{"id":25048,"date":"2026-05-11T14:00:03","date_gmt":"2026-05-11T06:00:03","guid":{"rendered":"https:\/\/stemcell-malaysia.com\/?page_id=25048"},"modified":"2026-05-11T14:00:07","modified_gmt":"2026-05-11T06:00:07","slug":"severe-asthma","status":"publish","type":"page","link":"https:\/\/stemcell-malaysia.com\/ja\/conditions\/severe-asthma\/","title":{"rendered":"\u91cd\u75c7\u5598\u606f\u306e\u5e79\u7d30\u80de\u6cbb\u7642\uff5c\u30b9\u30c6\u30ed\u30a4\u30c9\u3092\u5897\u3084\u3055\u305a\u6c17\u9053\u306e\u708e\u75c7\u3092\u6291\u3048\u3089\u308c\u308b\u304b"},"content":{"rendered":"\n<h1 class=\"wp-block-heading has-text-align-center\">\u91cd\u75c7\u5598\u606f\u306e\u5e79\u7d30\u80de\u6cbb\u7642\uff5c\u30b9\u30c6\u30ed\u30a4\u30c9\u3092\u5897\u3084\u3055\u305a\u6c17\u9053\u306e\u708e\u75c7\u3092\u6291\u3048\u3089\u308c\u308b\u304b<\/h1>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img fetchpriority=\"high\" decoding=\"async\" width=\"800\" 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style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\"><mark style=\"background-color:#dce9f5\" class=\"has-inline-color\">\u76ee\u6b21<\/mark><\/h2>\n\n\n<div class=\"wp-block-aioseo-table-of-contents\"><ol><li><a class=\"aioseo-toc-item\" href=\"#aioseo-why-severe-asthma-resists-standard-control-8\">\u91cd\u75c7\u5598\u606f\u306f\u306a\u305c\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u304c\u96e3\u3057\u3044\u306e\u304b<\/a><ol><\/ol><\/li><li><a class=\"aioseo-toc-item\" href=\"#aioseo-\u5438\u5165\u85ac\u751f\u7269\u5b66\u7684\u88fd\u5264\u7d4c\u53e3\u30b9\u30c6\u30ed\u30a4\u30c9\u306e\u9650\u754c-18\">\u5438\u5165\u85ac\u30fb\u751f\u7269\u5b66\u7684\u88fd\u5264\u30fb\u7d4c\u53e3\u30b9\u30c6\u30ed\u30a4\u30c9\u306e\u9650\u754c<\/a><ol><\/ol><\/li><li><a class=\"aioseo-toc-item\" href=\"#aioseo-how-mesenchymal-stem-cells-act-on-severe-asthma-inflammation-28\">\u5e79\u7d30\u80de\u304c\u91cd\u75c7\u5598\u606f\u306e\u708e\u75c7\u306b\u4f5c\u7528\u3059\u308b\u4ed5\u7d44\u307f<\/a><ol><\/ol><\/li><li><a class=\"aioseo-toc-item\" href=\"#aioseo-\u91cd\u75c7\u5598\u606f\u306b\u5bfe\u3059\u308b\u5e79\u7d30\u80de\u6cbb\u7642\u306e\u81e8\u5e8a\u524d\u81e8\u5e8a\u30a8\u30d3\u30c7\u30f3\u30b9-45\">\u91cd\u75c7\u5598\u606f\u306b\u5bfe\u3059\u308b\u5e79\u7d30\u80de\u6cbb\u7642\u306e\u81e8\u5e8a\u30fb\u524d\u81e8\u5e8a\u30a8\u30d3\u30c7\u30f3\u30b9<\/a><ol><\/ol><\/li><li><a class=\"aioseo-toc-item\" href=\"#aioseo-\u91cd\u75c7\u5598\u606f\u306e\u30d5\u30a7\u30ce\u30bf\u30a4\u30d7\u5225\u306e\u9069\u5fdc\u5224\u65ad-59\">\u91cd\u75c7\u5598\u606f\u306e\u30d5\u30a7\u30ce\u30bf\u30a4\u30d7\u5225\u306e\u9069\u5fdc\u5224\u65ad<\/a><ol><\/ol><\/li><li><a class=\"aioseo-toc-item\" href=\"#aioseo-\u3042\u308b\u60a3\u8005\u3055\u3093\u306e\u7d4c\u904e-70\">\u3042\u308b\u60a3\u8005\u3055\u3093\u306e\u7d4c\u904e<\/a><ol><\/ol><\/li><li><a class=\"aioseo-toc-item\" href=\"#aioseo-the-treatment-process-for-severe-asthma-patients-in-malaysia-74\">\u30de\u30ec\u30fc\u30b7\u30a2\u3067\u306e\u6cbb\u7642\u30d7\u30ed\u30bb\u30b9<\/a><ol><\/ol><\/li><li><a class=\"aioseo-toc-item\" href=\"#aioseo-\u91cd\u75c7\u5598\u606f\u5e79\u7d30\u80de\u6cbb\u7642\u306e\u30ea\u30b9\u30af\u3068\u6b63\u76f4\u306a\u9650\u754c-105\">\u91cd\u75c7\u5598\u606f\u5e79\u7d30\u80de\u6cbb\u7642\u306e\u30ea\u30b9\u30af\u3068\u6b63\u76f4\u306a\u9650\u754c<\/a><ol><\/ol><\/li><li><a class=\"aioseo-toc-item\" href=\"#aioseo-severe-asthma-stem-cell-therapy-faq-100\">\u91cd\u75c7\u5598\u606f\u5e79\u7d30\u80de\u7642\u6cd5\u306b\u95a2\u3059\u308b\u3088\u304f\u3042\u308b\u8cea\u554f<\/a><\/li><li><a class=\"aioseo-toc-item\" href=\"#aioseo-if-you-are-considering-the-next-step-for-your-severe-asthma-106\">\u6b21\u306e\u30b9\u30c6\u30c3\u30d7\u3092\u691c\u8a0e\u3055\u308c\u3066\u3044\u308b\u65b9\u3078<\/a><\/li><li><a class=\"aioseo-toc-item\" href=\"#aioseo-references-112\">\u53c2\u8003\u6587\u732e<\/a><\/li><\/ol><\/div>\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"aioseo-why-severe-asthma-resists-standard-control-8\"><mark style=\"background-color:#dce9f5\" class=\"has-inline-color\">\u91cd\u75c7\u5598\u606f\u306f\u306a\u305c\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb\u304c\u96e3\u3057\u3044\u306e\u304b<\/mark><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"aioseo-the-persistent-inflammation-that-defines-severe-asthma-9\">\u6162\u6027\u7684\u306b\u6d3b\u6027\u5316\u3057\u305f\u6c17\u9053\u306e\u514d\u75ab\u30b7\u30b9\u30c6\u30e0<\/h3>\n\n\n\n<p 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class=\"wp-block-paragraph\">\u5e79\u7d30\u80de\u6cbb\u7642\u3092\u672c\u6c17\u3067\u691c\u8a0e\u3057\u59cb\u3081\u308b\u65b9\u306f\u3001\u307b\u307c\u4f8b\u5916\u306a\u304f\u3053\u306e\u30e9\u30a4\u30f3\u3001\u3064\u307e\u308a\u751f\u7269\u5b66\u7684\u88fd\u5264\u306e\u52b9\u679c\u304c\u9650\u5b9a\u7684\u3001\u3082\u3057\u304f\u306f\u7d4c\u53e3\u30b9\u30c6\u30ed\u30a4\u30c9\u4f9d\u5b58\u304c\u9577\u671f\u5316\u3057\u3066\u3044\u308b\u6bb5\u968e\u306b\u3044\u307e\u3059\u3002\u5947\u8de1\u3092\u6c42\u3081\u3066\u3044\u308b\u308f\u3051\u3067\u306f\u306a\u304f\u3001\u5f93\u6765\u30eb\u30fc\u30c8\u306e\u8cbb\u7528\u5bfe\u52b9\u679c\u304c\u81ea\u5206\u306b\u3068\u3063\u3066\u6210\u308a\u7acb\u305f\u306a\u304f\u306a\u3063\u305f\u304b\u3089\u3001\u6b21\u3092\u63a2\u3057\u3066\u3044\u308b\u306e\u3067\u3059\u3002<\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"aioseo-how-mesenchymal-stem-cells-act-on-severe-asthma-inflammation-28\"><mark style=\"background-color:#dce9f5\" class=\"has-inline-color\">\u5e79\u7d30\u80de\u304c\u91cd\u75c7\u5598\u606f\u306e\u708e\u75c7\u306b\u4f5c\u7528\u3059\u308b\u4ed5\u7d44\u307f<\/mark><\/h2>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img decoding=\"async\" width=\"800\" height=\"436\" src=\"https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/05\/Article-Image-1-2.webp\" alt=\"\u91cd\u75c7\u5598\u606f\u306b\u5bfe\u3059\u308b\u9593\u8449\u7cfb\u5e79\u7d30\u80de\u6cbb\u7642\u306e3\u3064\u306e\u4f5c\u7528\u6a5f\u5e8f\u3092\u793a\u3059\u56f3\u89e3\uff08Th2\/ILC2\u6291\u5236\u3001\u597d\u9178\u7403\u6027\u708e\u75c7\u306e\u4f4e\u6e1b\u3001\u6c17\u9053\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u6291\u5236\uff09\" class=\"wp-image-25051\" style=\"aspect-ratio:1.8348992638512205;width:666px;height:auto\" srcset=\"https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/05\/Article-Image-1-2.webp 800w, https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/05\/Article-Image-1-2-300x164.webp 300w, https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/05\/Article-Image-1-2-768x419.webp 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><figcaption class=\"wp-element-caption\">\u9593\u8449\u7cfb\u5e79\u7d30\u80de\u306f\u3001\u7279\u5b9a\u306e\u30b7\u30b0\u30ca\u30eb\u5206\u5b50\u30921\u3064\u30d6\u30ed\u30c3\u30af\u3059\u308b\u306e\u3067\u306f\u306a\u304f\u3001\u91cd\u75c7\u5598\u606f\u306e\u708e\u75c7\u74b0\u5883\u5168\u4f53\u306b\u5bfe\u3057\u30663\u3064\u306e\u7d4c\u8def\u304b\u3089\u50cd\u304d\u304b\u3051\u307e\u3059\u3002<\/figcaption><\/figure>\n<\/div>\n\n\n<h3 class=\"wp-block-heading\" id=\"aioseo-suppressing-th2-cells-and-ilc2s-in-severe-asthma-31\">Th2\u7d30\u80de\u3068ILC2\u306e\u6d3b\u52d5\u3092\u9759\u3081\u308b<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u9593\u8449\u7cfb\u5e79\u7d30\u80de\uff08Mesenchymal Stem Cells\u3001\u7565\u3057\u3066MSC\uff09\u306f\u9aa8\u9ac4\u3001\u8102\u80aa\u3001\u81cd\u5e2f\uff08\u3078\u305d\u306e\u7dd2\uff09\u3068\u3044\u3063\u305f\u7d44\u7e54\u306b\u81ea\u7136\u306b\u5b58\u5728\u3059\u308b\u9593\u8cea\u7cfb\u306e\u7d30\u80de\u3067\u3001\u305d\u308c\u81ea\u4f53\u304c\u85ac\u306e\u3088\u3046\u306b\u4f5c\u7528\u3059\u308b\u308f\u3051\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002MSC\u306e\u672c\u8cea\u306f\u3001\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\uff08\u7d30\u80de\u304c\u5206\u6ccc\u3059\u308b\u30b7\u30b0\u30ca\u30eb\u5206\u5b50\uff09\u3001\u5897\u6b96\u56e0\u5b50\u3001\u30a8\u30af\u30bd\u30bd\u30fc\u30e0\uff08\u7d30\u80de\u819c\u306b\u5305\u307e\u308c\u305f\u5c0f\u3055\u306a\u60c5\u5831\u306e\u904b\u3073\u624b\uff09\u3068\u3044\u3063\u305f\u5206\u6ccc\u7269\u3092\u5468\u56f2\u306b\u653e\u51fa\u3059\u308b\u3053\u3068\u3067\u3001\u8fd1\u304f\u306e\u514d\u75ab\u74b0\u5883\u3092\u5909\u3048\u3066\u3044\u304f\u70b9\u306b\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Shin \u3089\u304c2021\u5e74\u306bMolecules and Cells\u8a8c\u306b\u767a\u8868\u3057\u305f\u7814\u7a76\u3067\u306f\u3001\u30d2\u30c8\u81cd\u5e2f\u7531\u6765MSC\u304c\u91cd\u75c7\u5598\u606f\u306e2\u7a2e\u985e\u306e\u30de\u30a6\u30b9\u30e2\u30c7\u30eb\u3067\u80ba\u306eType 2\u708e\u75c7\u3092\u6e1b\u3089\u3059\u3053\u3068\u304c\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u3055\u3089\u306b\u3001\u57f9\u990a\u76bf\u306e\u4e2d\u3067MSC\u3092\u5206\u5316\u3057\u305f\u30de\u30a6\u30b9Th2\u7d30\u80de\u3084\u5598\u606f\u60a3\u8005\u3055\u3093\u7531\u6765\u306e\u672b\u68a2\u8840\u5358\u6838\u7403\u3068\u4e00\u7dd2\u306b\u7f6e\u3044\u305f\u5b9f\u9a13\u3067\u306f\u3001Th2\u7d30\u80de\u304b\u3089\u306eIL-5\u30fbIL-13\u7523\u751f\u304c\u76f4\u63a5\u7684\u306b\u4f4e\u4e0b\u3057\u305f\u3053\u3068\u304c\u78ba\u8a8d\u3055\u308c\u3066\u3044\u307e\u3059\u3002\u751f\u7269\u5b66\u7684\u88fd\u5264\u304c\u3053\u308c\u3089\u306e\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u300c\u30d6\u30ed\u30c3\u30af\u3059\u308b\u300d\u306e\u306b\u5bfe\u3057\u3001MSC\u306f\u300c\u30b5\u30a4\u30c8\u30ab\u30a4\u30f3\u3092\u4f5c\u308b\u7d30\u80de\u305d\u306e\u3082\u306e\u3092\u9759\u304b\u306b\u3055\u305b\u308b\u300d\u3088\u3046\u306b\u50cd\u3044\u3066\u3044\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u5225\u306e\u7814\u7a76\u3067\u306f\u3001\u81cd\u5e2f\u7531\u6765MSC\u3092\u5598\u606f\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u306e\u6c17\u9053\u306b\u6295\u4e0e\u3059\u308b\u3068\u3001\u6c17\u9053\u904e\u654f\u6027\u3001Th2\u7d30\u80de\u6570\u3001ILC2\u6570\u304c\u6e1b\u5c11\u3057\u3001\u80ba\u306e\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\uff08\u5225\u306e\u514d\u75ab\u7d30\u80de\u7fa4\uff09\u304c\u708e\u75c7\u3092\u4fc3\u9032\u3059\u308b\u72b6\u614b\u304b\u3089\u7d44\u7e54\u4fee\u5fa9\u3092\u4fc3\u3059\u72b6\u614b\u3078\u3068\u30b7\u30d5\u30c8\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"aioseo-\u597d\u9178\u7403\u6027\u6c17\u9053\u708e\u75c7\u3092\u6e1b\u3089\u3059-39\">\u597d\u9178\u7403\u6027\u6c17\u9053\u708e\u75c7\u3092\u6e1b\u3089\u3059<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u597d\u9178\u7403\u306fType 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class=\"wp-block-paragraph\">\u3053\u308c\u306f\u6297IL-5\u751f\u7269\u5b66\u7684\u88fd\u5264\u306e\u52b9\u304d\u65b9\u3068\u306f\u69cb\u9020\u304c\u7570\u306a\u308a\u307e\u3059\u3002\u30e1\u30dd\u30ea\u30ba\u30de\u30d6\u3084\u30ec\u30b9\u30ea\u30ba\u30de\u30d6\u306fIL-5\u305d\u306e\u3082\u306e\u3092\u4e2d\u548c\u3057\u3001\u30d9\u30f3\u30e9\u30ea\u30ba\u30de\u30d6\u306f\u6297\u4f53\u4f9d\u5b58\u6027\u306e\u7d30\u80de\u50b7\u5bb3\u3067\u597d\u9178\u7403\u3092\u76f4\u63a5\u7834\u58ca\u3057\u307e\u3059\u3002MSC\u306f\u3053\u306e\u3069\u3061\u3089\u3067\u3082\u306a\u304f\u3001\u300c\u597d\u9178\u7403\u3092\u547c\u3076\u9700\u8981\u305d\u306e\u3082\u306e\u3092\u6e1b\u3089\u3059\u300d\u65b9\u5411\u3067\u50cd\u304d\u307e\u3059\u3002\u9577\u671f\u7684\u306b\u3053\u306e\u9055\u3044\u304c\u81e8\u5e8a\u7d50\u679c\u306b\u8868\u308c\u308b\u304b\u3069\u3046\u304b\u306f\u3001\u5927\u898f\u6a21\u8a66\u9a13\u3092\u5f85\u3064\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"aioseo-\u6c17\u9053\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u306e\u9032\u884c\u3092\u9045\u3089\u305b\u308b-42\">\u6c17\u9053\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u306e\u9032\u884c\u3092\u9045\u3089\u305b\u308b<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">3\u3064\u76ee\u306e\u4f5c\u7528\u306f\u3001\u9577\u671f\u7684\u306a\u75be\u60a3\u7d4c\u904e\u306b\u6700\u3082\u95a2\u4fc2\u3059\u308b\u90e8\u5206\u3067\u3059\u3002\u6c17\u9053\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u3001\u3064\u307e\u308a\u5e73\u6ed1\u7b4b\u30fb\u57fa\u5e95\u819c\u30fb\u30b3\u30e9\u30fc\u30b2\u30f3\u5c64\u306e\u69cb\u9020\u7684\u80a5\u539a\u306f\u3001\u6301\u7d9a\u7684\u306a\u708e\u75c7\u306b\u3088\u3063\u3066\u99c6\u52d5\u3055\u308c\u307e\u3059\u3002\u708e\u75c7\u74b0\u5883\u304c\u7d99\u7d9a\u7684\u306b\u9759\u307e\u308c\u3070\u3001\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u3092\u99c6\u52d5\u3059\u308b\u751f\u7269\u5b66\u7684\u30b7\u30b0\u30ca\u30eb\u3082\u6e1b\u308a\u307e\u3059\u3002\u524d\u81e8\u5e8a\u7814\u7a76\u3067\u306f\u3001\u6162\u6027\u5598\u606f\u30e2\u30c7\u30eb\u3067MSC\u6cbb\u7642\u304c\u30ea\u30e2\u30c7\u30ea\u30f3\u30b0\u9032\u884c\u3092\u5f31\u3081\u308b\u3053\u3068\u304c\u793a\u3055\u308c\u3066\u3044\u307e\u3059\u304c\u3001\u30d2\u30c8\u3067\u3069\u306e\u7a0b\u5ea6\u306e\u671f\u9593\u3067\u3053\u306e\u52b9\u679c\u304c\u73fe\u308c\u308b\u304b\u306f\u3001\u307e\u3060\u6d3b\u767a\u306b\u7814\u7a76\u3055\u308c\u3066\u3044\u308b\u9818\u57df\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u540c\u3058\u514d\u75ab\u8abf\u7bc0\u306e\u67a0\u7d44\u307f\u306f\u4ed6\u306e\u6162\u6027\u708e\u75c7\u75be\u60a3\u3067\u3082\u50cd\u3044\u3066\u304a\u308a\u3001\u95a2\u7bc0\u30ea\u30a6\u30de\u30c1\u306e\u5e79\u7d30\u80de\u6cbb\u7642\u3092\u691c\u8a0e\u3055\u308c\u308b\u65b9\u306e\u5fdc\u7b54\u30d1\u30bf\u30fc\u30f3\u3068\u3082\u751f\u7269\u5b66\u7684\u306b\u91cd\u306a\u308a\u307e\u3059\u3002Th2\u99c6\u52d5\u578b\u306e\u5598\u606f\u3068\u3001Th17\u512a\u4f4d\u306e\u81ea\u5df1\u514d\u75ab\u75be\u60a3\u306e\u9593\u306b\u3042\u308b\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u5171\u901a\u70b9\u306f\u3001\u3069\u306e\u30d5\u30a7\u30ce\u30bf\u30a4\u30d7\u306e\u65b9\u304c\u53cd\u5fdc\u3057\u3084\u3059\u3044\u304b\u3092\u8003\u3048\u308b\u4e0a\u3067\u306e\u6750\u6599\u306b\u306a\u3063\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"aioseo-\u91cd\u75c7\u5598\u606f\u306b\u5bfe\u3059\u308b\u5e79\u7d30\u80de\u6cbb\u7642\u306e\u81e8\u5e8a\u524d\u81e8\u5e8a\u30a8\u30d3\u30c7\u30f3\u30b9-45\"><mark style=\"background-color:#dce9f5\" class=\"has-inline-color\">\u91cd\u75c7\u5598\u606f\u306b\u5bfe\u3059\u308b\u5e79\u7d30\u80de\u6cbb\u7642\u306e\u81e8\u5e8a\u30fb\u524d\u81e8\u5e8a\u30a8\u30d3\u30c7\u30f3\u30b9<\/mark><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"aioseo-\u5f37\u3044\u524d\u81e8\u5e8a\u307e\u3060\u521d\u671f\u6bb5\u968e\u306e\u81e8\u5e8a-46\">\u5f37\u3044\u524d\u81e8\u5e8a\u3001\u307e\u3060\u521d\u671f\u6bb5\u968e\u306e\u81e8\u5e8a<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u91cd\u75c7\u5598\u606f\u5e79\u7d30\u80de\u6cbb\u7642\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u304c\u3069\u306e\u6bb5\u968e\u306b\u3042\u308b\u306e\u304b\u3092\u6b63\u76f4\u306b\u66f8\u304d\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u524d\u81e8\u5e8a\u3001\u3064\u307e\u308a\u52d5\u7269\u5b9f\u9a13\u3084\u57f9\u990a\u7d30\u80de\u3092\u4f7f\u3063\u305f\u8a66\u9a13\u306e\u30c7\u30fc\u30bf\u306f\u3001\u3059\u3067\u306b\u304b\u306a\u308a\u5145\u5b9f\u3057\u3066\u3044\u307e\u3059\u3002\u8907\u6570\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\u304c\u3001\u81cd\u5e2f\u30fb\u9aa8\u9ac4\u30fb\u8102\u80aa\u3092\u542b\u3080\u69d8\u3005\u306a\u7531\u6765\u306eMSC\u304c\u3001\u30a2\u30ec\u30eb\u30b2\u30f3\u8a98\u767a\u578b\u304a\u3088\u3073\u30cf\u30a6\u30b9\u30c0\u30b9\u30c8\u30de\u30a4\u30c8\u8a98\u767a\u578b\u306e\u91cd\u75c7\u5598\u606f\u30e2\u30c7\u30eb\u30de\u30a6\u30b9\u306b\u304a\u3044\u3066\u3001\u6c17\u9053\u708e\u75c7\u306e\u6e1b\u5c11\u3001\u597d\u9178\u7403\u6570\u306e\u6e1b\u5c11\u3001Th2\/ILC2\u6d3b\u6027\u306e\u6291\u5236\u3001\u6c17\u9053\u904e\u654f\u6027\u306e\u5f31\u307e\u308a\u3092\u793a\u3059\u3053\u3068\u3092\u518d\u73fe\u3057\u3066\u3044\u307e\u3059\u3002\u30e1\u30ab\u30cb\u30ba\u30e0\u306e\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u518d\u73fe\u6027\u304c\u9ad8\u304f\u3001\u5e74\u3005\u8a73\u7d30\u306b\u89e3\u660e\u3055\u308c\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30d2\u30c8\u3067\u306e\u81e8\u5e8a\u30a8\u30d3\u30c7\u30f3\u30b9\u306f\u3001\u5909\u5f62\u6027\u819d\u95a2\u7bc0\u75c7\u3084\u5fc3\u4e0d\u5168\u3068\u3044\u3063\u305f\u4ed6\u306e\u5fdc\u7528\u9818\u57df\u3088\u308a\u65e9\u3044\u6bb5\u968e\u306b\u3042\u308a\u307e\u3059\u30022026\u5e74\u6642\u70b9\u3067\u3001\u91cd\u75c7\u5598\u606f\u5e79\u7d30\u80de\u6cbb\u7642\u306b\u95a2\u3059\u308b\u5927\u898f\u6a21\u306a\u7b2cIII\u76f8\u7121\u4f5c\u70ba\u5316\u6bd4\u8f03\u8a66\u9a13\u306e\u8ad6\u6587\u516c\u8868\u306f\u307e\u3060\u3042\u308a\u307e\u305b\u3093\u3002\u5b58\u5728\u3059\u308b\u306e\u306f\u5c11\u6570\u306ePhase 1\u301c\u521d\u671fPhase 2\u8a66\u9a13\u3001\u75c7\u4f8b\u5831\u544a\u3001\u305d\u3057\u3066\u6d77\u5916\u3067\u6cbb\u7642\u3092\u63d0\u4f9b\u3059\u308b\u65bd\u8a2d\u3067\u84c4\u7a4d\u3055\u308c\u3064\u3064\u3042\u308b\u30ea\u30a2\u30eb\u30ef\u30fc\u30eb\u30c9\u306e\u81e8\u5e8a\u7d4c\u9a13\u3067\u3059\u3002\u691c\u8a0e\u3055\u308c\u3066\u3044\u308b\u65b9\u306b\u306f\u3001\u3053\u306e\u6587\u8108\u3092\u6700\u521d\u306b\u5171\u6709\u3057\u3066\u304a\u304f\u3079\u304d\u3060\u3068\u8003\u3048\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"aioseo-\u767b\u9332\u3055\u308c\u3066\u3044\u308b\u81e8\u5e8a\u8a66\u9a13\u3068\u521d\u671f\u5831\u544a-50\">\u767b\u9332\u3055\u308c\u3066\u3044\u308b\u81e8\u5e8a\u8a66\u9a13\u3068\u521d\u671f\u5831\u544a<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u6700\u3082\u95a2\u9023\u6027\u306e\u9ad8\u3044\u3001\u9032\u884c\u4e2d\u307e\u305f\u306f\u6700\u8fd1\u5b8c\u4e86\u3057\u305f\u8a66\u9a13\u306f\u4ee5\u4e0b\u3067\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The Foundation for Orthopaedics and Regenerative Medicine\u304c\u5b9f\u65bd\u3059\u308bNCT05147688\u306f\u3001\u80ba\u75be\u60a3\uff08\u5598\u606f\u3068\u6162\u6027\u9589\u585e\u6027\u80ba\u75be\u60a3\u3092\u542b\u3080\uff09\u306b\u5bfe\u3059\u308b\u4ed6\u5bb6\u6210\u4eba\u81cd\u5e2f\u7531\u6765MSC\u306e\u9759\u8108\u5185\u6295\u4e0e\u306e\u5b89\u5168\u6027\u3068\u6709\u52b9\u6027\u3092\u8a55\u4fa1\u3059\u308bPhase 1\u8a66\u9a13\u3067\u3059\u3002\u7dcf\u6295\u4e0e\u91cf\u306f\u7d041\u5104\u7d30\u80de\u3092\u5358\u56de\u6295\u4e0e\u3068\u3057\u3001\u8ffd\u8de1\u671f\u9593\u306f1\u30f6\u6708\u30016\u30f6\u6708\u300112\u30f6\u6708\u300124\u30f6\u6708\u300136\u30f6\u6708\u300148\u30f6\u6708\u3002\u6700\u521d\u306e\u5598\u606f\u53c2\u52a0\u8005\u306e\u521d\u671f\u6240\u898b\u306fSharan\u3089\u304c2023\u5e74\u306b\u5831\u544a\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u30a8\u30e2\u30ea\u30fc\u5927\u5b66\u304c\u5b9f\u65bd\u3057\u305fNCT05035862\u306f\u3001\u4e2d\u7b49\u5ea6\u301c\u91cd\u75c7\u6301\u7d9a\u6027\u5598\u606f\u306b\u5bfe\u3059\u308b\u30a4\u30f3\u30bf\u30fc\u30d5\u30a7\u30ed\u30f3\u03b3\u30d7\u30e9\u30a4\u30e0\u30c9MSC\u306ePhase 1\u8a66\u9a13\u3067\u3001\u7528\u91cf\u306f2\u767e\u4e07\u307e\u305f\u306f5\u767e\u4e07\u7d30\u80de\/kg\u3092\u9759\u8108\u5185\u6295\u4e0e\u3057\u307e\u3057\u305f\u3002\u8a66\u9a13\u306f\u8cc7\u91d1\u5207\u308c\u306b\u3088\u308a\u65e9\u671f\u7d42\u4e86\u3057\u307e\u3057\u305f\u304c\u3001\u7d42\u4e86\u524d\u306b\u767b\u9332\u3055\u308c\u305f\u53c2\u52a0\u8005\u306e\u5b89\u5168\u6027\u30c7\u30fc\u30bf\u306fMSC\u70b9\u6ef4\u306e\u5fcd\u5bb9\u6027\u306b\u95a2\u3059\u308b\u77e5\u898b\u306b\u5bc4\u4e0e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">NCT02192736\u306f\u3001\u81cd\u5e2f\u7531\u6765MSC\u305d\u306e\u3082\u306e\u3067\u306f\u306a\u304f\u3001MSC\u304c\u5206\u6ccc\u3059\u308b\u30b7\u30b0\u30ca\u30eb\u5206\u5b50\uff08\u6804\u990a\u56e0\u5b50\uff09\u3092\u7d4c\u9f3b\u6295\u4e0e\u306720\u540d\u306e\u5598\u606f\u60a3\u8005\u3055\u3093\u306b\u6295\u4e0e\u3057\u305fPhase 1\/2\u8a66\u9a13\u3067\u3001\u5b89\u5168\u6027\u3092\u4e3b\u8981\u8a55\u4fa1\u9805\u76ee\u3001\u80ba\u6a5f\u80fd\u3068QOL\u3092\u526f\u6b21\u8a55\u4fa1\u9805\u76ee\u3068\u3057\u307e\u3057\u305f\u3002<\/p>\n\n\n\n<div style=\"height:30px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"aioseo-\u73fe\u5b9f\u7684\u306a\u52b9\u679c\u306e\u30a4\u30e1\u30fc\u30b8-55\">\u73fe\u5b9f\u7684\u306a\u52b9\u679c\u306e\u30a4\u30e1\u30fc\u30b8<\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">\u5e7b\u60f3\u3067\u306f\u306a\u304f\u73fe\u5b9f\u7684\u306a\u6570\u5b57\u3092\u793a\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p 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style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"aioseo-\u91cd\u75c7\u5598\u606f\u306e\u30d5\u30a7\u30ce\u30bf\u30a4\u30d7\u5225\u306e\u9069\u5fdc\u5224\u65ad-59\"><mark style=\"background-color:#dce9f5\" class=\"has-inline-color\">\u91cd\u75c7\u5598\u606f\u306e\u30d5\u30a7\u30ce\u30bf\u30a4\u30d7\u5225\u306e\u9069\u5fdc\u5224\u65ad<\/mark><\/h2>\n\n\n\n<h3 class=\"wp-block-heading\" id=\"aioseo-type-2\u9ad8\u578b\u597d\u9178\u7403\u6027\u306e\u91cd\u75c7\u5598\u606f\u306e\u65b9-60\">Type 2\u9ad8\u578b\uff08\u597d\u9178\u7403\u6027\uff09\u306e\u91cd\u75c7\u5598\u606f\u306e\u65b9<\/h3>\n\n\n\n<p 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src=\"https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/05\/Article-Image-2-2.webp\" alt=\"\u65e5\u672c\u306e\u81ea\u5bb6\u5e79\u7d30\u80de\u6cbb\u7642\u3068\u30de\u30ec\u30fc\u30b7\u30a2\u306e\u4ed6\u5bb6\u81cd\u5e2f\u7531\u6765MSC\u6cbb\u7642\u3092\u6bd4\u8f03\u3057\u305f\u91cd\u75c7\u5598\u606f\u6cbb\u7642\u306e\u6982\u5ff5\u56f3\n\u30ad\u30e3\" class=\"wp-image-25053\" style=\"aspect-ratio:1.8348992638512205;width:641px;height:auto\" srcset=\"https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/05\/Article-Image-2-2.webp 800w, https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/05\/Article-Image-2-2-300x164.webp 300w, https:\/\/stemcell-malaysia.com\/wp-content\/uploads\/2026\/05\/Article-Image-2-2-768x419.webp 768w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><figcaption 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data-wp-context=\"{ &quot;autoclose&quot;: false, &quot;accordionItems&quot;: [] }\" data-wp-interactive=\"core\/accordion\" role=\"group\" class=\"wp-block-accordion is-layout-flow wp-block-accordion-is-layout-flow\">\n<div data-wp-class--is-open=\"state.isOpen\" data-wp-context=\"{ &quot;id&quot;: &quot;accordion-item-2&quot;, &quot;openByDefault&quot;: false }\" data-wp-init=\"callbacks.initAccordionItems\" data-wp-on-window--hashchange=\"callbacks.hashChange\" class=\"wp-block-accordion-item is-layout-flow wp-block-accordion-item-is-layout-flow\">\n<h4 class=\"wp-block-accordion-heading\"><button aria-expanded=\"false\" aria-controls=\"accordion-item-2-panel\" data-wp-bind--aria-expanded=\"state.isOpen\" data-wp-on--click=\"actions.toggle\" id=\"accordion-item-2\" type=\"button\" class=\"wp-block-accordion-heading__toggle\"><span 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data-wp-context=\"{ &quot;autoclose&quot;: false, &quot;accordionItems&quot;: [] }\" data-wp-interactive=\"core\/accordion\" role=\"group\" class=\"wp-block-accordion is-layout-flow wp-block-accordion-is-layout-flow\">\n<div data-wp-class--is-open=\"state.isOpen\" data-wp-context=\"{ &quot;id&quot;: &quot;accordion-item-3&quot;, &quot;openByDefault&quot;: false }\" data-wp-init=\"callbacks.initAccordionItems\" data-wp-on-window--hashchange=\"callbacks.hashChange\" class=\"wp-block-accordion-item is-layout-flow wp-block-accordion-item-is-layout-flow\">\n<h4 class=\"wp-block-accordion-heading\"><button aria-expanded=\"false\" aria-controls=\"accordion-item-3-panel\" data-wp-bind--aria-expanded=\"state.isOpen\" data-wp-on--click=\"actions.toggle\" id=\"accordion-item-3\" type=\"button\" class=\"wp-block-accordion-heading__toggle\"><span class=\"wp-block-accordion-heading__toggle-title\"><strong>\u91cd\u75c7\u5598\u606f\u5e79\u7d30\u80de\u6cbb\u7642\u3067\u751f\u7269\u5b66\u7684\u88fd\u5264\u3092\u3084\u3081\u3089\u308c\u307e\u3059\u304b\uff1f<\/strong><\/span><span class=\"wp-block-accordion-heading__toggle-icon\" aria-hidden=\"true\">+<\/span><\/button><\/h4>\n\n\n\n<div aria-labelledby=\"accordion-item-3\" data-wp-bind--hidden=\"state.isHidden\" data-wp-on--beforematch=\"actions.handleBeforeMatch\" id=\"accordion-item-3-panel\" role=\"region\" class=\"wp-block-accordion-panel is-layout-flow wp-block-accordion-panel-is-layout-flow\">\n<p 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data-wp-context=\"{ &quot;autoclose&quot;: false, &quot;accordionItems&quot;: [] }\" data-wp-interactive=\"core\/accordion\" role=\"group\" class=\"wp-block-accordion is-layout-flow wp-block-accordion-is-layout-flow\">\n<div data-wp-class--is-open=\"state.isOpen\" data-wp-context=\"{ &quot;id&quot;: &quot;accordion-item-4&quot;, &quot;openByDefault&quot;: false }\" data-wp-init=\"callbacks.initAccordionItems\" data-wp-on-window--hashchange=\"callbacks.hashChange\" class=\"wp-block-accordion-item is-layout-flow wp-block-accordion-item-is-layout-flow\">\n<h4 class=\"wp-block-accordion-heading\"><button aria-expanded=\"false\" aria-controls=\"accordion-item-4-panel\" data-wp-bind--aria-expanded=\"state.isOpen\" data-wp-on--click=\"actions.toggle\" id=\"accordion-item-4\" type=\"button\" class=\"wp-block-accordion-heading__toggle\"><span class=\"wp-block-accordion-heading__toggle-title\"><strong>\u91cd\u75c7\u5598\u606f\u5e79\u7d30\u80de\u6cbb\u7642\u306f\u4fdd\u967a\u9069\u7528\u3067\u3059\u304b\uff1f<\/strong><\/span><span class=\"wp-block-accordion-heading__toggle-icon\" aria-hidden=\"true\">+<\/span><\/button><\/h4>\n\n\n\n<div aria-labelledby=\"accordion-item-4\" data-wp-bind--hidden=\"state.isHidden\" data-wp-on--beforematch=\"actions.handleBeforeMatch\" id=\"accordion-item-4-panel\" role=\"region\" class=\"wp-block-accordion-panel is-layout-flow wp-block-accordion-panel-is-layout-flow\">\n<p class=\"wp-block-paragraph\">\u65e5\u672c\u3092\u542b\u3080\u307b\u307c\u3059\u3079\u3066\u306e\u5730\u57df\u3067\u3001\u4fdd\u967a\u9069\u7528\u5916\u306e\u81ea\u8cbb\u8a3a\u7642\u3068\u306a\u308a\u307e\u3059\u3002\u91cd\u75c7\u5598\u606f\u306b\u5bfe\u3059\u308b\u5e79\u7d30\u80de\u6cbb\u7642\u306f\u3001\u307b\u3068\u3093\u3069\u306e\u4fdd\u967a\u5236\u5ea6\u3067\u6a19\u6e96\u9069\u5fdc\u5916\u3068\u4f4d\u7f6e\u4ed8\u3051\u3089\u308c\u3066\u304a\u308a\u3001\u79c1\u7684\u306a\u30a8\u30ec\u30af\u30c6\u30a3\u30d6\u6cbb\u7642\u3068\u3057\u3066\u63d0\u4f9b\u3055\u308c\u307e\u3059\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div data-wp-context=\"{ &quot;autoclose&quot;: false, &quot;accordionItems&quot;: [] }\" data-wp-interactive=\"core\/accordion\" role=\"group\" class=\"wp-block-accordion is-layout-flow wp-block-accordion-is-layout-flow\">\n<div data-wp-class--is-open=\"state.isOpen\" data-wp-context=\"{ &quot;id&quot;: &quot;accordion-item-5&quot;, &quot;openByDefault&quot;: false }\" data-wp-init=\"callbacks.initAccordionItems\" data-wp-on-window--hashchange=\"callbacks.hashChange\" class=\"wp-block-accordion-item is-layout-flow wp-block-accordion-item-is-layout-flow\">\n<h4 class=\"wp-block-accordion-heading\"><button aria-expanded=\"false\" aria-controls=\"accordion-item-5-panel\" data-wp-bind--aria-expanded=\"state.isOpen\" data-wp-on--click=\"actions.toggle\" id=\"accordion-item-5\" type=\"button\" class=\"wp-block-accordion-heading__toggle\"><span class=\"wp-block-accordion-heading__toggle-title\"><strong>\u5598\u606f\u304c\u4eca\u4e0d\u5b89\u5b9a\u306a\u5834\u5408\u3067\u3082\u6cbb\u7642\u3092\u53d7\u3051\u3089\u308c\u307e\u3059\u304b\uff1f<\/strong><\/span><span class=\"wp-block-accordion-heading__toggle-icon\" aria-hidden=\"true\">+<\/span><\/button><\/h4>\n\n\n\n<div aria-labelledby=\"accordion-item-5\" data-wp-bind--hidden=\"state.isHidden\" data-wp-on--beforematch=\"actions.handleBeforeMatch\" id=\"accordion-item-5-panel\" role=\"region\" class=\"wp-block-accordion-panel is-layout-flow wp-block-accordion-panel-is-layout-flow\">\n<p class=\"wp-block-paragraph\">\u3044\u3044\u3048\u3002\u6d3b\u52d5\u6027\u306e\u5897\u60aa\u4e2d\u3001\u904e\u53bb6\u301c8\u9031\u4ee5\u5185\u306e\u5165\u9662\u6b74\u3001\u307e\u305f\u306f\u81e8\u5e8a\u7684\u306b\u660e\u78ba\u306a\u4e0d\u5b89\u5b9a\u6027\u304c\u3042\u308b\u5834\u5408\u3001\u6cbb\u7642\u306f\u5ef6\u671f\u3057\u307e\u3059\u3002\u3053\u306e\u6cbb\u7642\u306f\u6162\u6027\u75be\u60a3\u306e\u8abf\u6574\u3092\u76ee\u7684\u3068\u3057\u3066\u304a\u308a\u3001\u6025\u6027\u7ba1\u7406\u3092\u610f\u56f3\u3057\u305f\u3082\u306e\u3067\u306f\u3042\u308a\u307e\u305b\u3093\u3002\u6700\u8fd1\u306e\u4e0d\u5b89\u5b9a\u5316\u304c\u3042\u3063\u305f\u65b9\u306b\u306f\u3001\u6cbb\u7642\u4e88\u7d04\u306e\u524d\u306b\u4e00\u5b9a\u671f\u9593\u306e\u5b89\u5b9a\u3092\u78ba\u8a8d\u3059\u308b\u5fc5\u8981\u304c\u3042\u308a\u307e\u3059\u3002<\/p>\n<\/div>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"aioseo-if-you-are-considering-the-next-step-for-your-severe-asthma-106\"><mark style=\"background-color:#dce9f5\" class=\"has-inline-color\">\u6b21\u306e\u30b9\u30c6\u30c3\u30d7\u3092\u691c\u8a0e\u3055\u308c\u3066\u3044\u308b\u65b9\u3078<\/mark><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">\u3053\u3053\u307e\u3067\u8aad\u3093\u3067\u304f\u3060\u3055\u3063\u305f\u65b9\u306f\u3001\u6a19\u6e96\u7684\u306a\u91cd\u75c7\u5598\u606f\u6cbb\u7642\u3092\u3059\u3067\u306b\u4e00\u901a\u308a\u7d4c\u9a13\u3055\u308c\u3001\u5e79\u7d30\u80de\u6cbb\u7642\u304c\u3054\u81ea\u8eab\u306e\u72b6\u6cc1\u306b\u5bfe\u3059\u308b\u59a5\u5f53\u306a\u6b21\u306e\u4e00\u6b69\u306a\u306e\u304b\u3001\u305d\u308c\u3068\u3082\u307e\u305f\u5225\u306e\u5408\u308f\u306a\u3044\u9078\u629e\u80a2\u306a\u306e\u304b\u3092\u898b\u6975\u3081\u3088\u3046\u3068\u3055\u308c\u3066\u3044\u308b\u65b9\u3060\u3068\u601d\u3044\u307e\u3059\u3002\u79c1\u305f\u3061\u306f\u305d\u306e\u554f\u3044\u3092\u5c0a\u91cd\u3057\u3001\u540c\u3058\u59ff\u52e2\u3067\u304a\u8a71\u3057\u3057\u307e\u3059\u3002<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u79c1\u305f\u3061\u306f\u7121\u6599\u306e\u30aa\u30f3\u30e9\u30a4\u30f3\u76f8\u8ac7\u3092\u884c\u3063\u3066\u3044\u307e\u3059\u3002\u76f4\u8fd1\u306e\u30b9\u30d1\u30a4\u30ed\u30e1\u30c8\u30ea\u30fc\u3001\u8840\u4e2d\u597d\u9178\u7403\u6570\u3001\u751f\u7269\u5b66\u7684\u88fd\u5264\u306e\u4f7f\u7528\u6b74\u3001\u73fe\u5728\u306e\u51e6\u65b9\u4e00\u89a7\u3092\u304a\u6301\u3061\u3044\u305f\u3060\u3051\u308c\u3070\u3001\u79c1\u305f\u3061\u306e\u65b9\u3067\u30b1\u30fc\u30b9\u3092\u4e01\u5be7\u306b\u691c\u8a0e\u3057\u3001\u6cbb\u7642\u304c\u5408\u3046\u3068\u8003\u3048\u308b\u304b\u3069\u3046\u304b\u3001\u5408\u308f\u306a\u3044\u3068\u8003\u3048\u308b\u306a\u3089\u305d\u306e\u7406\u7531\u3092\u7387\u76f4\u306b\u304a\u4f1d\u3048\u3057\u307e\u3059\u3002\u4f55\u304b\u3092\u6c7a\u3081\u3066\u304b\u3089\u3054\u9023\u7d61\u3044\u305f\u3060\u304f\u5fc5\u8981\u306f\u3042\u308a\u307e\u305b\u3093\u3002<\/p>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"aioseo-references-112\"><mark style=\"background-color:#dce9f5\" class=\"has-inline-color\">\u53c2\u8003\u6587\u732e<\/mark><\/h2>\n\n\n\n<ol class=\"wp-block-list\">\n<li>GBD 2021 Asthma Collaborators. &#8220;Global, regional, national burden of asthma from 1990 to 2021, with projections of incidence to 2050: a systematic analysis of the global burden of disease study 2021.&#8221; eClinicalMedicine. 2024. <a href=\"https:\/\/doi.org\/10.1016\/j.eclinm.2024.102921\" target=\"_blank\" rel=\"noopener\" title=\"\">https:\/\/doi.org\/10.1016\/j.eclinm.2024.102921<\/a><\/li>\n\n\n\n<li>Shin JW, Ryu S, Ham J, Jung K, Lee S, Chung DH, Kang HR, Kim HY. &#8220;Mesenchymal Stem Cells Suppress Severe Asthma by Directly Regulating Th2 Cells and Type 2 Innate Lymphoid Cells.&#8221; Molecules and Cells. 2021;44(8):580\u2013590. <a href=\"https:\/\/doi.org\/10.14348\/molcells.2021.0101\" target=\"_blank\" rel=\"noopener\" title=\"\">https:\/\/doi.org\/10.14348\/molcells.2021.0101<\/a><\/li>\n\n\n\n<li>Sharan J, et al. &#8220;Safety of cultured allogeneic adult umbilical cord-derived mesenchymal stem cell intravenous infusion for the treatment of pulmonary diseases: Preliminary findings (NCT05147688).&#8221; 2023. ClinicalTrials.gov: <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05147688\" target=\"_blank\" rel=\"noopener\" title=\"\">https:\/\/clinicaltrials.gov\/study\/NCT05147688<\/a><\/li>\n\n\n\n<li>ClinicalTrials.gov NCT05035862. &#8220;A Phase 1 Study to Evaluate Safety, Toxicity, and Potential Mechanisms of Interferon Gamma-primed Mesenchymal Stromal Cells (MSCs) for Moderate-to-severe Persistent Asthma.&#8221; Emory University. <a href=\"https:\/\/clinicaltrials.gov\/study\/NCT05035862\" target=\"_blank\" rel=\"noopener\" title=\"\">https:\/\/clinicaltrials.gov\/study\/NCT05035862<\/a><\/li>\n\n\n\n<li>Wang LT, Liu KJ, Sytwu HK, Yen ML, Yen BL. &#8220;Advances in mesenchymal stem cell therapy for immune and inflammatory diseases: Use of cell-free products and human pluripotent stem cell-derived mesenchymal stem cells.&#8221; Stem Cells Translational Medicine. 2021;10(9):1288\u20131303. <a href=\"https:\/\/doi.org\/10.1002\/sctm.21-0021\" target=\"_blank\" rel=\"noopener\" title=\"\">https:\/\/doi.org\/10.1002\/sctm.21-0021<\/a><\/li>\n\n\n\n<li>Wang YH, Tsai DY, Ko YA, Yang TT, Lin IY, Hung KH, Lin KI. &#8220;Mesenchymal Stem\/Stromal Cells in Asthma Therapy: Mechanisms and Strategies for Enhancement.&#8221; Cell Transplantation. 2023. <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10278440\/\" target=\"_blank\" rel=\"noopener\" title=\"\">https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC10278440\/<\/a><\/li>\n\n\n\n<li>Bagnasco D, Caminati M, Menzella F, Milanese M, Rolla G, Lombardi C, Bucca C, Heffler E, Paoletti G, Testino E, et al. &#8220;One year of mepolizumab. Efficacy and safety in real-life in Italy.&#8221; Pulmonary Pharmacology &amp; Therapeutics. 2019;58:101836. <a href=\"https:\/\/doi.org\/10.1016\/j.pupt.2019.101836\" target=\"_blank\" rel=\"noopener\" title=\"\">https:\/\/doi.org\/10.1016\/j.pupt.2019.101836<\/a><\/li>\n\n\n\n<li>Volpato M, Vianello A, Antonicelli L, Bagnasco D, Caminati M, Canonica GW, et al. &#8220;Oral Corticosteroids Dependence and Biologic Drugs in Severe Asthma: Myths or Facts? A Systematic Review of Real-World Evidence.&#8221; International Journal of Molecular Sciences. 2021;22(13):7132. <a href=\"https:\/\/doi.org\/10.3390\/ijms22137132\" target=\"_blank\" rel=\"noopener\" title=\"\">https:\/\/doi.org\/10.3390\/ijms22137132<\/a><\/li>\n\n\n\n<li>Chung KF, Wenzel SE, Brozek JL, Bush A, Castro M, Sterk PJ, et al. &#8220;International ERS\/ATS guidelines on definition, evaluation and treatment of severe asthma.&#8221; European Respiratory Journal. 2014;43:343\u2013373. <a href=\"https:\/\/doi.org\/10.1183\/09031936.00202013\" target=\"_blank\" rel=\"noopener\" title=\"\">https:\/\/doi.org\/10.1183\/09031936.00202013<\/a><\/li>\n\n\n\n<li>Song N, Scholtemeijer M, Shah K. &#8220;Mesenchymal Stem Cell Immunomodulation: Mechanisms and Therapeutic Potential.&#8221; Trends in Pharmacological Sciences. 2020;41(9):653\u2013664. <a href=\"https:\/\/doi.org\/10.1016\/j.tips.2020.06.009\" target=\"_blank\" rel=\"noopener\" title=\"\">https:\/\/doi.org\/10.1016\/j.tips.2020.06.009<\/a><\/li>\n<\/ol>\n\n\n\n<div style=\"height:40px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\t\t<div data-elementor-type=\"section\" data-elementor-id=\"21873\" class=\"elementor elementor-21873\" data-elementor-post-type=\"elementor_library\">\n\t\t\t        <section class=\"elementor-section elementor-top-section elementor-element elementor-element-a6ebaad elementor-section-boxed elementor-section-height-default elementor-section-height-default pxl-row-scroll-none pxl-zoom-point-false pxl-section-overflow-visible pxl-section-fix-none pxl-bg-color-none pxl-section-overlay-none\" data-id=\"a6ebaad\" data-element_type=\"section\" data-e-type=\"section\">\n\n                \n                <div class=\"elementor-container elementor-column-gap-default \">\n                <div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d089a17 pxl-column-none 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