53\u7684\u3001\u5fc3\u7406\u793e\u4f1a\u7684\u3001\u304a\u3088\u3073\u6027\u7684\u306a\u9818\u57df\u3092\u30ab\u30d0\u30fc\u3059\u308b\u691c\u8a3c\u6e08\u307f\u306e\u9589\u7d4c\u7279\u7570\u7684QOL\uff08Menopause-Specific Quality of Life, MENQOL\uff09\u8cea\u554f\u7968\u3092\u4f7f\u7528\u3057\u3066\u8a55\u4fa1\u3055\u308c\u307e\u3057\u305f\u3002\u8ffd\u8de1\u671f\u9593\u3092\u901a\u3058\u3066\u3001\u3053\u308c\u30894\u3064\u306e\u3059\u3079\u3066\u306e\u9818\u57df\u3067\u30b9\u30b3\u30a2\u304c\u9032\u884c\u6027\u306b\u6539\u5584\u3057\u30015\u30f6\u6708\u306e\u6642\u70b9\u3067\u6700\u3082\u6301\u7d9a\u7684\u306a\u6539\u5584\u304c\u89b3\u5bdf\u3055\u308c\u307e\u3057\u305f\u3002\u8eab\u4f53\u75c7\u72b6\u30b9\u30b3\u30a2\u3068\u6027\u6a5f\u80fd\u30b9\u30b3\u30a2\u306e\u4e21\u65b9\u304c\u3001\u30d9\u30fc\u30b9\u30e9\u30a4\u30f3\u3068\u6bd4\u8f03\u3057\u3066\u7d71\u8a08\u7684\u306b\u6709\u610f\u306a\u6539\u5584\u3092\u793a\u3057\u307e\u3057\u305f\u3002<\/p>\n\n<h3 class=\"wp-block-heading\" style=\"text-align: center;\"><br \/>\u4ee5\u524d\u306eIVF\u5931\u6557\u5f8c\u306e\u63a1\u5375<\/h3>\n\n<p class=\"wp-block-paragraph\">35\u540d\u306e\u60a3\u8005\u306e\u3046\u3061\u30016\u540d\u306f\u8a66\u9a13\u306b\u53c2\u52a0\u3059\u308b\u524d\u306b\u4f53\u5916\u53d7\u7cbe\u30fb\u80da\u79fb\u690d\uff08In vitro fertilization and embryo transfer, IVF-ET\uff09\u306e\u30b5\u30a4\u30af\u30eb\u306b\u5931\u6557\u3057\u3066\u3044\u307e\u3057\u305f\u3002hAEC\u6cbb\u7642\u5f8c\u30016\u540d\u5168\u54e1\u304c\u63a1\u5375\u306b\u9032\u3080\u3053\u3068\u304c\u3067\u304d\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u3001\u4ee5\u524d\u306e\u6cbb\u7642\u306e\u8a66\u307f\u3067\u306f\u4e0d\u53ef\u80fd\u3060\u3063\u305f\u3053\u3068\u3067\u3059\u3002\u3042\u308b\u60a3\u8005\u306f\u3001\u5e79\u7d30\u80de\u51e6\u7f6e\u306e\u7d042\u30f6\u6708\u5f8c\u306b\u3001\u4ed8\u968f\u3059\u308b\u30db\u30eb\u30e2\u30f3\u523a\u6fc0\u3092\u4e00\u5207\u53d7\u3051\u305a\u306b\u30012\u3064\u306e\u751f\u5b58\u53ef\u80fd\u306a\u5375\u5b50\u3092\u63a1\u53d6\u3057\u30012\u3064\u306e\u51cd\u7d50\u80da\u3092\u5f97\u307e\u3057\u305f\u3002\u3053\u308c\u306f\u5358\u4e00\u306e\u30b1\u30fc\u30b9\u3067\u3059\u304c\u3001\u5c06\u6765\u306e\u751f\u6b96\u80fd\u529b\u306b\u7126\u70b9\u3092\u5f53\u3066\u305f\u7814\u7a76\u306e\u6587\u8108\u306b\u304a\u3044\u3066\u6ce8\u76ee\u306b\u5024\u3059\u308b\u767a\u898b\u3067\u3059\u3002<\/p>\n\n<h3 class=\"wp-block-heading\" style=\"text-align: center;\"><br \/>\u5b89\u5168\u6027<\/h3>\n\n<p 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class=\"wp-block-heading\" style=\"text-align: center;\"><br \/>\u80cc\u666f\u3068\u9650\u754c<\/h2>\n\n<figure><img decoding=\"async\" class=\"aligncenter\" src=\"https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/03\/1-2-1024x653.jpg\" alt=\"\" \/><\/figure>\n\n<p class=\"wp-block-paragraph\" 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data-path-to-node=\"153\">\u307e\u305f\u3001\u5375\u80de\u4e88\u5099\u80fd\u304c\u8457\u3057\u304f\u67af\u6e07\u3057\u3066\u3044\u308b\u60a3\u8005\u306f\u3001\u5358\u4e00\u306e\u6cbb\u7642\u30b5\u30a4\u30af\u30eb\u306b\u5341\u5206\u306b\u5fdc\u7b54\u3057\u306a\u3044\u53ef\u80fd\u6027\u304c\u3042\u308b\u3053\u3068\u306b\u3082\u6ce8\u610f\u304c\u5fc5\u8981\u3067\u3059\u3002\u4e00\u90e8\u306e\u60a3\u8005\u306f\u3001\u521d\u671f\u306e\u53cd\u5fdc\u3092\u7dad\u6301\u307e\u305f\u306f\u69cb\u7bc9\u3059\u308b\u305f\u3081\u306b\u53cd\u5fa9\u7684\u306a\u6ce8\u5165\u3092\u5fc5\u8981\u3068\u3059\u308b\u5834\u5408\u304c\u3042\u308a\u3001\u5375\u5de3\u4e88\u5099\u80fd\u306e\u30de\u30fc\u30ab\u30fc\u3067\u3042\u308b\u6297\u30df\u30e5\u30e9\u30fc\u7ba1\u30db\u30eb\u30e2\u30f3\uff08Anti-M\u00fcllerian Hormone, AMH\uff09\u5024\u306f\u30011\u56de\u306e\u30bb\u30c3\u30b7\u30e7\u30f3\u3060\u3051\u3067\u306f\u6709\u610f\u306a\u5909\u5316\u3092\u53cd\u6620\u3057\u306a\u3044\u53ef\u80fd\u6027\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<p data-path-to-node=\"154\">\u65e9\u767a\u5375\u5de3\u4e0d\u5168\u306b\u5bfe\u3059\u308b\u5e79\u7d30\u80de\u6cbb\u7642\u304c\u7814\u7a76\u74b0\u5883\u4ee5\u5916\u3067\u306e\u81e8\u5e8a\u5fdc\u7528\u3068\u3057\u3066\u8003\u616e\u3055\u308c\u308b\u3088\u3046\u306b\u306a\u308b\u307e\u3067\u306b\u306f\u3001\u3088\u308a\u9577\u671f\u306e\u8ffd\u8de1\u671f\u9593\u3092\u4f34\u3046\u3001\u3088\u308a\u5927\u898f\u6a21\u306a\u7121\u4f5c\u70ba\u5316\u5bfe\u7167\u8a66\u9a13\u304c\u5fc5\u8981\u3067\u3059\u3002<\/p>\n\n<h2 class=\"wp-block-heading\" style=\"text-align: center;\"><br \/>\u7d50\u8ad6<\/h2>\n\n<p class=\"wp-block-paragraph\" 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