{"id":25241,"date":"2026-05-19T13:30:30","date_gmt":"2026-05-19T05:30:30","guid":{"rendered":"https:\/\/stemcell-malaysia.com\/?page_id=25241"},"modified":"2026-07-31T12:26:41","modified_gmt":"2026-07-31T04:26:41","slug":"crohns-disease","status":"publish","type":"page","link":"https:\/\/stemcell-malaysia.com\/ja\/conditions\/crohns-disease\/","title":{"rendered":"\u30af\u30ed\u30fc\u30f3\u75c5\u306e\u5e79\u7d30\u80de\u6cbb\u7642\uff5c\u751f\u7269\u5b66\u7684\u88fd\u5264\u304c\u52b9\u304b\u306a\u304f\u306a\u3063\u305f\u3068\u304d\u624b\u8853\u4ee5\u5916\u306e\u9078\u629e\u80a2\u306f\u3042\u308b\u306e\u304b"},"content":{"rendered":"\n<h1 class=\"wp-block-heading has-text-align-center\">\u30af\u30ed\u30fc\u30f3\u75c5\u306e\u5e79\u7d30\u80de\u6cbb\u7642\uff5c\u751f\u7269\u5b66\u7684\u88fd\u5264\u304c\u52b9\u304b\u306a\u304f\u306a\u3063\u305f\u3068\u304d\u624b\u8853\u4ee5\u5916\u306e\u9078\u629e\u80a2\u306f\u3042\u308b\u306e\u304b<\/h1>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"533\" src=\"https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/05\/pexels-mart-production-8471918.webp\" alt=\"\u4eba\u9593\u306e\u9aa8\u683c\u3068\u5185\u81d3\u306e\u89e3\u5256\u6a21\u578b\u306b\u3001\u300c\u80c3\u300d\u3068\u66f8\u304b\u308c\u305f\u4ed8\u7b8b\u304c\u8cbc\u3089\u308c\u3066\u3044\u308b\u3002\" class=\"wp-image-25235\" style=\"aspect-ratio:1.79380711140571;object-fit:cover;width:616px;height:auto\" srcset=\"https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/05\/pexels-mart-production-8471918.webp 800w, https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/05\/pexels-mart-production-8471918-300x200.webp 300w, https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/05\/pexels-mart-production-8471918-768x512.webp 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><figcaption 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style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><mark style=\"background-color:#dce9f5\" class=\"has-inline-color\">\u76ee\u6b21<\/mark><\/h2>\n\n\n<div class=\"wp-block-aioseo-table-of-contents\"><ol><li><a class=\"aioseo-toc-item\" href=\"#aioseo-the-two-faces-of-crohns-disease-that-make-it-so-hard-to-treat-9\">\u30af\u30ed\u30fc\u30f3\u75c5\u304c\u6cbb\u308a\u306b\u304f\u3044\u4e8c\u3064\u306e\u7406\u7531<\/a><ol><\/ol><\/li><li><a class=\"aioseo-toc-item\" href=\"#aioseo-\u6a19\u6e96\u6cbb\u7642\u304c\u3076\u3064\u304b\u308b\u5929\u4e95-20\">\u6a19\u6e96\u6cbb\u7642\u304c\u3076\u3064\u304b\u308b\u5929\u4e95<\/a><ol><\/ol><\/li><li><a class=\"aioseo-toc-item\" href=\"#aioseo-how-stem-cell-therapy-targets-crohns-disease-differently-33\">\u30af\u30ed\u30fc\u30f3\u75c5\u306b\u5bfe\u3059\u308b\u5e79\u7d30\u80de\u6cbb\u7642\u306e\u3057\u304f\u307f<\/a><ol><\/ol><\/li><li><a class=\"aioseo-toc-item\" href=\"#aioseo-clinical-trial-evidence-for-crohns-disease-stem-cell-therapy-49\">\u30af\u30ed\u30fc\u30f3\u75c5\u306e\u5e79\u7d30\u80de\u6cbb\u7642\u306b\u95a2\u3059\u308b\u81e8\u5e8a\u8a66\u9a13\u30c7\u30fc\u30bf<\/a><ol><\/ol><\/li><li><a class=\"aioseo-toc-item\" href=\"#aioseo-\u81ea\u5bb6\u7d30\u80de\u3068\u4ed6\u5bb6\u81cd\u5e2f\u7531\u6765msc\u306e\u9055\u3044-63\">\u81ea\u5bb6\u7d30\u80de\u3068\u4ed6\u5bb6\u81cd\u5e2f\u7531\u6765MSC\u306e\u9055\u3044<\/a><ol><\/ol><\/li><li><a class=\"aioseo-toc-item\" href=\"#aioseo-\u5e79\u7d30\u80de\u6cbb\u7642\u304c\u5411\u304f\u65b9\u3068\u5411\u304b\u306a\u3044\u65b9-73\">\u5e79\u7d30\u80de\u6cbb\u7642\u304c\u5411\u304f\u65b9\u3068\u5411\u304b\u306a\u3044\u65b9<\/a><ol><\/ol><\/li><li><a class=\"aioseo-toc-item\" href=\"#aioseo-\u6cbb\u7642\u3092\u53d7\u3051\u305f\u65b9\u306e\u7d4c\u904e-97\">\u6cbb\u7642\u3092\u53d7\u3051\u305f\u65b9\u306e\u7d4c\u904e<\/a><ol><\/ol><\/li><li><a class=\"aioseo-toc-item\" href=\"#aioseo-\u5e79\u7d30\u80de\u6cbb\u7642\u306e\u30ea\u30b9\u30af\u3068\u6b63\u76f4\u306a\u9650\u754c-107\">\u5e79\u7d30\u80de\u6cbb\u7642\u306e\u30ea\u30b9\u30af\u3068\u6b63\u76f4\u306a\u9650\u754c<\/a><ol><\/ol><\/li><li><a class=\"aioseo-toc-item\" href=\"#aioseo-faq-about-crohns-disease-stem-cell-therapy-118\">\u30af\u30ed\u30fc\u30f3\u75c5\u306e\u5e79\u7d30\u80de\u6cbb\u7642\u306b\u95a2\u3059\u308b\u3088\u304f\u3042\u308b\u8cea\u554f<\/a><\/li><li><a class=\"aioseo-toc-item\" href=\"#aioseo-if-you-are-weighing-whether-this-is-a-reasonable-next-step-145\">\u6b21\u306e\u4e00\u6b69\u3092\u8003\u3048\u3066\u3044\u3089\u3063\u3057\u3083\u308b\u65b9\u3078<\/a><\/li><li><a class=\"aioseo-toc-item\" href=\"#aioseo-references-149\">\u53c2\u8003\u6587\u732e<\/a><\/li><\/ol><\/div>\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"aioseo-the-two-faces-of-crohns-disease-that-make-it-so-hard-to-treat-9\"><mark style=\"background-color:#dce9f5\" class=\"has-inline-color\">\u30af\u30ed\u30fc\u30f3\u75c5\u304c\u6cbb\u308a\u306b\u304f\u3044\u4e8c\u3064\u306e\u7406\u7531<\/mark><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"aioseo-how-chronic-inflammation-damages-the-crohns-disease-bowel-10\">\u6162\u6027\u7684\u306a\u708e\u75c7\u304c\u8178\u58c1\u306e\u6df1\u90e8\u3092\u50b7\u3064\u3051\u7d9a\u3051\u308b<\/h3>\n\n\n\n<p 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class=\"wp-block-paragraph\">\u7b2c\u4e00\u306f\u514d\u75ab\u306e\u8abf\u6574\u3002\u514d\u75ab\u30b7\u30b9\u30c6\u30e0\u3092\u5e83\u304f\u6291\u3048\u8fbc\u3080\u306e\u3067\u306f\u306a\u304f\u3001\u30d0\u30e9\u30f3\u30b9\u3092\u53d6\u308a\u623b\u3059\u65b9\u5411\u306b\u50cd\u304d\u304b\u3051\u307e\u3059\u3002\u7b2c\u4e8c\u306f\u5c40\u6240\u306e\u7d44\u7e54\u4fee\u5fa9\u3002\u75d4\u763b\u306e\u9589\u9396\u3084\u3001\u50b7\u3064\u3044\u305f\u8178\u7c98\u819c\u306e\u6cbb\u7652\u3092\u652f\u63f4\u3057\u307e\u3059\u3002\u7b2c\u4e09\u306f\u7dda\u7dad\u5316\u306e\u6291\u5236\u3002\u72ed\u7a84\u306e\u539f\u56e0\u3068\u306a\u308b\u7622\u75d5\u5f62\u6210\u3092\u9045\u3089\u305b\u308b\u53ef\u80fd\u6027\u304c\u5831\u544a\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u3044\u305a\u308c\u3082\u5373\u52b9\u6027\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u30b9\u30c6\u30ed\u30a4\u30c9\u306e\u3088\u3046\u306b\u6570\u65e5\u3067\u52b9\u679c\u304c\u51fa\u308b\u85ac\u3067\u306f\u306a\u304f\u3001\u751f\u7269\u5b66\u7684\u306a\u30d7\u30ed\u30bb\u30b9\u304c\u52d5\u304d\u51fa\u3059\u307e\u3067\u306b\u6570\u9031\u9593\u304b\u3089\u6570\u30f6\u6708\u3092\u8981\u3057\u307e\u3059\u3002\u3053\u308c\u306f\u6cbb\u7642\u3092\u691c\u8a0e\u3059\u308b\u4e0a\u3067\u3001\u305c\u3072\u6b63\u78ba\u306b\u7406\u89e3\u3057\u3066\u304a\u3044\u3066\u3044\u305f\u3060\u304d\u305f\u3044\u70b9\u3067\u3059\u3002 <\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"aioseo-clinical-trial-evidence-for-crohns-disease-stem-cell-therapy-49\"><mark style=\"background-color:#dce9f5\" class=\"has-inline-color\">\u30af\u30ed\u30fc\u30f3\u75c5\u306e\u5e79\u7d30\u80de\u6cbb\u7642\u306b\u95a2\u3059\u308b\u81e8\u5e8a\u8a66\u9a13\u30c7\u30fc\u30bf<\/mark><\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" width=\"942\" height=\"714\" src=\"https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/05\/Article-2-2.webp\" alt=\"\u30af\u30ed\u30fc\u30f3\u75c5\u306e\u96e3\u6cbb\u6027\u75d4\u763b\u306b\u5bfe\u3059\u308b\u5e79\u7d30\u80de\u6cbb\u7642\u3068\u507d\u6cbb\u7642\u3092\u6bd4\u8f03\u3057\u305f\u81e8\u5e8a\u8a66\u9a13ADMIRE-CD\u306e\u5bdb\u89e3\u7387\u3092\u793a\u3059\u30b0\u30e9\u30d5\" class=\"wp-image-25243\" style=\"aspect-ratio:1.2328192112456071;width:466px;height:auto\" srcset=\"https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/05\/Article-2-2.webp 942w, https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/05\/Article-2-2-300x227.webp 300w, https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/05\/Article-2-2-768x582.webp 768w, https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/05\/Article-2-2-937x710.webp 937w\" sizes=\"(max-width: 942px) 100vw, 942px\" \/><figcaption class=\"wp-element-caption\">ADMIRE-CD\u8a66\u9a13\uff08Pan\u00e9s et al., Lancet 2016\uff09\uff1a24\u9031\u6642\u306852\u9031\u6642\u306e\u8907\u5408\u5bdb\u89e3\u7387\u3002\u4ed6\u5bb6\u8102\u80aa\u7531\u6765MSC\u7fa4\u3068\u507d\u6cbb\u7642\u7fa4\u306e\u6bd4\u8f03\u3002<\/figcaption><\/figure>\n<\/div>\n\n\n<h3 class=\"wp-block-heading\" id=\"aioseo-the-admire-cd-trial-mscs-for-perianal-crohns-disease-fistulas-50\">ADMIRE-CD\u8a66\u9a13\u304c\u793a\u3057\u305f\u30af\u30ed\u30fc\u30f3\u75c5\u75d4\u763b\u3078\u306e\u52b9\u679c<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u30af\u30ed\u30fc\u30f3\u75c5\u306e\u5e79\u7d30\u80de\u6cbb\u7642\u306b\u304a\u3044\u3066\u3001\u6700\u3082\u5f37\u529b\u306a\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u75d4\u763b\u306b\u5bfe\u3059\u308b\u7814\u7a76\u304b\u3089\u5f97\u3089\u308c\u3066\u3044\u307e\u3059\u3002Pan\u00e9s\u3089\u304c2016\u5e74\u306b\u533b\u5b66\u8a8cLancet\u306b\u767a\u8868\u3057\u305fADMIRE-CD\u8a66\u9a13\u306f\u3001\u7b2c3\u76f8\u306e\u30e9\u30f3\u30c0\u30e0\u5316\u4e8c\u91cd\u76f2\u691c\u30d7\u30e9\u30bb\u30dc\u5bfe\u7167\u8a66\u9a13\u3068\u3044\u3046\u3001\u81e8\u5e8a\u7814\u7a76\u306e\u4e2d\u3067\u6700\u3082\u4fe1\u983c\u6027\u306e\u9ad8\u3044\u8a2d\u8a08\u3067\u884c\u308f\u308c\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5bfe\u8c61\u306f\u3001\u751f\u7269\u5b66\u7684\u88fd\u5264\u3092\u542b\u3080\u5f93\u6765\u6cbb\u7642\u306b\u62b5\u6297\u6027\u3092\u793a\u3057\u305f\u8907\u96d1\u75d4\u763b\u306e\u30af\u30ed\u30fc\u30f3\u75c5\u60a3\u8005212\u540d\u3002\u4ed6\u5bb6\u8102\u80aa\u7531\u6765MSC\uff08darvadstrocel\uff09\u306e\u5358\u56de\u5c40\u6240\u6ce8\u5165\u3092\u884c\u3046\u7fa4\u3068\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u306b\u7121\u4f5c\u70ba\u306b\u5272\u308a\u4ed8\u3051\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">24\u9031\u6642\u70b9\u3067\u306e\u8907\u5408\u5bdb\u89e3\u7387\uff08\u6cbb\u7642\u3057\u305f\u5916\u763b\u5b54\u306e\u5168\u9589\u9396\u3001\u304b\u3064MRI\u30672cm\u3092\u8d85\u3048\u308b\u81bf\u760d\u306e\u4e0d\u5728\u3068\u5b9a\u7fa9\uff09\u306f\u3001MSC\u7fa4\u306750%\u3001\u30d7\u30e9\u30bb\u30dc\u7fa4\u306734%\u3002\u7d71\u8a08\u5b66\u7684\u306b\u6709\u610f\u306a\u5dee\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u540c\u3058\u8a66\u9a13\u306e52\u9031\u6642\u70b9\u306e\u7d50\u679c\uff08Pan\u00e9s et al., Gastroenterology 2018\uff09\u3067\u3082\u3001MSC\u7fa456.3%\u5bfe\u30d7\u30e9\u30bb\u30dc\u7fa438.6%\u3068\u3001\u52b9\u679c\u306f1\u5e74\u6642\u70b9\u3067\u3082\u6301\u7d9a\u3057\u3066\u3044\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5b89\u5168\u6027\u3082\u826f\u597d\u3067\u3001\u6700\u3082\u591a\u3044\u6709\u5bb3\u4e8b\u8c61\u306f\u6ce8\u5c04\u90e8\u4f4d\u306e\u8efd\u5ea6\u306e\u75db\u307f\u3067\u3001\u3044\u305a\u308c\u3082\u51e6\u7f6e\u306a\u304f\u8efd\u5feb\u3057\u307e\u3057\u305f\u3002\u3053\u306e\u7d50\u679c\u3092\u53d7\u3051\u3001\u6b27\u5dde\u533b\u85ac\u54c1\u5e81\u306f2018\u5e74\u306bdarvadstrocel\u3092\u3001\u975e\u6d3b\u52d5\u6027\u307e\u305f\u306f\u8efd\u5ea6\u6d3b\u52d5\u6027\u306e\u8178\u7ba1\u75c5\u5909\u3092\u6709\u3059\u308b\u6210\u4eba\u30af\u30ed\u30fc\u30f3\u75c5\u60a3\u8005\u306e\u8907\u96d1\u75d4\u763b\u6cbb\u7642\u85ac\u3068\u3057\u3066\u627f\u8a8d\u3057\u307e\u3057\u305f\u3002\u30a8\u30d3\u30c7\u30f3\u30b9\u306e\u5f37\u3055\u3092\u793a\u3059\u91cd\u8981\u306a\u4e8b\u5b9f\u3067\u3059\u3002<\/p>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"aioseo-\u8178\u7ba1\u75c5\u5909\u306b\u5bfe\u3059\u308b\u70b9\u6ef4\u6295\u4e0e\u306e\u8a66\u9a13\u30c7\u30fc\u30bf-58\">\u8178\u7ba1\u75c5\u5909\u306b\u5bfe\u3059\u308b\u70b9\u6ef4\u6295\u4e0e\u306e\u8a66\u9a13\u30c7\u30fc\u30bf<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u8178\u7ba1\u305d\u306e\u3082\u306e\u306e\u708e\u75c7\uff08\u7ba1\u8154\u578b\u30af\u30ed\u30fc\u30f3\u75c5\uff09\u306b\u5bfe\u3059\u308b\u7d4c\u9759\u8108\u7684MSC\u6295\u4e0e\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u3001\u75d4\u763b\u307b\u3069\u6210\u719f\u3057\u3066\u3044\u307e\u305b\u3093\u304c\u3001\u3044\u304f\u3064\u304b\u306e\u91cd\u8981\u306a\u8a66\u9a13\u304c\u767a\u8868\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Forbes\u3089\u304c2014\u5e74\u306bClinical Gastroenterology and Hepatology\u8a8c\u306b\u5831\u544a\u3057\u305f\u7b2c2\u76f8\u8a66\u9a13\u3067\u306f\u3001\u751f\u7269\u5b66\u7684\u88fd\u5264\u3092\u542b\u3080\u5f93\u6765\u6cbb\u7642\u306b\u62b5\u6297\u6027\u3092\u793a\u3057\u305f\u7ba1\u8154\u578b\u30af\u30ed\u30fc\u30f3\u75c5\u60a3\u800515\u540d\u3092\u5bfe\u8c61\u306b\u3001\u4ed6\u5bb6\u9aa8\u9ac4\u7531\u6765MSC\u3092\u90311\u56de\u8a084\u56de\u70b9\u6ef4\u6295\u4e0e\u3057\u307e\u3057\u305f\u300215\u540d\u4e2d12\u540d\u3067CDAI\uff08Crohn&#8217;s Disease Activity Index\u3001\u30af\u30ed\u30fc\u30f3\u75c5\u306e\u6d3b\u52d5\u6027\u3092\u793a\u3059\u6a19\u6e96\u7684\u6307\u6a19\uff09\u304c100\u70b9\u4ee5\u4e0a\u4f4e\u4e0b\u3057\u3001\u81e8\u5e8a\u7684\u53cd\u5fdc\u304c\u5f97\u3089\u308c\u307e\u3057\u305f\u30023\u540d\u306f\u81e8\u5e8a\u7684\u5bdb\u89e3\u306b\u81f3\u308a\u307e\u3057\u305f\u3002\u91cd\u7be4\u306a\u7d30\u80de\u95a2\u9023\u6709\u5bb3\u4e8b\u8c61\u306f\u8a8d\u3081\u3089\u308c\u307e\u305b\u3093\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Molendijk\u3089\u304c2015\u5e74\u306bGastroenterology\u8a8c\u306b\u5831\u544a\u3057\u305f\u5225\u306e\u8a66\u9a13\u3067\u306f\u3001\u96e3\u6cbb\u6027\u75d4\u763b\u306b\u5bfe\u3059\u308b\u4ed6\u5bb6\u9aa8\u9ac4\u7531\u6765MSC\u306e\u5c40\u6240\u6ce8\u5165\u3067\u3001\u6709\u610f\u306a\u9589\u9396\u7387\u306e\u6539\u5584\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u3002Dhere\u3089\u306e\u7b2c1\u76f8\u8a66\u9a13\uff08Aliment Pharmacol Ther 2016\uff09\u3067\u3082\u3001\u5b89\u5168\u6027\u30d7\u30ed\u30d5\u30a1\u30a4\u30eb\u306f\u826f\u597d\u3067\u3057\u305f\u3002<\/p>\n\n\n\n<p 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style=\"background-color:#dce9f5\" class=\"has-inline-color\">\u81ea\u5bb6\u7d30\u80de\u3068\u4ed6\u5bb6\u81cd\u5e2f\u7531\u6765MSC\u306e\u9055\u3044<\/mark><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"aioseo-\u65e5\u672c\u3067\u306e\u81ea\u5bb6\u79fb\u690d\u3068\u6d77\u5916\u3067\u306e\u4ed6\u5bb6\u79fb\u690d\u306e\u69cb\u56f3-64\">\u65e5\u672c\u3067\u306e\u81ea\u5bb6\u79fb\u690d\u3068\u6d77\u5916\u3067\u306e\u4ed6\u5bb6\u79fb\u690d\u306e\u69cb\u56f3<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u5e79\u7d30\u80de\u6cbb\u7642\u306f\u3001\u81ea\u5206\u306e\u8eab\u4f53\u304b\u3089\u63a1\u53d6\u3057\u305f\u7d30\u80de\u3092\u4f7f\u3046\u300c\u81ea\u5bb6\u79fb\u690d\u300d\u3068\u3001\u5065\u5eb7\u306a\u30c9\u30ca\u30fc\u304b\u3089\u63d0\u4f9b\u3055\u308c\u305f\u7d30\u80de\u3092\u4f7f\u3046\u300c\u4ed6\u5bb6\u79fb\u690d\u300d\u306b\u5927\u304d\u304f\u5206\u304b\u308c\u307e\u3059\u3002<\/p>\n\n\n\n<p 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data-wp-context=\"{ &quot;autoclose&quot;: false, &quot;accordionItems&quot;: [] }\" data-wp-interactive=\"core\/accordion\" role=\"group\" class=\"wp-block-accordion is-layout-flow wp-block-accordion-is-layout-flow\">\n<div data-wp-class--is-open=\"state.isOpen\" data-wp-context=\"{ &quot;id&quot;: &quot;accordion-item-4&quot;, &quot;openByDefault&quot;: false }\" data-wp-init=\"callbacks.initAccordionItems\" data-wp-on-window--hashchange=\"callbacks.hashChange\" class=\"wp-block-accordion-item is-layout-flow wp-block-accordion-item-is-layout-flow\">\n<h4 class=\"wp-block-accordion-heading\"><button aria-expanded=\"false\" aria-controls=\"accordion-item-4-panel\" data-wp-bind--aria-expanded=\"state.isOpen\" data-wp-on--click=\"actions.toggle\" id=\"accordion-item-4\" type=\"button\" class=\"wp-block-accordion-heading__toggle\"><span 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&quot;accordionItems&quot;: [] }\" data-wp-interactive=\"core\/accordion\" role=\"group\" class=\"wp-block-accordion is-layout-flow wp-block-accordion-is-layout-flow\">\n<div data-wp-class--is-open=\"state.isOpen\" data-wp-context=\"{ &quot;id&quot;: &quot;accordion-item-5&quot;, &quot;openByDefault&quot;: false }\" data-wp-init=\"callbacks.initAccordionItems\" data-wp-on-window--hashchange=\"callbacks.hashChange\" class=\"wp-block-accordion-item is-layout-flow wp-block-accordion-item-is-layout-flow\">\n<h4 class=\"wp-block-accordion-heading\"><button aria-expanded=\"false\" aria-controls=\"accordion-item-5-panel\" data-wp-bind--aria-expanded=\"state.isOpen\" data-wp-on--click=\"actions.toggle\" id=\"accordion-item-5\" type=\"button\" class=\"wp-block-accordion-heading__toggle\"><span class=\"wp-block-accordion-heading__toggle-title\">\u30af\u30ed\u30fc\u30f3\u75c5\u306e\u5e79\u7d30\u80de\u6cbb\u7642\u306f\u4fdd\u967a\u9069\u7528\u306b\u306a\u308a\u307e\u3059\u304b\uff1f<\/span><span class=\"wp-block-accordion-heading__toggle-icon\" aria-hidden=\"true\">+<\/span><\/button><\/h4>\n\n\n\n<div aria-labelledby=\"accordion-item-5\" data-wp-bind--hidden=\"state.isHidden\" data-wp-on--beforematch=\"actions.handleBeforeMatch\" id=\"accordion-item-5-panel\" role=\"region\" class=\"wp-block-accordion-panel is-layout-flow wp-block-accordion-panel-is-layout-flow\">\n<p 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style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"aioseo-references-149\"><mark style=\"background-color:#dce9f5\" class=\"has-inline-color\">\u53c2\u8003\u6587\u732e<\/mark><\/h2>\n\n\n\n<ol class=\"wp-block-list\">\n<li>Pan\u00e9s J, Garc\u00eda-Olmo D, Van Assche G, et al. Expanded allogeneic adipose-derived mesenchymal stem cells (Cx601) for complex perianal fistulas in Crohn&#8217;s disease: a phase 3 randomised, double-blind controlled trial. Lancet. 2016;388(10051):1281\u20131290. <a href=\"https:\/\/doi.org\/10.1016\/S0140-6736(16)31203-X\" target=\"_blank\" rel=\"noopener\" title=\"\">https:\/\/doi.org\/10.1016\/S0140-6736(16)31203-X<\/a><\/li>\n\n\n\n<li>Pan\u00e9s J, Garc\u00eda-Olmo D, Van Assche G, et al. Long-term efficacy and safety of stem cell therapy (Cx601) for complex perianal fistulas in patients with Crohn&#8217;s disease. Gastroenterology. 2018;154(5):1334\u20131342.e4. <a href=\"https:\/\/doi.org\/10.1053\/j.gastro.2017.12.020\">https:\/\/doi.org\/10.10<\/a><a href=\"https:\/\/doi.org\/10.1053\/j.gastro.2017.12.020\" target=\"_blank\" rel=\"noopener\" title=\"\">5<\/a><a href=\"https:\/\/doi.org\/10.1053\/j.gastro.2017.12.020\">3\/j.gastro.2017.12.020<\/a><\/li>\n\n\n\n<li>Forbes GM, Sturm MJ, Leong RW, et al. A phase 2 study of allogeneic mesenchymal stromal cells for luminal Crohn&#8217;s disease refractory to biologic therapy. Clin Gastroenterol Hepatol. 2014;12(1):64\u201371. <a href=\"https:\/\/doi.org\/10.1016\/j.cgh.2013.06.021\" target=\"_blank\" rel=\"noopener\" title=\"\">https:\/\/doi.org\/10.1016\/j.cgh.2013.06.021<\/a><\/li>\n\n\n\n<li>Molendijk I, Bonsing BA, Roelofs H, et al. Allogeneic bone marrow-derived mesenchymal stromal cells promote healing of refractory perianal fistulas in patients with Crohn&#8217;s disease. Gastroenterology. 2015;149(4):918\u2013927.e6. <a href=\"https:\/\/doi.org\/10.1053\/j.gastro.2015.06.014\" target=\"_blank\" rel=\"noopener\" title=\"\">https:\/\/doi.org\/10.1053\/j.gastro.2015.06.014<\/a><\/li>\n\n\n\n<li>Dhere T, Copland I, Garcia M, et al. The safety of autologous and metabolically fit bone marrow mesenchymal stromal cells in medically refractory Crohn&#8217;s disease \u2014 a phase 1 trial with three doses. Aliment Pharmacol Ther. 2016;44(5):471\u2013481. <a href=\"https:\/\/doi.org\/10.1111\/apt.13717\" target=\"_blank\" rel=\"noopener\" title=\"\">https:\/\/doi.org\/10.1111\/apt.13717<\/a><\/li>\n\n\n\n<li>Ng SC, Shi HY, Hamidi N, et al. Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies. Lancet. 2017;390(10114):2769\u20132778. <a href=\"https:\/\/doi.org\/10.1016\/S0140-6736(17)32448-0\" target=\"_blank\" rel=\"noopener\" title=\"\">https:\/\/doi.org\/10.1016\/S0140-6736(17)32448-0<\/a><\/li>\n\n\n\n<li>Ben-Horin S, Kopylov U, Chowers Y. Optimizing anti-TNF treatments in inflammatory bowel disease. Autoimmun Rev. 2014;13(1):24\u201330. <a href=\"https:\/\/doi.org\/10.1016\/j.autrev.2013.06.002\" target=\"_blank\" rel=\"noopener\" title=\"\">https:\/\/doi.org\/10.1016\/j.autrev.2013.06.002<\/a><\/li>\n\n\n\n<li>Le Blanc K, Mougiakakos D. Multipotent mesenchymal stromal cells and the innate immune system. Nat Rev Immunol. 2012;12(5):383\u2013396. <a href=\"https:\/\/doi.org\/10.1038\/nri3209\" target=\"_blank\" rel=\"noopener\" title=\"\">https:\/\/doi.org\/10.1038\/nri3209<\/a><\/li>\n<\/ol>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\t\t<div data-elementor-type=\"section\" data-elementor-id=\"21873\" class=\"elementor elementor-21873\" data-elementor-post-type=\"elementor_library\">\n\t\t\t        <section class=\"elementor-section elementor-top-section elementor-element elementor-element-a6ebaad elementor-section-boxed elementor-section-height-default elementor-section-height-default pxl-row-scroll-none pxl-zoom-point-false pxl-section-overflow-visible pxl-section-fix-none pxl-bg-color-none pxl-section-overlay-none\" data-id=\"a6ebaad\" data-element_type=\"section\" data-e-type=\"section\">\n\n                \n                <div class=\"elementor-container elementor-column-gap-default \">\n                <div 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